Twisted gastrulation, a BMP antagonist, exacerbates podocyte injury. by Sachiko Yamada, Jin Nakamura, Misako Asada, Masayuki Takase, Taiji Matsusaka, Taku Iguchi, Ryo Yamada, Mari Tanaka, Atsuko Y Higashi, Tomohiko Okuda, Nariaki Asada, Atsushi Fukatsu, Hiroshi Kawachi, Daniel Graf, Eri Muso, Toru Kita, Takeshi Kimura, Ira Pastan, Aris N Economides, Motoko Yanagita

“…Here we show that the product of Twisted gastrulation (Twsg1), a Bmp antagonist, is the central negative regulator of Bmp function in podocytes and that Twsg1 null mice are resistant to podocyte injury. …”
Get full text

Neuroglial Dysregulation in Autism Spectrum Disorder: Pathogenetic Insights, Genetic Threads, and Therapeutic Horizons by Nikola Ilic, Adrijan Sarajlija

“…Recent studies highlight the crucial roles of neuroglial cells—astrocytes, microglia, and oligodendrocytes—in synaptic function, neural connectivity, and neuroinflammation. …”
Get full text

S100A9 Regulated M1/M2 Macrophage Polarization in Interleukin-10-Induced Promotion of Malignant Pleural Effusion by Xue-Bin Pei, Feng-Shuang Yi, Shu-Feng Dong, Qing-Yu Chen, Xin-Yu Shi

“…Previous studies have elucidated the pathogenesis from the view of the immune-regulation function of CD4+ T-cells. However, the underlying mechanism is still not fully understood. …”
Get full text

Anthropogenic Habitat Loss and Fragmentation May Alter Coevolutionary Progress as Examined in a Brood Parasitism Model by Wei Wang, Timothy Van Deelen, Fuwen Wei, Sheng Li, Luping Wang

Get full text

Femtosecond laser ablation of nitrocellulose for spatio-temporal flow control in µPADs by Esteban Builes Münden, Andreas Dietzel

“…Line ablation characteristics were investigated as a function of the temporal and spatial pulse separation and laser wavelength. …”
Get full text

Opposing action of the FLR-2 glycoprotein hormone and DRL-1/FLR-4 MAP kinases balance p38-mediated growth and lipid homeostasis in C. elegans. by Sarah K Torzone, Aaron Y Park, Peter C Breen, Natalie R Cohen, Robert H Dowen

“…Here, we demonstrate that DRL-1 and FLR-4, which share similarity with mammalian mitogen-activated protein kinases, maintain lipid homeostasis in the C. elegans intestine. DRL-1 and FLR-4 function in a protein complex at the plasma membrane to promote development, as mutations in drl-1 or flr-4 confer slow growth, small body size, and impaired lipid homeostasis. …”
Get full text

Exploring the potential of Cucumis melo phytoconstituents for treating diabetic neuropathy using in silico molecular docking and simulation: An experimental study by Fahaad S Alenazi, Sadaf Anwar, Halima Mustafa Elagib, Malik Asif Hussain, Tulika Bhardwaj, Mohd. Adnan Kausar

“…Background Diabetic nephropathy (DN) is a serious kidney disease that damages and declines kidney function and is associated with long-term diabetes. …”
Get full text

Anti-Inflammatory and Antioxidant Activity of Vitamin E-infused Nanogel Formulation: An In-Vitro Study by Turaga Amani, Mouttoukichenin Surenthar

“…It plays a crucial role in immune cell function, gene expression, and modulation of inflammatory mediators. …”
Get full text

c-Myc-dependent LAMP3 regulates the proliferation, metastasis and metabolic reprogramming of tongue squamous cell carcinoma by Jing Feng, Wei He, Jin Fang

“…LAMP3 knockdown plasmid was constructed for a variety of biological function assays to verify the involvement of LAMP3 in TSCC. …”
Get full text

Exosomes in Dermatology: Emerging Roles in Skin Health and Disease by Salman Bin Dayel, Ramadan S. Hussein

“…<b>Methods:</b> A comprehensive review of the existing literature was conducted to elucidate the biological composition of exosomes, their roles in skin homeostasis, and their involvement in processes, such as wound healing, tissue regeneration, and barrier function maintenance. This review also examined the diagnostic and therapeutic potential of exosomes in conditions such as psoriasis, eczema, acne, and skin cancer. …”
Get full text

The anti-inflammatory properties of simvastatin can benefit statin-naïve rheumatoid arthritis patients with associated risks for cardiovascular disease by A.O. Komolafe, M.M.T.M. Ally, J.J. van Tonder, O.B.W. Greeff

“…Conclusions: The addition of 20 mg simvastatin to conventional DMARDs in statin-naïve RA patients at risk for cardiovascular disease may add benefit, apart from modifying lipid profiles, by modulating immune function and suppressing disease activity.…”
Get full text

Computational simulation study of the impact of isotropic GDL thermal conductivity on PEMFC characteristics by Mahmut Kaplan

“…The power function provided a good fit with the calculated data. …”
Get full text

siRNA Treatment Enhances Collagen Fiber Formation in Tissue-Engineered Meniscus via Transient Inhibition of Aggrecan Production by Serafina G. Lopez, Lara A. Estroff, Lawrence J. Bonassar

“…The complex collagen network of the native meniscus and the gradient of the density and alignment of this network through the meniscal enthesis is essential for the proper mechanical function of these tissues. This architecture is difficult to recapitulate in tissue-engineered replacement strategies. …”
Get full text

Integration of canonical and noncanonical Wnt signaling pathways patterns the neuroectoderm along the anterior-posterior axis of sea urchin embryos. by Ryan C Range, Robert C Angerer, Lynne M Angerer

“…Because these different Wnt pathways converge on the same cell fate specification process, our data suggest they may function as integrated components of an interactive Wnt signaling network. …”
Get full text

The Use of Tricyclic Antidepressants for Postherpetic Neuralgia – A Case Series by Jamal Hasoon, Syed Mahmood

“…All four patients experienced notable reductions in pain intensity on the Numeric Rating Scale (NRS), resulting in improved daily function and better pain tolerance. Side effects were minimal, with only one patient reporting mild sedation and another reporting transient dry mouth, both of which were manageable. …”
Get full text

Downregulation of adaptor protein MyD88 compromises the angiogenic potential of B16 murine melanoma. by Lucas Daniel Trucco, Emiliano Roselli, Paula Araya, Nicolás Gonzalo Nuñez, Hebe Agustina Mena, José Luis Bocco, Soledad Negrotto, Mariana Maccioni

“…Our results imply that cell-autonomous signaling through MyD88 is required to sustain tumor growth and underscore its function as an important positive modulator of tumor angiogenesis.…”
Get full text

Impact of probiotics on chicken gut microbiota, immunity, behavior, and productive performance—a systematic review by Peter A. Idowu, Takalani J. Mpofu, Aletta M. Magoro, Mamokoma C. Modiba, Khathutshelo A. Nephawe, Bohani Mtileni

“…Probiotics, as a natural alternative, have gained considerable attention due to their ability to modulate the gut microbiota, enhance immune function, and improve productive performance. …”
Get full text

Microbiota and Mental Health: Decoding the Gut-Brain Axis by Alicja Grzelak

“…By systematically reviewing current research, the study aims to provide a comprehensive understanding of microbial mechanisms influencing brain function and their implications for novel therapeutic interventions. …”
Get full text

Neuroprotective Effect of Benzyl Ferulate on Ischemia/Reperfusion Injury via Regulating NOX2 and NOX4 in Rats by Yu Xiang, Li Mao, Zhao-Hui Dai, Xiao-Hua Liu, Zhong-Bao Yang

“…The extent of oxidative stress was assessed through evaluations of neurobiological function, cerebral infarct volume, reactive oxygen species (ROS), apoptosis levels, etc. …”
Get full text

Targeting TP53TG1: a promising prognostic biomarker and therapeutic target for personalized cancer therapy by Haodong He

“…Notwithstanding considerable advancements in comprehending the molecular function of TP53TG1, some challenges persist, especially regarding the efficient and targeted administration of TP53TG1-based therapeutics. …”
Get full text