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9421
Prenatal linguistic exposure shapes language brain responses at birth
Published 2025-08-01“…Within 3 days of life, neonates’ brain responses were recorded using functional near-infrared spectroscopy (fNIRS) whilst they listened to the same story in their native language and in two foreign languages, one of which neonates had been prenatally exposed to. …”
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9422
Maternal gut microbiota influences immune activation at the maternal-fetal interface affecting pregnancy outcome
Published 2025-05-01“…Notably, glucose supplementation restores placental NK cell function and reduces fetal resorption, suggesting that the observed impairment is reversible and dependent on a lower glycolytic rate. …”
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9423
Mitochondria-associated non-coding RNAs and their impact on drug resistance
Published 2025-02-01“…Our aim is to provide insights and strategies for overcoming drug resistance by modulating mtncRNAs.…”
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9424
Recent applications, future perspectives, and limitations of the CRISPR-Cas system
Published 2025-09-01“…By utilizing a programmable RNA protein complex to introduce targeted double-strand breaks, the CRISPR-Cas system enables the correction of pathogenic mutations and the modulation of gene function with unprecedented efficiency. …”
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9425
Revolutionizing heat stress tolerance in Glycine max: Exploring the latest advances in microbial application
Published 2025-03-01“…Heat stress (HS) has become ubiquitous hazardous environmental stress, eliciting concerns regarding its adverse impacts on terrestrial and agroecosystems. Plant hormones function as signaling molecules essential for stress tolerance, defense mechanisms, and facilitation of plants' overall physiological growth and development. …”
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9426
Synthesis of ladder diagrams in the control of the transport line of rolling elements
Published 2025-07-01“…By using a two-level control of the filling level of the storages, it is possible to control the emptying status of the storages as a function of the technological time of removal of the items from the storage between the two control points. …”
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9427
Insulator Defect Detection Algorithm Based on Improved YOLOv11n
Published 2025-02-01“…Key innovations include a redesigned C3k2 module that incorporates multidimensional dynamic convolutions (ODConv) for improved feature extraction, the introduction of Slimneck to reduce model complexity and computational cost, and the application of the WIoU loss function to optimize anchor box handling and to accelerate convergence. …”
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9428
Impairment of neuronal activity in the dorsolateral prefrontal cortex occurs early in parkinsonism
Published 2025-01-01“…Little is known, however, regarding how neuronal activity in the executive control network of the brain changes in the parkinsonian condition.ObjectiveInvestigate the impact of parkinsonism on neuronal activity in the dorsolateral prefrontal cortex (DLPFC), a key region in executive control, during a go/nogo reaching task.MethodsUsing a within-subject design, single and multi-unit neuronal activity was recorded in the DLPFC of a nonhuman primate (n = 1) before and after the induction of mild parkinsonism using the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).ResultsCoincident with development of mild parkinsonian motor signs, there was a marked reduction in the percentage of DLPFC cells with significant task-related firing rate modulation during go and nogo conditions.ConclusionThese results suggest that DLPFC dysfunction may occur early in parkinsonism and contribute to cognitive impairments and disrupted executive function often observed in PD patients.…”
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9429
Liuweizhiji Gegen-Sangshen beverage protects against alcoholic liver disease in mice through the gut microbiota mediated SCFAs/GPR43/GLP-1 pathway
Published 2024-12-01“…Moreover, LGS had a favorable effect on maintaining intestinal barrier function through reducing epithelial injury and increasing expression of occludin. 16S rRNA sequencing results showed that LGS remarkably modulated gut microbiota structure in ALD mice via recovering alcohol-induced microbial changes and specifically mediating enrichment of several bacterial genera (Alloprevotella, Monoglobus, Erysipelatoclostridium Parasutterella, Harryflintia and unclassified_c_Clostridia). …”
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9430
Microenvironment Self-Adaptive Ce-Ag-Doped Mesoporous Silica Nanomaterials (CA@MSNs) for Multidrug-Resistant Bacteria-Infected Diabetic Wound Treatment
Published 2025-04-01“…Notably, CA@MSNs also demonstrated the ability to scavenge a broad spectrum of ROS, including hydroxyl free radicals, hydrogen peroxide, and superoxide radicals, in inflammatory microenvironments. This dual functionality helped mitigate inflammation and promote endothelial cell migration. …”
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9431
Exosomal non-coding RNAs: gatekeepers of inflammation in autoimmune disease
Published 2025-05-01“…We then discuss the regulatory roles of exosomal ncRNAs in immune modulation, detailing their types, functions, and mechanisms of action. …”
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9432
Effect of transcranial magnetic stimulation combined with transcutaneous auricular vagus nerve stimulation on mild cognitive impairment: a study protocol for a randomized controlle...
Published 2025-05-01“…The primary outcome measure will be the Chinese version of the Montreal Cognitive Assessment Basic (MoCA-B), while secondary outcome measures will include the Rivermead Behaviour Memory Test (RBMT), the modified Barthel Index (MBI) for activities of daily living, and the latency and amplitude of event-related potential (ERP) P300.DiscussionThis study is a clinical randomized controlled trial, which innovatively combines two non-invasive modulation techniques to improve cognitive function in patients with MCI. …”
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9433
Unveiling Size-Driven Effects of Silver Nanoparticles on Dissolved Organic Matter and Bacterial Interactions in Lakes
Published 2025-01-01“…Size-dependent effects of AgNPs substantially altered microbial functions related to carbon and nitrogen cycling, affecting bacterial metabolism and the environmental behavior of functional genes. …”
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9434
Hsp70: A Multifunctional Chaperone in Maintaining Proteostasis and Its Implications in Human Disease
Published 2025-03-01“…It interacts with the DnaJ family of co-chaperones to modulate the functions of client proteins involved in various cellular processes, including transmembrane transport, extracellular vesicle trafficking, complex formation, and proteasomal degradation. …”
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9435
Chronic Stress and Glucocorticoids: From Neuronal Plasticity to Neurodegeneration
Published 2016-01-01“…Stress and stress hormones, glucocorticoids (GCs), exert widespread actions in central nervous system, ranging from the regulation of gene transcription, cellular signaling, modulation of synaptic structure, and transmission and glial function to behavior. …”
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9436
A diet rich in fibre and vegetable protein during gestation and lactation shapes maternal immunity, intestinal microbiota and lipid metabolismResearch in context
Published 2025-07-01“…D1 also influenced the cecal microbiota composition, impacting its functions such as the production of short-chain fatty acids in the caecum. …”
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9437
Higher dopamine D1 receptor expression in prefrontal parvalbumin neurons underlies higher distractibility in marmosets versus macaques
Published 2025-07-01“…Here we compare the two species using a visual fixation task with distractors, perform molecular and anatomical analyses in dlPFC, and link functional microcircuitry with cognitive performance using computational modeling. …”
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9438
Repair-associated macrophages increase after early-phase microglia attenuation to promote ischemic stroke recovery
Published 2025-03-01“…We find that early-phase microglia attenuation promotes long-term functional recovery. This intervention amplifies a subset of monocyte-derived macrophages (RAMf) with reparative properties, characterized by high expression of GPNMB and CD63, enhanced lipid metabolism, and pro-angiogenic activity. …”
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9439
Stimulator-multiplexing framework of microwave-infrared compatible reconfigurable metasurface integrated with LED array
Published 2025-03-01“…Metasurface can accurately control and manipulate electromagnetic (EM) waves with high degree of freedom, which is mainly due to their subwavelength structures and functional arrangements. However, most reconfigurable metasurfaces are currently limited to modulating EM waves in a single band. …”
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9440
Gibberellin signaling regulates pectin biosynthesis in Arabidopsis
Published 2025-04-01“…Genetic analyses validate that GA-mediated pectin biosynthesis relies on functional TTG2 and MBW proteins. Moreover, the pectin biosynthesis mediated by the GA-DELLA-MBW-TTG2 module contributes to GA-regulated seedling growth. …”
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