ih-RIDME: a pulse EPR experiment to probe the heterogeneous nuclear environment by S. Kuzin, V. N. Syryamina, M. Qi, M. Fischer, M. Hülsmann, A. Godt, G. Jeschke, M. Yulikov

“…Therefore, the fitted distribution function can further serve as a method for heterogeneity characterization, quantification and structure-based analysis. …”
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In vitro and in vivo study of concentrated growth factor (CGF) mediating macrophage polarization in bone defect repair by Deng xin, Zheng Junwen, Zou Jiacheng, Xun Qiongyu, He Huanzong, Li peng, Liao juan

“…Mechanistically, CGF promotes the phosphorylation of STAT3, which in turn induces M2 macrophage polarization, suggesting that the function of CGF-mediated macrophages may be associated with the STAT3 signaling pathway. …”
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Probiotic membrane vesicles ameliorate atherosclerotic plaques by promoting lipid efflux and polarization of foamy macrophages by Boping Jing, Yu Gao, Lufang Wang, Feng Guo, Dawei Jiang, Saimei Qin, Mengrong He, Ying Bai, Rui An, Mingxing Xie, Li Zhang

“…This study is significant as it introduces MVs as a novel therapeutic platform for the targeted delivery of anti-inflammatory agents to atherosclerotic sites. By specifically modulating macrophage function, MVs hold considerable potential for the treatment of atherosclerosis and related cardiovascular diseases, addressing an unmet need in current therapeutic strategies.…”
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SSB Pruned DFT-Spread FBMC Signal With Low PAPR in Direct-Detection PONs by Xiaoling Zhang, Chongfu Zhang, Mingyue Zhu, Wei Jin, Chen Chen, Xiang Gao, Kun Qiu

“…Filter bank multi-carrier (FBMC) using offset quadrature amplitude modulation (OQAM) has recently attracted increasing interests for the next-generation high-speed optical transmission systems, due to the salient FBMC modulation advantages in terms of high spectrum efficiency by completely removing the cyclic prefix. …”
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Various Designs of Spoke-Type Permanent Magnet Motor for Performance Optimization by Vasilija Sarac, Dragan Minovski, Sara Aneva, Petar Janiga, Miroslava Farkas Smitkova, Darko Bogatinov, Ana Atanasova

“…The application of optimetric analysis also enables the execution of a sensitivity analysis, examining the impact of each varied parameter on the corresponding objective function. The presented methodology offers the designer a range of solutions that can be identified as optimal, providing greater flexibility in the construction of appropriate prototypes.…”
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Extracellular vesicles from adipose-derived mesenchymal stem cells alleviate acute lung injury via the CBL/AMPK signaling pathway by Yan Xiong, Lulu Wang, Bohao Li, Beibei Fu, Zhou Sha, Jin Liu, Rong Tian, Rui Yao, Feng Lin, Zixuan Cong, Yongliang Du, Xiaoyuan Lin, Haibo Wu

“…Results We showed that ADSCs and ADSCs-derived EVs supplementation could improve lung injury, restore mitochondrial function, and inhibit inflammation and apoptosis in ALI mice. …”
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Self‐Selective Crossbar Synapse Array with n‐ZnO/p‐NiOx/n‐ZnO Structure for Neuromorphic Computing by Peter Hayoung Chung, Jiyeon Ryu, Daejae Seo, Dwipak Prasad Sahu, Minju Song, Junghwan Kim, Tae‐Sik Yoon

“…The built‐in potential barrier at p‐NiOx/n‐ZnO junction and the Zener tunneling effect provided nonlinear current–voltage characteristics at both voltage polarities for self‐selecting function for synaptic potentiation and depression operations. …”
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Elastic Relaxation of Coherent InGaN/GaN Interfaces at the Microwire LED Sidewall by Jongil Kim, Jinwook Yeo, Bumsu Park, Jeehun Jeong, Seunghwa Ryu, Sang Ho Oh

“…An analytical model is developed based on the Airy stress function, which incorporates the superposition of alternating in‐plane pre‐stress and the image stress to satisfy the boundary condition. …”
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A Mechanistic Approach to Replacing Antibiotics with Natural Products in the Treatment of Bacterial Diarrhea by Mingbang Wei, Huaizhi Liu, Zhefan Hu, Peixiao Wen, Yourong Ye, Yangzom Chamba, Hongliang Zhang, Peng Shang

“…Natural products, containing a wide array of bioactive compounds, can not only directly inhibit the growth of pathogenic bacteria, disrupt bacterial membrane synthesis, and reduce toxin production, but also modulate inflammatory responses, enhance immune function, repair intestinal barriers, and restore gut microbial ecology—highlighting their systemic and multi-targeted therapeutic potential. …”
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Adenosinergic Signalling in Cervical Cancer Microenvironment by Isabele Cristiana Iser, Ana Paula Santin Bertoni, Liziane Raquel Beckenkamp, Marcia Edilaine Lopes Consolaro, Silvya Stuchi Maria-Engler, Marcia Rosângela Wink

“…We herein reviewed the pathophysiological function of CD73 in cervical cancer and performed in silico analysis of the main components of the adenosinergic signalling in human tissues of cervical cancer compared to non-tumour cervix tissue. …”
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Unsupervised Anomaly Detection with Continuous-Time Model for Pig Farm Environmental Data by Heng Zhou, Seyeon Chung, Malik Muhammad Waqar, Muhammad Ibrahim Zain Ul Abideen, Arsalan Ahmad, Muhammad Ans Ilyas, Hyongsuk Kim, Sangcheol Kim

“…The model is trained in a self-supervised manner and optimized using a reconstruction-based loss function. Extensive experiments are conducted on a multivariate multi-sequence dataset collected from real-world pig farming environments. …”
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Multifunctional dual-layer microneedles loaded with selenium-doped carbon quantum dots and Astilbin for ameliorating diabetic wound healing by Zhen Zhang, Yulin Zhang, Liang Peng, Yi Xing, Xinru Zhou, Shuo Zheng, Yanli Zhang, Longquan Shao

“…Preliminary findings suggest these effects may involve the modulation of cytoskeletal dynamics and peroxisome function, contributing to endothelial cell migration and angiogenesis. …”
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Distribution of two CD4+FOXP3+ T cell subpopulations reflects disease phenotypes and prognosis in COPD by Jia Hou, Jiale Zhao, Hua He, Weirong Ma, Dan Wang, Xinru Peng, Xiahui Ge, Juan Chen

“…Type B COPD patients, who demonstrated more severe emphysema, heightened inflammatory responses, faster lung function decline, and more pronounced osteoporosis, showed a significant increase in FOXP3lo non-suppressive T cells. …”
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Naltriben promotes tumor growth by activating the TRPM7-mediated development of the anti-inflammatory M2 phenotype by Viviane Nascimento Da Conceicao, Yuyang Sun, Manigandan Venkatesan, Jorge De La Chapa, Karthik Ramachandran, Rahul S. Jasrotia, Victor Drel, Xiufang Chai, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh

“…Abstract Macrophage plasticity is critical for maintaining immune function and developing solid tumors; however, the macrophage polarization mechanism remains incompletely understood. …”
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Novel Hyperplastic Expansion of White Adipose Tissue Underlies the Metabolically Healthy Obese Phenotype of Male LFABP Null Mice by Anastasia Diolintzi, Yinxiu Zhou, Angelina Fomina, Yifei Sun, Seema Husain, Labros S. Sidossis, Susan K. Fried, Judith Storch

“…Transcriptomic analysis of SAT revealed that <i>Lfabp</i> deletion alters the expression of multiple pathways that modulate adipose expansion and function including cholesterol biosynthesis, adipogenesis, and extracellular matrix remodeling. …”
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Putting a Kink in HIV-1 Particle Infectivity: Rocaglamide Inhibits HIV-1 Replication by Altering Gag-Genomic RNA Interaction by Paul Rosenfeld, Gatikrushna Singh, Amanda Paz Herrera, Juan Ji, Bradley Seufzer, Xiao Heng, Kathleen Boris-Lawrie, Alan Cochrane

“…Our examination of RNA helicases for effects on HIV-1 protein production and particle assembly identified Rocaglamide (RocA), a known modulator of eIF4A1 function, as an inhibitor of HIV-1 replication in primary CD4⁺ T cells and three cell systems. …”
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Deciphering the role of classical oestrogen receptor in insulin resistance and type 2 diabetes mellitus: From molecular mechanism to clinical evidence by Haryati Ahmad Hairi, Nurul Izzah Ibrahim, Muhammad Zulfiqah Sadikan, Putri Ayu Jayusman, Ahmad Nazrun Shuid

“…Numerous in vivo and in vitro studies have demonstrated that loss of circulating oestrogen modulated by classical ERα and ERβ led to rapid changes in pancreatic β-cell and islet function, GLUT4 expression, insulin sensitivity and glucose tolerance, dysfunctional lipid homeostasis, oxidative stress, and inflammatory cascades. …”
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Multiple roles of ALDH1 in health and disease by Wenqi Zhao, Wenqi Zhao, Yu Xia, Yu Xia, Zhiqi Gao, Zhiqi Gao, Jian Chen, Jian Chen, Erlong Zhang, Erlong Zhang

“…Aldehyde dehydrogenase 1 (ALDH1) is an important aldehyde-metabolizing enzyme that plays a key role in various biological processes, such as regulating cellular growth, modulating retinoic acid (RA) signaling pathways, and contributing to stem cell function. …”
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Uncovering the mechanisms underlying the efficacy of probiotic strains in mitigating food allergies: an emphasis on gut microbiota and indoleacrylic acid by Zhangming Pei, Zhangming Pei, Li Qian, Li Qian, Taolin Miao, Hongchao Wang, Hongchao Wang, Wenwei Lu, Wenwei Lu, Wenwei Lu, Yuqing Chen, Qianger Zhuang

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Bioinformatics analysis reveals shared molecular pathways for relationship between ulcerative colitis and primary sclerosing cholangitis by Pooya Jalali, Malihe Rezaee, Alireza Yaghoobi, Moein Piroozkhah, Mohammad Reza Zabihi, Shahram Aliyari, Zahra Salehi

“…Gene expression analysis identified 56 common DEGs between the two diseases. Following functional enrichment analysis, 207 significant biological processes (BP), 48 molecular functions (MF), and 8 KEGG pathways, with notable enrichment in mRNA-related processes such as mRNA splicing and RNA binding, were defined. …”
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