Role of right dorsolateral prefrontal cortex–left primary motor cortex interaction in motor inhibition in Parkinson’s disease by Zhen Wang, Zhen Wang, Jianing Wei, Yuyu Song, Yuting Li, Yuting Li, Yin Wu, Robert Chen, Robert Chen, Zhen Wang, Jian Zhang, Xiaoyin Tan, Ke Liu

“…BackgroundImpaired motor inhibition in Parkinson’s disease (PD) is associated with functional alterations in the frontal-basal ganglia (BG) neural circuits. …”
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Zingiber officinale mitigates monosodium glutamate-induced hepatic pathology: insights into CD68-macrophge activation and inflammatory/apoptotic/oxidative mediators crosstalk in ra... by Alya Mashaal, Mai Mousa, Hanan Taher Hamza, Hemmat Mansour Abdelhafez, Fatma Eid, Sawsan Abd EL-Maksoud EL-Shamy, Asmaa A. Abo Elqasem

“…Ginger intake partially reversed pathological changes and improved liver function, likely through modulation of CD68-macrophage activation and associated protective pathways. …”
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Insights into Cysteine Protease Complexes with Grafted Chitosan–Poly(<i>N</i>-vinylpyrrolidone) Copolymers: Catalytic Activity and Storage Stability by Maria S. Lavlinskaya, Andrey V. Sorokin, Anastasia N. Dubovitskaya, Anastasia I. Yutkina, Maxim S. Kondratyev, Marina G. Holyavka, Yuriy F. Zuev, Valeriy G. Artyukhov

“…The investigation of structure–function relationships in enzyme polysaccharide complexes provides a theoretical foundation for modulating enzyme properties and expanding their industrial applications. …”
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Mitochondrial transplantation normalizes transcriptomic and proteomic shift associated with ischemia reperfusion injury in neonatal hearts donated after circulatory death by Ilias P. Doulamis, Aspasia Tzani, Victor S. Alemany, Rio S. Nomoto, Aybuke Celik, Dominic P. Recco, Mossab Y. Saeed, Alvise Guariento, Jorge Plutzky, Sitaram M. Emani, Pedro J. del Nido, James D. McCully

“…We have previously shown that mitochondrial transplantation preserves myocardial function and viability in neonatal swine DCD hearts to levels similar to that observed in donation after brain death (DBD). …”
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Whispers of the polycystic ovary syndrome theater: Directing role of long noncoding RNAs by Xiuying Lin, Xinyu Nie, Ping Deng, Luyao Wang, Cong Hu, Ningyi Jin

“…We examine the dynamic regulatory networks orchestrated by lncRNAs that impact GC function, steroidogenesis, insulin resistance, and inflammatory pathways. …”
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Curcumin's Protective Role in Heatstroke‐Induced Acute Liver Injury: Targeting Pyroptosis and Enhancing SIRT1 Expression by Yizhan Wu, Fei Guo, Yan Ma, Weihao Chai, Jiajia Li, Wenhui Shi, Jiangwei Liu

“…Abstract Heatstroke (HS) is a severe systemic condition that significantly impacts organ function, with the liver being particularly vulnerable. …”
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Regulation of dynamic spatiotemporal inflammation by nanomaterials in spinal cord injury by Zeping Liu, Chunyu Xiang, Xu Zhao, Toshimi Aizawa, Renrui Niu, Jianhui Zhao, Fengshuo Guo, Yueying Li, Wenqi Luo, Wanguo Liu, Rui Gu

“…Abstract Spinal cord injury (SCI) is a common clinical condition of the central nervous system that can lead to sensory and motor impairment below the injury level or permanent loss of function in severe cases. Dynamic spatiotemporal neuroinflammation is vital to neurological recovery, which is collectively constituted by the dynamic changes in a series of inflammatory cells, including microglia, neutrophils, and astrocytes, among others. …”
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Fluorous-tagged bortezomib supramolecular nanomedicine for cancer therapy by Changping Wang, Xin Gao, Zhan Li, Xinyu Wang, Yiwen Li, Yiyun Cheng

“…Lipidation is a well-established post-translational modification strategy to modulate the structure and function of proteins and peptides. …”
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Lactobacillus amylovorus extracellular vesicles mitigate mammary gland ferroptosis via the gut-mammary gland axis by Qianzi Zhang, Dongpang Chen, Hanting Ding, Qihui Li, Siyu Yuan, Haobin Li, Wutai Guan, Shihai Zhang

“…In this study, we identify a novel function for gut microbiota in regulating maternal lactation through the modulation of ferroptosis in the mammary gland under oxidative stress. …”
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Harnessing the power of marine terpenoids against diabetes-associated oxidative stress by Derren David Christian Homenta Rampengan, Juan Alessandro Jeremis Maruli Nura Lele, Raffaele Romano, Nurpudji Astuti Taslim, Raymond Rubianto Tjandrawinata, Antonello Santini, Fahrul Nurkolis, Fahrul Nurkolis, Fahrul Nurkolis

“…Preclinical studies underscore their efficacy in reducing hyperglycemia, enhancing insulin sensitivity, preserving pancreatic β-cell function, and protecting against diabetic complications, including nephropathy and cardiovascular diseases. …”
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Exploring the Neuroprotective Effects of Grape Seed Procyanidins on Amyloid-β-Induced Toxicity in <i>Caenorhabditis elegans</i> by Susana González-Manzano, Begoña Ayuda-Durán, Roberto Martín-Sanz, Lidia Garzón-García, Celestino Santos-Buelga, Ana María González-Paramás

“…The obtained results show that GSPE not only significantly attenuates Aβ-induced paralysis but also extends the lifespan and improves sensory responses in these models, suggesting improved neural function and overall health. Additionally, GSPE treatment reduces proteasomal activity, which could lead to a reduction in the accumulation of misfolded proteins. …”
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Zinc deficiency as possible link between immunosenescence and age-related diseases by Michael Tobias Schulz, Lothar Rink

“…Abstract As global life expectancy increases, research reveals a critical challenge in aging: the progressive deterioration of immune function, termed immunosenescence. This age-related immune decline is characterized by a complex dysregulation of immune responses, which leaves older adults increasingly vulnerable to infections, chronic inflammatory states, and various degenerative diseases. …”
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Dexmedetomidine in cardiac surgery: Emphasis on interleukin-18 signaling pathway by Bassim Mohammed Jabbar Hatemi, Ayesheh Enayati, Ali Movafegh, Ali Jabbari

“…Conclusion: Dex is posited to enhance postoperative cardiac function by modulating the immune system through the attenuation of IL-18 secretion from immune cells, consequently mitigating inflammatory responses in the context of cardiac surgery. …”
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An Immunogenic Cell Death-Related Gene Signature Predicts the Prognosis and Immune Infiltration of Cervical Cancer by Fangfang Sun, Yuanyuan Sun, Hui Tian

“…Objectives: Immunogenic cell death (ICD) has been demonstrated to play a critical role in the development and progression of malignant tumors by modulating the anti-tumor immune response. However, its function in cervical cancer (CC) remains largely unexplored. …”
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Nucleolar proteomics identifies S100A16 as a key nucleolar protein driving breast cancer metastasis by Brandon J. Metge, Mohamed H. Elbahoty, Amr R. Elhamamsy, Anne E. Popple, Bhavya Papineni, Rajeev S. Samant, Lalita A. Shevde

“…To further elucidate the interplay between nucleolar function and metastasis, we performed a comprehensive analysis of nucleolar proteomes from primary and metastatic breast cancer cell lines and identified proteins differentially enriched in the nucleoli of metastatic cells, of which 48 showed statistically significant enrichment. …”
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Transcriptome analysis of corpora lutea in domestic cats (Felis catus) reveals strong differences in gene expression of various hormones, hormone receptors and regulators across di... by Beate C. Braun, Michał M. Hryciuk, Dorina Meneghini

“…The large changes in the expression levels of some genes indicate that the endocrine function of the CL may not be restricted to progesterone (P4) secretion. …”
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Utilization of Garcinia mangostana L. Peel as an Immunomodulator to Improve the Quality of Human Resources: A Systematic Review by Yunita Satya Pratiwi, Dina Mustika Rini, Ifwarisan Defri, Tawaffani Qubra, Nadien Mutia Intan Maulidi

“…Background: Mangosteen (Garcinia mangostana L.) is recognized for its immunomodulatory properties, which can rejuvenate, regulate, and modulate immune system function. As a rich source of antioxidants, mangosteen peel has the potential to enhance immune responses and improve overall health status. …”
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Crosstalk between metabolism and epigenetics during macrophage polarization by Kangling Zhang, Chinnaswamy Jagannath

“…These epigenetic modifications control gene expression by regulating chromatin accessibility, thereby modulating macrophage function and polarization. Histone acetylation generally promotes a more open chromatin structure conducive to gene activation, while histone methylation can either activate or repress gene expression depending on the specific residue and its methylation state. …”
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Liver Disease and Central Nervous System Dysfunction: Linking the Two - A Narrative Review by Maciej Tenderenda, Bartosz Buczkowski, Piotr Oleksy, Agnieszka Klecza, Aleksandra Broniak, Magdalena Reclik, Karol Zieliński, Aarushi Chourasia, Krzysztof Nowakowski, Martyna Chraścina

“…The gut-liver-brain axis, involving gut microbiota's role in CNS functioning, presents promising avenues for adjunctive treatment. …”
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3D-MRI brain glioma intelligent segmentation based on improved 3D U-net network. by Tingting Wang, Tong Wu, Defu Yang, Ying Xu, Dongyang Lv, Tong Jiang, Hengjiao Wang, Qi Chen, Shengnan Xu, Ying Yan, Baoguang Lin

“…Secondly, in order to enhance the perception ability of the network to different scale features, we introduce the space pyramid pool module. Then, by making the model focus on glioma details and suppressing irrelevant background information, we propose a multi-scale fusion attention mechanism; And finally, to address class imbalance and enhance learning of misclassified voxels, a combination of Dice and Focal loss functions was employed, creating a loss function, this method not only maintains the accuracy of segmentation, It also improves the recognition of challenge samples, thus improving the accuracy and generalization of the model in glioma segmentation.…”
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