The BRCA1 Breast Cancer Suppressor: Regulation of Transport, Dynamics, and Function at Multiple Subcellular Locations by Beric R. Henderson

“…This paper will focus on the transport, dynamics, and multiple intracellular destinations of BRCA1 with emphasis on how regulation of these events has impact on, and determines, a broad range of important cellular functions.…”
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Sea dragon metabolome and lipidome unveil bioactive functional food candidates with sepsis therapeutic activities by Huixiang Wu, Miaoyu Li, Lijun Ge, Weibo Lu, Xuewei Shen, Yu Zhang, Zengyan Wu, Jianding Wang, Yonghui Wu, Huijuan Mao, Jianliang Zhang, Qingcheng Wang, Jing Xue, Qing Shen, Yuexing Tu

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Effects of Human Umbilical Cord Mesenchymal Stem Cells on Human Trophoblast Cell Functions In Vitro by Yajing Huang, Yanming Wu, Xinwen Chang, Yan Li, Kai Wang, Tao Duan

“…To identify whether hUCMSCs can regulate trophoblast cell functions, we treated trophoblast cells with hUCMSC supernatant or cocultured them with hUCMSCs. …”
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The deubiquitinase Rpn11 functions as an allosteric ubiquitin sensor to promote substrate engagement by the 26S proteasome by Zaw Min Htet, Ken C. Dong, Andreas Martin

“…Here, we use biochemical, mutational, and single-molecule fluorescence resonance energy transfer (FRET)-based approaches to show that the proteasomal deubiquitinase Rpn11 functions as an allosteric sensor and facilitates the early steps of degradation. …”
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Flavonoid pathway intermediates implicate UVR8 in functions beyond canonical UV-B signaling by Nan Jiang, Tatiana García Navarrete, Yun Sun Lee, Emily G. Pawlowski, Sunyoung Park, Erich Grotewold

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Small open reading frame-encoded microproteins in cancer: identification, biological functions and clinical significance by Tingting Zhang, Zhang Li, Jiao Li, Yong Peng

“…Abstract The human genome harbors approximately twenty thousand protein-coding genes, and a significant portion of life science research focuses on elucidating their functions and the underlying mechanisms. Recent studies have revealed that small open reading frame (sORF), originating from non-coding RNAs or the 5’ leader sequences of messenger RNAs, can be translated into small peptides called microproteins through cap-dependent or cap-independent mechanisms. …”
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Transcription Factor 4 loss-of-function is associated with deficits in progenitor proliferation and cortical neuron content by Fabio Papes, Antonio P. Camargo, Janaina S. de Souza, Vinicius M. A. Carvalho, Ryan A. Szeto, Erin LaMontagne, José R. Teixeira, Simoni H. Avansini, Sandra M. Sánchez-Sánchez, Thiago S. Nakahara, Carolina N. Santo, Wei Wu, Hang Yao, Barbara M. P. Araújo, Paulo E. N. F. Velho, Gabriel G. Haddad, Alysson R. Muotri

“…We identify a mechanism through which TCF4 loss-of-function leads to decreased Wnt signaling and then to diminished expression of SOX genes, culminating in reduced progenitor proliferation in vitro. …”
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Nucleus-translocated glucokinase functions as a protein kinase to phosphorylate TAZ and promote tumour growth by Gaoxiang Zhao, Shudi Luo, Hong Zhao, Qingxia Ma, Hongfei Jiang, Lin Wang, Juanjuan Liu, Dong Guo, Runze Wang, Qianqian Xu, Jie Lun, Ranran Xie, Yixin Duan, Leina Ma, Wensheng Qiu, Jing Fang, Zhimin Lu

“…These findings reveal an instrumental mechanism by which a glycolytic enzyme regulates the Hippo pathway under hypoxic conditions and highlight the moonlighting function of GCK as a protein kinase in modulating TAZ activity and tumour growth.…”
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Determination of the state and functioning of the equipment of rod well pumping units in the operation process by the parameters of the wattmetrogram by V. A. Manakhov, A. N. Tsvetkov

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Pseudomonas intra-genus competition determines the protective function of synthetic bacterial communities in Arabidopsis thaliana. by Anton Amrhein, Mingxiao Zhang, Stéphane Hacquard, Anna Heintz-Buschart, Kathrin Wippel

“…We use bacterial culture collections derived from the two model species Arabidopsis thaliana (At) and Lotus japonicus (Lj) to design synthetic communities (SynComs) and test their protective function upon exposure of At Col-0 to the detrimental root-colonizing At-derived Pseudomonas isolate R401. …”
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Development of Thermo-Responsive and Salt-Adaptive Ultrafiltration Membranes Functionalized with PNIPAM-co-PDMAC Copolymer by Lauran Mama, Johanne Pirkin-Benameur, Vincent Bouad, David Fournier, Patrice Woisel, Joël Lyskawa, Karim Aissou, Damien Quemener

“…In response, this study presents the development and characterization of thermo-responsive and salt-adaptive ultrafiltration membranes functionalized with a poly(N-isopropylacrylamide)–co-poly(dimethylacrylamide) (PNIPAM-co-PDMAC) copolymer. …”
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Black ginger (Kaempferia parviflora): A source of functional ingredient for food, nutraceutical and pharmaceutical applications by Sook Chin Chew, Kar Lin Nyam

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Oncogenic functions of the cancer-testis antigen SSX on the proliferation, survival, and signaling pathways of cancer cells. by Padraig D'Arcy, Wessen Maruwge, Barry Wolahan, Limin Ma, Bertha Brodin

“…SSX is a transcription factor with elusive oncogenic functions expressed in a variety of human tumors of epithelial and mesenchymal origin. …”
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Functional characterization of the small heat shock protein Hsp12p from Candida albicans. by Man-Shun Fu, Luisa De Sordi, Fritz A Mühlschlegel

“…To study the function of Hsp12p in C. albicans we generated a null mutant, in which all four CaHSP12 genes have been deleted. …”
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PRELP functions via multiple interactions with intrinsically weak affinity relying on ECM anchoring and remodeling by Hirofumi Kosuge, Makoto Nakakido, Susana de Vega, Shin-ichi Ohnuma, Kouhei Tsumoto

“…Results of this study suggest that PRELP modulates multiple interactions with intrinsically weak binding affinities through the anchoring to ECM proteins and also promotes the ECM protein expression to maintain the preferred environment to exert the molecular functions.…”
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Developmental exposure to low doses of dichlorodiphenyltrichloroethane disrupts functional and morphologic maturation of the spleen in prepubertal rats by Bella B. Gagulaeva, Nataliya V. Yaglova, Sergey S. Obernikhin, Ekaterina P. Timokhina

“…Dichlorodiphenyltrichloroethane (DDT) is a versatile persistent pollutant with endocrine disrupting properties and an alleged immune modulator. Objective — to evaluate the parameters of functional and morphological maturation of the spleen in prepubertal rats exposed to low doses of DDT. …”
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Leveraging Text Signed Distance Function Map for Boundary-Aware Guidance in Scene Text Segmentation by Ho Jun Kim, Hak Gu Kim

“…In this paper, we introduce leveraging text signed distance function (SDF) map, which encodes distance information from text boundaries, in scene text segmentation to explicitly provide text boundary information. …”
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Corn Oil Supplementation Enhances Locomotor Performance and Mitochondrial Function in <i>Drosophila melanogaster</i> by Jadyellen Rondon Silva, Thiago Henrique Oliveira Alves, Eric Bruno Silva Santos, Marylu Mardegan Lima, Giulia Covolo Spegiorim, Carlos Antônio Couto-Lima, Luciane Carla Alberici, Marcos José Jacinto, Anderson Oliveira Souza

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SPOCK2 controls the proliferation and function of immature pancreatic β-cells through MMP2 by Katarzyna Blaszczyk, Anna P. Jedrzejak, Natalia Ziojla, Ekaterina Shcheglova, Karolina Szarafin, Artur Jankowski, Christine A. Beamish, Jolanta Chmielowiec, Omaima M. Sabek, Ashok Balasubramanyam, Sanjeet Patel, Malgorzata Borowiak

“…In contrast, newly formed β-cells, including SC-β-cells, display higher proliferative capacity and distinct transcriptional and functional profiles. Through bidirectional expression modulation and single-cell RNA-seq, we identified SPOCK2, an ECM protein, as an inhibitor of immature β-cell proliferation. …”
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Probiotic Bifidobacterium bifidum strains desialylate MUC13 and increase intestinal epithelial barrier function by Celia Segui-Perez, Liane Z. X. Huang, Fernanda L. Paganelli, Elke Lievens, Karin Strijbis

“…Here, we screened probiotic bacterial strains for their capacity to modulate MUC13 and enhance intestinal barrier function. …”
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