Advancements in mitochondrial-targeted nanotherapeutics: overcoming biological obstacles and optimizing drug delivery by Yang Li, Yang Li, Xiao-meng Li, Li-si Wei, Jun-feng Ye

“…This has propelled the development of nanomedicines aimed at precise mitochondrial targeting to modulate their function, marking a research hotspot. …”
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Therapeutic Horizons: Gut Microbiome, Neuroinflammation, and Epigenetics in Neuropsychiatric Disorders by Shabnam Nohesara, Hamid Mostafavi Abdolmaleky, Ahmad Pirani, Sam Thiagalingam

“…Gut microbes and their metabolites influence immune cell activity and brain function, thereby contributing to neuroinflammation and the development and progression of NPD. …”
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The Essential Oil Component Terpinyl Acetate Alters Honey Bee Energy Levels and Foraging Behavior by Trey Mathews, Ella Joyce, Charles I. Abramson, Harrington Wells, Robert J. Sheaff

“…Using a cell culture model system, we found that terpinyl acetate is a potent and specific inhibitor of mitochondrial ATP production, suggesting it might function as a plant toxin. Remarkably, however, terpinyl acetate was not cytotoxic because cells switched to glycolysis to maintain ATP levels. …”
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Connecting Molecular Characteristics of Intrauterine Growth-Retarded Piglets to Targeted Nutritional Interventions: A Review by Janghan Choi, Emma Traylor, Rachel Husak, Annabelle Foster, Aubrey Akere-Nkongho Tambe

“…These approaches consistently show that IUGR piglets exhibit systemic dysfunction, including compromised gut health, increased inflammation and oxidative stress, and impaired function of multiple organs such as the intestine, liver, kidney, and immune-related tissues. …”
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High intensity exercise before sleep boosts memory encoding the next morning by Daniela Ramirez Butavand, Juliane Nagel, Gordon B. Feld, Simon Steib

“…However, at the systems level and behaviorally, support for this process playing a major role for memory function remains scarce. In the current study, we investigated the utility of moderate- and high-intensity evening exercise as a low-cost low-tech intervention to modulate sleep and its influence on subsequent encoding in the morning. …”
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Alternative splicing across the C. elegans nervous system by Alexis Weinreb, Erdem Varol, Alec Barrett, Rebecca M. McWhirter, Seth R. Taylor, Isabel Courtney, Manasa Basavaraju, Abigail Poff, John A. Tipps, Becca Collings, The CeNGEN Consortium, Smita Krishnaswamy, David M. Miller, Marc Hammarlund

“…Abstract Alternative splicing is a key mechanism that shapes transcriptomes, helping to define neuronal identity and modulate function. Here, we present an atlas of alternative splicing across the nervous system of Caenorhabditis elegans. …”
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A combination of systemic mannitol and mannitol modified polyester nanoparticles for caveolae-mediated gene delivery to the brain by Betsy Reshma Gilbert, Chirag Miglani, Arundhati Karmakar, Muneesh Pal, Vysakh C. Chandran, Sarika Gupta, Asish Pal, Munia Ganguli

“…This delivery platform offers a simple, scalable, and controlled delivery solution and holds promise for treating brain diseases with functional targets.…”
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NOTCH Signaling Is Activated through Mechanical Strain in Human Bone Marrow-Derived Mesenchymal Stromal Cells by Fani Ziouti, Regina Ebert, Maximilian Rummler, Melanie Krug, Sigrid Müller-Deubert, Martin Lüdemann, Franz Jakob, Bettina M. Willie, Franziska Jundt

“…Our data indicate a functional link between NOTCH activation and mechanotransduction in human BMSCs. …”
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Multidrug resistance and major facilitator superfamily antimicrobial efflux pumps of the ESKAPEE pathogen Staphylococcus aureus by Ebenezer Aborah, Matthew Ayitah, Kwesi Felix Boafo, Anely Ortiz-Alegria, Manjusha Lekshmi, Chandrashekar K. Dhanush, Sanath Kumar, Manuel F. Varela

“…As such, the multidrug efflux pumps of the MFS are thought to operate by a similar solute transport mechanism and, thus, represent suitable targets for modulating their transport activities. This review article addresses MRSA as a serious pathogen, the mechanisms of antimicrobial resistance, and the functional and structural roles of the multidrug efflux pumps of the MFS in conferring pathogenicity.…”
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β-Arrestin1/miR-326 Transcription Unit Is Epigenetically Regulated in Neural Stem Cells Where It Controls Stemness and Growth Arrest by Agnese Po, Federica Begalli, Luana Abballe, Vincenzo Alfano, Zein Mersini Besharat, Giuseppina Catanzaro, Alessandra Vacca, Maddalena Napolitano, Marco Tafani, Felice Giangaspero, Franco Locatelli, Elisabetta Ferretti, Evelina Miele

“…How intragenic microRNAs and their host genes are transcriptionally coregulated and their functional relationships for the control of neural stem cells (NSCs) are poorly understood. …”
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Automatic Acne Detection Model Based on Improved YOLOv7 by Delong Zhang, Chunyang Jin, Zhidong Zhang, Xiyuan Cao, Chenyang Xue

“…Specifically, the ELAN module in backbone is improved to enhance feature extraction functionality. …”
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Resolvin D2/GPR 18 axis ameliorates pressure overload-induced heart failure by inhibiting pro-inflammatory macrophage polarization by Zihui Zheng, Mengmeng Zhao, Yao Xu, Jishou Zhang, Shanshan Peng, Jianfang Liu, Wei Pan, Zheng Yin, Cheng Wei, Juan-Juan Qin, Jun Wan, Menglong Wang

“…In conclusion, RvD2/GPR18 axis improved cardiac remodeling and function in pressure overload-induced HF mice by modulating macrophage phenotype via STAT1 and NF-κB p65 pathways. …”
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Circulating Current Suppression Strategy of Modular Multilevel Matrix Converter Based on Quasi-Proportional Resonant Control by JIANG Yafeng, LI Yibo, WU Qiuwei, LIU Shenquan, WU Xiaodan, ZHOU Qian

“…First, the ripple voltage of the sub-module capacitor in steady state is studied. The mechanism of harmonic current generated by the coupling of sub-module ripple voltage and switching function is analyzed in detail. …”
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Coordinated changes in midkine expression and midkine-associated multiomic profile in glioma microenvironment by Mieszko Lachota, Katarzyna Zielniok, Agata Góźdź, Patrycja Szpak, Ilona Kalaszczyńska, Radosław Zagożdżon

“…To investigate MDK’s function in glioma, we integrated four RNA-Seq datasets into a harmonized cohort of 1,017 adult gliomas, including 256 GBM samples. …”
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PARP7 as a new target for activating anti-tumor immunity in cancer by Katerina Popova, Johannes Benedum, Magdalena Engl, Carola Lütgendorf-Caucig, Piero Fossati, Joachim Widder, Klaus Podar, Dea Slade

“…PARP7 also ADP-ribosylates the ligand-bound androgen receptor (AR), which is recognized by DTX3L-PARP9 that modulate the AR transcriptional activity. In this review, we discuss PARP7 enzymatic properties, biological functions and known substrates, its role in various cancers, and its targeting by specific inhibitors.…”
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Detecting age-related changes in faecal vasoactive intestinal polypeptide using a 3D-printed electrochemical immunosensor by Khalil K. Hussain, Chloe Miller, Mark Yeoman, Bhavik Anil Patel

“…Vasoactive intestinal polypeptide (VIP) is a 28-amino acid neuropeptide with a multitude of diverse physiological functions, including vasodilation, immune modulation, and most notable gastrointestinal regulation. …”
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Do microglia metabolize fructose in Alzheimer’s disease? by Annalise M. Sturno, James E. Hassell Jr., Miguel A. Lanaspa, Kimberley D. Bruce

“…We also evaluate emerging literature targeting fructose metabolism in the brain and periphery to assess its ability to modulate microglial function in AD. The ability of microglia to transport and utilize fructose, coupled with the well-established role of fructose in metabolic dysfunction, supports the notion that microglial fructose metabolism may be a novel potential therapeutic target for AD.…”
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Molecular characterization of chicken DA systems reveals that the avian personality gene, DRD4, is expressed in the mitral cells of the olfactory bulb by Toshiyuki Fujita, Naoya Aoki, Chihiro Mori, Koichi J. Homma, Shinji Yamaguchi

“…In mammals, our understanding of the role of the dopamine (DA) system in higher cognitive functions and psychiatric disorders is improving, and we are beginning to understand the relationship between the neural circuits modulating the DA system and personality traits. …”
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Multifaceted role of galanin in brain excitability by Nicolas N Rieser, Milena Ronchetti, Adriana Lea Lea Hotz, Stephan CF Neuhauss

“…This extensive range of functions aligns with implications of galanin in diverse pathologies, including anxiety disorders, depression, and epilepsy. …”
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Genome-Wide In Silico Analysis of 1-Aminocyclopropane-1-carboxylate oxidase (ACO) Gene Family in Rice (<i>Oryza sativa</i> L.) by Jing Xia, Yingsheng Qiu, Wanli Li, Yingcheng Zhang, Linxin Liu, Yi Wang, Wangshu Mou, Dawei Xue

“…These findings pave the way for the further investigation of OsACO functions and their potential applications in improving rice growth and stress resilience by modulating ethylene biosynthesis.…”
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