Neuropeptide-Driven Cross-Modal Plasticity following Sensory Loss in Caenorhabditis elegans. by Ithai Rabinowitch, Patrick Laurent, Buyun Zhao, Denise Walker, Isabel Beets, Liliane Schoofs, Jihong Bai, William R Schafer, Millet Treinin

“…Our results indicate that under normal function, ongoing touch receptor neuron activation evokes FLP-20 release, suppressing synaptic communication and thus dampening odor sensation. …”
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Melanopic Contribution of Display Image to Alertness, Attention, Brightness Perception, and Visual Fatigue by Nianfang Zhu, Yan Tu, Lili Wang, Yunyang Shi

“…The metameric images were modulated at two melanopic luminance levels (higher and lower). …”
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ConvNeXt embedded U-Net for semantic segmentation in urban scenes of multi-scale targets by Yanyan Wu, Qian Li

“…The main advantage of this algorithm is to explore the specific loss function and segmentation strategy suitable for urban scene in the face of the complexity and diversity of urban scene images.…”
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Efficacy and safety of pharmacological treatments in inclusion body myositis: a systematic review by Pedro M Machado, Eduardo José Ferreira Santos, Nicholas Yapp, Pedro Sousa, Bayram Farisogullari, Hermaleigh Townsley

“…Treatments included various immunosuppressive and immunomodulatory agents, alongside interventions modulating muscle growth and protein homoeostasis. Efficacy was assessed across multiple outcomes, namely muscle strength, physical function, mobility and muscle trophicity. …”
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The regulation and mechanism of the cAMP-PKA pathway on PTSD-like behaviors exacerbated by alcohol exposure by Shuang Zhao, Wei Zhao, Ziqi Wang, Xiaofei Chen, Fangjiao Zong, Hanting Zhang

“…Activation of cAMP-PKA signaling enhanced the downregulation of brain-derived neurotrophic factor (BDNF) and tyrosine kinase receptor B (TrkB), upregulated the expression of PSD95, synaptophysin, AMPA, and NMDA receptor subtypes, and reversed the impairment of CA1 synaptic function and dendritic structure in the hippocampus.ConclusionActivation of the cAMP-PKA pathway facilitated fear extinction in PTSD mice with early alcohol exposure, alleviated anxiety-like behavior, attenuated symptoms of AUD following ethanol relapses. …”
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The effect of transcranial random noise stimulation on the movement time and components of noise, co-variation, and tolerance in a perceptual-motor task by Fatemeh Salehi, Mohammadreza Doustan, Esmaeel Saemi

“…In addition, tRNS improved the function of the sensorimotor wave (p ≤ 0.05). Moreover, the results indicate that tRNS elicited a significant reduction in both spatial error and movement execution time, (p ≤ 0.05). …”
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DCPNet: Distribution Calibration Prototypical Network for Few-Shot Image Classification by Ranhui Xu, Kaizhong Jiang, Lulu Qi, Shaojie Zhao, Mingming Zheng

“…DCPNet incorporates a parallel hierarchical feature extraction module and a few-shot differentiation loss function to fine-tune the metric learning for better feature representation. …”
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T Cell Aging: An Important Target for Perioperative Immunomodulation by Lan H, Xu S, Li H, Guo R, Feng Z, Wang Y

“…Haoning Lan, Songchao Xu, Huili Li, Ruijuan Guo, Zhong Feng, Yun Wang Department of Anaesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, People’s Republic of ChinaCorrespondence: Yun Wang, Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, No. 95, Yong’ an Road, Beijing, 100050, People’s Republic of China, Tel +86-10-63133069, Email wangyun129@ccmu.edu.cnAbstract: Although T cells are crucially involved in maintaining immune function, their roles change with age. Furthermore, T cell aging has a unique onset and progression mechanism and several clinical indicators have been developed to detect it. …”
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Influence of surface coal mining on carbon storage in semi-arid steppe by Zhenhua Wu, Qiao Yu

“…The transformation from high carbon-density land to low carbon-density land weakened the carbon fixation function of the study area. (2) From 2002 to 2023, the carbon loss caused by mining in the study area was as high as 91.92 kiloton, with an average annual carbon loss of 4.38 kiloton, and the carbon sequestration capacity of the ecosystem was gradually degraded. (3) The carbon storage in the study area is dominated by insignificant change, accounting for 73% of the total area of the study area. …”
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Characterisation of the fibroblast growth factor dependent transcriptome in early development. by Peter A Branney, Laura Faas, Sarah E Steane, Mary Elizabeth Pownall, Harry V Isaacs

“…We have found a widespread role for FGF signaling in regulating the expression of genes mediating the function of the Spemann organizer. In addition, we have found that the FGF targets MKP1 and DUSP5 are likely to contribute to the complex feedback loops involved in modulating responses to FGF signaling. …”
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A common variant associated with dyslexia reduces expression of the KIAA0319 gene. by Megan Y Dennis, Silvia Paracchini, Thomas S Scerri, Ludmila Prokunina-Olsson, Julian C Knight, Richard Wade-Martins, Penny Coggill, Stephan Beck, Eric D Green, Anthony P Monaco

“…Our study thus pinpoints a common variant as altering the function of a dyslexia candidate gene and provides an illustrative example of the strategic approach needed to dissect the molecular basis of complex genetic traits.…”
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Platelets express adaptor proteins of the extrinsic apoptosis pathway and can activate caspase-8. by Nadine Goelz, Julia J M Eekels, Milica Pantic, Christoph T Kamber, Oliver Speer, Francesca D Franzoso, Markus Schmugge

“…<h4>Background</h4>Apoptotic pathways in platelets are important for their survival and function. Platelet apoptosis may be involved in the pathogenesis of immune thrombocytopenia (ITP), an autoimmune-mediated disease. …”
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Cathepsin-L can resist lysis by human serum in Trypanosoma brucei brucei. by Sam Alsford, Rachel B Currier, José Afonso Guerra-Assunção, Taane G Clark, David Horn

“…TLF resistance mechanisms of T. b. gambiense and T. b. rhodesiense are now known to arise through either gain or loss-of-function, but our understanding of factors that render T. b. brucei susceptible to lysis by human serum remains incomplete. …”
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HSV-2 infection of dendritic cells amplifies a highly susceptible HIV-1 cell target. by Elena Martinelli, Hugo Tharinger, Ines Frank, James Arthos, Michael Piatak, Jeffrey D Lifson, James Blanchard, Agegnehu Gettie, Melissa Robbiani

“…Thus, we propose that HSV-2 modulates its microenviroment, influencing DC function, increasing RA production capability and amplifying a α₄β₇ (high)CD4⁺ T cells. …”
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Common genetic origins for EEG, alcoholism and anxiety: the role of CRH-BP. by Mary-Anne Enoch, Pei-Hong Shen, Francesca Ducci, Qiaoping Yuan, Jixia Liu, Kenneth V White, Bernard Albaugh, Colin A Hodgkinson, David Goldman

“…The resting EEG is a dynamic index of cortical activation, cognitive function and consciousness and is therefore an intermediate phenotype for many behaviors in which arousal is implicated such as anxiety and alcoholism. …”
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Impact of intraocular lens decentration and tilt on higher-order aberrations in patients with high and super-high myopia following cataract surgery by Yu Wang, Bo Zang, Qianlong Bi, Jing Huang, Wei Xu, Chunmeng Dai, Xiaoxia Ding, Dong Li, Zixi Zhou

“…At 3 months, IOL decentration negatively correlated with overall visual quality, measured by the modulation transfer function, in the high myopia group (rs = -0.558, P = 0.001), but no significant correlation was observed in the super-high myopia group. …”
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RORα-activated mitophagy attenuating hypoxic-ischemic encephalopathy via suppression of microglial cGAS-STING axis by Lei Song, Haiyan Shen, Fei Hong, Weiyan Zhang, Hongyi Lu

“…This correlated with improved cognitive/motor function in HIE rats (p &lt; 0.05) and attenuated ROS/IL-1β levels. …”
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Identification of 17 HrpX-regulated proteins including two novel type III effectors, XOC_3956 and XOC_1550, in Xanthomonas oryzae pv. oryzicola. by Xiao-bo Xue, Li-fang Zou, Wen-xiu Ma, Zhi-yang Liu, Gong-you Chen

“…The function of some hypothetical proteins, possibly regulated by key hrp regulators, in the pathogenicity of phytopathogenic bacteria remains largely unknown. …”
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The Impact of Modifiable Risk Factors on the Endothelial Cell Methylome and Cardiovascular Disease Development by Hashum Sum, Alison C. Brewer

“…This renders their activities subject to modulation by hypoxia, metabolic flux and cellular redox. …”
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RTDETR-MARD: A Multi-Scale Adaptive Real-Time Framework for Floating Waste Detection in Aquatic Environments by Baoshan Sun, Haolin Tang, Liqing Gao, Kaiyu Bi, Jiabao Wen

“…Third, we implement the Wise-IoU loss function to optimize localization accuracy through high-quality anchor supervision. …”
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