Antioxidant, Osteogenic, and Neuroprotective Effects of Homotaurine in Aging and Parkinson’s Disease Models by Arianna Minoia, Francesca Cristiana Piritore, Silvia Bolognin, João Pessoa, Bruno Bernardes de Jesus, Natascia Tiso, Maria Grazia Romanelli, Jens Christian Schwamborn, Luca Dalle Carbonare, Maria Teresa Valenti

“…This contributes to the functional decline in various tissues, including the brain and skeletal system, which closely interplay. …”
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Band engineering and phonon softening enable the achievement of significant enhancement in the thermoelectric performance of EuMg2Sb2 by Zn doping by Qingzhi Song, Linyu Bai, Xi Gao, Lei Wei, Xian Zhao, Yanlu Li

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Indoleamine-2,3-dioxygenase: An important controller in maintaining mesenchymal stem cell-mediated immunomodulatory homeostasis by Yufei Hui, Xue Jiao, Li Yang, Dejin Lu, Yanbo Han, Wen Yang, Yanli Cao, Yuxi Miao, Shiqiang Gong, Minjie Wei

“…In this review, we explore how IDO functions as a critical regulator of MSC immunoregulatory plasticity. …”
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Nanotherapies Based on ROS Regulation in Oral Diseases by Xin Luo, Yanli Zhang, Yuting Zeng, Dehong Yang, Zhiyan Zhou, Ziting Zheng, Ping Xiao, Xian Ding, Qianlin Li, Jiaping Chen, Qianwen Deng, Xincen Zhong, Sijie Qiu, Wenjuan Yan

“…The concentration of reactive oxygen species (ROS) within cells has been demonstrated as a pivotal player in modulating these intricate pathological processes, exerting significant roles in restoring oral functionality and maintaining tissue structural integrity. …”
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Oxidative stress and cellular senescence: Roles in tumor progression and therapeutic opportunities by Ping Jin, Xu‐Dong Feng, Cheng‐Shuang Huang, Jia Li, Hui Wang, Xian‐Mei Wang, Lei Li, Lan‐Qing Ma

“…Emerging evidence suggests that oxidative stress may promote tumor development by influencing various aspects of cellular senescence, such as its onset, pro‐inflammatory secretion, and alteration of cellular function and structure. Modulating oxidative stress to target cellular senescence offers a novel strategy for cancer prevention and treatment. …”
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Novel Role of Parathyroid Hormone-Related Protein in the Pathophysiology of the Diabetic Kidney: Evidence from Experimental and Human Diabetic Nephropathy by Montserrat Romero, Arantxa Ortega, Nuria Olea, María Isabel Arenas, Adriana Izquierdo, Jordi Bover, Pedro Esbrit, Ricardo J. Bosch

“…Parathyroid hormone-related protein (PTHrP) and its receptor type 1 (PTH1R) are extensively expressed in the kidney, where they are able to modulate renal function. Renal PTHrP is known to be overexpressed in acute renal injury. …”
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HMGB1 Is Involved in the Protective Effect of the PPARα Agonist Fenofibrate against Cardiac Hypertrophy by Zhankui Jia, Rui Xue, Gangqiong Liu, Ling Li, Jinjian Yang, Guofu Pi, Shengli Ma, Quancheng Kan

“…High mobility group box 1 (HMGB1) is a ubiquitous nuclear DNA-binding protein whose function is dependent on its cellular location. Extracellular HMGB1 is regarded as a delayed mediator of proinflammatory cytokines for initiating and amplifying inflammatory responses, whereas nuclear HMGB1 has been found to prevent cardiac hypertrophy and heart failure. …”
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DNA glycosylases Ogg1 and Mutyh influence gene expression of PRC2 targets associated with cognition by Andreas Abentung, Teri Sakshaug, Rabina Dumaru, Nina-Beate Liabakk, Mingyi Yang, Junbai Wang, Magnar Bjørås, Katja Scheffler

“…Finally, human genetic data link DNA glycosylase-regulated genes to cognitive function, highlighting a novel role for Ogg1 and Mutyh in modulating the epigenome to control transcriptional responses relevant for brain-related diseases. …”
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The Intricate Relationship Between Thyroid Disorders and Type 2 Diabetes—A Narrative Review by Dana-Mihaela Tilici, Diana Loreta Paun, Ana Maria Arnautu, Alexandra Mirica, Carmen Duta, Mirona Costea, Cristian Guja

“…A thorough investigation into the underlying mechanisms of thyroid function could reveal new insights into the development and progression of T2DM. …”
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Investigating the sources of variable impact of pathogenic variants in monogenic metabolic conditions by Angela Wei, Richard Border, Boyang Fu, Sinéad Cullina, Nadav Brandes, Seon-Kyeong Jang, Sriram Sankararaman, Eimear E. Kenny, Miriam S. Udler, Vasilis Ntranos, Noah Zaitlen, Valerie A. Arboleda

“…Here, we investigate underlying mechanisms for this heterogeneity: variable variant effect sizes, carrier polygenic backgrounds, and modulation of carrier effect by genetic background (marginal epistasis). …”
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IDDNet: Infrared Object Detection Network Based on Multi-Scale Fusion Dehazing by Shizun Sun, Shuo Han, Junwei Xu, Jie Zhao, Ziyu Xu, Lingjie Li, Zhaoming Han, Bo Mo

“…A dedicated dehazing loss function, DhLoss, further improves the dehazing effect. …”
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Targeting programmed cell death with natural products: a potential therapeutic strategy for diminished ovarian reserve and fertility preservation by Wenhan Ju, Shuai Zhao, Danping Li, Jinfu Zhang, Jinfu Zhang, Shan Xiang, Fang Lian

“…This review discusses the roles and underlying mechanisms of various forms of PCD in diminished ovarian reserve, while summarizing the current findings on natural products that influence granulosa cells PCD to protect ovarian function. These insights may contribute to the future development of novel, targeted strategies aimed at preserving female reproductive potential.…”
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Enhancing TREM2 expression activates microglia and modestly mitigates tau pathology and neurodegeneration by Kai Chen, Fuyao Li, Shuwen Zhang, Yixing Chen, Tadafumi C. Ikezu, Zonghua Li, Yuka A. Martens, Wenhui Qiao, Axel Meneses, Yiyang Zhu, Gisela Xhafkollari, Guojun Bu, Na Zhao

“…In contrast, TREM2-R47H overexpression exhibits a loss-of-function phenotype, with no significant impact on tau levels, neurodegeneration, or microglial activation. …”
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The roles of lncMALAT1 in coronary artery disease regulation and therapeutic perspective: A systematic review by Jia Zheng, Arimi Fitri Mat Ludin, Nor Fadilah Rajab, Li Shaolong, Nurul Farhana Jufri

“…Analyzing 23 experimental studies (PRISMA-guided, PROSPERO-registered), we have identified key findings including MALAT1 modulation altered cardiac function, microstructure via miRNAs-mediated- pathways through in-vivo studies. …”
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A Multi-Feature Fusion Approach for Sea Fog Detection Under Complex Background by Shuyuan Yang, Yuzhu Tang, Zeming Zhou, Xiaofeng Zhao, Pinglv Yang, Yangfan Hu, Ran Bo

“…Based on the spatial distribution characteristics of sea fog and clouds, we redesigned the loss function to integrate total variation loss, focal loss, and dice loss. …”
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Acteoside ameliorates cerebral ischemia/reperfusion injury in MCAO rats as a natural plasma Kallikrein inhibitor from Osmanthus fragrans flower by Hui-hao Wang, Kai-rui Feng, Ping Li, Zhi-Yong Wang, Li Liu

“…Our study suggested that treatment with OFFE or acteoside significantly reduced cerebral infarct area in MCAO rats. Coagulation function measurement suggested that acteoside treatment increased activated partial thromboplastin time (APTT) and prothrombin time (PT) in vitro. …”
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PARALLELS BETWEEN THE HEMODYNAMIC PROFILE AND BIOMARKERS ACTIVITY IN DIFFERENT FORMS OF ACUTE HEART FAILURE IN THE EARLY PERIOD AFTER AORTOCORONARY BYPASS by D. A. Laletin, A. E. Bautin, V. E. Rubinchik, V. S. Naumenko, A. A. Alekseyev, A. P. Mikhailov

“…Goal: to study the rates of central hemodynamics and clinical progress and to evaluate the activity of biomarkers of myocarditis overload and damage in patients with isolated reduction of systolic function of right or left ventricle in early period after aortocoronary bypass. 25 patients were enrolled into the study (14 men, 11 women, average age 58 ± 7 years), admitted to the intensive care department after aortocoronary bypass with artificial circulation and in need of inotropic therapy. …”
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Unveiling the placental bacterial microbiota: implications for maternal and infant health by Zhuojun Xie, Zhongsheng Chen, Yang Chai, Wang Yao, Guangyu Ma

“…Intervention strategies targeting microbial communities, which include modulation of placental microbiota composition or function, such as probiotics, may help prevent or treat complications related to abnormal placental microbiota during pregnancy.…”
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Piezo1 in microglial cells: Implications for neuroinflammation and tumorigenesis by Bo Yang, Zhenyu Li, Peiliang Li, Yuhan Liu, Xinghuan Ding, Enshan Feng

“…This review integrates findings from recent studies to provide a comprehensive overview of Piezo1’s mechanistic pathways in microglial function. These insights illuminate new possibilities for developing targeted therapies addressing CNS disorders with neuroinflammation and pathological tissue mechanics.…”
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Image Motion and Quality in Polar Imaging with a Large Wide-Space TDI Camera by Guoxiu Zhang, Chen Wang, Shuai Liu, Chunyu Liu, Xianren Kong, Yi Ding, Yingming Zhao

“…After correcting for the camera travelling frequency and bias angle, the value of the modulation transfer function at the edges decreased by less than 5% at 196 levels of integration. …”
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