DRP1 haploinsufficiency attenuates cardiac ischemia/reperfusion injuries. by Laura Bouche, Rima Kamel, Sophie Tamareille, Gabriel Garcia, Camille Villedieu, Bruno Pillot, Naïg Gueguen, Ahmad Chehaitly, Juan Manuel Chao de la Barca, Justine Beaumont, Delphine Baetz, Michel Ovize, Hiromi Sesaki, Daniel Henrion, Pascal Reynier, Guy Lenaers, Fabrice Prunier, Delphine Mirebeau-Prunier

“…Mitochondrial dynamics is a possible modulator of myocardial ischemia/reperfusion injuries (IRI). …”
Get full text

Investigating the Effects of Olanzapine in Changes in Metabolic Syndrome in High-fat diet-induced Obese Mice by Khadiza Begum, Md Abdur Rahman Ripon, Tabassum Akter, Md Monirul Islam, Rahima Begum, Mohammad Salim Hossain

“…Conclusion: After chronic OLA exposure, the results indicate that the declination of body and organ weight, lipid levels, liver function markers, and MCP-1 and PPAR-ɣ expression except for GLUT4 shows its effects in changing the metabolic disturbances in obese mice.…”
Get full text

Induction of indoleamine 2, 3-dioxygenase in human dendritic cells by a cholera toxin B subunit-proinsulin vaccine. by Jacques C Mbongue, Dequina A Nicholas, Kangling Zhang, Nan-Sun Kim, Brittany N Hamilton, Marco Larios, Guangyu Zhang, Kazuo Umezawa, Anthony F Firek, William H R Langridge

“…Heat map analysis of the proteomic data revealed an overall down-regulation of vaccinated DC functions, suggesting vaccine suppression of DC maturation. …”
Get full text

LSTGINet: Local Attention Spatio-Temporal Graph Inference Network for Age Prediction by Yi Lei, Xin Wen, Yanrong Hao, Ruochen Cao, Chengxin Gao, Peng Wang, Yuanyuan Guo, Rui Cao

“…The graph inference node aggregation and transfer functions fully capture the hidden dynamic correlation between brain aging and age. …”
Get full text

Attention-enhanced StrongSORT for robust vehicle tracking in complex environments by Wei Xu, Xiaodong Du, Ruochen Li, Bingjie Li, Yuhu Jiao, Lei Xing

“…Second, the F-EIoU loss function introduces dynamic size-dependent penalty terms and difficulty-adaptive weighting factors, effectively balancing learning priorities between small targets and normal instances. …”
Get full text

Deciphering the mechanistic roles of ADARs in cancer pathogenesis, tumor immune evasion, and drug resistance by Xiaoke Wang, Fei Yin, Yangfang He, Yue Qiao, Yan Yan, Jingru Ma

“…Beyond their catalytic editing function, ADARs also regulate cancer-relevant pathways through editing-independent mechanisms, including RNA binding and protein-protein interactions. …”
Get full text

An Artificial Intelligence QRS Detection Algorithm for Wearable Electrocardiogram Devices by Zihao Li, Wenliang Zhu, Yiheng Xu, Yunbo Guo, Junbo Li, Peng Song, Ying Liang, Binquan You, Lirong Wang

“…Methods: The proposed QRS detector comprises a leads-distillation module (LDM) and a QRS detection module. The LDM can distill multi-lead signals into single-lead ones. …”
Get full text

Neurostimulation on lumbosacral nerves as a new treatment for spinal cord injury impairments and its impact on cortical activity: a narrative review by Rodrigo Lantyer Marques Dantas, Diego N. Vilela, Mariana Cardoso Melo, Gustavo Fernandes, Gustavo Fernandes, Gustavo Fernandes, Nucelio Lemos, Nucelio Lemos, Nucelio Lemos, Jean Faber, Jean Faber

“…Recent findings have demonstrated significant improvements in mobility, sexual function, and bladder/bowel control in chronic SCI patients following LION therapy. …”
Get full text

Effect of fermented bee pollen on metabolic syndrome in high-fat diet-induced mice by Sha Yan, Kai Wang, Xiaoying Wang, Aiqun Ou, Feiran Wang, Liming Wu, Xiaofeng Xue

“…Overall, YB improved function and prevented MetS by modulating the gut microbiota and alleviating oxidative stress.…”
Get full text

Steviol rebaudiosides bind to four different sites of the human sweet taste receptor (T1R2/T1R3) complex explaining confusing experiments by Shuang Hao, Brian Guthrie, Soo-Kyung Kim, Sergej Balanda, Jan Kubicek, Babar Murtaza, Naim A. Khan, Pouyan Khakbaz, Judith Su, William A. Goddard

“…These findings provide a mechanistic understanding of the structure and function of this heterodimeric sweet taste receptor.…”
Get full text

Deep Metric Learning for Fine-Grained Ship Classification in SAR Images with Sidelobe Interference by Haibin Zhu, Yaxin Mu, Wupeng Xie, Kang Xing, Bin Tan, Yashi Zhou, Zhongde Yu, Zhiying Cui, Chuang Zhang, Xin Liu, Zhenghuan Xia

“…Then, a hybrid loss function is proposed to strengthen intra-class correlation and inter-class separability. …”
Get full text

Therapeutic potential of Lycium barbarum-derived exosome-like nanovesicles in combating photodamage and enhancing skin barrier repair by Ye Zhang, Bo Zhao, Jing Wang, Zeyi Zhang, Meiping Shen, Chengjie Ren, Mimi Li, Melanie Liu, Zhicheng You, Ping Li

“…-derived exosome-like nanovesicles (LB-EVs) in reinforcing skin barrier function were evaluated. Using a 3D skin model, expression levels of skin barrier proteins such as filaggrin, loricrin and claudin-1 were found to be modulated favorably upon treatment with LB-EVs, suggesting a role in maintaining cutaneous homeostasis. …”
Get full text

Redox Imbalance in Inflammation: The Interplay of Oxidative and Reductive Stress by Francesco Bellanti, Anna Rita Daniela Coda, Maria Incoronata Trecca, Aurelio Lo Buglio, Gaetano Serviddio, Gianluigi Vendemiale

“…This review offers a novel integrative perspective by analyzing how OS and RS act not merely in opposition, but as interconnected modulators of immune function. We explore the mechanisms through which OS activates inflammatory pathways, and how RS, when sustained, can paradoxically impair immune defense, alter redox-sensitive signaling, and contribute to disease progression. …”
Get full text

Ferroptosis, oxidative stress and hearing loss: Mechanistic insights and therapeutic opportunities by Chenyang Yuan, Tianyu Ma, Mengting Liu, Xiaoyun Zeng, Gongrui Tang, Yazhi Xing, Tianhong Zhang

“…By elucidating the molecular mechanisms underlying ferroptosis and oxidative stress, this review offers insights into novel therapeutic avenues for the treatment of hearing loss and underscores the importance of targeting these pathways to preserve auditory function.…”
Get full text

Postbiotics Derived from Lactic Acid Bacteria Fermentation: Therapeutic Potential in the Treatment of Muscular Complications in Inflammatory Bowel Disease by Emili Bruna Toso Bueno, Kimberlly de Oliveira Silva, Maria Eduarda Ferraz Mendes, Lívia Batista de Oliveira, Felipe Prado de Menezes, Anna Cardoso Imperador, Lucimeire Fernandes Correia, Lizziane Kretli Winkelstroter

“…Inflammatory bowel disease (IBD) is characterized by chronic inflammation in the gastrointestinal tract, which can result in several muscular complications, including sarcopenia, the loss of muscle mass, and impaired muscle function. Recently, postbiotics derived from lactic bacteria, such as <i>Lactobacillus</i> and <i>Bifidobacterium</i>, have emerged as potential therapeutic modulators for these complications. …”
Get full text

Bromodomain proteins IBD1 and IBD2 link histone acetylation to SWR1- and INO80-mediated H2A.Z regulation in Tetrahymena by Jyoti Garg, Alejandro Saettone, Syed Nabeel-Shah, Steven Dang, Abdul Hadi Khalid, Jérémy Loehr, Alexandra Petrova, James D. Burns, Peter Karabatsos, Sherin Shibin, Suzanne Wahab, Sean D. Taverna, Jack F. Greenblatt, Jean-Philippe Lambert, Jeffrey Fillingham

“…Results Here, we report that a closely related bromodomain-containing protein, IBD2, functions as an acetyl lysine reader module within a putative INO80 complex. …”
Get full text

Structural analysis of TRIM family PRYSPRY domains and its implications for E3-ligand design by Rezart Zhubi, Apirat Chaikuad, Christian J. Muñoz Sosa, Andreas C. Joerger, Stefan Knapp

“…Taken together, our data provide intriguing insights into the structural and functional divergence of TRIM family PRYSPRY domains, their potential druggability and substrate recognition, and the challenges of ligand design.…”
Get full text

Identification of PANoptosis related biomarkers to predict hepatic ischemia‒reperfusion injury after liver transplantation by Zhihong Chen, Junwei Zhang, Lei Zhang, Yaoge Liu, Ting Zhang, Xinting Sang, Yiyao Xu, Xin Lu

“…Multiple machine learning methods were utilized to screen for core biomarkers and construct a diagnostic predictive model. Functional and interaction analyses of the genes were also performed. …”
Get full text

Novel Acylated Naringin Enhances Propionate Release and Stimulates the Growth of Flavanone-Metabolizing Bacteria in an In Vitro Batch Fermentation Model by Blanca Elizabeth Ruiz-Álvarez, José Daniel Padilla-de la Rosa, Marisela González Avila, Georgina Sandoval, Yves Desjardins

“…These preliminary results highlight the potential of SCFA-acylated flavonoids as functional dietary components to increase SCFA bioavailability and support gut health, particularly from citrus-derived co-products.…”
Get full text

Enhancing Soil Phosphorus and Potassium Availability in Tea Plantation: The Role of Biochar, PGPR, and Phosphorus- and Potassium-Bearing Minerals by Wen Wei, Kunyu Li, Changjun Li, Siyu Wang, Lulu Li, Jinchuan Xie, Ting Li, Zijun Zhou, Shirong Zhang, Yulin Pu, Yongxia Jia, Xiaojing Liu, Xiaoxun Xu, Guiyin Wang

“…Analytical modeling identified <i>Chloroflexi</i> bacteria containing <i>pqqc</i> functional genes as key drivers of AP enhancement. The AP was further modulated by β-glucosidase activity, NaHCO₃-P, and AK levels. …”
Get full text