Human Cytomegalovirus Immune Evasion of Natural Killer Cells: A Virus for All Seasons? by Hannah Preston, Rowan Casey, Elizabeth Ferris, Lauren Kerr-Jones, Lauren Jones, Farah Latif, Mathew Clement, Rebecca J. Aicheler, Eddie C. Y. Wang, Richard J. Stanton, Ceri A. Fielding

“…As a result, the virus systematically subverts almost all aspects of antiviral immune defence to successfully establish a lifelong persistent infection, and in the process, dramatically reshapes the phenotype and function of host immunity to both HCMV and other diseases. …”
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Prevention and treatment of antibiotics-associated adverse effects through the use of probiotics: A review by Shuwei Yang, Jiaqi Qiao, Meng Zhang, Lai-Yu Kwok, Bojana Bogovič Matijašić, Heping Zhang, Wenyi Zhang

“…Key scientific concepts of review: Probiotics play a crucial role in preserving gut homeostasis, regulating intestinal function and metabolism, and modulating the host immune system. …”
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TLR4 as a therapeutic target: Antidepressant mechanism of saikosaponin A in regulating the NF-κB/BDNF axis and mitigating oxidative stress and inflammation in vivo and in vitro by Lin Tan, Jiayue Li, Dingcheng Sun, Xinyi Tian, Xiaoli Zhong, Yiyi Shan

“…These findings suggest SSA alleviates CUMS-induced depression-like behaviors in mice by modulating neuroinflammation and oxidative stress through the TLR4/NF-κB/BDNF signaling axis, indicating its potential as a functional food-derived therapy for depression.…”
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Glycyrrhizin attenuates renal inflammation in a mouse Con A-hepatitis model via the IL-25/M2 axis by Lingyun Li, Yuanyue Zhang, Zhongyan Wang, Xiangyu Chen, Min Fang

“…Hepatorenal syndrome (HRS) is a functional acute renal impairment that occurs in severe liver disease, and we found that kidney injury also occurs in Con A-induced experimental hepatitis in mice. …”
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Inhibition of histone deacetylases 3 attenuates imiquimod-induced psoriatic dermatitis via targeting cGAS-STING signaling in keratinocytes by Chong Zeng, Xiujuan Wen, Zibo Wei, Xinhuai Dong

“…However, its precise expression profile and functional contribution to psoriasis pathogenesis remain poorly defined. …”
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Implemetasi Komputasi Akar Kuadrat Resolusi Tinggi pada Field Programmable Gate Array (FPGA) by Muhammad Irfan, Hendra Setiawan

“…The system verification process is carried out in two stages, i.e. functional verification using the ModelSim-Altera and hardware verification using the FPGA Cylcone IV EP4CE6E228N. …”
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Potential involvement of peroxisome proliferator-activated receptors in the inhibition of mammary lipid synthesis during diet-induced milk fat depression by A. Haile, D.E. Oliveira, Y.R. Boisclair, D.E. Bauman, K.J. Harvatine

“…Overall, the results fail to support a functional role of the PPAR family in the inhibition of lipogenesis during MFD in dairy cows.…”
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CD105+ fibroblasts support an immunosuppressive niche in women at high risk of breast cancer initiation by Eric G. Carlson, Jennifer C. Lopez, Yukiko Yamaguchi, Jackson Gibson, Saul J. Priceman, Mark A. LaBarge

“…Co-cultures with fibroblasts, macrophages, and T cells were used to ascertain the functional role played by CD105+ fibroblasts in immune cell modulation. …”
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Identification of hub genes, non-coding RNAs and pathways in Renal cell carcinoma (RCC): A comprehensive in silico study by Ahmad Golestanifar, Hengameh Khedri, Parisa Noorabadi, Mohammadreza Saberiyan

“…Our approach combined differential expression analysis, functional enrichment through Gene Ontology (GO) and KEGG pathway mapping, and a Protein-Protein Interaction (PPI) network to identify crucial hub genes in KIRC progression. …”
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Celecoxib disrupts temporal coordination of TGF-β/α-SMA signaling in skeletal muscle repair: a time-dependent study of fibrosis and inflammation by Jia Li, Huan Chen, Qianying Xiong, Jinzhong Ni, Fangyun Sun, Xin Gong, Huachun Miao

“…These findings advocate for time-restricted administration of celecoxib in muscle injury therapy, emphasizing the need to balance acute symptom management with long-term functional recovery.…”
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Comparative genomics reveals key adaptive mechanisms in pathogen host-niche specialization by Menglu Zhang, Longxi Han, Caizhi Liao, Weiheng Su, Weiheng Su, Chunlai Jiang, Chunlai Jiang

“…Bioinformatics databases and machine learning approaches were used to identify genomic differences in functional categories, virulence factors, and antibiotic resistance genes across different ecological niches.ResultsSignificant variability in bacterial adaptive strategies was observed. …”
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Exploring the Potential Mechanism of Liupao Tea Using UPLC-Q-TOF/MS and Network Pharmacology by Fang Jia, Qi Yang, Lihao Yao, Yunfei Liu, Jiagang Deng, Jing Leng, Lili Fan, Erwei Hao

“…Network pharmacology and molecular docking analyses revealed 298 common targets between LPT and GMD, including IL-6, AKT1, and TP53. Functional enrichment analysis suggested that LPT may improve GMD through the regulation of immune, inflammatory, and cytokine signaling pathways. …”
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Reshaping the tumor microenvironment of cold soft-tissue sarcomas with anti-angiogenics: a phase 2 trial of regorafenib combined with avelumab by Maud Toulmonde, Jean-Philippe Guégan, Mariella Spalato-Ceruso, Thibaud Valentin, Rastilav Bahleda, Florent Peyraud, Christophe Rey, Michèle Kind, Coralie Cantarel, Carine Bellera, Lucile Vanhersecke, Alban Bessede, Antoine Italiano

“…Overall, these results indicate that anti-angiogenic therapy modulates the tumor microenvironment in patients with cold STS and highlight the need for complementary strategies to enhance the functional activity of immune cells in this particular setting. …”
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RETRACTED ARTICLE: Single-cell omics and machine learning integration to develop a polyamine metabolism-based risk score model in breast cancer patients by Xiliang Zhang, Hanjie Guo, Xiaolong Li, Wei Tao, Xiaoqing Ma, Yuxing Zhang, Weidong Xiao

“…The immune profiling and functional enrichment analyses revealed that the genes identified play a crucial role in cell cycle control and immune modulation. …”
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Computational analysis of congenital heart disease associated SNPs: unveiling their impact on the gene regulatory system by Shikha Vashisht, Costantino Parisi, Cecilia L. Winata

“…Subsequently, these CHD-SNPs were annotated and categorized into noncoding and coding regions based on their location. To study the functional implications of noncoding CHD-SNPs, we cross-validated them with enhancer-specific histone modification marks from developing human heart across 9 Carnegie stages and identified potential cardiac enhancers. …”
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Sam-Sam Association Between EphA2 and SASH1: In Silico Studies of Cancer-Linked Mutations by Marian Vincenzi, Flavia Anna Mercurio, Ida Autiero, Marilisa Leone

“…These interactions involve the first N-terminal Sam (sterile alpha motif) domain of SASH1 (SASH1-Sam1) and the Sam domain of Eph receptors. Currently, the functional meaning of the SASH1-Sam1/EphA2-Sam complex is unknown, but EphA2 is a well-established and crucial player in cancer onset and progression. …”
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Machine learning prediction of pKa of organic acids by Juda Baikété, Alhadji Malloum, Jeanet Conradie

“…Further molecular descriptors have been generated using density functional theory (DFT) calculations, and RDKit library. …”
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Review of the Evidence on Preventing and Managing Acute Kidney Injury after Cardiac Surgery with Amino Acids by Ali Jabbari, Behrang Nooralishahi, Alireza Jahangiri fard

“…These amino acids can enhance postoperative GFR and potentially lower the risk of AKI by bolstering renal functional reserve and stimulating local renal growth factors. …”
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Identification of IQGAP3 prognostic potential and involvement in immune cell infiltration in LUAD by Mingduan Chen, Peipei Zhang, Chengxiong You, Shuchen Chen

“…Survival analyses correlated expression levels with patient outcomes. Functional assays including CCK-8, colony formation, EdU incorporation, migration, and invasion assays were performed to evaluate the role of IQGAP3 in LUAD cells. …”
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The significance of melatonin as one of the signaling substrates in the expression of psychopathological disorders in the late period after traumatic brain injury by M. O. Ovcharenko, Ye. Yu. Verbytskyi, T. M. Radchenko, V. Ye. Kazakov, I. O. Chumakova

“…Aim. To discuss the functional properties of melatonin which plays a key role in the expression of psychopathological disorders following traumatic brain injury (TBI). …”
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