Identification of Arabidopsis meiotic cyclins reveals functional diversification among plant cyclin genes. by Petra Bulankova, Svetlana Akimcheva, Nicole Fellner, Karel Riha

“…Our phenotypic and expression data provide extensive evidence that multiplication of cyclins is in plants accompanied by functional diversification.…”
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METTL9 sustains vertebrate neural development primarily via non-catalytic functions by Azzurra Codino, Luca Spagnoletti, Claudia Olobardi, Alessandro Cuomo, Helena Santos-Rosa, Martina Palomba, Natasha Margaroli, Stefania Girotto, Rita Scarpelli, Shi-Lu Luan, Eleonora Crocco, Paolo Bianchini, Andrew J. Bannister, Stefano Gustincich, Tony Kouzarides, Riccardo Rizzo, Isaia Barbieri, Federico Cremisi, Robert Vignali, Luca Pandolfini

“…Overall, we demonstrate a developmental function of Mettl9 and link it to a 1MH-independent pathway, namely, the maintenance of the secretory system, which is essential throughout neural development.…”
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Altered GABAA receptor function in women with endometriosis: a possible pain‐related mechanism by Anton Sandström, Marie Bixo, Torbjörn Bäckström, Anna Möller, Sahruh Turkmen

“…The secondary objective was to investigate the relation between GABAA receptor function and serum levels of allopregnanolone, an endogenous positive modulator of the GABAA receptor, in the participating women. …”
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DNA G-quadruplex structures act as functional elements in α- and β-globin enhancers by Colm Doyle, Krzysztof Herka, Sean M. Flynn, Larry Melidis, Somdutta Dhir, Stefan Schoenfelder, David Tannahill, Shankar Balasubramanian

“…G-quadruplex DNA secondary structures (G4s) have recently been shown to co-occur with 3D chromatin interactions; however, the functional importance of G4s within enhancers remains unclear. …”
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Land drainage functioning and hydrological impacts in rural catchments: model development and field experiments by Zimmer, Daniel, Tournebize, Julien, Bouarfa, Sami, Kao, Cyril, Lesaffre, Benoît

“…We also demonstrate that these drain flow rates are a function of the level of water replenishment in the system (classically the water table elevation), of the recharge intensity of the aquifer and of a buffer function related to the swelling or deflation of the water table shape during recharge events. …”
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Regulation of stem cell fate and function by using bioactive materials with nanoarchitectonics for regenerative medicine by Wei Hu, Jiaming Shi, Wenyan Lv, Xiaofang Jia, Katsuhiko Ariga

“…Besides multipotent differentiation, immunomodulation is an important biological function of mesenchymal stem cells (MSCs). MSCs can modulate immune cells to treat multiple immune- and inflammation-mediated diseases. …”
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Transformer-based multimodal precision intervention model for enhancing diaphragm function in elderly patients by Ma Xinli, Zhao Jie, Yan Ming, Zhang Yanping, Li Fan, Jia Jing, Ding Lu

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Computational analysis of the functional impact of MHC-II-expressing triple-negative breast cancer by Yang Cui, Weihang Zhang, Xin Zeng, Yitao Yang, Sung-Joon Park, Kenta Nakai, Kenta Nakai

“…We implicated that this subpopulation is preferentially present in proximity to regions in immune infiltration of TNBC patient cohorts with a better prognosis, suggesting the functional importance of MHC-II-expressing tumor cells in modulating the immune landscape and influencing patient survival outcomes. …”
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Exercise Intervention in Autonomic Function, Immunity, and Cardiovascular Health: A Precision Medicine Approach by Jianyu Li, Junbei Bai, Guochun Liu, Ziyan Zhu, Chunmei Cao

“…Exercise significantly improves cardiovascular function through immunometabolic reprogramming, which includes suppressing sympathetic overactivity, enhancing vagal tone, and modulating the IL-6/IL-10 balance, as well as activating the short-chain fatty acid (SCFA)–Treg axis. …”
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Structure-Based Function of Humic Acid in Abiotic Stress Alleviation in Plants: A Review by Farhan Nabi, Ahmed Sarfaraz, Rakhwe Kama, Razia Kanwal, Huashou Li

“…Its molecular structure comprises functional groups such as carboxyl, phenolic, hydroxyl, and carbonyl functional groups, which enable HA to interact with soil particles, nutrients, and biological systems. …”
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Effects of M. tuberculosis and HIV-1 infection on in vitro blood-brain barrier function by Alizé Proust, Katalin A. Wilkinson, Robert J. Wilkinson

“…Methods Using human pericytes, astrocytes, endothelial cells, and microglia alone and combined in an in vitro blood-brain barrier model, we investigated the effect of Mycobacterium tuberculosis +/- HIV-1 co-infection on central nervous system cell entry and function. Cells and the blood-brain barrier model were infected with Mycobacterium tuberculosis and/or HIV-1 and we evaluated the effects of both infection on (i) cells susceptibility to Mycobacterium tuberculosis and its growth in cells by flow cytometry; (ii) modulation of blood-brain barrier permeability and Mycobacterium tuberculosis passage through it; (iii) viral and bacterial cytopathogenicity using the xCELLigence system; (iv) cell metabolic activity and ROS release using colorimetric assays; (v) extracellular glutamate concentration by fluorometric assay; (vi) the inflammatory response by Luminex; and (vii) endoplasmic reticulum stress by quantitative PCR. …”
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Myosin VIIA, important for human auditory function, is necessary for Drosophila auditory organ development. by Sokol V Todi, Elena Sivan-Loukianova, Julie S Jacobs, Daniel P Kiehart, Daniel F Eberl

“…These factors are therefore candidates for modulating MyoVIIA activity in vertebrates.<h4>Conclusions</h4>Our findings indicate that MyoVIIA plays evolutionarily conserved roles in auditory organ development and maintenance in invertebrates and vertebrates, enhancing our understanding of auditory organ development and function, as well as providing significant clues for future research.…”
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Morphology-driven photothermal performance of polymer-functionalized mos₂ nanoplatforms for targeted therapeutic applications by Ashima Sharma, Dinesh Bhalothia, Raviraj Vankayala, Ashima Bagaria

“…Abstract In this study, we report the synthesis and photothermal evaluation of polymer-functionalized molybdenum disulfide (MoS₂) nanoplatforms with distinct morphologies; three-dimensional (3D) nanoflowers (MNF) and two-dimensional (2D) nanorods (MNR), tailored for targeted drug delivery applications. …”
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Flood Wave Attenuation as a Function of Floodplain Storage, Secondary Channel Conveyance, and Discharge by N. Tull, P. Passalacqua

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Effects of orange juice formulation on prebiotic functionality using an in vitro colonic model system. by Adele Costabile, Gemma E Walton, George Tzortzis, Jelena Vulevic, Dimitris Charalampopoulos, Glenn R Gibson

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Effects of Transcranial Alternating Current Stimulation on Cognitive Functions in Healthy Young and Older Adults by Daria Antonenko, Miriam Faxel, Ulrike Grittner, Michal Lavidor, Agnes Flöel

“…Here, we provide a brief summary of the rationale behind tACS-induced effects on task-relevant brain oscillations and associated cognitive functions and review previous studies in young subjects that have applied tACS in cognitive paradigms. …”
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Cardiac function and architecture are maintained in a model of cardiorestricted overexpression of the prorenin-renin receptor. by Hasan Mahmud, Wellington Mardoqueu Candido, Linda van Genne, Inge Vreeswijk-Baudoin, Hongjuan Yu, Bart van de Sluis, Jan van Deursen, Wiek H van Gilst, Herman H W Silljé, Rudolf A de Boer

“…The (pro)renin-renin receptor, (P)RR has been claimed to be a novel element of the renin-angiotensin system (RAS). The function of (P)RR has been widely studied in renal and vascular pathology but the cardio-specific function of (P)RR has not been studied in detail. …”
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The gut-brain-metabolic axis: exploring the role of microbiota in insulin resistance and cognitive function by Gulshara Zh Abildinova, Gulshara Zh Abildinova, Valeriy V. Benberin, Valeriy V. Benberin, Tamara A. Vochshenkova, Tamara A. Vochshenkova, Alireza Afshar, Alireza Afshar, Nadiar M. Mussin, Asset A. Kaliyev, Zhanna Zhussupova, Amin Tamadon, Amin Tamadon, Amin Tamadon

“…These approaches have shown promising results in improving insulin sensitivity and cognitive function in both animal models and human studies. The article also emphasizes the need for further research to elucidate the specific microbial species and metabolites involved in modulating the gut-brain axis, as well as the long-term effects and safety of these therapeutic interventions. …”
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Auto-aggregation Properties of Probiotic Lactobacillus delbrueckii str. IAHAHI: From Genes to Function by Astghik PEPOYAN, Liana GRIGORYAN, Natalya HARUTYUNYAN, Susanna MIRZABEKYAN, Marine BALAYAN, Artak GALSTYAN, Vardan TSATURYAN, Anahit MANVELYAN

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Aquaporin 5 polymorphisms and rate of lung function decline in chronic obstructive pulmonary disease. by Nadia N Hansel, Venkataramana Sidhaye, Nicholas M Rafaels, Li Gao, Peisong Gao, Renaldo Williams, John E Connett, Terri H Beaty, Rasika A Mathias, Robert A Wise, Landon S King, Kathleen C Barnes

“…<h4>Conclusions</h4>Polymorphisms in AQP5 were associated with rate of lung function decline in continuous smokers with COPD. A missense mutation modulates AQP-5 expression in response to cigarette smoke extract and shear stress. …”
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