Investigating the Genetic Links Between Immune Cell Profiles and Bladder Cancer: A Multidisciplinary Bioinformatics Approach by Jin Zhang, Zhongji Jiang, Jiali Jin, Gaohaer Kadeerhan, Hong Guo, Dongwen Wang

“…Differential expression analysis identified immune-related differentially expressed genes (iDEGs), and a protein–protein interaction (PPI) network along with functional enrichment analysis were conducted to explore their roles in tumor development. …”
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Genome‐wide analysis of HD‐Zip genes in Sophora alopecuroides and their role in salt stress response by Youcheng Zhu, Di Wang, Fan Yan, Le Wang, Ying Wang, Jingwen Li, Xuguang Yang, Ziwei Gao, Xu Liu, Yajing Liu, Qingyu Wang

“…Transcriptome and quantitative real‐time polymerase chain reaction analyses showed that under salt stress, SaHDZ responded positively in S. alopecuroides, and that SaHDZ22 was significantly upregulated afterward. Functional verification experiments revealed that SaHDZ22 overexpression increased the tolerance of Arabidopsis to salt and osmotic stress. …”
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Polymorphic positions 349 and 725 of the autoimmunity-protective allotype 10 of ER aminopeptidase 1 are key in determining its unique enzymatic properties by Galateia Georgaki, Galateia Georgaki, Anastasia Mpakali, Anastasia Mpakali, Myrto Trakada, Athanasios Papakyriakou, Efstratios Stratikos, Efstratios Stratikos

“…ERAP1 allotype 10 is highly protective toward developing some forms of autoimmunity and displays unusual functional properties, including very low activity versus some substrates.MethodsTo understand the molecular mechanisms that underlie the biology of allotype 10, we studied its enzymatic and biophysical properties focusing on its unique polymorphisms V349M and Q725R.ResultsCompared to ancestral allotype 1, allotype 10 is much less effective in trimming small substrates but presents allosteric kinetics that ameliorate activity differences at high substrate concentrations. …”
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TMEM132A: a novel susceptibility gene for lung adenocarcinoma combined with venous thromboembolism identified through comprehensive bioinformatic analysis by Pei Xie, Yingli Liu, Pingping Bai, Yue Ming, Qi Zheng, Li Zhu, Yong Qi

“…Molecular crosstalk analysis identified candidate genes through differential expression algorithms and disease-association metrics. Functional annotation employed GO and KEGG analyses to elucidate the biological significance of identified CGs. …”
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Eggerthella lenta down regulated flavone and flavonol biosynthesis promoted Kawasaki disease by Yao-Tsung Yeh, Kuang-Den Chen, Cheng-Hsieh Huang, Jia-Rong Tsai, Ho-Chang Kuo

“…PICRUSt 2 was used to analyse the potential functional pathways involved in gut dysbiosis. Alpha (p < 0.042) and beta (p < 0.001) diversity in KD were significantly decreased when compared to the control group. …”
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Lipopolysaccharide-Induced Transcriptional Changes in LBP-Deficient Rat and Its Possible Implications for Liver Dysregulation during Sepsis by Zhixiang He, Zichen Song, Leilei Meng, Wenhui Cheng, Fan Huang, Mao Zheng, Wenhui Xu, Rong Xiao, Haoshu Fang, Yaling Zhu

“…Lipopolysaccharide-binding protein (LBP) binds to lipopolysaccharide (LPS) and modulates the inflammatory response. A rare systematic study has been reported to detect the effect of LBP gene during LPS-induced sepsis. …”
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Platelet-Rich Plasma and Adipose-Derived Mesenchymal Stem Cells in Association with Arthroscopic Microfracture of Knee Articular Cartilage Defects: A Pilot Randomized Controlled Tr... by Michele Venosa, Francesco Calafiore, Manuel Mazzoleni, Emilio Romanini, Simone Cerciello, Vittorio Calvisi

“…At the 12-month follow-up, both groups showed a comparable functional improvement. The scores on the IKDC form, KOOS, pain VAS, and SF-12 significantly improved from baseline (p<0.05) to 12 months postoperatively in both treatment groups. …”
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Investigation of sphingolipid-related genes in lung adenocarcinoma by Jibin Mao, Li Li, Hui Sun, Jie Han, Jinqiao Li, Chang-Sheng Dong, Hongyu Zhao

“…The study also delved into the clinical relevance, functional capabilities, and immune implications of prognostic signals associated with sphingolipid metabolism. …”
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Comparative miRNome analysis of colostrum- and mature milk–derived extracellular vesicles from Holstein and Jersey cows by Daye Mun, Sangdon Ryu, Dong-Hyun Lim, Sangnam Oh, Younghoon Kim

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Time-Delayed Cold Gelation of Low-Ester Pectin and Gluten with CaCO₃ to Facilitate Manufacture of Raw-Fermented Vegan Sausage Analogs by Maurice Koenig, Kai Ahlborn, Kurt Herrmann, Myriam Loeffler, Jochen Weiss

“…Gluten as well as pectin had a significant influence on the functional properties of the matrices, especially water holding capacity (increasing with higher pectin or gluten content), hardness (increasing with higher pectin or gluten content), tensile strength (increasing with higher pectin or gluten content) and cohesiveness (decreasing with higher pectin or gluten content). …”
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Anxiolytic and Antidepressant Effects of Organic Polysulfide, Dimethyl Trisulfide Are Partly Mediated by the Transient Receptor Potential Ankyrin 1 Ion Channel in Mice by Kitti Göntér, Viktória Kormos, Erika Pintér, Gábor Pozsgai

“…<b>Results</b>: Results showed that CUMS induces depression-like behaviour, with the response being modulated by the TRPA1 status and that DMTS treatment significantly reduced these effects when TRPA1 channels were functional. …”
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Novel L-asparaginase from Paucilactobacillus vaccinostercus: Insights into anti-cancer potential using metagenomic, molecular docking and molecular dynamics simulation by Rohit Das, Buddhiman Tamang, Anil Bhattarai, Ishfaq Nabi Najar

“…The current study presents the identification and characterization of six high-quality MAGs isolated from fermented bamboo shoots, namely Lacticaseibacillus pantheris, Enterococcus italicus, and Paucilactobacillus vaccinostercus from DBMD, Enterococcus italicus DBMK, Pediococcus pentosaceus PBMD, and Lactococcus lactis PBMA. Functional annotation revealed gene clusters associated with immune modulation, probiotic properties, and stress tolerance. …”
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RUNX2 mediated epithelial mesenchymal transition induced by TGF beta and Smad signaling promotes malignant progression in glioma by Peng Zhou, Qianfeng Wei, Haoqian Wang, Tao Yu, Lin Chen, Qiliang Huang, Li Wei, Jingting Jiang

“…We further validated RUNX2 expression in glioma tissues and cell lines using RT-qPCR and Western blotting. Functional experiments, including CCK-8, wound healing, transwell invasion, and apoptosis assays, were conducted in U251 glioma cells with RUNX2 knockdown via siRNA. …”
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Comparison of Atmospheric O₃ Dose–Response Effects Under N Addition on Gas Exchange, Growth, and Biomass of <i>Raphanus sativus</i> L. by Li Li, Jinling Li

“…Soil N addition offers a short-term strategy to mitigate O₃ impacts on short-lived root vegetables such as cherry radish but does not influence key functional traits over the long term. This study highlights the potential of N addition to alleviate acute oxidative stress, while underscoring its limitations in mitigating the effects of prolonged O₃ exposure in root vegetables.…”
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The Development of Publications on Catheter-Related Bladder Discomfort: A Bibliometric Analysis by Jiang W, Chen X, Peng Y, Zhai W, Zhang X, Zhou Y, Zhou R

“…Wencai Jiang,1 Xuemeng Chen,1 Yanhua Peng,1 Wenhu Zhai,1 Xianjie Zhang,1 Yukai Zhou,1 Rui Zhou2 1Department of Anesthesiology, Deyang People’s Hospital, Deyang, 618000, People’s Republic of China; 2Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Department of Anesthesiology and Perioperative Medicine, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200434, People’s Republic of ChinaCorrespondence: Rui Zhou, Shanghai Fourth People’s Hospital, No. 1279, Sanmen Road, Shanghai, 200434, People’s Republic of China, Email ruizhoukepler@126.comBackground: Catheter-related bladder discomfort (CRBD) is a risk factor that impacts postoperative recovery and still troubles patients and healthcare staff. …”
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Hypothalamus Transcriptome Reveals Key lncRNAs and mRNAs Associated with Fecundity in Goats by Yingshi Wei, Caiye Zhu, Xiaoyun He, Mingxing Chu

“…The hypothalamus (hyp) serves as the regulatory hub of the neuroendocrine system, synthesizing and secreting reproductive hormones that modulate estrus, follicular maturation, and embryonic development in goats. …”
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Signs of Nervous System Sensitization in Female Runners with Chronic Patellofemoral Pain by Brian J. Eckenrode, David M. Kietrys, Allison Brown, J. Scott Parrott, Brian Noehren

“…QST consisted of pressure pain threshold testing to three local and three distant sites to the knee, heat temporal summation, heat pain threshold, and conditioned pain modulation. Data was analyzed utilizing independent t-tests for comparison of between-group data, effect sizes for QST measures (Pearson's r), and Pearson's correlation coefficient between pressure pain threshold values at the knee and functional testing…”
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Assessing fiber quality variability among modern upland cotton cultivars and incorporating it into the GOSSYM-based fiber quality simulation model by Sahila Beegum, Muhammad Adeel Hassan, Krishna N. Reddy, Vangimalla Reddy, Kambham Raja Reddy

“…Abstract Background GOSSYM is a mechanistic, process-based cotton model that can simulate cotton crop growth and development, yield, and fiber quality. Its fiber quality module was developed based on controlled experiments explicitly conducted on the Texas Marker-1 (TM1) variety, potentially making its functional equations more aligned with this cultivar. …”
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Exploring Clec9a in dendritic cell-based tumor immunotherapy for molecular insights and therapeutic potentials by Zubair Hussain, Yueteng Zhang, Lu Qiu, Shanshan Gou, Kangdong Liu

“…Furthermore, it discusses the role of Clec9a in the induction and functional activation of Clec9a+ cDC1s, with a particular focus on addressing the challenges related to off-target effects and immune tolerance in the development of tumor vaccines. …”
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A genetic modifier links integrin α5 to the phenotypic variation in fibronectin 1a mutant zebrafish. by Samuel J Capon, Anastasia Maroufidou, McKenna Feltes, Yanli Xu, Darpan Kaur Matharoo, Dörthe Jülich, Scott A Holley, Steven A Farber, Didier Y R Stainier

“…Fibronectin mutants in both mouse and zebrafish fail to form a functional cardiovascular system, although the penetrance and expressivity of this phenotype vary depending on the genetic background. …”
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