The nonstructural protein 13 of porcine deltacoronavirus coordinates ATP-driven duplex unwinding and ATP-independent strand annealing for nucleic acid remodeling by Lihan Tao, Quanyong Zhou, Chengcheng Wu, Hongping Jiang, Jianzhen Huang

“…Results In this study, we systematically investigated the biochemical properties of PDCoV NSP13 through recombinant expression and functional assays. Our findings revealed that PDCoV NSP13 exhibited a 5ʹ-to-3ʹ directional unwinding activity powered by broad-spectrum nucleoside triphosphate hydrolysis, with the enhanced unwinding efficiency for dsDNA over dsRNA. …”
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Characterization of four structurally diverse inhibitors of SUR2-containing KATP channels by Kangjun Li, Vaishali Satpute Janve, Jerod Denton

“…Vascular smooth muscle ATP-sensitive potassium (KATP) channels play critical roles in modulating vascular tone and thus represent important drug targets for diverse cardiovascular pathologies. …”
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Siponimod supports remyelination in the non-supportive environment by Johann Krüger, Newshan Behrangi, David Schliep, Leo Heinig, Elise Vankriekelsvenne, Nicole Wigger, Markus Kipp

“…Abstract Inflammatory demyelination, a hallmark of multiple sclerosis (MS) lesions, leads to functional impairments and progressive axonal loss over time. …”
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Influence of endoscopic sinus surgery on the quality of life of patients with early nasopharyngeal carcinoma and the analysis of prognosis-related factors by Yong-Feng Si, Gui-Ping Lan, Zhuo-Xia Deng, Jing-Jin Weng, Jin-Yuan Si, Yang-Da Qin, Bo Huang, Yong-Li Wang, Yong Yang, Yin Qin, Ben-Jian Zhang, Xing Han, Wei-Ming Xiong

“…The quality of life of patients before and after treatment was evaluated based on the FACT-H&N (Functional Assessment of Cancer Therapy-Head and Neck) and QLQ-H&N35 (Head and Neck Cancer Specific Module) questionnaires. …”
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IMMUNE DISTURBANCES IN PATIENTS WITH EPILEPSY AND OPPORTUNITY OF IMMUNOMODULATION BY RECOMBINANT HUMAN IL-2 by L. V. Lipatova, N. B. Serebryanya, N. A. Sivakova, A. V. Vasilenko, T. V. Kapustina

“…These results might be used to optimize treatment of PE due to modulation of inflammatory process and increase of neurotrophic factors production required for the processes of brain neuroplasticity and neurogenesis.…”
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The SOX18-OTUB1-YAP1 axis: a new endometriosis target by Ying Feng, Jiamei Yue, Si Fan, Jiayan Wu

“…Abstract Background EMS (Endometriosis) is characterized by the presence of functional endometrial tissue outside the uterus and is one of the most common gynecological disorders. …”
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Association between anxiety and non-coding genetic variants of the galanin neuropeptide. by Gergely Keszler, Zsuzsanna Molnár, Zsolt Rónai, Mária Sasvári-Székely, Anna Székely, Eszter Kótyuk

“…These promoter polymorphisms are supposed to participate in epigenetic regulation of galanin expression by creating potentially methylatable CpG dinucleotides. The functional importance of the rs1042577_T allele remains to be elucidated.…”
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Reprogrammed immuno-metabolic environment of cancer: the driving force of ferroptosis resistance by Sramana Bhowmick, Saptak Banerjee, Viji Shridhar, Susmita Mondal

“…The reprogrammed metabolism section further comprehends the functional role of lipids, iron and glucose metabolism against ferroptosis defense separately. …”
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Comprehensive analysis of LRRC42 as a potential biomarker and key cellular processes in cancer development by Rongfu Huang, Jianfeng Yao, Lei Liu, Hua Li, Baoshan Huang

“…Focusing on LRRC42’s potential role in hepatocellular carcinoma (HCC), the study uncovered co-expression relationships with Th2 cells and identified genes enriched in mRNA processing and cell cycle regulation pathways. Functional validation through LRRC42 knockdown experiments revealed its critical involvement in promoting cell proliferation, migration, and invasion in HCC cell lines. …”
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Dynamic Response and Computational Modeling of Truss-Reinforced Phosphogypsum-Concrete Composite Slabs Subjected to Impact Loading: A Parametric Finite Element Analysis by Lirong Sha, Yan Han, Lijie Zhang

“…Nonlinear dynamic analysis revealed that the peak impact load demonstrates an inverse proportional functional decay relationship with increasing c, yielding an empirical predictive model. …”
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Differential expression of RHD and RHCE in immune cell populations of acute myeloid leukaemia: insights from TCGA and GTEx transcriptomic analysis using GEPIA platforms by A. Aslam, S. Kabrah

“…Conclusions: The differential expression of RHD and RHCE in immune cells suggests their potential roles in modulating the immune microenvironment in AML. These findings provide a foundation for future research into the functional implications of RHD and RHCE in leukaemia progression and immune regulation. …”
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Identification of Therapeutic Targets in Autism Spectrum Disorder through CHD8-Notch Pathway Interaction Analysis. by Hewei Zhang, Shenghao Hua, Daiyan Jiao, Dong Chen, Qin Gu, Chao Bao

“…We intersected these DEGs with genes related to the Notch signaling pathway and performed functional enrichment analyses, including Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment, as well as protein-protein interaction (PPI) analyses, to identify key genes. …”
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DEP-1 is a brain insulin receptor phosphatase that prevents the simultaneous activation of counteracting metabolic pathways by Simran Chopra, Otsuware Linda-Josephine Kadiri, Jannis Ulke, Robert Hauffe, Wenke Jonas, Sahar Cheshmeh, Luisa Schmidt, Christopher A. Bishop, Selma Yagoub, Mareike Schell, Michaela Rath, Janine Krüger, Rachel N. Lippert, Marcus Krüger, Kai Kappert, André Kleinridders

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SPDC-YOLO: An Efficient Small Target Detection Network Based on Improved YOLOv8 for Drone Aerial Image by Jingxin Bi, Keda Li, Xiangyue Zheng, Gang Zhang, Tao Lei

“…Finally, SPDC-YOLO adopts EIoU as the loss function to optimize target localization accuracy. …”
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A Deep Learning Strategy for the Retrieval of Sea Wave Spectra from Marine Radar Data by Giovanni Ludeno, Giuseppe Esposito, Claudio Lugni, Francesco Soldovieri, Gianluca Gennarelli

“…A performance analysis of the proposed deep-learning estimation strategy is carried out, along with a comparison to the classical modulation transfer function approach. The results demonstrate that the proposed approach is effective in reconstructing the directional wave spectrum across different sea states.…”
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Fault Feature Extraction Based on Variational Modal Decomposition and Lifting Wavelet Transform: Application in Gear of Mine Scraper Conveyor Gearbox by Zhengxiong Lu, Linyue Li, Chuanwei Zhang, Shuanfeng Zhao, Lingxiao Gong

“…Secondly, an intrinsic mode function (IMF) sub-band fault information extraction method based on lifting wavelet transform is proposed. …”
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Systemic Chronic Inflammation: Integrative Strategies for Health Improvement and Prevention of Inflammatory Receptor Overexpression by Abraham Puga-Olguín, María Fernanda Hernández-Hernández, Rafael Fernández-Demeneghi, Carlos Iván López-Miranda, Luis Ángel Flores-Aguilar

“…The body’s physiology during physical injuries and diseases depends heavily on the function of acute inflammation. On the other hand, many variables, including iatrogenic, immune system deficiencies, lifestyle, and social and environmental factors, are significant in developing systemic chronic inflammation (SCI). …”
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Post-Translational Modifications in Multiple Myeloma: Mechanisms of Drug Resistance and Therapeutic Opportunities by Shuoyang Hu, Jirun Xu, Weiyan Cui, Haoran Jin, Xiaoyu Wang, Yasen Maimaitiyiming

“…Post-translational modifications (PTMs), including phosphorylation, ubiquitination, acetylation, and glycosylation, play pivotal roles in regulating protein function, stability, and interactions, thereby influencing MM pathogenesis and therapeutic resistance. …”
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RETRACTED: LncRNA CCAT2 promotes the proliferation and metastasis of colorectal cancer through activation of the ERK and Wnt signaling pathways by regulating GNB2 expression by Jinhai Tian, Xu Cao, Zongying Jiang, Jia Wang, Wan Fan, Shaoting Zhang, Sien Zhao, Jianmin Sun

“…Methods High‐throughput sequencing and RT‐qPCR were used to detect CCAT2 expression in CRC. Functional analyses including CCK8, colony formation, wound healing migration, transwell chamber, and Muse® Cell Analyzer assays were performed to study the effects of CCAT2 gene deletion on CRC cells. …”
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An In Vitro Gut–Liver–Adipose Axis Model to Evaluate the Anti-Obesity Potential of a Novel Probiotic–Polycosanol Combination by Simone Mulè, Rebecca Galla, Francesca Parini, Mattia Botta, Sara Ferrari, Francesca Uberti

“…These findings underline a possible biological relevance of probiotics and polycosanols in modulating metabolic pathways, improving gut barrier integrity, and reducing inflammation, supporting their role as functional ingredients for metabolic health.…”
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