Paraprobiotics and postbiotics from the probiotic Streptococcus lutetiensis isolated from Indian fermented food demonstrates immunomodulatory potential by Jeet P. Mehta, Puspalata Sahoo, Sonal Ayakar, Rekha S. Singhal

“…This study investigates the functional potential of Streptococcus lutetiensis isolated from pakhala bhata, a traditionally fermented Indian food, focusing on its probiotic characteristics, paraprobiotic and postbiotic preparations, metabolite profiling, and immunomodulatory effects. …”
Get full text

Friend leukemia virus integration 1 is a predictor of poor prognosis of breast cancer and promotes metastasis and cancer stem cell properties of breast cancer cells by Xu Yan, Yu Yu, Lingyu Li, Naifei Chen, Wei Song, Hua He, Jie Dong, Xiangliang Liu, Jiuwei Cui

“…To further verify the effect of FLI‐1 in promoting the metastasis of TNBC, we performed a series of functional experiments in vitro and orthotopic xenograft experiments in the mammary fat pad of nude mice. …”
Get full text

Development of Immune-Regulatory Pseudo-Protein-Coated Iron Oxide Nanoparticles for Enhanced Treatment of Triple-Negative Breast Tumor by Ying Ji, Juan Li, Li Ma, Zhijie Wang, Bochu Du, Hiu Yee Kwan, Zhaoxiang Bian, Chih-Chang Chu

“…This research developed functional polymers that are complexed with therapeutic molecules as a coating strategy for iron oxide nanoparticles. …”
Get full text

Age-related and postmenopausal breast cancer progression and treatment management: The significance of pro-inflammatory cytokines and CXC chemokines by Amin Ullah, Rajeev K. Singla, Dan Cao, Boyang Chen, Bairong Shen

“…Therefore, in this review, we focus on the functional significance studies of proinflammatory cytokines, CXCs, and CXCRs and describe their roles in influencing breast cancer progression in older women and their factors, such as obesity in postmenopausal women. …”
Get full text

Targeting Latent HIV Reservoirs: Effectiveness of Combination Therapy with HDAC and PARP Inhibitors by Hasset Tibebe, Dacia Marquez, Aidan McGraw, Sophia Gagliardi, Cailyn Sullivan, Grace Hillmer, Kedhar Narayan, Coco Izumi, Adleigh Keating, Taisuke Izumi

“…The “Kick and Kill” strategy, which aims to reactivate latent HIV reservoirs and facilitate the clearance of reactivated HIV-infected cells, has yet to achieve a functional cure due to the limited efficacy of current latency reversal agents. …”
Get full text

Crucian Carp-Derived ACE-Inhibitory Peptides with In Vivo Antihypertensive Activity: Insights into Bioactivity, Mechanism, and Safety by Runxi Han, Jingshan Tian, Yingge Han, Guoxiang Wang, Guanghong Zhou, Chen Dai, Chong Wang

“…These findings suggest that GA-Hyp-GAR is a promising natural ACE inhibitor with potential application in functional foods or as a nutraceutical for hypertension management.…”
Get full text

Oleic acid activates TGFβ-Smad3 signaling to promote ovarian cancer progression by Zhengyang Guo, Yinjia Li, Yunyun Guo, Aosong Zhang, Xiao Huo, Ying Song, Bing Li, Yuanjun Tang, Tianhui He, Tong Liu, Lixiang Xue, Yi Qu, Jiagui Song

“…Notably, oleic acid is abundant in ovarian cancer ascites, though its functional significance in TME modulation and tumor metastatic regulation remains poorly characterized. …”
Get full text

Insulin like growth factor 2 mRNA binding protein 2 regulates vascular development in cerebral arteriovenous malformations by Lin-jian Wang, Lin-jian Wang, Lin-jian Wang, Yangyang Wu, Yangyang Wu, Yangyang Wu, Sha Xie, Hongkai Lian, Hongkai Lian, Hongkai Lian

“…The roles of specific genes in vascular development were assessed using endothelial cell cultures and zebrafish models.ResultsOur analysis of RNA-seq data from cerebral AVMs and normal tissues identified IGF2BP2, a key N6-methyladenosine (m6A) reader, as significantly downregulated in cerebral AVMs. Functional studies showed that IGF2BP2 knockdown resulted in abnormal angiogenesis in endothelial cells and disrupted vascular development in zebrafish models. …”
Get full text

Single-cell and multi-omics integration reveals cholesterol biosynthesis as a synergistic target with HER2 in aggressive breast cancer by Tzu-Yang Tseng, Chiao-Hui Hsieh, Jie-Yu Liu, Hsuan-Cheng Huang, Hsueh-Fen Juan

“…In this study, we developed an integrative computational framework that combines single-cell RNA sequencing (scRNA-seq) and multi-omics analyses to delineate the functional characteristics of malignant cell subsets in breast cancer patients. …”
Get full text

Rheological Behavior, Textural Properties, and Antioxidant Activity of <i>Porphyra yezoensis</i> Polysaccharide by Chenyang Ji, Xiaoshan Long, Jingjie Wang, Bo Qi, Yang Cao, Xiao Hu

“…Furthermore, PYPS possessed significant scavenging ability against DPPH, ABTS, and HO• radicals, demonstrating its potential application as a natural antioxidant in functional foods.…”
Get full text

SETDB1 knockdown boosts recombinant protein in CHO cells via epigenetic transcriptional silencing by Jiang-Tao Lu, Miao Zhang, Yan-Ping Gao, Lu-Lu Yang, Zhao-Ming Cui, Ming-Ming Han, Xi Zhang, Hong-Yan Xu, Xiao-Yin Wang, Le-Le Qiu, Zi-Chun Hua, Tian-Yun Wang, Yan-Long Jia

“…SET domain bifurcated histone lysine methyltransferase 1 (SETDB1) catalyzes histone 3 lysine 9 trimethylation (H3K9me3), a critical epigenetic modification regulating gene expression. Despite its functional importance, the dynamics of SETDB1 expression and its regulatory impacts in CHO cells remain poorly characterised. …”
Get full text

Proteome Profiling of <i>Cucurbita pepo</i> Phyllosphere After Infection by <i>Podosphaera xanthii</i> and Application of <i>Reynoutria sachalinensis</i> Extract by Ioannis Theologidis, Manousos Makridakis, Aikaterini Termentzi, Eirini Baira, Jerome Zoidakis, Dimosthenis Kizis

“…In these three comparisons, KEGG and Gene Ontology functional analyses highlighted unique differentially enriched pathways—some of which included highly expressed proteins—in PX-related (proteasome, pentose phosphate pathway, and carbon fixation), RS-related (biosynthesis of secondary metabolites, flavonoids, and starch and sucrose metabolism), and RSPX-related (pyruvate metabolism and polycomb repressive complex) comparisons, respectively, suggesting distinct mechanisms of early plant responses modulated by PX and RS. …”
Get full text

Platelet-Rich Plasma in Cardiovascular Regeneration: Mechanistic Insights, Technological Innovations, and Future Directions by Ju Tian, Jing Chen, Xiuling Lai, Jing Ding, Jie Sun, Dandan Shi, Xiaoying He, Xingqi Chen

“…PRP exerts therapeutic effects through three primary mechanisms: promoting angiogenesis by stimulating endothelial cell proliferation and migration, exerting anti-inflammatory and immunomodulatory effects by balancing cytokine release, and enhancing myocardial repair and functional recovery by activating resident cardiac progenitor cells. …”
Get full text

Effect of Kinases in Extracellular Vesicles from HIV-1-Infected Cells on Bystander Cells by Gifty A. Mensah, Anastasia Williams, Pooja Khatkar, Yuriy Kim, James Erickson, Alexandra Duverger, Heather Branscome, Kajal Patil, Hafsa Chaudhry, Yuntao Wu, Olaf Kutsch, Fatah Kashanchi

“…Although great strides have been made in treatment options for HIV-1, and our understanding of the HIV-1 life cycle has vastly improved since the start of this global health crisis, a functional cure remains elusive. One of the main barriers to a cure is latency, which allows the virus to persist despite combined antiretroviral therapy (cART). …”
Get full text

Application of improved graph convolutional network for cortical surface parcellation by Jia Tan, Xiaomei Ren, Yong Chen, Xianju Yuan, Feiba Chang, Rui Yang, Chengqun Ma, Xiaoyu Chen, Miao Tian, Wei Chen, Zihong Wang

“…Abstract Accurate cortical surface parcellation is essential for elucidating brain organizational principles, functional mechanisms, and the neural substrates underlying higher cognitive and emotional processes. …”
Get full text

Osteosarcoma Cell‐Derived Migrasomes Promote Macrophage M2 Polarization to Aggravate Osteosarcoma Proliferation and Metastasis by Wanshun Liu, Lei Li, Xiaoming Bai, Mengxue Zhang, Wei Lv, Yongbin Ma, Yuzhi Sun, Hongjing Zhang, Qing Jiang, Qingqiang Yao, Zhi‐Yuan Zhang

“…Further studies revealed that migrasome‐associated nanoparticles (MANPs) are the functional unit of OCDMs and that OCDMs promote M2 polarization of macrophages in the TME in a MANPs‐dependent manner. …”
Get full text

Astrocyte heterogeneity in ischemic stroke: Molecular mechanisms and therapeutic targets by Daxing Li, Xinchen Huo, Ling Shen, Minjie Qian, Jindou Wang, Shijie Mao, Wenjing Chen, Runheng Li, Tianhao Zhu, Beicheng Zhang, Kunxuan Liu, Feifei Wu, Ying Bai

“…Astrocytes are the most ubiquitous cells in the brain, and they undergo morphological and functional changes after brain insults, which has been known as astrocyte reactivity. …”
Get full text

Pre-clinical model of dysregulated FicD AMPylation causes diabetes by disrupting pancreatic endocrine homeostasis by Amanda K. Casey, Nathan M. Stewart, Naqi Zaidi, Hillery F. Gray, Hazel A. Fields, Masahiro Sakurai, Carlos A. Pinzon-Arteaga, Bret M. Evers, Jun Wu, Kim Orth

“…The bi-functional enzyme FicD catalyzes AMPylation and deAMPylation of the endoplasmic reticulum chaperone BiP to modulate ER homeostasis and the unfolded protein response (UPR). …”
Get full text

Neonatal-Inspired Reprogramming of Microglial Pan-Programmed Cell Death Enhances Regeneration in Adult Spinal Cord Injury by Beibei Yu, Yongfeng Zhang, Yujie Yang, Shijie Yang, Haining Wu, Xue Gao, Yiming Hao, Shengyou Li, Bing Xia, Jintao Liu, Lingli Guo, Borui Xue, Mingze Qin, Huangtao Chen, Jianzhong Li, Shouping Gong, Teng Ma, Jinghui Huang

“…According to computational drug screening, withaferin A can revert microglial pan-PCD in adults to a neonatal-like regenerative state. Histological, functional, and molecular analyses corroborated that withaferin A enhances SCI recovery in adults by modulating microglial pan-PCD. …”
Get full text

A dynamically phase-adaptive regulating hydrogel promotes ultrafast anti-fibrotic wound healing by Fan Zhang, Haijuan Zhang, Shengfu Wang, Mingying Gao, Kaiyi Du, Xinyuan Chen, Yang Lu, Qianqian Hu, Anyu Du, Shenghu Du, Jian Wang, Keqing Shi, Zimiao Chen, Zhuo Li, Zhenglin Li, Jian Xiao

“…Herein, a dynamically Schiff base-crosslinked hydrogel (F/R gel) with phase-adaptive regulating functions is constructed to integratedly promote rapid re-epithelization with suppressed scars on chronic infected wounds. …”
Get full text