New Insights into Chronic Pancreatitis: Potential Mechanisms Related to Probiotics by Yingyu Pan, Jianing Li, Zhengyang Fan, Yonghao Chen, Xiaoxuan Huang, Dong Wu

“…Although direct causative evidence is lacking, it is hypothesized that the gut microbiota may play a pivotal role in modulating pancreatic function via the gut–pancreas axis. …”
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The alleviating effects and mechanisms of Enterococcus faecium Kimate-X and Lactobacillus plantarum Kimate-F combination on canine inflammatory bowel disease by Rui Zhang, Wanjin Hu, Saiwei Zhong, Weiyang Chen, Shuang Xie, Meiru Chen, Qinghua Yu

“…Metagenomic sequencing was performed on canine fecal samples to analyze microbiota composition and functional pathways. Short-chain fatty acid (SCFA) levels were quantified, and key host signaling pathways were examined.ResultsKimate-F showed strong antibacterial effects against Escherichia coli, Salmonella enteritidis, and Yersinia enterocolitica. …”
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Unraveling the transcriptomic effects of leucine supplementation on muscle growth and performance in basketball athletes. by Sinan Wang, Weishuai Guo, Rui Dong

“…Participants were then given a functional drink containing either leucine (50 mg/kg body weight) or a placebo for 28 days. …”
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Coexpressed Genes That Promote the Infiltration of M2 Macrophages in Melanoma Can Evaluate the Prognosis and Immunotherapy Outcome by Kexin Yan, Yutao Wang, Yuxiu Lu, Zhangyong Yan

“…The model’s essential genes were analyzed using functional enrichment, GSEA, and subgroup and total carcinoma. …”
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A GWAS approach identifies Dapp1 as a determinant of air pollution-induced airway hyperreactivity. by Hadi Maazi, Jaana A Hartiala, Yuzo Suzuki, Amanda L Crow, Pedram Shafiei Jahani, Jonathan Lam, Nisheel Patel, Diamanda Rigas, Yi Han, Pin Huang, Eleazar Eskin, Aldons J Lusis, Frank D Gilliland, Omid Akbari, Hooman Allayee

“…In summary, our results indicate that some of the genetic determinants for asthma-related phenotypes may be shared between mice and humans, as well as the existence of GxE interactions in mice that modulate lung function in response to air pollution exposures relevant to humans.…”
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24-hour rhythms of DNA methylation and their relation with rhythms of RNA expression in the human dorsolateral prefrontal cortex. by Andrew S P Lim, Gyan P Srivastava, Lei Yu, Lori B Chibnik, Jishu Xu, Aron S Buchman, Julie A Schneider, Amanda J Myers, David A Bennett, Philip L De Jager

“…We assessed for 24-hour rhythmicity of 420,132 DNA methylation sites throughout the genome by considering methylation levels as a function of clock time of death and parameterizing these data using cosine functions. …”
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Key Modulatory Role of Presynaptic Adenosine A2A Receptors in Cortical Neurotransmission to the Striatal Direct Pathway by César Quiroz, Rafael Luján, Motokazu Uchigashima, Ana Patrícia Simoes, Talia N. Lerner, Janusz Borycz, Anil Kachroo, Paula M. Canas, Marco Orru, Michael A. Schwarzschild, Diane L. Rosin, Anatol C. Kreitzer, Rodrigo A. Cunha, Masahiko Watanabe, Sergi Ferré

“…Adenosine A2A receptors are considered novel antiparkinsonian targets, based on their selective postsynaptic localization in the indirect pathway, where they modulate D2 receptor function. The present study provides evidence for the existence of an additional, functionally significant, segregation of A2A receptors at the presynaptic level. …”
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Decidual/placental and first trimester plasma levels of hsa-miR-199a-3p|hsa-miR-199b-3p and hsa-miR-3150b-3p are associated with insulin secretion in pregnancy by Amélie Taschereau, Frédérique White, Catherine Allard, Andrea G. Edlow, François Aguet, Kristin G. Ardlie, Jose C. Florez, Jose C. Florez, Jose C. Florez, Jose C. Florez, Pierre-Étienne Jacques, Pierre-Étienne Jacques, Pierre-Étienne Jacques, S. Ananth Karumanchi, Camille E. Powe, Camille E. Powe, Camille E. Powe, Camille E. Powe, Luigi Bouchard, Luigi Bouchard, Luigi Bouchard, Marie-France Hivert, Marie-France Hivert, Marie-France Hivert

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A Case Report of Clinical Features Analysis of a Novel IKBKG Variant Leading to Anhidrotic Ectodermal Dysplasia and Immunodeficiency by HUANG Xiaomei, LUO Ying, HE Tingyan, XU Yongbin, XIA Yu, YANG Zhi, ZHU Xiaona, HUANG Yanyan, WENG Ruohang, YANG Jun, WANG Linlin

“…In addition, genetic analysis is needed to exclude pseudogene interference and functional evaluations are required.…”
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A molecular proximity sensor based on an engineered, dual-component guide RNA by Junhong Choi, Wei Chen, Hanna Liao, Xiaoyi Li, Jay Shendure

“…Here, we demonstrate a strategy termed ‘P3 editing’, which links protein-protein proximity to the formation of a functional CRISPR-Cas9 dual-component guide RNA. By engineering the crRNA:tracrRNA interaction, we demonstrate that various known protein-protein interactions, as well as the chemically induced dimerization of protein domains, can be used to activate prime editing or base editing in human cells. …”
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Fingerprint patterns of human brain activity reveal a dynamic mix of emotional responses during virtual intergroup encounters by Gloria Mendoza-Franco, Inga Jasinskaja-Lahti, Matthias B. Aulbach, Ville J. Harjunen, Anna Peltola, J. Niklas Ravaja, Matilde Tassinari, Saana Vainio, Iiro P. Jääskeläinen

“…In this study, we used machine learning to identify emotional brain patterns using functional magnetic resonance imaging. Subsequently, those patterns were used to monitor emotional reactions during virtual intergroup encounters. …”
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Engineering high-density microcrystalline boundary with V-doped RuO2 for high-performance oxygen evolution in acid by Han Wu, Zhanzhao Fu, Jiangwei Chang, Zhiang Hu, Jian Li, Siyang Wang, Jingkun Yu, Xue Yong, Geoffrey I. N. Waterhouse, Zhiyong Tang, Junbiao Chang, Siyu Lu

“…As a result, the adsorbate evolution mechanism pathway becomes dominant, even at high current densities. Density functional theory analyses confirm that GBs can stabilize V dopant and that the synergy between them modulates the electronic structure of RuO2, thus optimizing the adsorption of OER intermediate species and enhancing electrocatalyst stability. …”
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Prototype of a Multimodal and Multichannel Electro-Physiological and General-Purpose Signal Capture System: Evaluation in Sleep-Research-like Scenario by Pablo Cevallos-Larrea, Leimer Guambaña-Calle, Danilo Andrés Molina-Vidal, Mathews Castillo-Guerrero, Aluizio d’Affonsêca Netto, Carlos Julio Tierra-Criollo

“…Key features of the MADQ include individually configurable bipolar recording, lead-off detection capability, and real-time online filtering. The system’s functional performance was characterized through metrics such as Input-Referred Noise (IRN), Noise-Free Bits (NFB), and Effective Number of Bits (ENOB) across varying gain and sampling frequencies. …”
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Engineering Magnetic Heterostructures with Synergistic Regulation of Charge‐Transfer and Spin‐Ordering for Enhanced Water Oxidation by Chongyan Hao, Yang Wu, Xiaobo Zheng, Yumeng Du, Yameng Fan, Weikong Pang, Anton Tadich, Shujun Zhang, Thomas Frauenheim, Tianyi Ma, Xiaoning Li, Zhenxiang Cheng

“…Experimental results and density functional theory calculations confirmed that the magnetic heterostructure exhibits both charge transfer and spin polarization. …”
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Ras and Rab interactor 3 as a prognostic biomarker and its impact on immune cell infiltration in cancer by Xin Xu, Ningfeng Zhou, Shasha Zhang, Tingxin Cheng, Jun Ren, Dian Yang, Ying Liu, Shiyan Wang, Aijun Sun, Fengze Cai

“…Abstract RIN3, a member of the RIN protein family, plays a pivotal role in disease progression by modulating Rab5 activity and influencing cell signaling pathways, which in turn affect tumor proliferation and migration. …”
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Antioxidant Activity and Anti-Inflammatory Effect of Blood Orange By-Products in Treated HT-29 and Caco-2 Colorectal Cancer Cell Lines by Rosa Calvello, Giusy Rita Caponio, Antonia Cianciulli, Chiara Porro, Melania Ruggiero, Giuseppe Celano, Maria De Angelis, Maria Antonietta Panaro

“…Moreover, the results of this study demonstrate that BO-pf extracts can enhance the expression of anti-inflammatory cytokines, such as IL-10 and TGFβ, suggesting that BO-pf extracts may represent a promising functional ingredient to counteract the intestinal inflammatory responses involved in IBD.…”
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A novel miR-4536-3p inhibition ameliorates Alzheimer’s disease by reducing Aβ accumulation and tau phosphorylation by Jiyun Choi, Dohee Kim, Haewon Jeong, Jinsu Hwang, Mahesh Ramalingam, Sujin Han, Hyong-Ho Cho, Byeong C. Kim, Han-Seong Jeong, Sujeong Jang

“…Apoptosis, neuronal markers, and signaling pathways were assessed through functional assays. Cognitive effects were evaluated via the Morris water maze. …”
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Optimal information gain at the onset of habituation to repeated stimuli by Giorgio Nicoletti, Matteo Bruzzone, Samir Suweis, Marco dal Maschio, Daniel Maria Busiello

“…Our work makes a fundamental step towards uncovering the functional mechanisms that shape habituation in biological systems from an information-theoretic and thermodynamic perspective.…”
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Nanoparticle-mediated SIRT1 inhibition suppresses M2 macrophage polarization and hepatocarcinogenesis in chronic hepatitis B by He Zhang, Feng Yuan, Nan Zhao, Wenqiang Tang, Pengwei Zhao, Chunfa Liu, Shan Chen, Xiaolin Hou, Changyou Xia, Jun Chu

“…A transgenic mouse model of CHB was established, and RNA sequencing (RNA-seq) and proteomics analyses revealed significant dysregulation of genes associated with M2 macrophage polarization, particularly SIRT1. Functional enrichment analysis highlighted key pathways, including PI3K-Akt and NF-κB, that contribute to CHB-driven immune alterations. …”
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Arginine Relieves the Inflammatory Response and Enhances the Casein Expression in Bovine Mammary Epithelial Cells Induced by Lipopolysaccharide by Tianyou Wu, Chao Wang, Luoyang Ding, Yizhao Shen, Huihui Cui, Mengzhi Wang, Hongrong Wang

“…As one of functional active amino acids, L-arginine holds a key position in immunity. …”
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