Complementary and alternative medicine for treating amyotrophic lateral sclerosis: a narrative review by Mudan Cai, Eun Jin Yang

“…Results: In the ALS animal model, CAM modulated the immune system to increase motor function by reducing the expression levels of neuroinflammatory proteins in the spinal cord. …”
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Cellular Senescence in Health, Disease, and Lens Aging by Ying Qin, Haoxin Liu, Hongli Wu

“…This review examines the dual role of senescence in LEC function and its implications for age-related cataractogenesis, alongside emerging senotherapeutic interventions. …”
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Hypochlorous acid-induced heme degradation from lactoperoxidase as a novel mechanism of free iron release and tissue injury in inflammatory diseases. by Carlos Eduardo A Souza, Dhiman Maitra, Ghassan M Saed, Michael P Diamond, Arlindo A Moura, Subramaniam Pennathur, Husam M Abu-Soud

“…On the basis of the present results we concluded that a complex bi-directional relationship exists between LPO activity and HOCl levels at sites of inflammation; LPO serve as a catalytic sink for HOCl, while HOCl serves to modulate LPO catalytic activity, bioavailability, and function.…”
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EV-D68 cleaves LARP1 and PABPC1 by 3Cpro to redirect host mRNA translation machinery toward its genomic RNA. by Ruyang Tan, Yuling Zhang, Mengqian Huang, Honghua Chen, Zixiang Liu, Zining Wang, Xiaoyan Li, Tao Wang, Zhiyun Wang

“…We found that LARP1 interacts with the 5'UTR of EV-D68 RNA through its LAM domain, and this interaction is crucial for its antiviral function. LARP1 translation modulation is also influenced by the mTOR and CDK1 signaling pathways. …”
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Organelle symphony: Nuclear factor erythroid 2-related factor 2 and nuclear factor-kappa B in stroke pathobiology by Ziliang Hu, Mingyue Zhao, Hangyu Shen, Liangzhe Wei, Jie Sun, Xiang Gao, Yi Huang

“…It plays a significant role in post-stroke neuroprotection and repair by influencing mitochondrial function, endoplasmic reticulum stress, and lysosomal activity and regulating metabolic pathways and cytokine expression. …”
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Adipocyte-specific deletion of Dbc1 does not recapitulate healthy obesity phenotype but suggests regulation of inflammation signaling. by Leonardo Santos, Rafael Sebastián Fort, Geraldine Schlapp, Karina Cal, Valentina Perez-Torrado, Maria Noel Meikle, Ana Paula Mulet, Camila Espasandín, Camila Chiesa, José R Sotelo-Silveira, Jose M Verdes, Paola Contreras, Aldo J Calliari, Martina Crispo, Jose L Badano, Carlos Escande

“…These results suggest that the protective phenotype observed in whole-body Dbc1 KO obese mice is not attributable to Dbc1's function within mature adipocytes but likely involves other cell types in adipose tissue. …”
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CIAPIN1 promotes survival, proliferation, migration and glycolysis of endometrial cancer cells through PI3K/Akt pathway by Huanmei Sun, Juan Shao, Yingchun Duan, Jiashi Gu

“…This study aimed to assess the potential function of this molecule in curbing the proliferation, migration, and glycolysis of endometrial cancer cells and to elucidate its molecular mechanism. …”
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Contrastive cross-domain sequential recommendation with attention-aware mechanism by Wei Zhao, Bo Li, Xian Mo

“…Specifically, we first develop an attention-aware framework over GNNs to capture collaborative relationships among inter-sequence items, then propose an attenuation function to assess the rationality of item representations. …”
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NANOVESICLES IN THE GUT–BRAIN AXIS: INSIGHTS FROM PROBIOTIC SUPPLEMENTATION IN IRRITABLE BOWEL SYNDROME

“…Our findings suggest that probiotic-induced nanovesicles may influence CNS function through the gut–brain axis and help maintain gut homeostasis under stress. …”
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MDA-DETR: Enhancing Offending Animal Detection with Multi-Channel Attention and Multi-Scale Feature Aggregation by Haiyan Zhang, Huiqi Li, Guodong Sun, Feng Yang

“…Additionally, the VariFocal Loss function is utilized to assign pixel weights, enhancing detail focus and maintaining accuracy. …”
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Human integrin α(3)β(1) regulates TLR2 recognition of lipopeptides from endosomal compartments. by Meghan L Marre, Tanja Petnicki-Ocwieja, Alicia S DeFrancesco, Courtney T Darcy, Linden T Hu

“…Adaptors and co-receptors that mediate this process, as well as the mechanisms by which these adaptors and co-receptors function, are still being discovered.<h4>Methodology/principal findings</h4>Using shRNA, blocking antibodies, and fluorescent microscopy, we show that U937 macrophage responses to the TLR2/1 ligand, Pam(3)CSK(4), are dependent upon an integrin, α(3)β(1). …”
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Maternal Oxytocin Is Linked to Close Mother-Infant Proximity in Grey Seals (Halichoerus grypus). by Kelly J Robinson, Sean D Twiss, Neil Hazon, Patrick P Pomeroy

“…Oxytocin's structure and function is widely conserved across mammalian mothers, including humans. …”
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DBS-NET: A Dual-Branch Network Integrating Supervised and Contrastive Self-Supervised Learning for Birdsong Classification by Ziyi Wang, Hao Shi, Yan Zhang, Yong Cao, Danjv Lv

“…Additionally, to address class imbalance in the dataset, a weighted loss function is introduced to adjust the cross-entropy loss with optimized class weights. …”
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Detection and recognition of foreign objects in Pu-erh Sun-dried green tea using an improved YOLOv8 based on deep learning. by Houqiao Wang, Xiaoxue Guo, Shihao Zhang, Gongming Li, Qiang Zhao, Zejun Wang

“…The method employs an MPDIoU optimized loss function to enhance target detection performance, thereby increasing the model's precision in targeting. …”
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Expression and regulation of the Escherichia coli O157:H7 effector proteins NleH1 and NleH2. by Ashleigh Holmes, Cecilia S Lindestam Arlehamn, Dai Wang, Tim J Mitchell, Tom J Evans, Andrew J Roe

“…This was tested by creating reporter fusions and examining their expression in different genetic backgrounds, media and on contact with host cells. The function of the proteins was also tested following transfection into host cells.…”
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Wide-viewing-angle color holographic 3D display system with high brightness encoding by Yi-Wei Zheng, Fan Chu, Fan-Chuan Lin, Yi-Xiao Hu, Yi-Long Li, Yi Zheng, Di Wang, Qiong-Hua Wang

“…Additionally, a high brightness hologram encoding method is developed, which introduces a frequency loss function with dynamic weights to ensure that differences of all frequency components in the frequency domain can be learned. …”
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A Small Protein Associated with Fungal Energy Metabolism Affects the Virulence of Cryptococcus neoformans in Mammals. by Erin E McClelland, Udupi A Ramagopal, Johanna Rivera, James Cox, Antonio Nakouzi, Moses M Prabu, Steven C Almo, Arturo Casadevall

“…This gene, hereafter identified as HVA1 (hypervirulence-associated protein 1), encodes a protein that has homologs of unknown function in plant and animal fungi, consistent with a conserved mechanism. …”
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Signal peptide-binding drug as a selective inhibitor of co-translational protein translocation. by Kurt Vermeire, Thomas W Bell, Victor Van Puyenbroeck, Anne Giraut, Sam Noppen, Sandra Liekens, Dominique Schols, Enno Hartmann, Kai-Uwe Kalies, Mark Marsh

“…Despite their common function in Sec61 targeting and ER translocation, SPs have diverse but unique primary sequences. …”
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The Roles of AMPK in Revascularization by Ming-Hong Chen, Qiong-Mei Fu

“…Usually, AMPK can be activated by ADP or AMP, upstream kinases or other cytokines, and pharmacological agents, and then it phosphorylates key molecules that are involved in energy metabolism, autophagy, anti-inflammation, oxidative stress, and aging process to keep cellular homeostasis and finally keeps cell normal activity and function. This review makes a summary on the subunits, activation and downstream targets of AMPK, the mechanism of revascularization, the effects of AMPK in endothelial cells, angiogenesis, and arteriogenesis along with some prospects.…”
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Guanylate cyclase promotes osseointegration by inhibiting oxidative stress and inflammation in aged rats with iron overload by Zhou-Shan Tao, Cai-Liang Shen

“…Our findings indicate that iron accumulation suppressed the activity of MC3T3-E1 while enhancing RAW264.7 function. Furthermore, iron overload significantly decreased oxidative stress levels; however, these detrimental effects can be mitigated by VIT treatment. …”
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