The Impact of Non-coding RNAs in the Epithelial to Mesenchymal Transition by Bashdar Mahmud Hussen, Hamed Shoorei, Mahdi Mohaqiq, Marcel E. Dinger, Hazha Jamal Hidayat, Mohammad Taheri, Soudeh Ghafouri-Fard

“…Non-coding RNAs (ncRNAs) have been shown to exert critical function in the regulation of cellular processes that are involved in the EMT. …”
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Spatial Heterogeneity of Intratumoral Microbiota: A New Frontier in Cancer Immunotherapy Resistance by Qiwen Tan, Xiongjing Cao, Falong Zou, Hanwenchen Wang, Lijuan Xiong, Shenghe Deng

“…Moreover, certain bacterial metabolites form concentration gradients between the tumor core and margins, thereby regulating immune cell function. Therefore, understanding and manipulating the spatial distribution of intratumoral microbiota, particularly in resistant patients, holds promise for developing new strategies to overcome immunotherapy resistance. …”
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On the Sufficiency of a Single Hidden Layer in Feed-Forward Neural Networks Used for Machine Learning of Materials Properties by Ye Min Thant, Sergei Manzhos, Manabu Ihara, Methawee Nukunudompanich

“…As SLNNs offer a number of advantages (including ease of construction and use, more favorable scaling of the number of nonlinear parameters, and ease of the modulation of properties of the NN model by the choice of the neuron activation function), we hope that this work will entice researchers to have a closer look at when an MLNN is genuinely needed and when an SLNN could be sufficient.…”
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Tower view object detection based on ECIOU structure embedded in YOLO by QIAN Jide, YAN Hao, LIANG Yan, ZENG Changchang, MOU Yihao

“…Thirdly，the ECIOU Loss is used to replace the original CIOU loss function to improve its detection performance in complex environments. …”
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pH-dependent Osteoimmunomodulation: Molecular mechanisms and therapeutic targeting in bone disorders by Chuanlong Wu, Zujun Sun, Chuan He, Ruixin Sun

“…Notably, even subtle pH fluctuations within this microenvironment can exert profound effects on both bone and immune cell function. This review provides a comprehensive examination of: (1) the physiological principles governing acid-base balance in bone, (2) the pathological consequences of its dysregulation on bone remodeling via osteoimmune networks, and (3) the therapeutic promise of pH-modulating strategies for bone disorders such as osteoporosis and osteoarthritis. …”
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Molecular and cognitive signatures of ageing partially restored through synthetic delivery of IL2 to the brain by Pierre Lemaitre, Samar HK Tareen, Emanuela Pasciuto, Loriana Mascali, Araks Martirosyan, Zsuzsanna Callaerts‐Vegh, Suresh Poovathingal, James Dooley, Matthew G Holt, Lidia Yshii, Adrian Liston

“…These results identify immune modulation as a potential path to preserving cognitive function for healthy aging.…”
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Ropivacaine-loaded tumor-derived vesicles targeting CCNB1 and autophagy in nasopharyngeal carcinoma by Xue Zhang, Zhenrong Ji, Yi Chang, Ge Qu

“…These promising results advocate for the further exploration of R-TMTP1 EVs as a dual-function therapeutic tool in NPC.…”
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Modeling and possible control of droplet-mediated spread of respiratory viruses by the study of the environmental conditions in closed rooms by C. Pirola, F. Manenti, F. Maestri, G. Silvestri, S. Copelli

“…A lagrangian model of droplet evaporation/settling was used to assess the lifespan of respiratory droplets as a function of Tair, RH and air velocity. In the presence of low Tair and high RH (independently on the air velocity considered), both the distance covered by the droplets and the percentage of viruses were significantly higher than in the presence of medium-high Tair and medium-low RH. …”
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An NF-kB/TNF-alpha signalling feedback loop acts to coordinate tissue regeneration and macrophage behaviour in zebrafish by Kalliopi Arkoudi, Yue Yuan, Antonia Pia Cumine, Carlene Dyer, Elisabeth Busch-Nentwich, Isabel Bravo, Yi Feng, Robert D. Knight

“…We have therefore investigated how NF-kB and TNFα regulate both macrophage function and behaviour in vivo using a zebrafish model of tissue repair. …”
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Software program development of a high-precision magnetometer system for human-occupied vehicles by Q. Zhang, Q. Zhang, K. Zhou, M. Deng, L. Huang, C. Li, Q. Zhang

“…The automatic switching function mitigates dead zones in the optically pumped probes, ensuring continuous data collection. …”
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Improved Discrete-Time Active Disturbance Rejection Control for Enhancing Dynamics of Current Loop in LC-Filtered SPMSM Drive System by Zibo Li, Haitao Yang, Jin Wang, Yali Wang, Libing Zhou

“…Furthermore, a discrete-domain transfer function of the control system is analytically derived, with the control parameters systematically designed using frequency-domain analysis to guarantee robust performance. …”
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Coordinated AR and microRNA regulation in prostate cancer by Ieva Eringyte, Joanna N. Zamarbide Losada, Sue M. Powell, Charlotte L. Bevan, Claire E. Fletcher

“…They display dysregulation during cancer progression, can function as oncogenes or tumour suppressors, and are increasingly recognised as targets or regulators of hormonal action. …”
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PixMed-Enhancer: An Efficient Approach for Medical Image Augmentation by M. J. Aashik Rasool, Akmalbek Abdusalomov, Alpamis Kutlimuratov, M. J. Akeel Ahamed, Sanjar Mirzakhalilov, Abror Shavkatovich Buriboev, Heung Seok Jeon

“…Our method features a hybrid loss function, uniquely combining binary cross-entropy (BCE) and a Structural Similarity Index Measure (SSIM), to ensure pixel-level precision while enhancing the perceptual realism. …”
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A feedback circuitry involving γ-actin, β-actin and nonmuscle myosin-2 A controls tight junction and apical cortex mechanics by Marine Maupérin, Yuze Sun, Thomas Glandorf, Tabea Anne Oswald, Niklas Klatt, Burkhard Geil, Annick Mutero-Maeda, Isabelle Méan, Lionel Jond, Andreas Janshoff, Jie Yan, Sandra Citi

“…However, their specific role in regulating the mechanics of the membrane cortex and the organization of junctions, and which biomechanical circuitries modulate their expression remain poorly understood. …”
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The role of peripheral innate immune cells in Alzheimer’s disease progression by Yanchun Cao, Ke Tang, Pengcheng Ma, Run Zhang, Yani Yang, Tingting Li, Ying Zhang, Xiaoming Peng

“…We further discuss preclinical strategies to modulate PIIC function, such as CCR2 inhibition, neutrophil depletion, and MDSC adoptive transfer. …”
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HDAC4: an emerging target in diabetes mellitus and diabetic complications by Yiqi Lin, Yuetong Li, Caiying Ke, Ying Jin, Wanwen Lao, Yiling Wu, Yang Liu, Xinyi Kong, Jie Qiao, Aixia Zhai, Changlong Bi

“…In this review, HDAC4 was reported to control the differentiation, growth, and function of pancreatic β-cells. Furthermore, HDAC4 regulates glucose metabolism by targeting GLUT4 and FOXO1 and further modulates insulin signaling pathways through cytoplasmic-nuclear shuttling. …”
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Metabolic interplay of SCFA’s in the gut and oral microbiome: a link to health and disease by Nireeksha, Alexander Maniangat Luke, Alexander Maniangat Luke, Suchetha Kumari N, Mithra N. Hegde, Nishmitha N. Hegde

“…Butyrate, in particular, plays a pivotal role in protecting the gut mucosa and modulating inflammatory processes. Beyond their intestinal functions, SCFAs affect systemic metabolic outcomes such as body weight regulation and appetite control by modulating the secretion of gut hormones and interacting with G-protein coupled receptors. …”
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The Effects of the Association Between a High-Fat Diet and Physical Exercise on BDNF Expression in the Hippocampus: A Comprehensive Review by Francisca Tayná da Silva Gomes, Antônio Vicente Dias de Andrade, Paloma Katlheen Moura Melo, Roque Ribeiro da Silva Júnior, Débora Lopes Silva de Souza, Élyssa Adriolly Freitas Tavares, Ingrid Garcia de Sena, Thales Allyrio Araújo de Medeiros Fernandes, Paulo Leonardo Araújo de Góis Morais, Ivana Alice Teixeira Fonseca, Cibele dos Santos Borges, José Rodolfo Lopes de Paiva Cavalcanti

“…The studies analysed highlight a neuroprotective effect of exercise, capable of positively modulating BDNF levels and, consequently, improving the cognitive functions of these animals.…”
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Phenotypic and genetic characteristics of retinal vascular parameters and their association with diseases by Sofía Ortín Vela, Michael J. Beyeler, Olga Trofimova, Ilaria Iuliani, Jose D. Vargas Quiros, Victor A. de Vries, Ilenia Meloni, Adham Elwakil, Florence Hoogewoud, Bart Liefers, David Presby, Wishal D. Ramdas, Mattia Tomasoni, Reinier Schlingemann, Caroline C. W. Klaver, Sven Bergmann

“…Our analyses provide evidence that large-scale analysis of image-derived vascular phenotypes has sufficient power for obtaining functional and causal insights into the processes modulating the retinal vasculature.…”
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From Genes to Healing: The Protective Mechanisms of <i>Poria cocos</i> Polysaccharide in Endometrial Health by Yongxi Huang, Pupu Yan, Jun Zhu, Yinuo Gong, Man Liu, Haishan Cheng, Tilin Yi, Fuxian Zhang, Xiaolin Yang, Yingbing Su, Liwei Guo

“…Initially, an inflammation model was induced using LPS-treated bovine endometrial epithelial cells (BEND) to identify the differentially expressed genes (DEGs) between the control and LPS groups by transcriptome sequencing, and GO functional annotation and KEGG enrichment analysis were performed. …”
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