MicroRNA-1303 in cancer pathogenesis and therapy: clinical implications for biomarker development and targeted treatment strategies by Lingzi Zheng, Ling Hu, Bita Badehnoosh

“…We also discuss its functional role in tumor development and progression, supported by both in vitro and in vivo studies. …”
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Host cellular transcriptional response to respiratory syncytial virus infection in HEp-2 cells: insights from cDNA microarray and quantitative PCR analyses by Manoj K. Pastey, Christopher Lupfer

“…We identified 12 host genes that were significantly upregulated in RSV-infected cells from the cDNA microarray (≥2-fold increase, P<0.01), confirmed by qPCR, encompassing functional categories including cell cycle regulation, cytoskeletal organization, apoptosis modulation, immune evasion, and inflammation. …”
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Uncovering active ingredients and mechanisms of Pholiota adiposa in the treatment of Alzheimer’s disease based on network pharmacology and bioinformatics by Ma Xiaoying, Huo Zhiming, Shi Mingwen, Wang Hong, Yang Tao, Xiao Jun, Gong Na

“…We constructed a network of AD-relevant target proteins using databases like TCMSP, CTD, and GeneCards, and performed gene enrichment and functional analysis with DAVID, GO, and KEGG via Hiplot. …”
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The Mystery of Certain <i>Lactobacillus acidophilus</i> Strains in the Treatment of Gastrointestinal Symptoms of COVID-19: A Review by Belén Bertola, Amparo Cotolí-Crespo, Nadia San Onofre, Jose M. Soriano

“…Understanding the gut–lung axis and its role in immune response regulation, together with the need for a thorough characterization of the specific strains, including biochemical, genomic, and functional properties, before testing in humans, may provide deeper insights into the therapeutic potential of probiotics in viral infections.…”
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More than Just Protein Folding: The Epichaperome, Mastermind of the Cancer Cell by Haneef Ahmed Amissah, Maxwell Hubert Antwi, Tawfeek Ahmed Amissah, Stephanie E. Combs, Maxim Shevtsov

“…In this review, we explore the multifaceted roles of the epichaperome, delving into its diverse cellular locations, factors that modulate its formation and function, its liquid–liquid phase separation, and the key signaling and crosstalk pathways it regulates, including cellular metabolism and intracellular signal transduction. …”
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Piperlongumine regulates genes involved in the skin barrier in epidermal keratinocyte HaCaT cells by Kyung-Ha Lee, Deok Gyeong Kang, Dae-Wook Kim, Hwan-Kwon Do, Do-Yeon Kim, Wanil Kim

“…Given that the skin is the largest tissue in the human body, performing external barrier functions with innate and adaptive immunity and undergoing substantial changes during aging, it is under investigation as a major target of various bioactive molecules. …”
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The Role of Ion Channels in Pulmonary Hypertension: A Review by Han‐Fei Li, Xin‐Yao Li, Yu‐Qing Sun, Ze‐Ying Zhi, Liao‐Fan Song, Meng Li, Yi‐Ming Feng, Zhi‐Hao Zhang, Yan‐Feng Liu, Yu‐Jing Chen, Fan‐Rong Zhao, Tian‐Tian Zhu

“…These channels, abundant on the membranes of pulmonary artery smooth muscle cells (PASMCs) and pulmonary artery endothelial cells (PAECs), pivotally navigate the nuanced interplay of cell proliferation, migration, and endothelial function, each vital to the pulmonary vascular remodeling (PVR) hallmark of PH. …”
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Balancing Microglial Density and Activation in Central Nervous System Development and Disease by Shunqi Wang, Liangjing Pan, Chong Sun, Chaolin Ma, Haili Pan

“…This review summarizes microglial contributions to neurodevelopment and also outlines their function across various neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis, highlighting both protective and detrimental effects. …”
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Tissue extracellular vesicles suppress neonatal cardiac regeneration: a Pak2-Erk1/2-mediated macrophage paracrine signaling by Li Yongwei, Zhang Laihai, Wu Yating, Wei Lu, Zhang Zhenchun, Mo Hanling, Liu Zhongmin, Wang Xianyun, Shen Yunli, Zhu Hongming

“…However, by leveraging bioinformatics, high-throughput omics, and single-cell analyses, we unveil that P8-EVs are enriched with the key gene p21 activated kinase 2 (Pak2), a regulator of macrophage reparative function. Through single-cell sequencing of P8 myocardial tissue, we identify macrophages as the cell type with the highest Pak2 content, implying a close association between macrophages and P8-EV function. …”
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Adipokines as Cardioprotective Factors: BAT Steps Up to the Plate by Keely McLeod, Victoria Datta, Scott Fuller

“…This narrative review focuses on four types of batokines (FGF21, neuregulin 4, 12,13-diHOME, and BAT-derived microRNAs) for which evidence of modulation of cardiovascular function exists in the context of pathological states such as hypertension, atherosclerosis, and ischemia/reperfusion injury. …”
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Unveiling the role of gasdermin B in cancer and inflammatory disease: from molecular mechanisms to therapeutic strategies by Weixiao Yang, Xu Hu, Xiang Li

“…At the molecular level, GSDMB induces pyroptosis by forming pores in the cell membrane, leading to membrane rupture. This function is common across the GSDM protein family; however, GSDMB also exhibits unique non-pyroptotic functions, such as modulating cell proliferation, migration, and immune responses. …”
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Digital Spectral Analysis by means of the Method of Averag Modified Periodograms Using Binary-Sign Stochastic Quantization of Signals by V. N. Yakimov

“…As a result, the calculation of PSD estimates was reduced to discrete processing of the cosine and sine Fourier transforms for window functions. These Fourier transforms are calculated analytically based on the applied window functions. …”
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Global research trends and prospects on immune-related therapy in ischemic stroke: a bibliometric analysis by Qi Wang, Lei Yuan, Fei Wang, Fei Sun

“…Investigating the functions and regulation of these cells, particularly immune cells, deepens our understanding of the complex mechanisms of neuroinflammation and immune modulation after ischemic stroke and provides new perspectives and methods for immune-related therapy.MethodsThe annual distribution, journals, authors, countries, institutions, and keywords of articles published between 2015 and 2024 were visualized and analyzed using CiteSpace and other bibliometric tools.ResultsA total of 1,089 relevant articles or reviews were included, demonstrating an overall upward trend; The terms “cerebral ischemia,” “immune response,” “brain ischemia,” “cerebral inflammation,” “neurovascular unit,” and “immune infiltration,” etc. are hot keywords in this field.ConclusionIn recent years, research on immune-related therapy for ischemic stroke has focused on mechanisms of occurrence, protection and repair of the blood-brain barrier (BBB) by non-neuronal cells, and regulation of immunosuppression and inflammation. …”
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Anti-obesity and hepatoprotective effects of pyridoxal phosphate in rats with metabolic syndrome by raising anti-oxidant potential in both serum and liver tissue, while also decrea... by Sina Mahdavifard, Amir Hasani

“…It improved metabolism and organ (liver and kidney) functions by modulating NF-κB expression, glutathione metabolism, carbonyl stress, and oxidative stress.…”
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RNA helicase maheshvara interacts with TDP-43 and exacerbates neurodegeneration in Drosophila model of amyotrophic lateral sclerosis by Pranjali Pandey, Rituparna Das, Harshita Yadav, Ashim Mukherjee, Mousumi Mutsuddi

“…Drosophila maheshvara (mahe) encodes a conserved DEAD box RNA helicase that regulates various important signaling pathways like Notch and JAK/STAT, pathways that have been functionally implicated in neuronal development. In order to identify novel modulators of mahe as well as to unravel its role in neurodegenerative disorders, a genetic modifier screen using Drosophila models of neurodegenerative disorders was carried out. …”
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Kans-Unet Model and Its Application in Image Patch-Shaped Detection by Xingsu Li, Zhong Li, Jianping Huang, Ying Han, Kexin Zhu, Bo Hao, Junjie Song, Yumeng Huo

“…Specifically, the method embeds a convolution module based on Kans (Kan-Conv) in the encoder. The module applies a learnable activation function at the edge of the network, which not only reduces the number of model parameters but also significantly improves the generalization performance of the network. …”
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Identification of YAP regulators through high-throughput screening and NanoBiT-based validation-drug repositioning for cancer therapy by Ji-Youn Lim, Eui-Hwan Choi, Yujeong Kim, Minseong Kim, Dongkyu Choi, Wantae Kim, Boksik Cha

“…In this study, we conducted high-throughput screening of FDA-approved drugs to discover potential YAP modulators. Using a NanoBiT-based system, which enables real-time and quantitative measurement of protein interactions, combined with phenotype-based assays in EGFP-YAP-expressing cells, we identified compounds that activate or inhibit YAP function. …”
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Exploring the prognostic value and immune landscape of EGLN1 in colorectal cancer: insights from bioinformatics analysis by Xiawu Chen, Chengqing Huang, Yingping Liao, Xiaoxun Chen

“…To explore the potential biological functions and signaling pathways associated with EGLN, we performed gene set enrichment analysis (GSEA). …”
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3D printed near-infrared high-numerical aperture achromatic metalens by Heming Wei, Wenchen Hu, Jingtian Hu, Guoqiang He, Fufei Pang, Sridhar Krishnaswamy, Jan Nedoma, Carlos Marques

“…The presented work demonstrates the great potential of 3D printing and inverse design for realizing functional meta-devices for aerospace sector.…”
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Fronto-occipital dyscommunication associates with brain hierarchy in schizophrenia by Haonan Pei, Hechun Li, Changyue Hou, Yayun Liu, Jiashuo Liu, Mingjun Duan, Dezhong Yao, Sisi Jiang, Cheng Luo

“…We measured the brain’s functional separation and quantified bidirectional information transfer changes between the frontal and occipital regions. …”
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