RNASEL and MIR146A SNP-SNP interaction as a susceptibility factor for non-melanoma skin cancer. by Shohreh F Farzan, Margaret R Karagas, Brock C Christensen, Zhongze Li, Jacquelyn K Kuriger, Heather H Nelson, New Hampshire Skin Cancer Study

“…Immunity and inflammatory pathways are important in the genesis of non-melanoma skin cancers (NMSC). Functional genetic variation in immune modulators has the potential to affect disease etiology. …”
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Regulation of the cytokine profile of NK cells by the microenvironment factors typical for pregnancy by P. V. Grebenkina, V. A. Mikhailova, O. N. Bespalova, S. A. Selkov, D. I. Sokolov

“…Decidual NK cells exhibit distinct phenotypic and functional characteristics as compared to peripheral NK cells. …”
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Effects of Brassica rapa L. Polysaccharides on Bile Acid Metabolism and Intestinal Microbiota in Humanized Mice by ZHANG Mengying, TI Jiayi, LI Wei, BI Kaiyue, WU Yuhan, LI Yanbo, ZHAO Yu, WANG Wei

“…This study provides theoretical insights into the promotion of intestinal health and bile acid metabolism by BRAP1-1, offering new perspectives for the deep processing of B. rapa and the development of related functional foods.…”
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Mechanistic Insights into Salvigenin for Glucocorticoid-Induced Femoral Head Osteonecrosis: A Network Pharmacology and Experimental Study by Zhengjie Zhu, Yujian Zhong, Ruyuan He, Changheng Zhong, Junwen Chen, Hao Peng

“…Salvigenin significantly reduced Dex-induced oxidative stress and apoptosis in osteoblasts while restoring osteogenic differentiation and <i>ESR1</i> expression. Functional assays showed improved mineralized nodule formation, ALP activity, and mitochondrial integrity in salvigenin-treated cells. …”
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Trypsin- and Chymotrypsin-like serine proteases in schistosoma mansoni-- 'the undiscovered country'. by Martin Horn, Pavla Fajtová, Liliana Rojo Arreola, Lenka Ulrychová, Pavla Bartošová-Sojková, Zdeněk Franta, Anna V Protasio, David Opavský, Jiří Vondrášek, James H McKerrow, Michael Mareš, Conor R Caffrey, Jan Dvořák

“…To address this, we investigated SmSPs using genomic, transcriptomic, phylogenetic and functional proteomic approaches.<h4>Methodology/principal findings</h4>Genes encoding five distinct SmSPs, termed SmSP1 - SmSP5, some of which comprise disparate protein domains, were retrieved from the S. mansoni genome database and annotated. …”
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Multi-omics integration reveals the role of N6-methyladenosine in epilepsy, ischemic stroke, and vascular dementia by Xudong Zhang, Yuhao Xu, Hai Hu, Zhenhua Liao, Changli Lou, Xiang Zou

“…Results We identified 218 m6A sites significantly associated with the three diseases, highlighting 3,430 associations between m6A sites and gene expression. Functional enrichment analysis revealed key pathways, including base excision repair and chemokine-mediated signaling. …”
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ADP-ribosylation factor 6 expression and activation are reduced in myometrium in complicated pregnancies. by Venkateswarlu Kanamarlapudi, Sian E Owens, Jon Lartey, Andrés López Bernal

“…<h4>Conclusions</h4>We have demonstrated a functional ARF6 system in human myometrium and a correlation between ARF6 level and activity in uterine and abnormal pregnancy.…”
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Prussian‐Blue Catalysis and NFC Synergy: a Battery‐Free Laser‐Induced Graphene‐Based Platform for Urine Glucose Monitoring at Point‐of‐Care by Sinan Uzunçar, Gabriel Maroli, Massimo Urban, Arben Merkoçi

“…Chemical polymerization of Prussian‐blue (PB) and poly(3,4‐ethylenedioxythiophene) (PEDOT) with gelatin as a polycationic soft template yields a self‐assembled PB‐infused Catalytic Hetero‐interface Architecture (PB‐CHIA) that remarkably improves the stability of PBNPs and offers functional groups for enzyme immobilization, supporting robust biosensing applications. …”
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gdf6a is required for cone photoreceptor subtype differentiation and for the actions of tbx2b in determining rod versus cone photoreceptor fate. by Michèle G Duval, A Phillip Oel, W Ted Allison

“…Functional vision restoration is within reach via stem cell therapy, but one of the largest obstacles is the derivation of colour-sensitive cone photoreceptors that are required for high-acuity daytime vision. …”
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Enhancing the bioaccessibility of L-Citrulline using chitosan-coated nanoliposomes: Physicochemical properties and release kinetics in simulated gastrointestinal conditions by Mahsa Mohseni, Mohammad Mousavi, Hossein Kiani, Mina Homayoonfal, Amir Khademi

“…In conclusion, this study demonstrated that chitosan-coated nanoliposomes are a promising and innovative delivery system for bioactive compounds like L-Citrulline, offering improved stability, encapsulation efficiency, and controlled release profiles, making them suitable for functional food and pharmaceutical applications.…”
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Suppressing mitochondrial inner membrane protein (IMMT) inhibits the proliferation of breast cancer cells through mitochondrial remodeling and metabolic regulation by Li Liu, Qingqing Zhao, Daigang Xiong, Dan Li, Jie Du, Yunfei Huang, Yan Yang, Rui Chen

“…Mitochondria, as pivotal organelles, play a crucial role in the metabolic regulation of tumor cells, and their morphological and functional alterations are intricately linked to the biological characteristics of tumors. …”
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Aryl hydrocarbon receptor signaling in male fertility: Protective role of resveratrol and disruptive effects of CH223191 in adult male rats by Ghadeer Sabah Bustani, Hasan Falah Kashef Alghetaa

“…Background and Aim: The aryl hydrocarbon receptor (AhR) plays a pivotal role in spermatogenesis through its regulatory functions in redox balance and gene expression. This study aimed to investigate the effects of resveratrol (RES), a polyphenolic AhR modulator, and CH223191, a selective AhR antagonist, on male reproductive function in rats by assessing sperm quality, oxidative stress, testicular histopathology, and AhR gene expression. …”
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Investigation of an Efficient Multi-Class Cotton Leaf Disease Detection Algorithm That Leverages YOLOv11 by Fangyu Hu, Mairheba Abula, Di Wang, Xuan Li, Ning Yan, Qu Xie, Xuedong Zhang

“…To lower the computational complexity, the SPPF module is substituted with SimSPPF. The C3k2_RCM module is appended for long–range context modeling, and the ARelu activation function is employed to alleviate the vanishing gradient problem. …”
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Extracellular vesicles derived from mesenchymal stem cells alleviate renal fibrosis via the miR-99b-5p/mTOR/autophagy axis in diabetic kidney disease by Rongrong Li, Hongyan Tao, Kai Pan, Rui Li, Zhikun Guo, Xiaoniao Chen, Zongjin Li

“…Results Treatment with hP-MSC-derived EVs significantly alleviated renal fibrosis and improved renal function in DKD models. These EVs were enriched with miR-99b-5p, which targeted and inhibited mTOR signaling, thereby increasing autophagic activity and reducing cellular proliferation and extracellular matrix accumulation in renal tissues. …”
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The Role of Plant-Derived Natural Products as a Regulator of the Tyrosine Kinase Pathway in the Management of Lung Cancer by Faris Alrumaihi, Arshad Husain Rahmani, Sitrarasu Vijaya Prabhu, Vikalp Kumar, Shehwaz Anwar

“…Tyrosine kinases (TKs), a subclass of protein kinases, regulate vital cellular function by phosphorylating tyrosine residues in proteins. …”
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AER-Net: Attention-Enhanced Residual Refinement Network for Nuclei Segmentation and Classification in Histology Images by Ruifen Cao, Qingbin Meng, Dayu Tan, Pijing Wei, Yun Ding, Chunhou Zheng

“…Moreover, the coarse predictions and refined predictions are combined by using a loss function that employs cross-entropy loss and generalized dice loss to efficiently tackle the challenge of class imbalance among nuclei in histology images. …”
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Plug-and-Play Robust Aerial Object Detection Under Hazy Conditions by Wei Wu, Hao Chang, Zhiwen Chen, Zhu Li

“…Moreover, we also propose a detection feature pyramid loss function to more accurately restore object features. …”
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Expanding our understanding of (mal)adapted stress physiology in psychiatric disorders: achieving single-cell characterisation of steroids and neuropeptides by Katrina Z. Edmond, Natalie Matosin

“…Despite their central role in brain function, these signalling systems remain historically understudied, exposing a major gap in our understanding of stress-related psychiatric disorders, and posing a valuable opportunity for therapeutic innovation. …”
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Regulatory roles of circular RNAs in Wnt and other oncogenic signaling pathways in breast cancer progression: a comprehensive review by Amirreza Khalaji, Yousef Nazari, Mojtaba Pandeh, Aram Farhoudian, Leila Ghorbi, Pedram Naderi, Elham Mohebi Janagard, Samira Amin Afshari, Reza Morovatshoar

“…This comprehensive review elucidates the regulatory roles of key circRNAs, including circABCC4, circFAT1, circARL8B, and circDONSON, in modulating BC behavior. These circRNAs primarily function as microRNA sponges, influencing essential processes such as proliferation, metastasis, drug resistance, and cell survival. …”
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Mechanistic Insights into Autophagy-Dependent Cell Death (ADCD): A Novel Avenue for Cancer Therapy by Md Ataur Rahman, Maroua Jalouli, Mohammed Al-Zharani, Ehsanul Hoque Apu, Abdel Halim Harrath

“…Autophagy regulates cellular breakdown and stress responses, serving a dual function—either inhibiting tumorigenesis or facilitating the survival of cancer cells in advanced stages. …”
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