Lactylation: From Homeostasis to Pathological Implications and Therapeutic Strategies by Xi Chen, Yixiao Yuan, Fan Zhou, Lihua Li, Jun Pu, Yong Zeng, Xiulin Jiang

“…Unlike traditional modifications, lactylation directly links metabolic intermediates, such as lactate, to protein function and cellular behavior. Emerging evidence highlights the critical involvement of lactylation in diverse biological processes, including immune response modulation, cellular differentiation, and tumor progression. …”
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The Influence of Endogenous Derivatives on the Self-Assembly of Carbonized Polymer Dots by Yingxi Qin, Wenkai Zhang, Ziwei Liu, Mingyan Jia, Jie Chi, Yujia Liu, Yue Wang, Aimiao Qin, Yu Wang, Liang Feng

“…Carbonized polymer dots (CPDs) have emerged as a fascinating class of functional nanomaterials with unique physicochemical properties. …”
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Deciphering a volcano-shaped relationship between radical stability and reticular electrochemiluminescence by Haocheng Xu, Rengan Luo, Haifeng Lv, Tianrui Liu, Qiaobo Liao, Yandong Wang, Ziyan Zhong, Xiaojun Wu, Jianping Lei, Kai Xi

“…Density functional theoretical calculations indicate that CN-COF-2 exhibits moderate radical stabilization capacity as well as efficient electron transport between the pyrene cores, facilitating ECL generation. …”
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Emerging regulated cell death mechanisms in bone remodeling: decoding ferroptosis, cuproptosis, disulfidptosis, and PANoptosis as therapeutic targets for skeletal disorders by Hai-Ting Hu, Zhen-Yu Zhang, Zi -Xin Luo, Hui-Bo Ti, Jun-Jie Wu, Hao Nie, Zheng-Dong Yuan, Xian Wu, Ke-Yue Zhang, Shu-Wen Shi, Yi-Qing Qian, Xin-Chen Wang, Jing-Jing Wu, Xia Li, Feng-Lai Yuan

“…Abstract The adult skeleton preserves its structural and functional integrity through continuous bone remodeling, a process tightly regulated by osteoblasts, osteoclasts, and osteocytes. …”
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Pre-treatment subjective sleep quality as a predictive biomarker of tDCS effects in preclinical Alzheimer's disease patients: Secondary analysis of a randomised clinical trial. by Hanna Lu, Xi Ni, Sandra Sau Man Chan, Calvin Pak Wing Cheng, Waichi Chan, Linda Chiu Wa Lam

“…This study sought to determine how tDCS affected sleep quality and cognition, as well as how well pre-treatment sleep quality predicted tDCS effects on domain-specific cognitive functions in patients with mild neurocognitive disorder due to Alzheimer's disease (NCD-AD).…”
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Catechol-O-methyltransferase Val158Met polymorphism associates with individual differences in sleep physiologic responses to chronic sleep loss. by Namni Goel, Siobhan Banks, Ling Lin, Emmanuel Mignot, David F Dinges

“…<h4>Background</h4>The COMT Val158Met polymorphism modulates cortical dopaminergic catabolism, and predicts individual differences in prefrontal executive functioning in healthy adults and schizophrenic patients, and associates with EEG differences during sleep loss. …”
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Stress contingent changes in Hog1 pathway architecture and regulation in Candida albicans. by Alison M Day, Min Cao, Alessandra da Silva Dantas, Olga Ianieva, Carmen Herrero-de-Dios, Alistair J P Brown, Janet Quinn

“…Notably, we find Ssk1 regulates Hog1 in a two-component independent manner by functioning to promote interactions between the Ssk2 and Pbs2 kinases. …”
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Dissection of estrogen receptor alpha signaling pathways in osteoblasts using RNA-sequencing. by Matthew M Roforth, Elizabeth J Atkinson, Ellis R Levin, Sundeep Khosla, David G Monroe

“…These data provide a comprehensive list of genes and pathways targeted by these specific modes of ERα action and suggest that "mode-specific" ligands could be developed to modulate specific ERα functionality in bone.…”
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Reputation and Image from the Perspective of Management Sociology by M. V. Shutova

“…In contrast, reputation emerges as a verbalized evaluation shaped through social interaction within a pragmatic context, acting in the digital society as a tool for modulating control. The image functions as an “entry point”, drawing attention from audiences unfamiliar with its subject. …”
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Migrasome Marker Epidermal Growth Factor Domain-Specific <i>O</i>-GlcNAc Transferase: Pan-Cancer Angiogenesis Biomarker and the Potential Role of circ_0058189/miR-130a-3p/EOGT Axis... by Zhe Yu, Jing Luo, Wen An, Herui Wei, Mengqi Li, Lingling He, Fan Xiao, Hongshan Wei

“…<b>Methods</b>: Multi-omics analysis integrated TCGA/GTEx data from 33 cancer types with spatial/single-cell transcriptomics and 10 HCC cohorts. Functional validation employed Huh7 cell models with <i>EOGT</i> modulation, RNA sequencing, and ceRNA network construction. …”
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Revealing a novel Decorin-expressing tumor stromal subset in hepatocellular carcinoma via integrative analysis single-cell RNA sequencing by Chi Hsiao, Wen-Chieh Liao, Ju-Pi Li, Yu-Cheng Chou, Yu-Lun Chou, Jeng-Rong Lin, Chia-Hua Chen, Chiung-Hui Liu

“…Furthermore, functional assays demonstrated that CS-DCN significantly inhibited HCC cell proliferation and invasion. …”
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Integrative Transcriptome‐Wide Association Study With Expression Quantitative Trait Loci Colocalization Identifies a Causal VAMP8 Variant for Nasopharyngeal Carcinoma Susceptibilit... by Yan Liang, Xiang‐Yu Xiong, Guo‐Wang Lin, Xiaomeng Bai, Fugui Li, Josephine Mun‐Yee Ko, Yun‐He Zhou, An‐Yi Xu, Shu‐Qiang Liu, Shuai He, Pan‐Pan Wei, Qiu‐Yan Chen, Lin‐Quan Tang, Vivien Ya‐Fan Wang, Hai‐Qiang Mai, Chun‐Ling Luo, Yanni Zeng, Maria Li Lung, Mingfang Ji, Jin‐Xin Bei

“…Collectively, the findings shed light on the genetic predisposition to NPC and underscore the critical role of the functional axis involving miR‐185, VAMP8, DHX9, and the NF‐κB pathway in NPC pathogenesis.…”
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Inducible Fgf13 ablation alleviates cardiac fibrosis via regulation of microtubule stability by Wang Cong, Wang Xiangchong, Zhang Yiyi, Mi Yuan, Han Yanxue, Zhi Yaxin, Zhao Ran, Cui Nanqi, Ma Qianli, Zhang Huaxing, Xue Dazhong, Qiao Ruoyang, Han Jiabing, Yu Yulou, Li Jiaxuan, Shaiea Mohammed, Liu Demin, Gu Guoqiang, Wang Chuan

“…Overexpression of FGF13, but not FGF13 mutants defective in microtubule binding and stabilization, rescues the decrease in collagen and α-SMA protein and weakens the proliferation and migration function of the Fgf13 knockdown group. Furthermore, Fgf13 knockdown decreases ROCK protein expression via microtubule disruption. …”
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Spatial metabolic analysis of the regulatory effects of DL-3-n-butylphthalide in a cerebral ischemia-reperfusion mouse model by Yuxuan Lu, Jianwen Deng, Yining Huang, Jingjing Jia, Qing Peng, Ran Liu, Zhiyuan Shen, Weiping Sun, Haiqiang Jin, Zhaoxia Wang

“…Our study found that NBP could significantly reduce the ischemic area and restore physical function by potentially modulating pathways of the citrate cycle, pyruvate metabolism, autophagy, and unsaturated fatty acid biosynthesis. …”
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Gut-brain axis and vascular dementia: a review on mechanisms and Chinese herbal medicine therapeutics by Dexiu Wang, Huiying Yao, Luoqi Wang, Bowen Lu, Wenkai Liu, Jinghan Li, Yujin Gong, Yuhao Cai, Yuehan Li, Xin Cai, Rui Zhang, Rui Zhang

“…The gut-brain axis (GBA) serves as a critical bidirectional pathway through which intestinal flora influences brain physiology and function. Notably, accumulating studies have demonstrated the therapeutic potential of Chinese herbal medicine (CHM) in VD management via modulation of gut microbial composition. …”
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A Defect Detection Algorithm for Optoelectronic Detectors Utilizing GLV-YOLO by Xinfang Zhao, Qinghua Lyu, Hui Zeng, Zhuoyi Ling, Zhongsheng Zhai, Hui Lyu, Saffa Riffat, Benyuan Chen, Wanting Wang

“…Furthermore, it improves generalization performance through the utilization of the WIoU loss function, which minimizes geometric penalties. The experimental results showed that the proposed algorithm achieved 98.9% accuracy, with 2.1 million parameters and a computational cost of 7.0 GFLOPs. …”
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Strong and Weak Prompt Engineering for Remote Sensing Image-Text Cross-Modal Retrieval by Tianci Sun, Chengyu Zheng, Xiu Li, Yanli Gao, Jie Nie, Lei Huang, Zhiqiang Wei

“…Finally, the adaptive hard sample elimination module optimizes the triplet loss function by training the model with negative sample pairs of varying difficulty, assigning higher weights to simpler pairs. …”
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Molecular basis for the calcium-dependent activation of the ribonuclease EndoU by Florian Malard, Kristen Dias, Margaux Baudy, Stéphane Thore, Brune Vialet, Philippe Barthélémy, Sébastien Fribourg, Fedor V. Karginov, Sébastien Campagne

“…Abstract Ribonucleases (RNases) are ubiquitous enzymes that process or degrade RNA, essential for cellular functions and immune responses. The EndoU-like superfamily includes endoribonucleases conserved across bacteria, eukaryotes, and certain viruses, with an ancient evolutionary link to the ribonuclease A-like superfamily. …”
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Identification of key LncRNAs and mRNAs in fat deposition of Saba pigs based on comparative analysis of transcriptomics by Xinxing Dong, Xinpeng Li, Xiaoyi Wang, Qiang Chen, Mingli Li, Dawei Yan, Guoxiang Lan, Shaoxing Lu

“…We employed cis-regulatory analysis to explore the function of LncRNAs. Gene Ontology (GO) enrichment revealed pathways and enzyme activity-related terms, indicating that LncRNAs may modulate gene expression to influence biological processes. …”
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Exploring the role of neuromodulation in neurodegenerative disorders: Insights from Alzheimer's and Parkinson's diseases by Mega Obukohwo Oyovwi, Kehinde Henrietta Babawale, Ejayeta Jeroh, Benneth Ben-Azu

“…TMS showed significant improvement in cognitive functions in AD patients, while DBS resulted in substantial relief of motor symptoms and improved quality of life in PD patients. …”
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