Mitchell-Riley Syndrome: A rare genetic disorder, case report by Shria Sadhu, Nibal Albitar, Mai AlKhouly, Aqeel Farooque

“…A better understanding of RFX6 function among both intestine and pancreas cells is essential for the identification of using new drugs that could modulate the enteroendocrine system. …”
Get full text

When the days are(n’t) numbered: Calendar calculations in transparent and opaque systems by Ziyi Zhuang, Norbert Vanek

“…These findings bring new evidence for linguistic relativity in the form of modulations of calendar processing speed changing as a function of linguistic transparency, input type and task demand.…”
Get full text

Long axial range 3D single-particle tracking using birefringent substrates by Shuho Nozue, Rfaqat Ali, Ying Wu, Satoshi Habuchi

“…Most high-throughput 3D tracking techniques rely on the engineering of the point spread function of the optical system to precisely determine the 3D coordinate of the particle using spatial light modulators. …”
Get full text

YOLOv11-ND: A Method for Identifying Traffic Targets in Nighttime Urban Environments by Danyang Zhu, Hao Zhou, Yunlong Gao, Yongjuan Wang

“…Lastly, the model is optimized using the Focaler-GIoU loss function to further enhance the detection performance. …”
Get full text

E2F activity determines mitosis versus whole-genome duplication in G2-arrested cells by Kibum Kim, Jessica Armand, Sungsoo Kim, Hee Won Yang

“…Abstract While mitogenic signaling is known to regulate cell-cycle entry during the G1 phase, its function in the G2 phase remains elusive. Here we show that mitogenic signaling controls whether G2-arrested cells proceed through mitosis or undergo whole-genome duplication. …”
Get full text

GAG Protein of <i>Arabidopsis thaliana</i> LTR Retrotransposon Forms Retrosome-like Cytoplasmic Granules and Activates Stress Response Genes by Alexander Polkhovskiy, Roman Komakhin, Ilya Kirov

“…LTR retrotransposons are widespread genomic elements that significantly impact genome structure and function. In <i>Arabidopsis thaliana</i>, the EVD LTR retrotransposon encodes a GAG protein essential for retrotransposon particle assembly. …”
Get full text

Design of high phase-sensitivity BlueP/TMDC heterostructure-based SPR biosensor using improved artificial bee colony algorithm by Chong Yue, Mantong Chen, Yaopu Lang, Qinggang Liu

“…In the optimization function of the IABC method, the reflectivity at resonance angle is incorporated as a constraint to achieve high phase sensitivity. …”
Get full text

Numerical Simulation of Typhoon Waves in an Offshore Wind Farm Area of the South China Sea by Baofeng Zhang, Xu Li, Lizhong Wang, Yangyang Gao

“…By constructing a joint distribution function of sea wind and wave elements, the joint distribution characteristics of wind speed and significant wave height for different return periods can be obtained, providing important oceanic environmental inputs for the design analysis of offshore wind structures.…”
Get full text

Design and Optimization of a Fan-Out Wafer-Level Packaging- Based Integrated Passive Device Structure for FMCW Radar Applications by Jiajie Yang, Lixin Xu, Ke Yang

“…Using this metric as a loss function, we apply the support vector machine (SVM) for electromagnetic simulation and the genetic algorithm (GA) for optimization. …”
Get full text

Application of an improved pelican optimization algorithm based on comprehensive strategy in PV parameter identification by Xu Yong, Sang Bicong, Zhang Yi

“…Finally, the reverse solution generated by the lens imaging principle can provide a new search direction through the mirror reverse learning strategy when the Pelican optimization algorithm falls into the local optimal. The CEC2022 test function performed analysis and comparison with eight meta-heuristic algorithms. …”
Get full text

A heat-shock protein axis regulates VEGFR2 proteolysis, blood vessel development and repair. by Alexander F Bruns, Nadira Yuldasheva, Antony M Latham, Leyuan Bao, Caroline Pellet-Many, Paul Frankel, Sam L Stephen, Gareth J Howell, Stephen B Wheatcroft, Mark T Kearney, Ian C Zachary, Sreenivasan Ponnambalam

“…Vascular endothelial growth factor A (VEGF-A) binds to the VEGFR2 receptor tyrosine kinase, regulating endothelial function, vascular physiology and angiogenesis. However, the mechanism underlying VEGFR2 turnover and degradation in this response is unclear. …”
Get full text

Gene Silencing Therapies for Huntington’s Disease by Chunlan Hao, Hanfeng Ji

“…Mutant huntingtin (mHTT) imposes a toxic gain‑of‑function that progressively compromises neuronal circuitry, culminating in the distinctive triad of motor, cognitive and psychiatric symptoms. …”
Get full text

Selective transfer learning with adversarial training for stock movement prediction by Yang Li, Hong-Ning Dai, Zibin Zheng

“…All three tasks are jointly trained with a loss function. As a result, the pre-trained shared base model can be fine-tuned with the stock data in target domain. …”
Get full text

Nitric oxide and chronic colitis by Matthew B Grisham, Satoshi Aiko

“…Nitric oxide (NO) is thought to play an important role in modulating the inflammatory response by virtue of its ability to affect bloodflow, leukocyte function and cell viability. …”
Get full text

A segmented differential evolution with enhanced diversity and semi-adaptive parameter control by Huarong Xu, Zhiyu Zhang, Qianwei Deng, Shengke Lin

“…Secondly, building on the idea of parameter restriction in the evolutionary stage of delineation, a semi-adaptive parameter control method based on the fitness of the irrelevant function is proposed which effectively solves the instability problem of excessive fluctuations in the convergence of adaptive parameters. …”
Get full text

Neurofibromin 1 mediates sleep depth in Drosophila. by Elizabeth B Brown, Jiwei Zhang, Evan Lloyd, Elizabeth Lanzon, Valentina Botero, Seth Tomchik, Alex C Keene

“…Together, these findings suggest Nf1 acts in GABA-sensitive neurons to modulate sleep depth in Drosophila.…”
Get full text

Propagation Factors of Partially Coherent Model Beams in Oceanic Turbulence by Xianwei Huang, Yanfeng Bai, Xiquan Fu

“…Based on the extended Huygens&#x2013;Fresnel principle and second-order moments of the Wigner distribution function, we have derived the analytical expressions of the propagation factor of four kinds of partially coherent model beams in oceanic turbulence, including Gaussian Schell-model (GSM), Bessel&#x2013;Gaussian Schell-model, Laguerre&#x2013;Gaussian Schell-model, and cosine-Gaussian Schell-model (CGSM). …”
Get full text

Impact of helicobacter pylori infection on the efficacy of ICIs in gastric cancer by Yuxin Huang, Yi Hu

“…Additionally, infection-associated dysbiosis of the gut microbiota and suppression of T cell function are implicated in diminished ICI efficacy. …”
Get full text

Denoising and deconvolving CT images of unknown origin: comparing linear Wiener-deconvolution with deep convolutional neural network Noise2Inverse by Simon Zabler, Antoine Klos, Pierre Lhuissier, Luc Salvo, Maziyar Farahmandi, Simon Wittl

“…It may apply in 2D or 3D and requires merely estimates of the Signal-to-Noise Ratio SNR2 as well as the system Modulation Transfer Function (MTF). Meanwhile, any linear filter is unable to adapt to local contrast variations in the images. …”
Get full text

The Role of HDAC6 in Glioblastoma Multiforme: A New Avenue to Therapeutic Interventions? by Francesco Spallotta, Barbara Illi

“…In this review article, the available information related to HDAC6 function in GBM will be presented, with the aim of proposing its inhibition as a valuable therapeutic route for this deadly brain tumour.…”
Get full text