Metabolic reprogramming of tumor-associated neutrophils in tumor treatment and therapeutic resistance by Jun Lin, Jun Lin, Xian-Lu He, Wei-Wei Zhang, Chun-Fen Mo, Chun-Fen Mo

“…The metabolic reprogramming of TANs not only modulates their functional phenotypes but also reshapes tumor biological behaviors and therapeutic responses by regulating metabolic intermediates and cellular interactions within the TME. …”
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Role of the NO-GC/cGMP signaling pathway in platelet biomechanics by Aylin Balmes, Johanna G. Rodríguez, Jan Seifert, Daniel Pinto-Quintero, Akif A. Khawaja, Marta Boffito, Maike Frye, Andreas Friebe, Michael Emerson, Francesca Seta, Robert Feil, Susanne Feil, Tilman E. Schäffer

“…Our results corroborate a functional role of the NO-GC/cGMP pathway in platelet biomechanics, indicating that biomechanical properties such as stiffness or shape could be used as novel biomarkers in clinical research.…”
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Nicotinamide phosphoribosyltransferase in NAD+ metabolism: physiological and pathophysiological implications by Weijia Zhang, Haoyu Ren, Wangwang Chen, Bo Hu, Chao Feng, Peishan Li, Yufang Shi, Jiankai Fang

“…Notably, NAMPT exacerbates cancer immune evasion mechanisms by influencing immune cell functions and the metabolic environment of tumors. …”
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Unveiling the crossroads of STING signaling pathway and metabolic reprogramming: the multifaceted role of the STING in the TME and new prospects in cancer therapies by Siwei Wang, Lu Qin, Furong Liu, Zhanguo Zhang

“…We also synthesize current knowledge on the antitumor functions of STING, and the metabolic targets within the tumor microenvironment (TME) that could be exploited for STING activation. …”
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Exercise in atherosclerosis: its beneficial effects and underlying mechanism by Meng-ting Yin, Meng-ting Yin, Meng-ting Yin, Meng-ting Yin, Liang Guo, Liang Guo, Liang Guo, Liang Guo

“…Exercise exerts beneficial effects on atherosclerosis through modulation of diverse pathways, including exerkines, browning of adipose tissue, the renin-angiotensin system (RAS), metabolites, gut microbiota, cell death pathways, microRNAs, nervous system, and immune function. …”
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Role of noncoding RNA and protein interaction in pancreatic cancer by Zhang Li, Tingting Zhang, Xiaojuan Yang, Yong Peng, Sihan Zhou, Xiuyuan Hao

“…Their aberrant expression can arise from chromosomal abnormalities, dysregulated transcriptional control, and epigenetic modifications. ncRNAs function as protein scaffolds or molecular decoys to modulate interactions between proteins and other biomolecules, thereby regulating gene expression and contributing to pancreatic cancer progression. …”
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Intranasal delivery of hMSC-derived supernatant for treatment of ischemic stroke by inhibiting the pro-inflammatory polarization of neutrophils by Yixiang Jiang, Ning Wang, Jingyi Liu, Haoran Ren, Wenkang Jiang, Yanting Lei, Xidan Fu, Miao Hao, Xiujuan Lang, Yumei Liu, Xijun Liu, Rui Li, Hulun Li

“…Results TTC staining, behavioral experiments, and pathological assessments reveal intranasal delivery of hMSC-L and hMSC-M significantly reduces the infarct volume of mice with cerebral ischemia, improves neurological function scores, and promotes motor function recovery. …”
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The extracellular matrix protein type I collagen and fibronectin are regulated by β-arrestin-1/endothelin axis in human ovarian fibroblasts by Ilenia Masi, Flavia Ottavi, Valentina Caprara, Danila Del Rio, Martina Kunkl, Francesca Spadaro, Valerio Licursi, Loretta Tuosto, Anna Bagnato, Laura Rosano’

“…At the molecular level, ET-1 triggers the activation of COL1A1 promoter activity and its enhanced expression via β-arr1 nuclear function. Transcriptome analysis of β-arr1-silenced HOFs confirms the nuclear role of β-arr1 in collagen and ECM remodeling-related protein transcriptional regulation. …”
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Real-World Effectiveness of a Novel AI-Software Dependent Neuromodulation (ASDN) with Remote Monitoring Capability Field Stimulation Device for Chronic Pain: A 24-Month Analysis of... by Green M, Cabble A, Bailey M, Kappell ML, Billet B, Kim CW, Singh JR, Suthar M, Kalia H, Kappell S, Chakravarthy K

“…All users completed at least one therapy session and submitted symptom data via a mobile application.Intervention: EcoAI delivers transcutaneous electrical nerve stimulation (TENS) to modulate afferent pain signaling and electrical muscle stimulation (EMS) to improve local circulation and neuromuscular function. …”
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Hesperidin facilitating gastrointestinal motility by “Gut-brain axis” and “SCF/C-Kit signaling pathways” by Yunfei Li, Xinying Zhou, Yusong Du, Mingyuan An, Shasha Wan, Zewei Sun, Qingzhen Zhong

“…ABSTRACT: Hesperidin shows promising results as a potential feed additive for enhancing gastrointestinal motility in animals. Gastrointestinal function plays a pivotal role in animal growth and the digestibility of dietary nutrients, with gastrointestinal motor function serving as a crucial component. …”
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Analysis of molecular mechanisms of the development of experimental diabetes in Wistar rats under conditions of intermittent hypoxia by T. V. Ivanenko

“…The key elements of hypoxic training in diabetes encompass activities geared toward activating metabolic pathways, enhancing mitochondrial function, and regulating blood glucose levels. Such interventions can potentially lead to improvements in insulin resistance, a reduction in glycemia, and an overall enhancement of cardiorespiratory function. …”
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Piperine protects against cerebral ischemic injury by regulating the Caspase-1-mediated pyroptosis pathway by Jiayuan Lu, Jiayuan Lu, Xinwen Dai, Siyu Xi, Bo Wang, Peng Zhang, Xueyan Fu, Xueyan Fu, Juan Liu, Yiwei Zhang, Yiwei Zhang

“…By contrast, the Pip group demonstrated notable improvements in behavioral function, brain tissue morphology, and the expression levels of pyroptosis-related factors compared with the Model group. …”
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Beyond the surface: P2Y receptor downstream pathways, TLR crosstalk and therapeutic implications for infection and autoimmunity by Lena Rueschpler, Sebastian Schloer

“…It is therefore essential to achieve a nuanced fine regulation of pro- and anti-inflammatory signals to orchestrate the optimal immune function and restore homeostatic conditions. In this process, the purinergic system plays the dual role of promoting host antimicrobial effector mechanisms while simultaneously limiting the immune response to the site and duration of infection. …”
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Interplay of thyroid dysfunction and burning mouth syndrome: a case report by Ramya Suresh, Ramya Ramadoss, Nitya Krishnasamy, Suganya Paneer Selvam, Sandhya Sundar, Hemashree K

“…These findings highlight the need for a multidisciplinary approach in the diagnosis and treatment of BMS, considering both systemic and local factors, including thyroid function. This case underscores the importance of evaluating thyroid health in patients presenting with BMS symptoms and suggests potential therapeutic targets for optimizing patient care.…”
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MSPB-YOLO: High-Precision Detection Algorithm of Multi-Site Pepper Blight Disease Based on Improved YOLOv8 by Xiaodong Zheng, Zichun Shao, Yile Chen, Hui Zeng, Junming Chen

“…Furthermore, we optimized CIOU to DIOU by integrating the center distance of bounding boxes into the loss function; as a result, the model achieved an impressive mAP@0.5 score of 96.4%. …”
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Tuning the Properties of Polyvinylidene Fluoride/Alkali Lignin Membranes to Develop a Biocatalytic Membrane Reactor for an Organophosphorus Pesticide Degradation by Serena Regina, Giuseppe Vitola, Rosalinda Mazzei, Lidietta Giorno

“…In particular, the performance of the BMR was studied as a function of the thickness of the membrane, which allowed us to modulate the residence time into the enzyme-loaded membrane pores while maintaining the flow rate through the pores at a constant.…”
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Gut Microbiota in Rheumatic Diseases Pathogenic Role and Therapeutic Potential by Bartłomiej Kusy, Maciej Dudziński, Martyna Różańska, Michał Robak, Agnieszka Bajkacz, Marcin Płonka, Mateusz Michalak

“…The work presents examples of alterations in gut microbial composition in patients with selected rheumatic conditions and explores the possible consequences of these changes for immune system function. Furthermore, the paper discusses potential therapeutic strategies aimed at modulating the gut microbiota, including the use of probiotics, prebiotics, dietary interventions, and the innovative approach of fecal microbiota transplantation (FMT). …”
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Projectile Explosion Weak Firelight Image Recognition Method Using Multi-Scale Adaptive Enhancement Network by Xuebin Liu, Hanshan Li, Shaopeng Liang

“…The Focal-Dice Loss is used as the joint supervision loss function of the network model, which can effectively solve the problem of sample imbalance and improve the recognition accuracy of the network. …”
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Fault detection for Li-ion batteries of electric vehicles with feature-augmented attentional autoencoder by Yunsheng Fan, Zhiwu Huang, Heng Li, Wei Yuan, Lisen Yan, Yongjie Liu, Zheng Chen

“…The commonly used autoencoder is improved by applying a memory module to amplify the fault features between normal and abnormal cells and employing a similarity loss function to enhance the similarity of features for normal batteries. …”
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A Low-Cost Remotely Configurable Electronic Trap for Insect Pest Dataset Generation by Fernando León-García, Jose M. Palomares, Meelad Yousef-Yousef, Enrique Quesada-Moraga, Cristina Martínez-Ruedas

“…Quality metrics are presented through an experimental study conducted on the constructed demonstrator, emphasizing trap reliability, stability, performance, and energy consumption, along with an objective analysis of image quality using metrics such as RMS contrast, Image Entropy, Image sharpness metric, Natural Image Quality Evaluator (NIQE), and Modulation Transfer Function (MFT). This study contributes to the optimization of the current knowledge regarding automated insect pest monitoring techniques and offers advanced solutions for the current systems.…”
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