Identification of immune-related hub genes and potential molecular mechanisms involved in COVID-19 via integrated bioinformatics analysis by Rui Zhu, Yaping Zhao, Hui Yin, Linfeng Shu, Yuhang Ma, Yingli Tao

“…IRGs were sourced from the ImmPort database. We conducted functional enrichment analysis, pathway analysis, and immune infiltration assessments to determine the biological significance of the identified IRGs. …”
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Unveiling the causative role of promoter variant rs113823671 in MMP7 in gallbladder cancer susceptibility by Vinay Jeeyar, Kusumbati Besra, Shivaram Prasad Singh, Manjusha Dixit

“…We hypothesized that promoter SNPs could modulate MMP7 expression, thus impacting GBC susceptibility. …”
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Up-regulation of microRNA-190b plays a role for decreased IGF-1 that induces insulin resistance in human hepatocellular carcinoma. by Tzu-Min Hung, Cheng-Maw Ho, Yen-Chun Liu, Jia-Ling Lee, Yow-Rong Liao, Yao-Ming Wu, Ming-Chih Ho, Chien-Hung Chen, Hong-Shiee Lai, Po-Huang Lee

“…Restoration of IGF-1 expression reversed miR-190b-mediated impaired insulin signaling in Huh7 cells, supporting that IGF-1 was a direct and functional target of miR-190b. Additionally, low serum IGF-1 level was associated with insulin resistance and poor overall survival in HCC patients.…”
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Nisin-preconditioned mesenchymal stem cells combatting nosocomial Pseudomonas infections by Sara Enayati, Raheleh Halabian, Parvaneh Saffarian, Hossein Aghamollaei, Pardis Saeedi

“…MSCs preconditioned with Nisin were characterized using microscopy, flow cytometry, gene expression analysis, and functional assays. The effects of preconditioning on the viability, phenotype, differentiation capacity, antimicrobial peptide expression, and antibacterial activity of MSCs against Pseudomonas aeruginosa were tested in vitro. …”
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Decoding tinnitus progression: neurochemical shifts in the anterior cingulate cortex revealed by magnetic resonance spectroscopy by Mengfang Gong, Shuting Han, Yongcong Shen, Yonggang Li, Ji-Sheng Liu, Duo-Duo Tao

“…Tinnitus severity was assessed via tinnitometry and Tinnitus Functional Index (TFI).ResultsRO patients exhibited significantly reduced ACC GABA+/Cr compared to CH and HC groups (p < 0.05), while CH and HC showed no differences. …”
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Micro-RNA profiling in human serum reveals compartment-specific roles of miR-571 and miR-652 in liver cirrhosis. by Christoph Roderburg, Tobias Mollnow, Brenda Bongaerts, Natalia Elfimova, David Vargas Cardenas, Katharina Berger, Henning Zimmermann, Alexander Koch, Mihael Vucur, Mark Luedde, Claus Hellerbrand, Margarete Odenthal, Christian Trautwein, Frank Tacke, Tom Luedde

“…<h4>Background and aims</h4>Micro-RNAs (miRNAs) have recently emerged as crucial modulators of molecular processes involved in chronic liver diseases. …”
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Cis-eQTL-based trans-ethnic meta-analysis reveals novel genes associated with breast cancer risk. by Joshua D Hoffman, Rebecca E Graff, Nima C Emami, Caroline G Tai, Michael N Passarelli, Donglei Hu, Scott Huntsman, Dexter Hadley, Lancelote Leong, Arunabha Majumdar, Noah Zaitlen, Elad Ziv, John S Witte

“…This approach provided an avenue for deciphering the functional relevance of genes and genetic variants involved in breast cancer.…”
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LINC01871 facilitates cervical cancer cell migration and immune escape by targeting miR‐873‐3p/MAP3K2 axis by Yan Li, Li Wei, Hui‐Hui Zhang, Hong‐Fei Ci, Duo‐Jie Li

“…In this study, we examined the expression levels and subcellular localization of LINC01871 in CC cell lines. Functional assays, including transwell migration and invasion assays as well as macrophage phagocytosis assays, were conducted to estimate CC cell invasiveness, migration, and immune response. …”
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Identifying drug targets for neurological and psychiatric disease via genetics and the brain transcriptome. by Denis A Baird, Jimmy Z Liu, Jimmy Z Liu, Jie Zheng, Solveig K Sieberts, Thanneer Perumal, Benjamin Elsworth, Tom G Richardson, Chia-Yen Chen, Minerva M Carrasquillo, Mariet Allen, Joseph S Reddy, Philip L De Jager, Nilufer Ertekin-Taner, Lara M Mangravite, Ben Logsdon, Karol Estrada, Philip C Haycock, Gibran Hemani, Heiko Runz, George Davey Smith, Tom R Gaunt, AMP-AD eQTL working group

“…Genetic variants that modulate the expression of potential drug targets can be utilized to assess the efficacy of therapeutic interventions. …”
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Gene expression analysis reveals mir-29 as a linker regulatory molecule among rheumatoid arthritis, inflammatory bowel disease, and dementia: Insights from systems biology approach... by Devi Soorya Narayana S, Vino Sundararajan

“…Subsequently, topology analysis for hub gene identification, cluster and functional enrichment, and regulatory network analysis were performed. …”
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Exploring the neuroprotective mechanisms of Jiawei Suanzaoren decoction in depression: insights from network pharmacology and molecular docking by Ruiting Ma, Wenjing Zhang, Lixia Chen, Lijun Tong

“…A protein–protein interaction (PPI) network was constructed, followed by functional enrichment analyses, including Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. …”
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Frequency-specific changes in prefrontal activity associated with maladaptive belief updating in volatile environments in euthymic bipolar disorder by Marina Ivanova, Ksenia Germanova, Dmitry S. Petelin, Aynur Ragimova, Grigory Kopytin, Beatrice A. Volel, Vadim V. Nikulin, Maria Herrojo Ruiz

“…Alterations in frequency-domain amplitude and functional connectivity within the PFC, OFC, and ACC during belief updating underlie the computational effects and could serve as potential indicators for predicting relapse in future research.…”
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Analysis of Crucial Genes and Pathways Associated with Spared Nerve Injury-Induced Neuropathic Pain by Dong Mao, Huang Zhai, Gang Zhao, Jingyi Mi, Yongjun Rui

“…Subsequently, comprehensive bioinformatic analyses were performed, including functional enrichment analysis, protein-protein interaction (PPI) network and module analysis, and transcription factor- (TF-) gene and miRNA-target interaction predictions. …”
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Pharmacological Mechanisms of Cryptotanshinone: Recent Advances in Cardiovascular, Cancer, and Neurological Disease Applications by Zheng Z, Ke L, Ye S, Shi P, Yao H

“…Ziyao Zheng,1 Liyuan Ke,1 Shumin Ye,1 Peiying Shi,2 Hong Yao1,3 1Department of Pharmaceutical Analysis, School of Pharmacy, Fujian Medical University, Fuzhou, 350122, People’s Republic of China; 2Department of Traditional Chinese Medicine Resource and Bee Products, College of Animal Sciences (College of Bee Science), Fujian Agriculture and Forestry University, Fuzhou, 350002, People’s Republic of China; 3Fujian Key Laboratory of Drug Target Discovery and Structural and Functional Research, Fujian Medical University, Fuzhou, 350122, People’s Republic of ChinaCorrespondence: Peiying Shi; Hong Yao, Email peiyshi@126.com; yauhung@126.com, hongyao@mail.fjmu.edu.cnAbstract: Cryptotanshinone (CTS) is an important active ingredient of Salvia miltiorrhiza Bge. …”
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Using siRNA-Based Anti-Inflammatory Lipid Nanoparticles for Gene Regulation in Psoriasis by Zeng A, Liu Y, Wang P, Cao Y, Guo W

“…The therapeutic effect of modified anti-inflammatory LNP delivery of Stat3 siRNA on psoriasis was evaluated both in vitro and in an imiquimod-induced mice.Results: LNPs exhibit both superior transfection efficiency and significant anti-inflammatory effects. In vitro functional studies showed that in an inflammatory DC model, anti-inflammatory LNP (C8B2) inhibited inflammatory mediators much better than classical LNPs by delivering Stat3 siRNA; in pathological HaCat cells, Stat3 siRNA reduced cell proliferation and promoted apoptosis. …”
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Roles of ACSL4/GPX4 and FSP1 in oxalate-induced acute kidney injury by Keng Ye, Ruilong Lan, Zhimin Chen, Kunmei Lai, Yankun Song, Guoping Li, Huabin Ma, Hong Chen, Yanfang Xu

“…Furthermore, renal tubule-specific deficiency of Acsl4 conferred significant protection against oxalate-induced AKI, as evidenced by alleviated structural and functional renal damage, reduced oxidative stress and decreased inflammatory cell infiltration, all of which collectively contribute to a reduction in ferroptosis. …”
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EEG–fNIRS signal integration for motor imagery classification using deep learning and evidence theory by Mohammed E. Seno, Niladri Maiti, Maulik Patel, Mihirkumar M. Patel, Kalpesh B. Chaudhary, Ashish Pasaya, Babacar Toure

“…To address the limitations of traditional unimodal brain-computer interface BCI) technologies based on electroencephalography (EEG) such as low spatial resolution and high susceptibility to noise an increasing number of neuroscience-driven studies have begun to focus on BCI systems that fuse EEG signals with functional near-infrared spectroscopy (fNIRS) signals. …”
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Study on the mechanism of hsa_circ_0074763 regulating the miR-3667-3P/ACSL4 axis in liver fibrosis by Yanling Cheng, Tiantian Song, Jiachen Yao, Qirong Wang, Chunyan Meng, Fumin Feng

“…Validation through dual-luciferase reporter gene assays confirms the interaction between hsa_circ_0074763 and miR-3667-3P. Functional cell experiments demonstrate that overexpression of hsa_circ_0074763 promotes proliferation of LX-2 cells, elevates inflammation levels, and inhibits apoptosis. …”
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Agonist-Antagonist Coactivation Enhances Corticomotor Excitability of Ankle Muscles by Trisha M. Kesar, Andrew Tan, Steven Eicholtz, Kayilan Baker, Jiang Xu, Joanna T. Anderson, Steven L. Wolf, Michael R. Borich

“…A majority of studies using transcranial magnetic stimulation- (TMS-) evoked MEPs to evaluate the excitability of the corticospinal pathway focus on upper extremity muscles. Due to functional and neural control differences between lower and upper limb muscles, there is a need to evaluate methodological factors influencing TMS-evoked MEPs specifically in lower limb musculature. …”
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Unveiling the Pathological Landscape of Intrauterine Adhesion: Mechanistic Insights and Exosome-Biomaterial Therapeutic Innovations by Qin Z, Yu Q, Long Y

“…Zhimin Qin,1,&amp;ast; Qicheng Yu,2,&amp;ast; Yan Long1 1Department of Obstetrics and Gynecology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, People’s Republic of China; 2Emergency Department of Xuanwu Hospital, Capital Medical University, Beijing, 100053, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Yan Long, Department of Obstetrics and Gynecology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, People’s Republic of China, Email longyan_doc@163.comAbstract: Intrauterine adhesion (IUA) is a fibrotic disorder caused by endometrial injury, characterized by structural damage and functional impairment of the endometrium, which severely impacts female reproductive health. …”
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