Allochrony in Atlantic Lumpfish: Genomic and Otolith Shape Divergence Between Spring and Autumn Spawners by Mathilde Horaud, Núria Raventós, Kim Præbel, Carles Galià‐Camps, Cinta Pegueroles, Carlos Carreras, Marta Pascual, Victor M. Tuset, Shripathi Bhat, Arve Lynghammar

“…Genomic differences between the two groups were concentrated in three chromosomes, with a region of chromosome 1 encompassing the same single nucleotide polymorphisms (SNPs) driving differential season spawning for both localities, suggesting parallel responses. The functional analysis of the SNPs in this region revealed genes associated with responses to environmental stressors, possibly adaptations to seasonal variations at high latitudes. …”
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Association between oral microbial nitrate metabolism and poor prognosis in acute ischemic stroke patients with a history of hypertension by Yueran Ren, Jingru Liang, Weike Hu, Jiahui Xie, Yifeng Zheng, Wei Song, Jiajia Zhu, Hongwei Zhou, Qiheng Wu, Yan He, Jia Yin

“…Microbial composition was analyzed using LEfSe and PICRUSt2 for bacterial and functional pathway identification.Results Significant differences in oral microbiota composition were observed between hypertensive AIS patients with varying CVs. …”
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CD73 Expression on Mesenchymal Stem Cells Dictates the Reparative Properties via Its Anti-Inflammatory Activity by Kezhe Tan, Hongtao Zhu, Jianfang Zhang, Weili Ouyang, Jianfeng Tang, Youming Zhang, Linlin Qiu, Xueqing Liu, Zhaoping Ding, Xiaoming Deng

“…Transplantation of two types of cells into mouse hearts after myocardial infarction (MI) revealed that the CD73high pMSC preferentially brought about structural and functional repair in comparison to the PBS control and CD73low pMSC. …”
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Traditional Chinese herbal tea Psychotria rubra suppresses inflammatory response caused by respiratory tract infections via STAT3/IL-6/TNF by Wenlan Li, Zijie Zhang, Zixiao Jiang, Jayanthi Barasarathi, Ying Zhou, Sui Liu, Shiou Yih Lee, Yangyang Liu

“…These findings provide scientific evidence for the development of PRHT as a functional anti-inflammatory agent and offer new insights into treatment strategies for respiratory infections.…”
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Insights into the Regulatory Roles of miRNAs in the Salivary Glands of the Soft Ticks <i>Ornithodoros moubata</i> and <i>Ornithodoros erraticus</i> by Ana Laura Cano-Argüelles, Ricardo Pérez-Sánchez, Cristian Gallardo-Escárate, Rocío Vizcaíno-Marín, María González-Sánchez, Ana Oleaga

“…In ticks, salivary miRNAs are proposed to play key roles in modulating host–vector interactions during blood feeding. …”
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The Regulatory Roles of RNA-Binding Proteins in Plant Salt Stress Response by Tangying Wang, Kaiyuan Meng, Zilin Zhu, Linxuan Pan, Thomas W. Okita, Laining Zhang, Li Tian

“…This review systematically evaluates the functional roles of RBPs localized in distinct subcellular compartments, including nuclear, cytoplasmic, chloroplastic, and mitochondrial systems, in mediating post-transcriptional regulatory networks under salinity challenges. …”
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Longevity cosmeceuticals as the next frontier in cosmetic innovation: a scientific framework for substantiating product claims by Wannita Klinngam, Athit Chaiwichien, Supawadee Osotprasit, Uracha Ruktanonchai, Mayuree Kanlayavattanakul, Mayuree Kanlayavattanakul, Nattaya Lourith, Nattaya Lourith, Amaraporn Wongrakpanich, Veerawat Teeranachaideekul, Tawin Iempridee

“…To clearly distinguish these scientifically validated products from marketing-driven claims, we define, for the first time, longevity cosmeceutical actives and products based on stringent criteria: (1) they must directly target and modulate established hallmarks of skin aging; (2) they must demonstrably extend “skinspan” over time, reflected by improved skin viability, structure, and functional integrity; and (3) their efficacy must be validated through clinical trials, preferably with post-trial skin biopsies to evaluate aging hallmark biomarkers, along with comprehensive safety assessments. …”
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Comprehensive Transcriptomic Analysis of Brain Tissues From the Infarcted Area of MCAO Rats Revealed That Acupuncture Attenuates Brain Injury via the Complement System by Yanlin Liu, Yuting Jin, Yuxin Liu, Jiaqi Gao, Xiaomei Wang, Hongbin Ren, Yabo Hao, Xibin Yang, Kaitao Luo

“…Seven complement‐related genes (C1QA, C1QB, C1QC, C2, C6, C7, and TREM2) were significantly downregulated by acupuncture. Functional enrichment revealed that these genes were involved in the inflammatory response, coagulation cascades, blood‒brain barrier regulation, and neutrophil extracellular trap (NET) formation. …”
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Role of ebv-circRPMS1–p53 interaction in the proliferation and clinical progression of Epstein–Barr virus-associated gastric carcinoma by Ling Yang, Meini Li, Guiming Xie, Xian Wu, Mingxiong Qin, Birong Guo, Jingyue Zhang

“…Background: Epstein–Barr virus-associated gastric carcinoma (EBVaGC) represents a distinct clinicopathological entity with unique molecular characteristics, including latent EBV infection and dysregulation of host tumor suppressors. However, the functional interplay between EBV circular RNAs (ebv-circRNAs) and p53 protein remains enigmatic. …”
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First-Principles Study on Periodic Pt₂Fe Alloy Surface Models for Highly Efficient CO Poisoning Resistance by Junmei Wang, Qingkun Tian, Harry E. Ruda, Li Chen, Maoyou Yang, Yujun Song

“…This study employs density functional theory (DFT) calculations and Monte Carlo simulations combined with the cluster-expansion approach to investigate atom distribution and Pt segregation in Pt-Fe alloys across varying Pt/Fe ratios. …”
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Excited-State-Altering Ratiometric Fluorescent Probes for the Response of <i>β</i>-Galactosidase in Senescent Cells by Ya-Nan Han, Lei Dong, Lu-Lu Sun, Wen-Jia Li, Jianjing Xie, Congyu Li, Shuhui Ren, Zhan Zhang, Hai-Hao Han, Zhong Zhang

“…The enzyme-responsive optical red-shifts are attributed to the excited-state transition from intramolecular charge transfer (ICT) state to local excited (LE) state, which was confirmed by density functional theory (DFT) calculations. Both fluorescent sensors display exceptional sensitivity and selectivity for the response of <i>β</i>-Gal in PBS solution and are capable of tracking <i>β</i>-Gal within senescent A549 cells. …”
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USP5‐Rich Apoptotic Extracellular Vesicles Regulate Nucleus Pulposus Cells Apoptosis and DNA Damage Repair by Preventing E2F1 Proteasomal Degradation by Pengzhi Shi, Haiyang Gao, Zhangrong Cheng, Wenbo Wu, Anran Zhang, Xianglong Chen, Wang Wu, Yukun Zhang

“…This cascade reduces DNA damage and apoptosis in NPCs and enhances their functional activity. Overall, our findings reveal a previously unrecognized mechanism by which apoptotic donor MSCs exert therapeutic effects through intercellular communication, specifically by modulating recipient NPCs apoptosis and DDR pathways. …”
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In Vitro Gastrointestinal Bioaccessibility of the Phenolic Fraction from <i>Agave inaequidens</i> Flower by Imelda N. Monroy-García, Laura Lucely González-Galván, Catalina Leos-Rivas, Mayra Z. Treviño-Garza, Eduardo Sánchez-García, Ezequiel Viveros-Valdez

“…These findings underscore its potential as a functional food ingredient, offering bioaccessible phenolic compounds with antioxidant and enzyme inhibitory properties.…”
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Understanding the molecular mechanism responsible for developing therapeutic radiation-induced radioresistance of rectal cancer and improving the clinical outcomes of radiotherapy... by Samatha M Jain, Shruthi Nagainallur Ravichandran, Makalakshmi Murali Kumar, Antara Banerjee, Alexander Sun-Zhang, Hong Zhang, Rupak Pathak, Xiao-Feng Sun, Surajit Pathak

“…Therapeutic radiation-induced hypoxia and functional alterations in the stromal cells, specifically tumor-associated macrophage (TAM) and cancer-associated fibroblasts (CAF), play a crucial role in developing radioresistance. …”
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Targeting Streptococcus pyogenes atpF protein for multi-epitope vaccine development: a genomics-driven immunoinformatics strategy by Manisha Agarwal, Sanjeeb Handique, Sanchaita Rajkhowa, Abhichandan Das, Debashis Panda, Sami A. Al-Hussain, Magdi E.A. Zaki

“…The atpF protein was identified based on its high antigenicity and functional importance in S. pyogenes. Three vaccine constructs (SM1, SM2, and SM3) were designed by integrating antigenic B-cell and T-cell epitopes with immune-modulating adjuvants and linkers. …”
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Effects of Acidic Polysaccharide-Enriched Extracts from <i>Holothuria tubulosa</i> on Two- and Three-Dimensional Invasive Breast Cancer Cell Models by Cristina Ciampelli, Sylvia Mangani, Gabriele Nieddu, Marilena Formato, Paraskevi Ioannou, Spyros Kremmydas, Nikos Karamanos, Antonio Junior Lepedda

“…In this study, we investigated the effects of two acidic polysaccharide-enriched (APs) fractions (Ht1 and Ht2) from the sea cucumber species <i>Holothuria tubulosa</i> on the highly invasive cell line MDA-MB-231. Functional assays were performed to assess cell viability, migratory potential, adhesion on collagen I, and cell morphology, alongside gene expression analysis. …”
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Vincamine induces cytoprotective autophagy via regulation of ampk/mtor signaling pathway in gentamicin-induced hepatotoxicity and nephrotoxicity in rats by Alaa Abouelhamd, Nourhan Elpry Mahmoud Shehata, Sara Mohamed Naguib Abdel-Hafez, Dalia H. Abu-Baih

“….), and GET/VIN (received both VIN and GET) for 7 days. Liver and kidney function tests were performed. Serum total antioxidant capacity (TAC) and tissue malondialdehyde (MDA) were quantified. …”
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Multi-Strategy Enhancement of YOLOv8n Monitoring Method for Personnel and Vehicles in Mine Air Door Scenarios by Lei Zhang, Hongjing Tao, Zhipeng Sun, Weixun Yi

“…Firstly, the Faster Block module, which incorporates partial convolution (PConv), is integrated with the C2f module of the backbone network. …”
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Cotton Leaf Disease Detection Using LLM-Synthetic Data and DEMM-YOLO Model by Lijun Gao, Tiantian Ran, Hua Zou, Huanhuan Wu

“…Lastly, we replace the traditional regression loss with the MPDIoU loss function, enhancing bounding box accuracy and accelerating model convergence. …”
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Pathogenetic therapeutic approaches for endocrine diseases based on antisense oligonucleotides and RNA-interference by Olga Golounina, Ildar Minniakhmetov, Ramil Salakhov, Rita Khusainova, Ekaterina Zakharova, Igor Bychkov, Natalia Mokrysheva

“…Antisense oligonucleotides (ASOs) and small interfering RNAs (siRNAs) are two well-known strategies used to modulate gene expression. RNA-targeted therapy can precisely modulate the function of target RNA with minimal off-target effects and can be rationally designed based on sequence data. …”
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