SPON2 facilitates osteosarcoma development by inducing M2 macrophage polarization through activation of the NF-κB/VEGF signaling axis by Xinchang Lu, Xueping Zhang, Fengzhen Zhang, Wenhao Wang, Ruijie Liu, Yubao Hou, Weiye Shi, Jiazhen Li, Changliang Peng

“…SPON2 is significantly upregulated in OS tissues and cell lines and correlates with shorter patient survival. Functional assays show that SPON2 promotes OS cell proliferation, migration, invasion, and angiogenesis by enhancing the secretion of IL10, CCL2, and CSF1, which leads to M2 macrophage polarization and an immunosuppressive tumor microenvironment. …”
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Deep brain stimulation of Hippocampus in Treatment-resistant Schizophrenia (DBS-HITS): protocol for a crossover randomized controlled trial by Chang Lu, Zhaolin Zhai, Kaiming Zhuo, Qiong Xiang, Jingxin Xue, Yuqing Zhao, Liqin Lang, Chunhong Shao, Liang Chen, Dengtang Liu

“…High-frequency deep brain stimulation (DBS) can disrupt the abnormal synchronization of functional circuits and modulate local brain networks. …”
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Microbial contributions to plant growth and stress tolerance: Mechanisms for sustainable plant production by Neha Sharma, Lovely Mahawar, Arti Mishra, Benedicte Riber Albrectsen

“…However, key challenges remain, including limited understanding of native soil microbiotas, the functional outcome of microbiome-soil-plant interactions, and the development of agricultural practices that efficiently integrate microbial solutions. …”
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Multi-Omics Analysis Provides Insights into Green Soybean in Response to Cold Stress by Yanhui Lin, Guangping Cao, Jing Xu, Honglin Zhu, Liqiong Tang

“…The DEGs and DEMs were further subjected to KEGG functional analysis. Finally, 11 metabolites (such as sucrose, lactose, melibiose, and dehydroascorbate) and 17 genes (such as <i>GOLS</i>, <i>GLA</i>, <i>UGDH</i>, and <i>ALDH</i>) were selected as candidates associated with cold tolerance. …”
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Effects of subliminal emotional facial expressions on language comprehension as revealed by event-related brain potentials by Miguel Rubianes, Laura Jiménez-Ortega, Francisco Muñoz, Linda Drijvers, Tatiana Almeida-Rivera, José Sánchez-García, Sabela Fondevila, Pilar Casado, Manuel Martín-Loeches

“…Furthermore, the functional independence of syntactic processing from other cognitive and affective processes remains a long-standing debate in the literature. …”
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Bone Marrow Aspirate Concentrate (BMAC) for Knee Osteoarthritis: A Narrative Review of Clinical Efficacy and Future Directions by Dojoon Park, Hae-Seok Koh, Youn-Ho Choi, Ilkyu Park

“…Clinical evidence suggests that BMAC provides short- to mid-term symptomatic relief and functional improvement, with some studies indicating a potential to delay total knee arthroplasty (TKA). …”
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The Pro12Ala Polymorphism of the Peroxisome Proliferator-Activated Receptor Gamma Gene Modifies the Association of Physical Activity and Body Mass Changes in Polish Women by Aleksandra Zarebska, Zbigniew Jastrzebski, Pawel Cieszczyk, Agata Leonska-Duniec, Katarzyna Kotarska, Mariusz Kaczmarczyk, Marek Sawczuk, Agnieszka Maciejewska-Karlowska

“…Peroxisome proliferator-activated receptor γ is a key regulator of adipogenesis, responsible for fatty acid storage and maintaining energy balance in the human body. Studies on the functional importance of the PPARG Pro12Ala polymorphic variants indicated that the observed alleles may influence body mass measurements; however, obtained results were inconsistent. …”
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Exosomes as Future Therapeutic Tools and Targets for Corneal Diseases by Joshua Gamez, Daxian Zha, Shaghaiegh M. Ebrahimi, Seok White, Alexander V. Ljubimov, Mehrnoosh Saghizadeh

“…Their contents enable them to function as multi-signaling and vectorized vehicles. …”
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Ultradense Dark Matter Halos with Poisson Noise from Stellar-mass Primordial Black Holes by Saeed Fakhry, Javad T. Firouzjaee

“…Specifically, increasing PBH mass shifts the differential mass function of UDMHs toward higher masses, while variations in the suppression parameter n modulate the efficiency of UDMH formation at small scales. …”
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Brg1 and RUNX1 synergy in regulating TRPM4 channel in mouse cardiomyocytes by Tao Ban, Tao Ban, Tao Ban, Xianhui Dong, Ziyue Ma, Jing Jin, Jing Li, Yunfeng Cui, Yuyang Fu, Yongzhen Wang, Yadong Xue, Tingting Tong, Kai Zhang, Yuxuan Han, Meimei Shen, Yu Zhao, Ling Zhao, Lingzhao Xiong, Hongzhao Lv, Yang Liu, Rong Huo

“…ChIP confirmed that Brg1 interacted with RUNX1 forming a transcriptional complex that located in TRPM4 promoter.ConclusionOur study demonstrated that Brg1 and RUNX1 formed a transcriptional complex that modulated TRPM4 expression and function, especially under hypoxic conditions. …”
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Gamma synchronization between the medial temporal lobe and medial frontal cortex for goal-directed visual attention in humans by Jie Zhang, Jing Xia, Huihui Zhou, Shuo Wang

“…Summary: Goal-directed visual attention is a fundamental cognitive function that engages multiple brain regions, yet the neural circuit mechanisms in humans remain unclear. …”
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Dysregulation of miRNAs in Soft Tissue Sarcomas by Stefano Zoroddu, Angela Lucariello, Antonio De Luca, Luigi Bagella

“…We explore how dysregulated miRNAs function as oncogenes or tumor suppressors, modulating critical pathways that define the aggressive nature of these cancers. …”
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Topological approach for optimization of liquid cooled plate with different inlet/outlet parameters by Tao Wang, Yizhong Wang, Hemin Hu

“…In this paper, a numerical simulation method is used to optimize the topology of the liquid cooled plate structure in the heat dissipation module of IGBT chips. The paper takes the flow resistance minimization and heat transfer maximization as the dual objectives, and assigns weights to the objective function, and realizes the topology optimization design of the liquid cooled plate through mathematical methods. …”
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The propagation characteristics of seismic waves in ultra-deep overburden by large-scale shaking table test by Yang Xing, Li Wentao, Wu Shibin, Chen Zhixiong, Ding Xuanming

“…In this study, the propagation characteristics of horizontal and vertical seismic waves in a deep overburden were systematically investigated using large-scale shaking table tests, with analysis based on acceleration and pore pressure data combined with stockwell transforms and coherence function methods. The results show clear differences in how the deep overburden modulates seismic waves in different directions. …”
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RDW-YOLO: A Deep Learning Framework for Scalable Agricultural Pest Monitoring and Control by Jiaxin Song, Ke Cheng, Fei Chen, Xuecheng Hua

“…Third, an enhanced Wise-Wasserstein IoU (WWIoU) loss function optimizes the matching mechanism and improves bounding-box regression. …”
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Research progress on ADAM28 in malignant tumors by Lanlan Zhao, Wei Liu, Fei Wang

“…In this article, the structure and function of ADAM28 and its correlation with the onset and progression of human malignant tumors are primarily examined. …”
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Latest Update on lncRNA in Epithelial Ovarian Cancer—A Scoping Review by Katarzyna Kwas, Maria Szubert, Jacek Radosław Wilczyński

“…These molecules are significantly engaged in cancer progression, development, metastasis, and chemoresistance. However, the function of lncRNAs in epithelial ovarian cancer (EOC) has not yet been thoroughly studied. …”
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Enhanced Orthogonal Matching Pursuit Algorithm and Its Application in Mechanical Equipment Fault Diagnosis by Yong Lv, Jie Luo, Cancan Yi

“…In this paper, an improved linear frequency-modulated (Ilfm) function as an atom is employed in the proposed enhanced orthogonal matching pursuit (EOMP) algorithm. …”
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Time-of-Day-Dependent Effects of Aerobic Exercise on Carotid Hemodynamics in Sedentary Adults by Bingyi Shen, Haibin Liu, Shuying Zhang, Lihong Chen, Guangrui Yang

“…Aerobic exercise (AE) modulates vascular function through hemodynamic responses, thereby influencing cardiovascular health and risk, with the circadian rhythm system playing a crucial role. …”
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Peroxisome Proliferator-Activated Receptors as a Therapeutic Target in Asthma by Oxana Yu. Kytikova, Juliy M. Perelman, Tatyana P. Novgorodtseva, Yulia K. Denisenko, Viktor P. Kolosov, Marina V. Antonyuk, Tatyana A. Gvozdenko

“…This review summarizes current views on the structure and function of PPARs, as well as their participation in the pathogenesis of chronic inflammation in asthma. …”
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