Exploring the role and mechanisms of MAGEA4 in tumorigenesis, regulation, and immunotherapy by Weijian Zhu, Qiang Yi, Zheng Chen, Jiaqi Wang, Kui Zhong, Xinting Ouyang, Kuan Yang, Bowei Jiang, Jianing Zhong, Jinghua Zhong

“…This review summarizes the mechanisms of action, regulatory functions, and immunotherapeutic applications of MAGEA4 in cancer.MAGEA4 promotes tumor initiation and progression through multiple pathways, including ubiquitination and degradation of the tumor suppressor P53, regulation of cell cycle and apoptosis, modulation of DNA damage repair, and enhancement of cancer cell survival. …”
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The Effect of High-Intensity Interval Training (HIIT) on Brain-Derived Neurotrophic Factor Levels (BNDF): A Systematic Review by Milosz Mielniczek, Tore Kristian Aune

“…Results: Twelve studies met the inclusion criteria, with most indicating significant increases in BDNF levels post-HIIT, suggesting HIIT’s potential to enhance neuroplasticity and cognitive functions. However, variations in BDNF responses were observed across different HIIT protocols and study populations. …”
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Multiple color images security by SPN over the residue classes of Gaussian integer $$\:Z{\left[i\right]}_{h}$$ by Muhammad Sajjad, Tariq Shah, Rafik Hamza, Bander Almutairi, Robinson Julian Serna

“…When the proposed SPN framework is utilized for a set of multiple RGB images, the mappings employed involves substitution-permutation-XOR operations that are severe nonlinear functions for differential or linear attacks. The incorporation of these Gaussian-integer-based S-boxes into the SPN scheme makes it possible for each image channel to be transformed independently but mutually connected to produce a secure and efficient encryption function. …”
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A Hybrid Model for Carbon Price Forecasting Based on Secondary Decomposition and Weight Optimization by Yongfa Chen, Yingjie Zhu, Jie Wang, Meng Li

“…Firstly, the original price series is decomposed into intrinsic mode functions (IMFs), using complete ensemble empirical mode decomposition with adaptive noise (CEEMDAN). …”
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Allosteric Regulation of Fibronectin/α5β1 Interaction by Fibronectin-Binding MSCRAMMs. by Xiaowen Liang, Xiaowen Liang, Brandon L Garcia, Livia Visai, Sabitha Prabhakaran, Nicola A G Meenan, Jennifer R Potts, Martin J Humphries, Magnus Höök

“…By correlating structural changes in Fn to a direct measurement of increased Fn/α5β1 affinity, this work significantly advances our understanding of the structural basis for the modulation of integrin function by Fn-binding MSCRAMMs.…”
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Grid cells, place cells, and geodesic generalization for spatial reinforcement learning. by Nicholas J Gustafson, Nathaniel D Daw

“…We consider this problem through the lens of spatial navigation, examining how two of the brain's location representations--hippocampal place cells and entorhinal grid cells--are adapted to serve as basis functions for approximating value over space for RL. …”
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Macrophage-derived human resistin is induced in multiple helminth infections and promotes inflammatory monocytes and increased parasite burden. by Jessica C Jang, Gang Chen, Spencer H Wang, Mark A Barnes, Josiah I Chung, Mali Camberis, Graham Le Gros, Philip J Cooper, Cathy Steel, Thomas B Nutman, Mitchell A Lazar, Meera G Nair

“…Murine resistin-like molecules (RELM) exhibit pleiotropic functions following helminth infection including modulating the host immune response; however, the relevance of human RELM proteins in helminth infection is unknown. …”
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Posttranscriptional Regulation of Intestinal Mucosal Growth and Adaptation by Noncoding RNAs in Critical Surgical Disorders by Cassandra A. Cairns, Lan Xiao, Jian-Ying Wang

“…Noncoding RNAs (ncRNAs), which include microRNAs (miRNAs), long ncRNAs (lncRNAs), circular RNAs (circRNAs), and small vault RNAs (vtRNAs), modulate a wide array of biological functions and have been identified as orchestrators of intestinal epithelial homeostasis. …”
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Macrophage MST1 protects against schistosomiasis-induced liver fibrosis by promoting the PPARγ-CD36 pathway and suppressing NF-κB signaling. by Jianyang Li, Xinyuan Cai, Yan Yang, Yulin Mao, Lin Ding, Qian Xue, Xunhao Hu, Yan Huang, Cong Sui, Yuxia Zhang

“…Overall, our data identified MST1 as a novel regulator for egg-induced liver fibrosis via modulation of macrophage function and phenotype by CD36-mediated phagocytosis and suppression of NF-κB pathway.…”
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CO confers neuroprotection via activating the PERK-calcineurin pathway and inhibiting necroptosis by Jeongmin Park, LiHua Jin, Hyun-Chul Song, Yingqing Chen, Eun Young Jang, Gyu Hwan Park, Chae Ha Yang, Stefan W. Ryter, Jeong Woo Park, Min Zheng, Yeonsoo Joe, Hun Taeg Chung

“…Furthermore, CO enhances the expression of Beclin 1, which inhibits necroptosis, independently of its autophagic function, by regulating MLKL oligomerization. Our findings suggest that modulation of the PERK-calcineurin pathway and downstream activation of cellular defense mechanisms by CO may serve as a promising therapeutic approach to mitigate neuronal loss in neurodegenerative diseases.…”
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MFN: Multi-Scale Frequency Feature Fusion Network for Multi-Classification Image Segmentation by Ji Xiao, Li Jianfang, Zhao Peng, Li Xiaochen, Zhang Chengchun, Zheng Junyi, Pang Yonghui, Huang Xiangsheng

“…And a combined loss function, integrating cross-entropy loss and the Dice coefficient, is designed to improve model training and achieve optimal segmentation performance. …”
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Cerebrospinal fluid-contacting neurons are sensory neurons with uniform morphological and region-specific electrophysiological properties in the mouse spinal cord by Elysa Crozat, Edith Blasco, Jorge Ramirez-Franco, Priscille Riondel, Nina Jurčić, Riad Seddik, Caroline Michelle, Jérôme Trouslard, Nicolas Wanaverbecq

“…The future challenges in the field, will be to elucidate the physiological stimuli activating CSF-cNs and the neuronal network they are integrated in to modulate body function through specific local spinal network.…”
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Lightweight insulator target detection algorithm based on improved YOLOX by Bing Zeng, Wei Hua, Dezhi Li, Zhihao Zhou, Hao Wan, Yunmin Xie, Tangbing Li, Yucong Chen, Jianglei Li, Shenli Wang, Shixun Fu, Zihan Jin, Wenhua Zhang

“…Finally, the σWIoU loss function replaces the traditional IoU to accelerate convergence and optimize overall performance. …”
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O-GlcNAcylation with ubiquitination stabilizes METTL3 to promoting HMGB1 degradation to inhibit ferroptosis and enhance gemcitabine resistance in pancreatic cancer by Qiuhong Wang, Dong Wei, Chunman Li, Xiawei Yang, Kun Su, Tao Wang, Renchao Zou, Lianmin Wang, Dongyun Cun, Bo Tang, Tao Wu

“…Methods By means of functional gain and loss experiments, the relationship between METTL3 and gemcitabine resistance as well as ferroptosis was explored. …”
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Bioinformatics and experimental unveiling of TIMP1 as a novel therapeutic target in colorectal cancer ferroptosis by Chao Tang, Zhenhan Li, Zhenhan Li, Tianyu Song, Linming Lu, Bofeng Chen, Tao Zhang, Yi Zhang, Jie Yang, Jianle Lao, Hao Chen, Hao Chen, Hao Chen

“…Immunohistochemistry demonstrated significantly higher TIMP1 levels in CRC tissues compared to healthy controls. Functional assays revealed that TIMP1 knockdown enhanced ferroptosis sensitivity, suppressed CRC cell proliferation and migration, and reduced expression of ferroptosis regulators GPX4 and SLC7A11.ConclusionThese findings indicate that TIMP1 drives CRC malignancy through ferroptosis modulation, positioning TIMP1 as a potential therapeutic target and offering novel insights for CRC-targeted therapies.…”
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Improving Plant Performance Through Microbiome Manipulation: The Potential Role of Current Bioengineering Approaches by Diksha Joshi, Amit Kaushik, Reetesh Kumar, Aditi Arya, Gustavo Santoyo, Vipin Kumar Singh, Nikhil Kashyap, Manoj Kumar Solanki, Madhuree Kumari, Nikunaj Bhardwaj, Ajay Kumar

“…The present review presents the significance of plant microbe interaction, vital functional aspects, collaborative action, potential constraints, and finally the latest developments in bioengineering approaches destined for microbiome modulation with an objective to improve the performance of a host plant challenged with environmental stressors.…”
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Optimizing grain refinement, mechanical properties, and oxidation resistance of Ni3Al intermetallic through Fe doping by Qian Li, Jia Wei, Yuqi Xie, Chuangchuang Wei, Weiwei Wang, Zhenfei Jiang, Junkai Liu

“…In this study, Fe was doped into Ni3Al at varying concentrations (0.1–1 wt%), and its effects were systematically investigated using both in-situ and ex-situ characterization techniques, complemented by density functional theory calculations. The results indicate that Fe doping effectively suppresses oxide scale spallation and enhances the oxidation resistance of Ni3Al, with the optimal performance observed at 0.5 wt% Fe. …”
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OLS-Based RBF Neural Network for Nonlinear and Linear Impairments Compensation in the CO-OFDM System by Ling Liu, Meihua Bi, Shilin Xiao, Jiafei Fang, Tiancheng Huang, Weisheng Hu

“…For the first time, we propose and experimentally verify a novel low-complexity orthogonal least square (OLS) based radial basis function (RBF) neural network (NN) nonlinear equalizer for high-speed coherent optical orthogonal frequency division multiplexing (CO-OFDM) system. …”
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Natural products in traditional Chinese medicine for renal fibrosis: a comprehensive review by Qianqian Zhao, Meihua Jin, Qiang Zhao, Zhimei Wang, Chun Zhao, Xiaocong Xue, Xikai Qiao, Peng Qu, Donghe Han, Ran Tao

“…Renal fibrosis represents the terminal pathological manifestation of most chronic kidney diseases, driving progressive loss of renal function. Natural products have emerged as promising therapeutic agents for preventing and ameliorating renal fibrosis due to their multi-target efficacy and favorable safety profiles. …”
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Targeting VCAM-1 with chimeric antigen receptor and regulatory T cell for abdominal aortic aneurysm treatment by Qingwei Gang, Yu Lun, Xiaoxu Zhang, Jamol Uzokov, Han Jiang, Yuchen He, Shikai Shen, Shiyue Wang, Philipp Erhart, Dittmar Böckler, Yuemeng Li, Yanshuo Han, Jian Zhang

“…By leveraging the specificity and regulatory function of CAR-Treg cells, our research aims to modulate the immune response and reduce inflammation in the aneurysmal wall. …”
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