The Forgotten Innate Immune Cells: Unraveling Their Prospective Interactions with Nanomaterials by González-Fernández Á, Maietta I

“…This review aims to highlight the role of these “forgotten” innate immune cells, providing insights into their function, available cell lines, applicable techniques to understand interactions with nanomaterials, and relevant in vitro and in vivo models.Keywords: eosinophils, basophils, mast cells, nanotechnology, immunogenicity, interaction…”
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Engineerable mesenchymal stem cell-derived extracellular vesicles as promising therapeutic strategies for pulmonary fibrosis by Yixiang Chen, Moxuan Li, Juntao Yang, Yuqi Chen, Jiancheng Wang

“…These nano-sized vesicles replicate the regenerative and immunomodulatory properties of their parent cells, targeting dysregulated signaling pathways and pathological cellular phenotypes associated with PF. MSC-EVs modulate fibrosis by restoring alveolar epithelial cell function, suppressing myofibroblast activation, and regulating immune responses, such as macrophage polarization and neutrophil infiltration. …”
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Application of transcranial brain stimulation in dementia by Yuncin Luo, Feng-Yi Yang, Raymond Y Lo

“…Medical devices serve as an alternative therapeutic approach to modulating neural activities and enhancing cognitive function. …”
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BDK-YOLOv8: An Enhanced Algorithm for UAV Infrared Image Object Detection by Nan Xiao, Xianggong Hong, Zixuan Zheng

“…An improved SIOU loss function is also proposed, prioritizing small object samples and those with average-quality annotations. …”
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Macrophage-Derived Extracellular Vesicles: A Novel Therapeutic Alternative for Diabetic Wound by Shi S, Ou X, Wang Q, Zhang L

“…Dysregulated macrophage function is a key factor in delayed wound healing. …”
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Targeting the epigenetic regulation of ferroptosis: a potential therapeutic approach for sepsis-associated acute kidney injury by Yuhang Yang, Xinqi Deng, Wenyuan Li, Yan Leng, Yonghong Xiong, Bihan Wang, Siyuan Gong, Yunhao Wang, Baichuan Yang, Wei Li

“…Epigenetic regulation modulates the content and function of nucleic acids and proteins within cells through various modifications. …”
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Novel Approaches in Glucose and Lipid Metabolism Disorder Therapy: Targeting the Gut Microbiota–Bile Acid Axis by Jin Jiang, Huange Zhang, Muhammad Hussain, Abdullah, Fengqin Feng, Rongfa Guan, Hao Zhong

“…The gut microbiota orchestrates the biotransformation of primary BAs into bioactive secondary BAs, which function as endocrine signaling molecules by activating the nuclear farnesoid X receptor (FXR) and G protein-coupled membrane receptor (TGR5), forming a communication network essential for metabolic homeostasis. …”
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Unleashing the therapeutic potential of tumor-draining lymph nodes: spotlight on bladder cancer by Xin Yang, Xiangyu Wu, Xuyang Hao, Tianhang Li, Hongqian Guo, Rong Yang

“…However, during tumor progression, various tumor-derived mediators modulate the TDLN microenvironment, impairing their protective function. …”
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Performance limitations of relay neurons. by Rahul Agarwal, Sridevi V Sarma

“…In this paper, we analyze a biophysical based model of a relay cell and use systems theoretic tools to construct analytic bounds on how well the cell transmits a driving input as a function of the neuron's electrophysiological properties, the modulating input, and the driving signal parameters. …”
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miRNAs involved in the regulation of exercise fatigue by Siyuan Niu, Xiupeng Yin, Qinglei Cao, Kaiyu Huang, Zhongyuan Deng, Jie Cao

“…This article provides an overview of fundamental concepts and biological functions associated with miRNAs, defines and classifies exercise fatigue while outlining its physiological changes, emphasizes alterations in miRNA expression during episodes of exercise-induced fatigue, and conducts an in-depth analysis regarding the mechanisms through which miRNAs influence this phenomenon via modulation of energy metabolism, inflammatory responses, and oxidative stress. …”
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Spinal Cord Hemisection Facilitates Aromatic L-Amino Acid Decarboxylase Cells to Produce Serotonin in the Subchronic but Not the Chronic Phase by Bushra Azam, Jacob Wienecke, Dennis Bo Jensen, Aleena Azam, Mengliang Zhang

“…These results suggest that plastic changes of the 5-HT system might happen primarily in the subchronic phase and for longer period its function could be compensated by plastic changes of other intrinsic and/or supraspinal modulation systems.…”
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An unexpected role of Nogo-A as regulator of tooth enamel formation by Pierfrancesco Pagella, Chai Foong Lai, Laurence Pirenne, Claudio Cantù, Martin E. Schwab, Thimios A. Mitsiadis

“…Furthermore, we demonstrated that inhibition of the intracellular, but not cell-surface, Nogo-A is responsible for gene expression modulation in ameloblasts. Taken together, these results reveal an unexpected function for Nogo-A in tooth enamel formation by regulating gene expression and cytodifferentiation events.…”
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An in silico approach deciphering the commensal dynamics in the cutaneous milieu by Sumathi Kalankariyan, Anjana Thottapillil, Abha Saxena, Manoj Srivatsn S, Vinitha Kadamkode, Renu Kapoor, Rupak Mitra, Janhavi Raut, KV Venkatesh

“…By offering insights into skin barrier function and immune responses, the model illuminates key interactions of commensals within the skin microenvironment which can ultimately benefit skin health.…”
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Electroconvulsive therapy improves distal colonic motility via the subdiaphragmatic vagus nerve in depressive-like mice by Mengyao Dai, Yanzhang Li, Yanghua Tian

“…This study explores the possibility that ECT may exert its therapeutic effects by modulating gastrointestinal function. In clinical investigation, a notable proportion of patients with major depressive disorder experienced significant alleviation of gastrointestinal symptoms, particularly constipation, following ECT. …”
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Mitochondrial calcium uptake orchestrates vertebrate pigmentation via transcriptional regulation of keratin filaments. by Jyoti Tanwar, Kriti Ahuja, Akshay Sharma, Paras Sehgal, Gyan Ranjan, Farina Sultan, Anushka Agrawal, Donato D'Angelo, Anshu Priya, Vamsi K Yenamandra, Archana Singh, Anna Raffaello, Muniswamy Madesh, Rosario Rizzuto, Sridhar Sivasubbu, Rajender K Motiani

“…Mitochondria regulate several physiological functions through mitochondrial Ca2+ dynamics. However, role of mitochondrial Ca2+ signaling in melanosome biology remains unknown. …”
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Superior growth performance in carp fry achieved with chitosan-alginate encapsulated A-ghrelin versus free peptide: Evidence from physiological, molecular, and morphological analys... by Mohammad Matinfar, Behrooz Heidari, AbdolMajid Valipour, Tahereh Rahdari, Sorour Ramezanpour, Mahvash Hadavi, S Mohsen Asghari

“…This study investigates the potential of delivering ghrelin via chitosan-alginate (Cs-Al) nanocapsules to enhance growth performance, immune function, and stress biomarker parameters in common carp fry (Cyprinus carpio). …”
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VPS35-Retromer: Multifunctional Roles in Various Biological Processes – A Focus on Neurodegenerative Diseases and Cancer by Fan X, Xie Y, Cao S, Zhu L, Wang X

“…As an integral component of the Retromer complex, VPS35 selectively recognizes and retrogradely transports membrane protein receptors to the trans-Golgi network, thereby preventing the degradation of transmembrane proteins by lysosomes after they have fulfilled their physiological functions, and facilitating their continued activity. …”
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The Role of Polyphenols in Abiotic Stress Tolerance and Their Antioxidant Properties to Scavenge Reactive Oxygen Species and Free Radicals by Muhammad Junaid Rao, Bingsong Zheng

“…This pathway produces an array of secondary metabolites, particularly polyphenols, which serve multiple functions in plant growth, development, regulating cellular processes, and stress responses. …”
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A comparative study of adrenalin and fluocinolon induced oxidative stress in male wistar rats by Erika KIS

“…Treatment with synthetic glucocorticoids as e.g. dexamethasone or dermocorticosteroids and repeated immobilization stress, decreases the total body weight gain of animals by disturbing the HPA axis function and accelerating the catabolism of the organism. …”
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Structure and post-translational modification of the prostaglandin transporter by Peixuan Yu, Melanie A. Orlando, Benjamin J. Orlando

“…In contrast, two inter-loop disulfides (C155-C587 and C143-C448) restricted maximal prostaglandin uptake, suggesting a possible regulatory role in modulating PGT activity. In total, our studies provide a fresh molecular perspective on the structure, post-translational modification, and overall function of PGT.…”
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