Impairment of lipid homeostasis causes lysosomal accumulation of endogenous protein aggregates through ESCRT disruption by John Yong, Jacqueline E Villalta, Ngoc Vu, Matthew A Kukurugya, Niclas Olsson, Magdalena Preciado López, Julia R Lazzari-Dean, Kayley Hake, Fiona E McAllister, Bryson D Bennett, Calvin H Jan

“…Lipid dysregulation leads to lysosomal membrane permeabilization but does not otherwise impact fundamental aspects of lysosomal and proteasomal functions. Together, these results demonstrate that lipid dysregulation disrupts ESCRT function and impairs proteostasis.…”
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Generation of Site‐Specifically Labeled Affinity Reagents via Use of a Self‐Labeling Single Domain Antibody by Stanley Fayn, Swarnali Roy, Chino C. Cabalteja, Woonghee Lee, Hima Makala, Kwamena Baidoo, Divya Nambiar, Julia Sheehan‐Klenk, Joon‐Yong Chung, Jesse Buffington, Mitchell Ho, Freddy E. Escorcia, Ross W. Cheloha

“…Using heterodimeric nanobody conjugates, comprised of an antigen recognition module and a self‐labeling module, enables us to attach the desired functional group at a location distal to the site of antigen recognition. …”
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A Violet‐Light‐Responsive ReRAM Based on Zn2SnO4/Ga2O3 Heterojunction as an Artificial Synapse for Visual Sensory and In‐Memory Computing by Saransh Shrivastava, Wei‐Sin Dai, Stephen Ekaputra Limantoro, Hans Juliano, Tseung‐Yuen Tseng

“…Abstract Due to the imitation of the neural functionalities of the human brain via optical modulation of resistance states, photoelectric resistive random access memory (ReRAM) devices attract extensive attraction for synaptic electronics and in‐memory computing applications. …”
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Tumor Microenvironment Lactate: Is It a Cancer Progression Marker, Immunosuppressant, and Therapeutic Target? by Eugene Y. Kim, Joyce Abides, Chandler R. Keller, Steve R. Martinez, Weimin Li

“…Additionally, lactate serves as a pH tuner, signaling ligand and transducer, epigenetic and gene transcription regulator, TME modifier, immune suppressor, chemoresistance modulator, and prognostic marker. With such broad functionalities, the production–consumption–reproduction of TME lactate fuels tumor growth and dissemination. …”
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Characteristics and Mechanisms of Single Event Effects Caused by Atmospheric Neutrons in System in Package Device by YE Jiefeng1, 2, LIANG Chaohui2, ZHANG Zhangang2, ZHENG Shunshun1, 2, LEI Zhifeng2, LIU Zhili3, GENG Gaoying3, HAN Hui1

“…To investigate the effects of atmospheric neutron radiation effects on a system-in-package (SiP) device, single event upset (SEU) and single event functional interruption (SEFI) were focused on in the experiment. …”
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Interaction of noncoding RNAs with hippo signaling pathway in cancer cells and cancer stem cells by Saba Abedimanesh, Reza Safaralizadeh, Zohreh Jahanafrooz, Souzan Najafi, Mohammad Amini, Shabnam Soltani Nazarloo, Seyedeh Zahra Bahojb Mahdavi, Behzad Baradaran, Asiyeh Jebelli, Amir Ali Mokhtarzadeh

“…The Hippo signaling pathway has a regulatory function in the organogenesis process and cellular homeostasis, switching the cascade reactions of crucial kinases acts to turn off/on the Hippo pathway, altering the downstream gene expression and thereby regulating proliferation, apoptosis, or stemness. …”
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Cell wall polysaccharide alters the surface electric potential of Lacticaseibacillus paracasei strain Shirota and enhances acid tolerance by Kosuke Kato, Madoka Nakamura, Masaki Serata, Takekazu Okumura

“…This enhanced understanding of CWPS function enables the development of more resilient probiotic strains, potentially improving their efficacy in various industrial and therapeutic applications.…”
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Bacteria enable tolerance to bile salt exposure in an immune-competent human intestinal model by Yuan Li, Chia-Ming Wang, Peng Zhao, Matthew T. Fernez, Rebecca L. Carrier

“…However, incorporation of a commensal bacterial consortium protected the epithelium from bile micelle-associated damage, as reflected in increased epithelial cell viability and preserved monolayer barrier function. Furthermore, the model bile enabled homeostasis when bacterial consortia were incorporated into epithelial-immune co-cultures, reducing barrier damage and inflammatory response induced by the consortia and modulating bacterial growth. …”
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Deciphering the angiogenic potential of Zhishi Xiebai Guizhi decoction in coronary heart disease: an in-depth network pharmacology and experimental investigation by Yingli Mo, Yuping Xu, Bei Lu, Xiaojuan Fan, Qingshuang Zhang, Shaowu Cheng, Qinghua Peng

“…In a double-blind RCT (n = 180), ZXGD adjunct therapy significantly improved angina frequency (35% reduction vs. control, p < 0.01) and endothelial function (FMD increase: 2.8% ± 0.5 vs. 1.2% ± 0.4, p < 0.05) over 12 weeks, with no severe adverse events. …”
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Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity. by J R Managbanag, Tarynn M Witten, Danail Bonchev, Lindsay A Fox, Mitsuhiro Tsuchiya, Brian K Kennedy, Matt Kaeberlein

“…<h4>Background</h4>Identification of genes that modulate longevity is a major focus of aging-related research and an area of intense public interest. …”
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A Novel Method for Traceability of Crude Oil Leakage on Offshore Platforms Based on Improved YOLOv5 Model Multi-Target Identification and Correlation Analysis by Zhenghua Wang, Shihai Zhang, Chongnian Qu, Zongyi Zhang, Feng Sun

“…The EIOU loss function is used to improve the model&#x2019;s convergence speed and its ability to identify small or partially occluded targets. …”
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Developmental effects of sulfated thyroid hormones in sea urchin skeletogenesis suggest activation of non-canonical thyroid hormone signaling pathway by Katherine Tieman, Andreas Heyland

“…We conclude that STHs have a developmental function in sea urchin skeletogenesis, likely mediated by the αPβG integrin rather than the NTHR. …”
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An Optimization Method for PCB Surface Defect Detection Model Based on Measurement of Defect Characteristics and Backbone Network Feature Information by Huixiang Liu, Xin Zhao, Qiong Liu, Wenbai Chen

“…Lastly, MPDIoU is used as the bounding box loss regression function, improving training efficiency by enhancing convergence speed and accuracy. …”
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Conformational targeting of fibrillar polyglutamine proteins in live cells escalates aggregation and cytotoxicity. by Erik Kvam, Brent L Nannenga, Min S Wang, Zongjian Jia, Michael R Sierks, Anne Messer

“…Moreover, our findings introduce a novel antibody-based tool that, as a consequence of its general specificity for fibrillar conformations and its ability to function intracellularly, offers broad research potential for a variety of human amyloid diseases.…”
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The Multifaceted Roles of MicroRNA-181 in Stem Cell Differentiation and Cancer Stem Cell Plasticity by Chun Yang, Rui Wang, Pierre Hardy

“…The epithelial–mesenchymal transition (EMT), a critical developmental process, enhances stem cell-like properties in cells, and is associated with both normal stem cell function and the formation of cancer stem cells. Cell stemness and the EMT often coexist and are interconnected in various contexts. …”
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Cholinergic Mechanisms of Target Oddball Stimuli Detection: The Late “P300-Like” Event-Related Potential in Rats by A. Ahnaou, R. Biermans, W. H. I. M. Drinkenburg

“…Event-related potentials (ERPs) and oscillations (EROs) provide powerful tools for studying the brain’s synaptic function underlying information processing. The P300 component of ERPs indexing attention and working memory shows abnormal amplitude and latency in neurological and psychiatric diseases that are sensitive to pharmacological agents. …”
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Endurance training promotes chromatin closure and timely repression of the post-exercise immediate early stress response by Laura M. de Smalen, Volkan Adak, Aurel B. Leuchtmann, Konstantin Schneider-Heieck, Stefan A. Steurer, Christoph Handschin

“…Objectives: Endurance training is known to elicit numerous changes in skeletal muscle to enhance performance and function. Many of these adaptations are controlled by the modulation of transcriptional programs in myonuclei. …”
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Role of miRNAs in Apoptosis Pathways of Immune Cells in Systemic Lupus Erythematosus by Amin Azizan, Elham Farhadi, Seyedeh Tahereh Faezi, Ahmadreza Jamshidi, Majid Alikhani, Mahdi Mahmoudi

“…Conversely, anti‐apoptotic miRNAs, including miR‐21, are upregulated, further disrupting the delicate balance of immune cell apoptosis. Dual‐function miRNAs, such as miR‐155, exhibit context‐dependent roles based on cellular environments and target gene interactions. …”
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Effectiveness of resveratrol in inducing adeno-associated virus as a potential definitive therapy for SCN5A mutation in Brugada syndrome: a narrative review by Andin Zahrani Pateda, Andi Alika Azzahra, Kuni Zakiyyah Sumargo, Muchtar Nora Ismail Siregar

“…Conclusion Experimental studies have demonstrated that AAV-MOG1 gene therapy can restore sodium channel function, improve cardiac electrophysiological abnormalities, and ameliorate the clinical manifestations of BrS. …”
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The ER retention protein RER1 promotes alpha-synuclein degradation via the proteasome. by Hyo-Jin Park, Daniel Ryu, Mayur Parmar, Benoit I Giasson, Nikolaus R McFarland

“…We expressed RER1 and a C-terminal mutant RER1Δ25, which lacks the ER retention/retrieval function, in HEK293 and H4 neuroglioma cells. RER1 overexpression significantly decreased levels of both wild type and A30P, A53T, and E46K disease causal mutants of αSyn, whereas the RER1Δ25 mutant had a significantly attenuated effect on αSyn. …”
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