Cas13d-mediated isoform-specific RNA knockdown with a unified computational and experimental toolbox by Megan D. Schertzer, Andrew Stirn, Keren Isaev, Laura Pereira, Stella H. Park, Anjali Das, Aline Réal, Erin D. Jeffery, Claire Harbison, Hans-Hermann Wessels, Gloria M. Sheynkman, Neville E. Sanjana, David A. Knowles

“…Two major challenges in characterizing the cellular function of alternative isoforms are the lack of experimental methods to specifically and efficiently modulate isoform expression and computational tools for complex experimental design and analysis. …”
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Perineuronal Net Alterations Following Early-Life Stress: Are Microglia Pulling Some Strings? by Reza Rahimian, Claudia Belliveau, Sophie Simard, Gustavo Turecki, Naguib Mechawar

“…The extracellular matrix plays a key role in synapse formation and in the modulation of synaptic function in the central nervous system. …”
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Dendritic Cells: Cellular Mediators for Immunological Tolerance by Chun Yuen J. Chung, Dirk Ysebaert, Zwi N. Berneman, Nathalie Cools

“…In this perspective, dendritic cells (DCs) can have an important immune-regulatory function, besides their notorious antigen-presenting capacity. …”
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Phase synchrony between prefrontal noradrenergic and cholinergic signals indexes inhibitory control by Yuxiang Andy Liu, Yuhan Nong, Jiesi Feng, Guochuan Li, Paul Sajda, Yulong Li, Qi Wang

“…Abstract This study investigates how norepinephrine (NE) and acetylcholine (ACh) in the prefrontal cortex (PFC) modulate inhibitory control, a critical executive function. …”
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Post-translational modifications of RGS protein family: Pivotal switches in cellular signaling transduction and diseases by Yan Song, Zihao An, Jiepu Wang, Qiang Xu, Jiayong Li, Chao Tang

“…Among the regulation patterns, post-translational modification (PTMs) can directly affect the regulation of G protein signaling by modulating the GAP activity of RGS proteins or indirectly regulate their function by affecting their subcellular localization and stability. …”
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Noncanonical terpene cyclases for the biosynthesis of diterpenoids regulating chlamydospore formation in plant-associated Trichoderma by Min-Jie Yang, De-Sen Li, Hua-Qin Deng, Wen-Yuan Li, Xin-Yu Zheng, Jonathan Gershenzon, Xue-Mei Niu, Yan Liu, Sheng-Hong Li

“…Functional studies implicated TriDTCs in fungal survival strategies by regulating formation of resistant propagules (chlamydospore in Trichoderma, sclerotia in Aspergillus oryzae). …”
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A Back-to-Back Gap Waveguide-Based Packaging Structure for E-Band Radio Frequency Front-End by Tao Xiu, Zhi Li, Lei Wang, Peng Lin

“…Additionally, its back-to-back structure enables structural stacking, which can reduce the overall packaging size. In terms of functionality, the structure integrates hybrid couplers, bandpass filters, and amplifier packaging structures. …”
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Contemporary insights into neuroimmune interactions across development and aging by Xin Yi Yeo, Yunseon Choi, Yeonhee Hong, Hyuk Nam Kwon, Hyuk Nam Kwon, Sangyong Jung

“…Initially considered distinct systems with independent physiological functions, recent evidence highlights the crucial role of active crosstalk between the nervous and immune systems in regulating critical physiological and neurological processes and immunological homeostasis. …”
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Multi-scale adversarial diffusion network for image super-resolution by Yanli Shi, Xianhe Zhang, Yi Jia, Jinxing Zhao

“…Furthermore, to mitigate blurring artifacts introduced during the denoising process, a high-frequency loss function is proposed, targeting the residuals of high-frequency features between images. …”
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A review of the complex interplay between chemoresistance and lncRNAs in lung cancer by Ghaliah Obaid Alnefaie

“…Different approaches, including RNA interference (RNAi) and antisense oligonucleotides (ASOs), are available to degrade lncRNAs or alter their function. ASO-based therapies are effective at reducing lncRNA expression levels, increasing chemotherapy sensitivity, and improving clinical outcomes. …”
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Genome-wide identification of selection signatures across altitudinal gradients in dairy sheep breeds by Slim Ben Jemaa, Salvatore Mastrangelo, Federica Carta, Silvia Riggio, Corrado Dimauro, Christian Persichilli, Baldassare Portolano, Gabriele Senczuk, Alberto Cesarani

“…By joinly analyzing the three ecotypes from each breed, we found strong signatures of selection at the KDM6A gene (X chromosome), a key epigenetic regulator involved in modulating gene expression in response to environmental stress. …”
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CACN-1/Cactin plays a role in Wnt signaling in C. elegans. by Melissa LaBonty, Cleo Szmygiel, Lauren E Byrnes, Samantha Hughes, Alison Woollard, Erin J Cram

“…CACN-1/Cactin is a well-conserved protein of unknown molecular function previously implicated in the regulation of several developmental signaling pathways. …”
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IQ-domain GTPase-activating protein 1 promotes the malignant phenotype of invasive ductal breast carcinoma via canonical Wnt pathway by Huan-Yu Zhao, Yang Han, Jian Wang, Lian-He Yang, Xiao-Ying Zheng, Jiang Du, Guang-Ping Wu, En-Hua Wang

“…However, the biological function and mechanism of IQ-domain GTPase-activating protein 1 in invasive ductal carcinoma (IDC) remain unknown. …”
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Discovering Molecules That Regulate Efferocytosis Using Primary Human Macrophages and High Content Imaging. by Sandra Santulli-Marotto, Alexis Gervais, Jamie Fisher, Brandy Strake, Carol Anne Ogden, Chelsea Riveley, Jill Giles-Komar

“…Though the specificities of the majority of antibodies are unknown, two of the antibodies that improved apoptotic cell uptake recognize recombinant MerTK; a receptor known to function in this capacity in vivo. The agonistic impact of these antibodies on efferocytosis could be demonstrated without addition of either of the MerTK ligands, Gas6 or ProS. …”
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Bidirectional crosstalk between microglia and serotonin signaling in neuroinflammation and CNS disorders by Yangchen Zheng, Limin Xu, Limin Xu

“…Activation of microglia toward a pro-inflammatory phenotype can disrupt serotonergic neurotransmission by altering the expression and function of the serotonin transporter (SERT) and modulating downstream 5-HT receptor signaling pathways. …”
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Effects of stem cell therapy on preclinical stroke by Gita Serafika Shannon, Ratih Rinendyaputri, Sunarno Sunarno, Amarila Malik

“…Preclinical in vitro and in vivo studies demonstrate the potential of the MSC secretomes to restore brain function after ischemic stroke. This is achieved by enhancing neuronal survival through mechanisms such as angiogenesis or vascular recovery, neuroprotection including modulation of immune or inflammatory responses, apoptosis, and autophagy–and promoting poststroke neurogenesis. …”
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Recent advances in gut microbiota and thyroid disease: pathogenesis and therapeutics in autoimmune, neoplastic, and nodular conditions by Lihua Fang, Jie Ning

“…Evidence suggests that probiotic adjunct therapy can modulate the gut microbiota, leading to improvements in thyroid function and patient outcomes. …”
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PPARγ ligands decrease hydrostatic pressure-induced platelet aggregation and proinflammatory activity. by Fang Rao, Ren-Qiang Yang, Xiao-Shu Chen, Jin-Song Xu, Hui-Min Fu, Hai Su, Ling Wang

“…Hypertension is known to be associated with platelet overactivity, but the direct effects of hydrostatic pressure on platelet function remain unclear. The present study sought to investigate whether elevated hydrostatic pressure is responsible for platelet activation and to address the potential role of peroxisome proliferator-activated receptor-γ (PPARγ). …”
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Oleoyl-lysophosphatidylcholine limits endothelial nitric oxide bioavailability by induction of reactive oxygen species. by Andrijana Kozina, Stefan Opresnik, Michael Sze Ka Wong, Seth Hallström, Wolfgang F Graier, Roland Malli, Katrin Schröder, Kurt Schmidt, Saša Frank

“…This results in NO scavenging by ROS, a limited endothelial NO bioavailability and impaired vascular function.…”
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Machine learning for QoS and security enhancement of RPL in IoT-Enabled wireless sensors by Abubakar Wakili, Sara Bakkali, Ahmed El Hilali Alaoui

“…Our approach integrates a random forest model for precise traffic classification, a reinforcement learning module for dynamic and adaptive routing, and a modified RPL objective function that incorporates classification outcomes into routing decisions. …”
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