FTO effects the proliferation, invasion, and glycolytic metabolism of colon cancer by regulating PKM2 by Kongyan Zhang, Fei Zhang, Jiahe Wang

“…However, research on the function of FTO in CRC is scarce. Methods Bioinformatics analysis of TCGA and UALCAN databases was conducted to examine FTO expression in CRC. …”
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Performance Analysis of Reconfigurable Intelligent Surface-Assisted Underwater Wireless Optical Communication Systems by Qi Zhang, Dian-Wu Yue, Xian-Ying Xu

“…In the RIS-assisted UWOC systems with intensity modulation and direct detection (IM-DD), we apply the approximate distribution of the sum of Gamma-Gamma random variables to derive the probability density function (PDF) of the instantaneous received signal-to-noise ratio (SNR) for the first time. …”
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MAPK phosphatase AP2C3 induces ectopic proliferation of epidermal cells leading to stomata development in Arabidopsis. by Julija Umbrasaite, Alois Schweighofer, Vaiva Kazanaviciute, Zoltan Magyar, Zahra Ayatollahi, Verena Unterwurzacher, Chonnanit Choopayak, Justyna Boniecka, James A H Murray, Laszlo Bogre, Irute Meskiene

“…In accordance with this, only AP2C3 ectopic expression is able to stimulate cell proliferation leading to excess stomata development. This function of AP2C3 relies on the domains required for MAPK docking and intracellular localization. …”
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Androgen receptor co-regulation in prostate cancer by Dhirodatta Senapati, Sangeeta Kumari, Hannelore V. Heemers

“…Novel therapeutic strategies are being explored that involve targeting other critical AR domains such as those that mediate its constitutively active transactivation function, its DNA binding ability, or its interaction with co-operating transcriptional regulators. …”
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Improved Aerial Surface Floating Object Detection and Classification Recognition Algorithm Based on YOLOv8n by Lili Song, Haixin Deng, Jianfeng Han, Xiongwei Gao

“…The proposed algorithm introduces several key enhancements: (1) an enhanced HorBlock module to facilitate multi-gradient and multi-scale superposition, thereby intensifying critical floating object characteristics; (2) an optimized CBAM attention mechanism to mitigate background noise interference and substantially elevate detection accuracy; (3) the incorporation of a minor target recognition layer to augment the model’s capacity to discern floating objects of differing dimensions across various environments; and (4) the implementation of the WIoU loss function to enhance the model’s convergence rate and regression accuracy. …”
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A novel c-di-GMP signal system regulates biofilm formation in Pseudomonas aeruginosa by Gukui Chen, Haihua Liang

“…However, the detailed function of this operon remains unknown. In our recent paper (Chen et al., doi: 10.15252/embj.2019103412), we have demonstrated that the siaABCD operon encodes a signaling network that regulates biofilm and aggregate formation by modulating the enzymatic activity of SiaD. …”
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Senataxin Attenuates DNA Damage Response Activation and Suppresses Senescence by Mingyang Li, Genbao Shao

“…This study uncovers a novel function of senataxin in modulating DDR and its impact on cellular senescence. …”
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Analysis of Rehabilitation Occupational Therapy Techniques Based on Instrumental Music Chinese Tonal Language Spectrogram Analysis by Ying Liao

“…Tone and clear tone training were achieved by linear predictive coding technique (LPC) and autocorrelation function. Using the DTW technique, isolated word speech recognition was achieved by extracting Mel-scale Frequency Cepstral Coefficients (MFCC) parameters of speech signals. …”
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Elucidating the Differential Mechanisms of Jingui Shenqi Pill and Mingmu Dihuang Pill in the Treatment of Diabetic Nephropathy Based on Yin-Yang Theory by Bi S, Xu Z, Yuan A, Wang Z, Liu Y, Yu B, Tian J, Liu C, Qiao L, Wang Z, Zhang Y

“…Transcriptomics showed JGSQ regulates the TGF-β pathway, and MMDH modulates the TNF pathway. Molecular docking confirmed key components binding to TGFB1 and TNFA.Conclusion: MMDH and JGSQ exhibit distinct chemical compositions, targets, and pathways, underscoring their Yin-Yang regulatory roles in kidney function. …”
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Accurate Detection and Tracking of Small-Scale Vehicles in High-Altitude Unmanned Aerial Vehicle Bird-View Imagery by Heshan Zhang, Xin Tan, Mengwei Fan, Cunshu Pan, Zhanji Zheng, Shuang Luo, Jin Xu

“…EIoU_Loss is introduced as the bounding box regression loss function in training to speed up their convergence and improve the localization accuracy of the small objects. …”
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YOLO-MARS: An Enhanced YOLOv8n for Small Object Detection in UAV Aerial Imagery by Guofeng Zhang, Yanfei Peng, Jincheng Li

“…Finally, a dynamic WIoU evaluation function is implemented, constructing adaptive penalty terms based on the spatial distribution characteristics of predicted and ground-truth bounding boxes, thereby optimizing the boundary localization accuracy of densely packed small targets from the UAV viewpoint. …”
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Revealing the role of RAB27 in HER receptor family expression and signaling in melanoma cells by Katarzyna Horodecka, Liliana Czernek, Łukasz Pęczek, Magdalena Klink

“…These proteins are mostly acknowledged as coordinators of the vesicular trafficking, however, their function in cellular signaling is less recognized. …”
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Dual-Ascent-Inspired Transformer for Compressed Sensing by Rui Lin, Yue Shen, Yu Chen

“…Second, DAT exhibits enhanced robustness to variations in initial learning rates, as evidenced by loss function analysis during training.…”
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SSD-YOLO: a lightweight network for rice leaf disease detection by Canlin Pan, Shen Wang, Shen Wang, Yahui Wang, Chaoyang Liu

“…Furthermore, Shape-aware Intersection over Union (ShapeIoU) Loss replaces the traditional Complete Intersection over Union (CIoU) loss function, boosting model performance in complex environments. …”
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Phytochemicals Targeting BDNF Signaling for Treating Neurological Disorders by Alka Ashok Singh, Shweta Katiyar, Minseok Song

“…Neurological disorders are defined by a deterioration or disruption of the nervous system’s structure and function. These diseases, which include multiple sclerosis, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and schizophrenia, are caused by intricate pathological processes that include excitotoxicity, neuroinflammation, oxidative stress, genetic mutations, and compromised neurotrophic signaling. …”
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Prevention and Treatment of Peritoneal Dialysis-Associated Fibrosis with Intraperitoneal Anti-Fibrotic Therapy in Experimental Peritoneal Fibrosis by Chiao-Yin Sun, Yu-Ting Hsieh, Shang-Chieh Lu, Chi-Ying F. Huang

“…Background/Objectives: Long-term peritoneal dialysis (PD) often results in peritoneal damage and fibrosis, impairing peritoneal membrane function and leading to ultrafiltration failure. This study aimed to explore the therapeutic potential of nintedanib and pirfenidone in preventing and treating PD-associated peritoneal fibrosis using experimental models. …”
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RS-DETR: An Improved Remote Sensing Object Detection Model Based on RT-DETR by Hao Zhang, Zheng Ma, Xiang Li

“…Finally, we propose a novel bounding box regression loss function, Focaler-GIoU, which makes the model focus more on difficult samples, improving detection performance for small and overlapping targets. …”
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Transnational economic development: Pakistani and Indian diaspora in focus by Kinza Tasleem Chauhdry

“…The aim of this study was to analyze the regulatory effect of Suaeda salsa extract (SSE) on T2DM and its effect on the intestinal flora of mice.ResultsThe results showed that SSE could significantly improve the body weight, fasting blood glucose (FBG), area under the curve (AUC) of the oral glucose tolerance test (OGTT), glycosylated serum protein (GSP) and islet function index. Moreover, 4-week body weight, FBG, AUC of OGTT, GSP, as well as intestinal acetic and butyric acid were significantly better in the SSE-L than in the MET group (p  <  0.05). …”
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Tandem Upregulation of Ion Transporters in Thick Ascending Limb of Henle’s Loop of Young Milan Hypertensive Strain of Rats by Abbas Shams, Laura Di Donato, Laura Zucaro, Anna Iervolino, Giovanna Capolongo, Mariadelina Simeoni, Yoko Suzumoto, Giovambattista Capasso

“…These data may suggest the interplay of apical and basolateral ion transporters in TAL for the modulation of TAL function in favor of enhancing the transepithelial sodium reabsorption, although this seems compensated by NCC and ENaC expressed at the downstream nephron segments in young MHS rats. …”
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Tacca chantrieri André Rhizome Extract Alleviates Scopolamine-Induced Cognitive Impairment and Neuroinflammation in Rats by Thaneeya Hawiset, Napatr Sriraksa, Shisanupong Anukanon, Utcharaporn Kamsrijai, Siwaporn Praman, Narudol Teerapattarakan, Prachak Inkaew

“…These bioactive compounds contributed to the neuroprotective effects of TCE by modulating neuroinflammation and cognitive function. …”
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