APOE genotype and brain amyloid are associated with changes in the plasma proteome in elderly subjects without dementia by Sarah M. Philippi, Kailash BP, Towfique Raj, Joseph M. Castellano

“…While age‐associated blood‐borne proteins have been targeted to restore function to the aged brain, it remains unclear whether other dysfunctional systemic states can be exploited for similar benefits. …”
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Toosendanin Induces Hepatotoxicity by Facilitating ALOX5-Mediated Lipid Peroxidation and Sensitizing Cells to Ferroptosis by Jiajie Ni, Liru Huang, Yifan Tian, Changxin Zhao, Ziyi Zhou, Feihai Shen, Zhiying Huang

“…Balb/c and C57BL/6 mice received various doses of TSN administration, and their liver function was assessed with serum biochemistry and histopathology. …”
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A crucial role of miR-155 in the pathomechanism of acute kidney injury by Hui Wang, Jian Liao, Wei Wang, Jianhua Zhang

“…Mechanistically, miR-155 exerts a promoting function in multiple types of AKI by regulating multiple proteins or signaling pathways, such as SOCS-1, ERRFI1, SOCS-1, TRF1, CDK12, and TCF4/Wnt/β-catenin pathway. …”
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S100A8/A9 in herpes zoster neuralgia: molecular mechanisms and therapeutic perspectives by Dongzhi Jiang, Ziyuan Zhang, Fei Ren, Wenqin Sun

“…Our investigation reveals S100A8/A9’s critical function in modulating neuroinflammatory processes through TLR4/TNF signaling pathways, demonstrating its potential as a sophisticated therapeutic target. …”
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Production and purification of methionine gamma-lyase from Iranian soil mulds: investigation of physicochemical properties and anticancer effects by Matin Nasirian, Ali Arab-SadeghAbadi, Mohsen Mobini-Dehkordi, Sadegh Farhadian

“…By reducing methionine availability, MGL may inhibit SAM formation, preserving tumor suppressor function and hindering cancer growth. Three novel Iranian fungal strains—Penicillium flavigenum, Stagonosporopsis cucurbitacearum, and Penicillium allii—were identified as MGL producers through ITS sequencing. …”
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DSCONV-GAN: a UAV-BASED model for Verticillium Wilt disease detection in Chinese cabbage in complex growing environments by Jun Zhang, Dongfang Zhang, Jingyan Liu, Yuhong Zhou, Xiaoshuo Cui, Xiaofei Fan

“…Based on YOLOv8, with the addition of the dynamic snake convolution (DSConv) module and the improved loss function maximum possible distance intersection-over-union (MPDIoU), we acquired enhanced complex structures and global characteristics in Chinese cabbage images under different growth conditions. …”
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EVALUATION OF ITERATIVE ALGORITHMS FOR TOMOGRAPHY IMAGE RECONSTRUCTION by Alexandre F. Velo, Alexandre G. Alvarez, Margarida Mizue Hamada, Carlos Henrique de Mesquita

“…The analyses involved the measurement of the contrast to noise ratio (CNR), the root mean square error (RMSE) and the Modulation Transfer Function (MTF),in order to know which algorithm fits the conditions to optimize the system better.   …”
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Surface Defect Detection Algorithm for Wind Turbine Blades Based on HSCA-YOLOv7 by Bing LI, Yunshan BAI, Kuan ZHAO, Congbin GUO, Yongjie ZHAI

“…The focal EIoU loss function is used to solve the problem that the length and width of the prediction box are wrongly amplified and improve the positioning ability of the model for blade defects. …”
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Genome-wide identification and expression analysis of the HvGATA gene family under abiotic stresses in barley (Hordeum vulgare L.) by Yan Zhao, Chengxin Yin, Ruixi Xing, Jianbin Zeng, Xuehuan Dai, Dengan Xu, Wenxing Liu, Wujun Ma

“…Conclusion In summary, this study contribute to our understanding of important role of HvGATAs in barley, providing a foundation for further exploration of gene function and target genes related to stress responses.…”
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Myokines and Their Potential Protective Role Against Oxidative Stress in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) by José Luis Bucarey, Isis Trujillo-González, Evan M. Paules, Alejandra Espinosa

“…Furthermore, we provide an in-depth analysis of key myokines, including myostatin, brain-derived neurotrophic factor (BDNF), and irisin, among others, and their potential impact on liver function. Finally, we discuss the molecular mechanisms through which these myokines influence oxidate stress and lipid metabolism, emphasizing their capacity to modulate antioxidant responses in the liver. …”
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Therapeutic Potential of Ginsenosides in Anthracycline-Induced Cardiotoxicity by Rongrong Bai, Zhigao Zhao, Xing Han, Mingying Shang, Guangxue Liu, Feng Xu, Shaoqing Cai

“…This review highlights the potential molecular targets and signaling pathways through which ginsenosides exert therapeutic effects on AIC, including the regulation of oxidative-stress-related pathways such as Keap1/Nrf2, MAPK, STAT, PI3K/Akt, and AMPK; the restoration of mitochondrial function; the modulation of autophagy; and the inhibition of pyroptosis, ferroptosis, and apoptosis. …”
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Enhanced lightweight infrared object detection algorithm for assistive navigation in visually impaired individuals by Zhimin Bai, Yang Yang, Jian Wang, Zhengyang Li, Jiajun Wang, Chunxin Liu

“…This is achieved by adding upsampling and downsampling in the P2 module. Additionally, the CIoU loss function is refined with Inner‐SIoU, elevating bounding box detection precision. …”
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A Transformer-Based Symmetric Diffusion Segmentation Network for Wheat Growth Monitoring and Yield Counting by Ziyang Jin, Wenjie Hong, Yuru Wang, Chenlu Jiang, Boming Zhang, Zhengxi Sun, Shijie Liu, Chunli Lv

“…By introducing an aggregated loss function, the model effectively optimizes both segmentation accuracy and growth measurement performance. …”
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Hsp90 <i>pan</i> and Isoform-Selective Inhibitors as Sensitizers for Cancer Immunotherapy by Shiying Jia, Neeraj Maurya, Brian S. J. Blagg, Xin Lu

“…In this review, we discuss the molecular bases for Hsp90 function and inhibition and emphasize recent advances in isoform-selective targeting. …”
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IUPHAR review: Microbiota-gut-brain axis and its role in neuropsychiatric disorders by Seung-Hoon Lee, Changsu Han, Cheolmin Shin

“…The human gut microbiome, composed of a vast array of microorganisms that have co-evolved with humans, is crucial for the development and function of brain systems. Research has consistently shown bidirectional communication between the gut and the brain through neuronal, endocrine, and immunological, and chemical pathways. …”
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Blind super-resolution network based on local fuzzy discriminative loss for fabric data augmentation by Ning Dai, Xiaohan Hu, Kaixin Xu, Xudong Hu, Yanhong Yuan, Bo Cao, Luhong Shi

“…Subsequently, a novel loss function named Local Blur Discrimination Loss is designed to address the local blur phenomenon and suppress the generation of fabric artifacts during the super-resolution process. …”
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Non-CpG Oligonucleotides Exert Adjuvant Effects by Enhancing Cognate B Cell-T Cell Interactions, Leading to B Cell Activation, Differentiation, and Isotype Switching by Melinda Herbáth, Krisztián Papp, Anna Erdei, József Prechl

“…Notably, nucleic acids are known to modulate immune function via several different pathways and various cell types, necessitating a complex interpretation of their effects. …”
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Anti-amyloidogenic properties of 5‑caffeoylquinic acid-capped selenium nanoparticles by Shubhangi D. Shirsat, Chunyi Li, Zhipeng Liu, Varenyam Achal, Olivier Habimana

“…The antioxidant traits of SeNPs were showcased (IC50 = 8.01 ± 1.21 µg/mL), by obstructing AChE (IC50 = 3.70 ± 0.02 µg/mL) and BChE (IC50 = 72 ± 0.5 µg/mL), while also diminishing Aβ fibrillation, thereby emphasizing their function in the modulation of amyloid clustering. Molecular dynamics simulations elucidated that CQA-SeNPs preferentially associate with hydrophobic residues (e.g., Leu34 and Phe19) of the Aβ peptide, obstructing β-sheet formation. …”
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Single-shot diffractive spectrometer for photonic orbital angular momentum by Yanwei Huang, Hanxiao Zhang, Tao Liu, Angyi Lin, Fucai Zhang

“…There is no need to conduct any calibration associated with the beam to be measured; the only prior knowledge required is the transmission function of a random diffusing wavefront modulator. …”
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Development of Low-Temperature Block Type Facility for Sea Water Desalination by Burdo O.G., Terziev S.G., Mordynskiy V.P., Sirotyuk I.V., Fateeva Ya.A., Molchanov M.Yu.

“…The system modeling of this equipment was carried out. The target function of the modeling determined the key parameters of the process of the ice block gravitational separation — energy and salinity. …”
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