Spatial expression of glucagon-like peptide 1 receptor and caveolin-1 in hepatocytes with macrovesicular steatosis in non-alcoholic steatohepatitis by Hiroaki Yokomori, Wataru Ando

“…Glucagon-like peptide 1 receptor (GLP-1R) mediates β cell function. Its receptor agonists, currently used to treat type 2 diabetes mellitus, might be effective against NASH. …”
Get full text

PR3 and elastase alter PAR1 signaling and trigger vWF release via a calcium-independent mechanism from glomerular endothelial cells. by Samantha P Tull, Anne Bevins, Sahithi Jyothsna Kuravi, Simon C Satchell, Bahjat Al-Ani, Stephen P Young, Lorraine Harper, Julie M Williams, George Ed Rainger, Caroline O S Savage

“…Therefore, PAR signaling and serine protease-induced alterations in endothelial function modulate glomerular inflammation via parallel but independent pathways.…”
Get full text

Design and investigation of charge plasma-based TMD heterojunction TFET biosensor for ultrasensitive detection by Monika Kumari, Niraj Kumar Singh, Vinay Kantipudi, Manodipan Sahoo

“…Non-equilibrium green’s function (NEGF)-based simulator and SILVACO TCAD, a 2-D device simulator have been utilized to simulate the electrical characteristics of the proposed biosensor. …”
Get full text

Electrical silencing of dendritic arborization neurons rescues toxic polyglutamine-induced locomotion defect by Hongyu Miao, Woo Jae Kim

“…This suggests that modulating the activity of these neurons could be a promising therapeutic approach for treating polyQ diseases. …”
Get full text

Chloride Accumulators NKCC1 and AE2 in Mouse GnRH Neurons: Implications for GABAA Mediated Excitation. by Carol Taylor-Burds, Paul Cheng, Susan Wray

“…Anion exchangers (AEs) are also potential modulators of responses to GABAA activation since they accumulate chloride and extrude bicarbonate. …”
Get full text

A study to identify novel biomarkers associated with multiple myeloma by Bhaskar Kalarani Iyshwarya, Veerabathiran Ramakrishnan

“…Background. multiple myeloma (mm) is a plasma cell cancer that affects white blood cells. plasma cells from the bone marrow grow abnormally, as a consequence of which patients have high amounts of monoclonal immunoglobulin in their blood and urine, poor renal function, and recurring infections due to this condition. osteolytic bone lesions and immunodeficiency also impact multiple myeloma patients’ longevity and quality of life. …”
Get full text

Quantifying the Wind‐Induced Bias of Rainfall Measurements for the Thies CLIMA Optical Disdrometer by E. Chinchella, A. Cauteruccio, L. G. Lanza

“…Catch ratios for monodisperse rain are obtained as a function of the particle Reynolds number and the wind direction and fitted to obtain site‐independent curves to support application of the simulation results. …”
Get full text

Robust Strategy Generation for Automatic Navigation of Unmanned Surface Vehicles through Improved DDPG Algorithm by Wei Wang, Subin Huang, Huabin Diao

“…Second, we ensure the decision adaptability of the USV by constraining the extent of action change between adjacent time-steps by using a reward-function, which improves the USV-action smoothly. Finally, we design typical USV-automatic-navigation-scenarios to validate the performance of the Algorithm. …”
Get full text

IMRMB-Net: A lightweight student behavior recognition model for complex classroom scenarios. by Caihong Feng, Zheng Luo, Deyao Kong, Yunhong Ding, Jingyu Liu

“…Meanwhile, a new loss function, Focaler-ShapeIoU, is designed in this study, aiming to improve the learning ability and robustness of the model to different samples thus further solving the occlusion problem. …”
Get full text

Smooth muscle cell-specific deletion of TXNIP ameliorates medial vascular calcification by Ae-Rang Hwang, Chang-Hoon Woo

“…The insights from this comprehensive study indicate that TXNIP not only amplifies oxidative stress and inflammation in vascular smooth muscle cells but also represents a potential therapeutic target for mitigating medial calcification. Modulating TXNIP expression or function may reduce the incidence of medial calcification in patients with cardiovascular diseases linked to metabolic disorders.…”
Get full text

Screening of VHL mutation in different types of kidney cancer in patients of West Bengal (India) by Vishal Jalan, Ravi Prakash Yadav, Madhusudan Das, Dilip Kumar Pal

“…The effect of these Single nucleotide polymorphism SNPs/mutations on VHL function were predicted by various bioinformatics software and it was found that rs1399097617 C>T, rs5030830 T>C, and rs1553620326 G>C are disease-causing. …”
Get full text

Tryptophan metabolism and ischemic stroke: An intricate balance by Chongjie Yao, Dong Xie, Yuchen Zhang, Yuanhao Shen, Pingping Sun, Zhao Ma, Jin Li, Jiming Tao, Min Fang

“…In contrast, neurotoxic substances such as quinolinic acid can hinder the development of vascular glucose transporter proteins, induce neurotoxicity mediated by reactive oxygen species, and disrupt mitochondrial function. Additionally, the enzymes involved in tryptophan metabolism play major roles in these processes. …”
Get full text

Alternaria alternata effector AaAlta1 targets CmWD40 and participates in regulating disease resistance in Chrysanthemum morifolium. by Shuhuan Zhang, Lina Liu, Wenjie Li, Mengru Yin, Qian Hu, Sumei Chen, Fadi Chen, Ye Liu, Zhiyong Guan, Jiafu Jiang

“…Notably, the CmWD40 gene showed rhythmic basal expression, and the overexpression of CmWD40 increased the resistance of chrysanthemum leaves against A. alternata, whereas its loss of function led to a decrease in this resistance. The results of the comparative transcriptomics and JA content analyses indicated that CmWD40 is possibly involved in the accumulation and signaling of JA. …”
Get full text

Modern ideas about the causes, pathogenesis and innovative areas of therapy for asthenic syndrome in clinical practice by S. A. Zhivolupov, A. A. Smirnova

“…An innovative direction in the treatment and prevention of asthenic syndrome is modulation of the function of the "gut-brain" axis. …”
Get full text

HybridFormer: a convolutional neural network-Transformer architecture for low dose computed tomography image denoising by Shanaz Sharmin Jui, Zhitao Guo, Rending Jiang, Jiale Liu, Bohua Li

“…Finally, using RSTB, we developed a deep feature refinement module (DFRM) to preserve image details. To avoid smoothing, we combined multi-scale perceptual loss from ResNet-50 with Charbonnier loss into a composite loss function. …”
Get full text

The Small RNA MicF Represses ObgE and SeqA in <i>Escherichia coli</i> by Aaron Y. Stibelman, Amy Y. Sariles, Melissa K. Takahashi

“…Our study suggests that, beyond its established role in membrane permeability management, MicF exerts control over chromosome dynamics in response to distinct environmental cues, implicating a more multifaceted regulatory function in bacterial stress adaptation.…”
Get full text

A steel surface defect detection method based on improved RetinaNet by Zhanglin Yang, Yu Liu

“…Secondly, a CA-BiFPN is proposed for feature fusion, which effectively integrates information from different feature layers using attention mechanisms and enhances the focus on defect features from the complete feature space with a CA attention module. Thirdly, an IA-BCELoss is introduced as the classification loss function, coupling classification and regression predictions to ensure high-quality detection boxes while maintaining classification accuracy. …”
Get full text

Exploring the Pivotal Immunomodulatory and Anti-Inflammatory Potentials of Glycyrrhizic and Glycyrrhetinic Acids by Seidu A. Richard

“…The extract usually consists of many components but the key ingredients are glycyrrhizic (GL) and glycyrrhetinic acid (GA). GL and GA function as potent antioxidants, anti-inflammatory, antiviral, antitumor agents, and immuneregulators. …”
Get full text

NPS-2143 suppresses malignant phenotypes of retinoblastoma cells involved in regulating NF-κB pathway by Cuiying Zhang, Tao Yu, Guanghua Sun, Miao Li

“…Abstract NPS-2143, as a CaSR allosteric antagonist, performs an important role in diverse cancers. However, the function and mechanism of NPS-2143 in human retinoblastoma have not been reported. …”
Get full text

Knowledge based convolutional transformer for joint estimation of PM2.5 and O3 concentrations by Ying Ren, Siyuan Wang, Bisheng Xia, Biesheng Xia

“…Knowledge is introduced into the model by the shared and specific inputs, the PM2.5-O3 interaction module, and the weighted loss function designed with the correlation between PM2.5 and O3 concentrations. …”
Get full text