CEBPD regulates CD47 and MAP4K4 via chromatin accessibility in canine mammary tumor monocytes by Jeong-Woon Lee, Dabin Lee, Kyung-Ju Shin, Keun Hong Son, Je-Yoel Cho

“…Our analysis revealed significant changes in chromatin accessibility near genes associated with immune function, neuronal activity, and lipid metabolism. …”
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MGL Receptor and Immunity: When the Ligand Can Make the Difference by Ilaria Grazia Zizzari, Chiara Napoletano, Federico Battisti, Hassan Rahimi, Salvatore Caponnetto, Luca Pierelli, Marianna Nuti, Aurelia Rughetti

“…We discuss the effects on DC function induced throughout the engagement of MGL, highlighting the importance of the antigen structure in the modulation of immune response. …”
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The Role of Nuclear Phosphoinositides in the p53-MDM2 Nexus by Jeong Hyo Lee, Muhammad Khalil Salah, Xiangqin Chen, Nickolas Vladimir Kucherenko, Vincent L. Cryns, Richard A. Anderson

“…Here, we dissect the molecular mechanisms by which nuclear PIP_ns stabilize p53 through the recruitment of small heat shock proteins (sHSPs), activate the nuclear phosphatidylinositol 3-kinase (PI3K)-AKT signaling cascade, and modulate MDM2 function to regulate the p53-MDM2 interaction. …”
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Bridging epigenomics and tumor immunometabolism: molecular mechanisms and therapeutic implications by Xiaowen Xie, Weici Liu, Zhiyuan Yuan, Hanqing Chen, Wenjun Mao

“…Concurrently, immune cells within the immunosuppressive TME undergo metabolic adaptations, leading to alterations in their immune function. The complicated interplay between metabolites and epigenomic modulation has spotlighted the significance of epigenomic regulation in tumor immunometabolism. …”
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TrainNet for locking state recognition of side door of railway freight car by Ning Xing, Cai Kangcheng, Zhou Shumin, Lan Xiangui, Lai Yihui

“…We designed an efficient layer aggregation network (ELAN)-S module in our TrainNet, which can be used with YOLOv7. …”
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Brain Neurotrophins and Plant Polyphenols: A Powerful Connection by Marco Fiore, Sergio Terracina, Giampiero Ferraguti

“…Together, these effects contribute to potentiated enhanced synaptic function, neuronal integrity, and better learning and memory processes. …”
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DRR-YOLO: A Study of Small Target Multi-Modal Defect Detection for Multiple Types of Insulators Based on Large Convolution Kernel by Mingming Hu, Jun Liu, Junfu Liu

“…The existing insulator defect detection algorithms are mainly characterized by their ability to identify only a single type of defect, accompanied by relatively low accuracy, a Dilated Re-parameterized Residual-YOLO (DRR-YOLO) algorithm is proposed, which is capable of identifying four defects of each of the four insulator types. Firstly, a new module DRR is proposed based on Dilated Re-param Block (DRB) and Dilation-wise Residual (DWR), which is combined with the C2f module of the YOLOv8 model to enhance the model’s detection effect for targets at different scales; Secondly, the Large Separable Kernel Attention SPPF (LSPPF) module is proposed to replace the SPPF in the original model, which enables the model to better preserve the feature information of the target while streamlining the structure; In addition, the advantages of MPDIoU and Inner-IoU are combined, and the loss function of the original model is replaced with Inner-MPDIoU. …”
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Advancing Traditional Dunhuang Regional Pattern Design with Diffusion Adapter Networks and Cross-Entropy by Yihuan Tian, Tao Yu, Zuling Cheng, Sunjung Lee

“…In addition, incorporating a cross-entropy loss function enhances the model’s capability in semantic understanding and the classification of Dunhuang patterns. …”
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YOLOv10-kiwi: a YOLOv10-based lightweight kiwifruit detection model in trellised orchards by Jie Ren, Wendong Wang, Yuan Tian, Jinrong He

“…In addition, a MPDIoU loss function is introduced to overcome the limitations of the traditional CIoU in terms of aspect ratio mismatch and bounding box regression, accelerating convergence and improving detection accuracy. …”
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Efficient remote sensing image classification using the novel STConvNeXt convolutional network by Bo Liu, Chenmei Zhan, Cheng Guo, Xiaobo Liu, Shufen Ruan

“…In terms of training strategy, a dynamic threshold loss function is introduced, utilizing a learnable inter-class margin to improve the model’s ability to distinguish difficult-to-classify samples. …”
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BiEHFFNet: A Water Body Detection Network for SAR Images Based on Bi-Encoder and Hybrid Feature Fusion by Bin Han, Xin Huang, Feng Xue

“…Finally, a composite loss function combining Dice loss and Active Contour loss is used to provide stronger boundary supervision. …”
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Daxx and HIRA go viral – How chromatin remodeling complexes affect DNA virus infection by Julia Mai, Masih Nazari, Thomas Stamminger, Sabrina Schreiner

“…During DNA virus infections, Daxx helps modulate the immune response and viral progression. …”
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YOLO-SRW: An Enhanced YOLO Algorithm for Detecting Prohibited Items in X-Ray Security Images by Minwei Chen, Zhixian Zhang, Nian Jiang, Xingxing Li, Xin Zhang

“…Finally, by combining SCYLLA-IoU (SIoU) and Wise-IoUv3 losses, we design the Wise-SIoU loss function to reduce false negatives and false positives in Prohibited item detection, enhancing the model’s generalization ability. …”
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Can EEG‐Neurofeedback Training Enhance Effective Connectivity in People With Chronic Secondary Musculoskeletal Pain? A Secondary Analysis of a Feasibility Randomized Controlled Cli... by Jerin Mathew, Divya Bharatkumar Adhia, Mark Llewellyn Smith, Dirk De Ridder, Ramakrishnan Mani

“…ABSTRACT Introduction Persistent musculoskeletal pain is associated with altered functional and effective connectivity (EC) between cortical regions involved in pain processing. …”
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Research Progress on Probiotics in Alleviating Cow’s Milk Allergy: A Review by Yangze Guo, Jiali Chen, Yezhi Qu, Xilin Wu, Shengyi Zhang, Jiale Wang, Xiqing Yue, Zhenmin Liu, Aijun Xie, Mohan Li

“…Probiotics, as a means to modulate the gut microbial composition, demonstrate potential in controlling allergic reactions by enhancing gut barrier functions, promoting immune responses in the intestinal mucosa, and degrading potential allergens. …”
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Broadband and Wide Field-of-View Refractive and Meta-Optics Hybrid Imaging System for Mid-Wave Infrared by Bo Liu, Yunqiang Zhang, Zhu Li, Bingyan Wei, Xuetao Gan, Xin Xie

“…Through a detailed analysis of modulation transfer function curves and spot diagrams, the system achieves 178° FOV while maintaining exceptional imaging performance across a temperature range of −40 °C to 60 °C. …”
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Enriched and Deprived Sensory Experience Induces Structural Changes and Rewires Connectivity during the Postnatal Development of the Brain by Harkaitz Bengoetxea, Naiara Ortuzar, Susana Bulnes, Irantzu Rico-Barrio, José Vicente Lafuente, Enrike G. Argandoña

“…Most of the cortical changes thus induced occur during the critical period, when the functional and structural properties of cortical neurons are particularly susceptible to alterations. …”
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<i>Volvariella volvacea</i> Polypeptide Mitigates Alcohol-Induced Liver Injury: A Multi-Omics Study by Bingzhi Chen, Juanqin Chen, Huihua Wu, Fangyi Zhang, Lili Chen, Weibin Zhang, Jing Yang, Li Yuan, Yuji Jiang, Youjin Deng

“…These findings demonstrate VVFP’s therapeutic potential as a functional food ingredient by highlighting its ability to simultaneously target hepatic stress responses and metabolic homeostasis during alcohol detoxification.…”
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Impact of high-fructose diet and metformin on histomorphological and molecular parameters of reproductive organs and vaginal microbiota of female rat by Mürşide Ayşe Demirel, Esra Şumlu, İbrahim Hanifi Özercan, Kazım Şahin, Mehmet Tuzcu, Veysel Bay, Öznur Ece Durmaz Kurşun, Mecit Orhan Uludağ, Fatma Akar

“…Although metformin has some functional effects on female fertility, its reproductive outcome on high fructose diet-induced metabolic syndrome is unclear. …”
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Herbivore-induced GABA signaling suppresses host plant growth to stabilize leaf-tie shelters by Gisuk Lee, Bo Eun Nam, Min-Soo Choi, Hangah Lim, Sang-Gyu Kim, Youngsung Joo

“…This work expands our understanding of plant signaling in biotic interactions and highlights growth suppression as a functional outcome of herbivore-induced manipulation.…”
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