Recent advances on the mechanism of acupuncture in the treatment of subjective tinnitus by Feifei Shi, Ziyu Ye, Bixiang Zha, Weixian Wu, Yating Zhang, Leiyu Yu, Wanting Liu, Yan Rong, Jun Yang

“…Additionally, the modulation of the thalamus and the functional reorganization of the auditory cortex and synaptic network may contribute to the achievement of therapeutic effects.ConclusionWhile acupuncture has demonstrated clinical efficacy in the treatment of subjective tinnitus, the underlying mechanism of action remains poorly understood. …”
Get full text

Enteromorpha prolifera soluble dietary fiber alleviates ulcerative colitis through restoration of mucosal barrier and gut microbiota homeostasis by Yuan-Yuan Ding, Yuan-Yuan Ding, Xin-Yi Tang, Yu Tian, Feng-Long Zhang, Xiang Ding, Meng-Chun Qi, Wei Dong, Chen-Guang Liu

“…Additionally, EDFM promoted the proliferation of beneficial probiotics (Alloprevotella, Lachnospiraceae_NK4A136_group, and Ruminococcaceae_UCG-014), while inhibiting pathogenic bacteria (Escherichia-Shigella, Parabacteroides, Rikenellaceae_RC9_gut_group, Odoribacter, and [Ruminococcus]_torques_group).ConclusionEDFM supplementation significantly ameliorates UC through dual modulation of gut microbiota and intestinal barrier integrity, indicating its potential as a functional food ingredient for UC prevention and treatment.…”
Get full text

Mpox Infection and Endocrine Health: Bridging the Knowledge Gap by Christos Savvidis, Manfredi Rizzo, Ioannis Ilias

“…While primarily known for cutaneous and systemic involvement, emerging evidence suggests that MPX may also disrupt endocrine function. This narrative review aims to synthesize current clinical, experimental, and epidemiological findings on MPX-related endocrine complications. …”
Get full text

Caloric restriction mimetic 2-deoxyglucose alters metabolic and transcriptomic phenotype in association with changes in chromatin accessibility in human astrocytes by Matthew Spencer, Jacqueline R. Kulbe, Vikram Venkatesh, Anna Laird, Mary Ford, Sydney O’Brien, Ali Boustani, Johannes C. M. Schlachetzki, Jerel Adam Fields

“…Abstract Caloric restriction and ketogenic diets may modify the progression of neurological disorders, including HIV-associated neurological disorders and Alzheimer’s disease, in part by influencing astrocyte function. This study examines how metabolic substrate availability affects metabolic processes and gene expression in human astrocytes. …”
Get full text

Invivo and in vitro analyses of surface whitening in hydrophobic trifocal intraocular lenses by Margarita Cabanás, Margarita Cabanás, Jorge Navalón, Rafael Luchena, William Lee, Alejandro Cerviño

“…Imaging and laboratory analysis suggested that whitening is caused by subsurface nanoglistening (SSNG), a previously unreported phenomenon in this IOL material. The modulation transfer function of the affected IOLs remained comparable to control lenses, and in vitro attempts to induce whitening were unsuccessful.DiscussionThis study provides the first evidence of SSNG in this hydrophobic IOL material, demonstrating that while whitening can occur, its clinical significance is generally low. …”
Get full text

The protective role of BMP-15 in infertility development with NLRP3 and IL-18 in infertility development in obese patients with PCOS: clinical and mouse model investigations by Qiaohong Guo, Yongjun Zhou, Lingli Li, Xi Chen, Liang Sun

“…While bone morphogenetic protein-15 (BMP-15) plays a recognized role in ovarian function, its specific impact on infertility in obese PCOS patients remains unclear Objective: This study aimed to investigate the influence of BMP-15, NOD-like receptor protein 3 (NLRP3), and interleukin-18 (IL-18) on infertility in this population and to evaluate their predictive clinical value. …”
Get full text

Sedimentary bed morphology in the wake of flexible aquatic vegetation by Dhanush Bhamitipadi Suresh, Daniel Wood, Yaqing Jin

“…Supported with measurements, a basic formula was established to quantify the shear stress acting on the sedimentary bed as a function of incoming flow velocity and blade aspect ratio.…”
Get full text

A Rotation Target Detection Network Based on Multi-Kernel Interaction and Hierarchical Expansion by Qi Wang, Guanghu Xu, Donglin Jing

“…Additionally, the Midpoint Offset Loss Function is employed to mitigate the impact of gradual scale changes on target direction perception, enabling precise regression for targets across various scales. …”
Get full text

GLS-YOLO: A Lightweight Tea Bud Detection Model in Complex Scenarios by Shanshan Li, Zhe Zhang, Shijun Li

“…To tackle the challenges posed by varying poses and occlusions of tea buds, Shape-IoU was employed as the loss function to improve the scoring of similarly shaped objects, reducing false positives and false negatives while improving the detection of non-rectangular or irregularly shaped objects. …”
Get full text

Natural variation of the amino-terminal glutamine-rich domain in Drosophila argonaute2 is not associated with developmental defects. by Daniel Hain, Brian R Bettencourt, Katsutomo Okamura, Tibor Csorba, Wibke Meyer, Zhigang Jin, Jason Biggerstaff, Haruhiko Siomi, Gyorgy Hutvagner, Eric C Lai, Michael Welte, H-Arno J Müller

“…Our data indicate that GRR variation does not modulate an essential function of Ago2 and that the amino-terminal domain of Ago2 is subject to rapid evolution.…”
Get full text

The dual role of autophagy in cancer stem cells: implications for tumor progression and therapy resistance by Haiqing Jia, Jing Wei, Wei Zheng, Zhuo Li

“…Autophagy, an evolutionarily preserved cellular mechanism for degradation and recycling, has a complex function in cancer by aiding cell survival during stress and preserving balance by eliminating damaged organelles and proteins. …”
Get full text

Multifunctional adaptive NS1 mutations are selected upon human influenza virus evolution in the mouse. by Nicole E Forbes, Jihui Ping, Samar K Dankar, Jian-Jun Jia, Mohammed Selman, Liya Keleta, Yan Zhou, Earl G Brown

“…Although we have shown gain-of-function properties for all mutant NS genes, the contribution of the NEP mutations to phenotypic changes remains to be assessed. …”
Get full text

Mitochondrial-derived peptides, HNG and SHLP3, protect cochlear hair cells against gentamicin by Yu Lu, Ewelina M. Bartoszek, Maurizio Cortada, Daniel Bodmer, Soledad Levano Huaman

“…Abstract Preservation of hair cells is critical for maintaining hearing function, as damage to sensory cells potentially leads to irreparable sensorineural hearing loss. …”
Get full text

Research on the Integration of Sensing and Communication Based on Fractional-Order Fourier Transform by Mingyan Qi, Yuelong Su, Zhaoyi Wang, Kun Lu

“…The results show that the integrated waveform can realize the detection function with guaranteed communication performance. …”
Get full text

Star-YOLO: A Lightweight Real-Time Wheat Grain Detection Model for Embedded Deployment by Zhihang Qu, Xiao Liang, Sicheng Liang, Xiumei Guo

“…A Shape-NWD loss function is designed, incorporating shape and scale information of target bounding boxes to refine regression, tackling the challenge of distinguishing overlapping wheat grains. …”
Get full text

PROTEIN TARGETING TO STARCH is required for localising GRANULE-BOUND STARCH SYNTHASE to starch granules and for normal amylose synthesis in Arabidopsis. by David Seung, Sebastian Soyk, Mario Coiro, Benjamin A Maier, Simona Eicke, Samuel C Zeeman

“…PTST fulfils a previously unknown function in targeting GBSS to starch. This sheds new light on the importance of targeting biosynthetic enzymes to sub-cellular sites where their action is required. …”
Get full text

Improved Clamped Z-Source Converter with Optimized Maximum Power Point Tracker for Hybrid Renewable Energy Systems Based Energy Management System by Saranya M., Giftson S. G.

“…Firefly optimization with an aid of Radial Basis Function Neural Network (RBFNN) technique is employed as an MPPT system for extracting optimal power from photovoltaic system. …”
Get full text

Biochemical, histological, and immunohistochemical study on the therapeutic effects and mechanism of coenzyme Q10 in type 2 diabetes mellitus by Manal Ismaeil Khalil, Ali Louei Monfared, Hussein Bashar Mahmood

“…Here, we reported that CoQ10 protects pancreatic β-cell structure and function by modulating the expression of mir-33a/mir-21/SREBP1 and described more detailed tissue alterations. …”
Get full text

Spatiotemporal Multivariate Weather Prediction Network Based on CNN-Transformer by Ruowu Wu, Yandan Liang, Lianlei Lin, Zongwei Zhang

“…After that, in order to ensure that the model has better prediction ability for global and local hotspot areas, we designed a composite loss function based on MSE and SSIM to focus on the global and structural distribution of weather to achieve more accurate multivariate weather prediction. …”
Get full text

Low resolution remote sensing object detection with fine grained enhancement and swin transformer by Zhijing Xu, Xin Wang, Kan Huang, Ren Chen

“…Finally, we incorporate the Shape-IoU loss function to optimize bounding box regression, significantly improving small target detection accuracy while maintaining computational efficiency. …”
Get full text