Bezafibrate-driven mitochondrial targeting enhances antitumor immunity and prevents lung cancer via CD8+ T cell infiltration and MDSC reduction by Jing Pan, Jiaheng Li, Qi Zhang, Mofei Huang, Yian Wang, Ming You

“…Recent studies uncovered that BEZ is a potent modulator of mitochondrial biogenesis through activation of PGC-1α/PPAR complexes, resulting in modulation of lipid metabolism and fatty acid oxidation. …”
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Acupuncture’s Immunomodulatory Effects on Macrophages in Allergic Disorders: A Systematic Review by Qu Y, Gu Y, Zhang X, Wang Y, Xing X

“…With the growing recognition of traditional medicine, acupuncture, an ancient Chinese therapeutic method, has gradually gained attention for its potential in immune modulation. Studies have shown that macrophages play a crucial role in the development of allergic diseases, and acupuncture may influence allergic reactions by modulating the function of macrophages. …”
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YOLO-SUMAS: Improved Printed Circuit Board Defect Detection and Identification Research Based on YOLOv8 by Ying Tang, Runhao Liu, Sheng Wang

“…Aiming at the demand for defect detection accuracy and efficiency under the trend of high-density and integration in printed circuit board (PCB) manufacturing, this paper proposes an improved YOLOv8n model (YOLO-SUMAS), which enhances detection performance through multi-module collaborative optimization. The model introduces the SCSA attention mechanism, which improves the feature expression capability through spatial and channel synergistic attention; adopts the Unified-IoU loss function, combined with the dynamic bounding box scaling and bi-directional weight allocation strategy, to optimize the accuracy of high-quality target localization; integrates the MobileNetV4 lightweight architecture and its MobileMQA attention module, which reduces the computational complexity and improves the inference speed; and combines ASF-SDI Neck structure with weighted bi-directional feature pyramid and multi-level semantic detail fusion to strengthen small target detection capability. …”
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Robust Low-Overlap Point Cloud Registration via Displacement-Corrected Geometric Consistency for Enhanced 3D Sensing by Xin Wang, Qingguang Li

“…Furthermore, a novel displacement loss function was developed to effectively constrain the geometric distribution of corrected point-pairs. …”
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The Role of Vitamin D in Allergic Diseases by Joanna Maria Szydziak, Aleksandra Hrapkowicz, Kinga Janowska, Daria Dąbkowska, Olga Szeidl, Dominika Rehan, Julia Wołoszczak, Agnieszka Mioskowska

“…Conversely, supplementation may help prevent allergies, reduce the severity of atopic dermatitis by supporting skin barrier function and antimicrobial peptide production, and relieve symptoms in patients with chronic urticaria.             …”
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Hybrid attention transformer integrated YOLOV8 for fruit ripeness detection by Jianyin Tang, Zhenglin Yu, ChangShun Shao

“…To more accurately evaluate the similarity between the prediction box and the real bounding box, this paper uses the EIoU loss function instead of CIoU, thereby improving detection accuracy and accelerating model convergence. …”
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The Teacher–Assistant–Student Collaborative and Competitive Network for Brain Tumor Segmentation with Missing Modalities by Junjie Wang, Huanlan Kang, Tao Liu

“…Second, a competitive function is formulated to promote collaboration and competition between the student network and the teacher network. …”
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ITIH4 attenuates acute lung injury by Fe-containing particulate matter in mice via Hippo pathway in type II alveolar epithelial cells by Vincent Laiman, Syue-Wei Peng, Lina Choridah, Didik Setyo Heriyanto, Fara Silvia Yuliani, Kang-Yun Lee, Ching-Huang Lai, Jer-Hwa Chang, Yueh-Lun Lee, Shu-Chuan Ho, Sheng-Ming Wu, Chia-Li Han, Cheng-Wei Lin, Kian Fan Chung, Hsiao-Chi Chuang

“…Results We observed correlation between lung function changes and Fe levels, both in bulk and single-cell Fe in peripheral blood mononuclear cells. …”
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TRPV1 Inhibits Ferroptosis and Mitophagy to Alleviate Heart Failure by Activating SFXN2 by Pan Liu, Shiguang Wang, Liya Li, Ruihua Li, Minming Fan, Jingjing Kong, Bing Gao, Jing Wang, Ran Xia

“…Transient receptor potential cation channel subfamily V member 1 (TRPV1) is a calcium-permeable channel that has been linked to cardiac disease and function. However, its significance in HF and underlying processes is unknown. …”
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Treatment with Rhizoma Dioscoreae Extract Has Protective Effect on Osteopenia in Ovariectomized Rats by Zhiguo Zhang, Lihua Xiang, Dong Bai, Xiaowei Fu, Wenlai Wang, Yan Li, Hong Liu, Jinghua Pan, Ya’nan Li, Gary Guishan Xiao, Dahong Ju

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VRU-YOLO: A Small Object Detection Algorithm for Vulnerable Road Users in Complex Scenes by Yunxiang Liu, Yuqing Shi

“…Finally, to alleviate the deficiencies of traditional loss functions in shape matching and computational efficiency, we propose the Wise-Powerful Intersection over Union (WPIoU) loss function, which further optimizes the regression of target bounding boxes. …”
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Distinct catecholaminergic pathways projecting to hippocampal CA1 transmit contrasting signals during navigation in familiar and novel environments by Chad Heer, Mark Sheffield

“…Therefore, to dissect the impacts of both VTA and LC circuits on hippocampal function, a thorough examination of how these pathways might differentially operate during behavior and learning is necessary. …”
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Streptococcus pneumoniae synchronizes the states of cell wall peptidoglycan acetylation and genome methylation by programmed DNA inversions. by Xiu-Yuan Li, Ping He, Shaomeng Wang, Yusong Wang, Dingfei Yan, Xiaohui Liu, Haiteng Deng, Zhixing Feng, Juanjuan Wang, Jing-Ren Zhang

“…However, it remains unclear if the fluctuation of NAM O-acetylation has any function. In this study, we show that NAM O-acetylation functions as a potential extracellular signal of cellular metabolism for epigenetic response to nutrient conditions in human pathogen Streptococcus pneumoniae (pneumococcus). …”
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Algorithm for managing the safety of remote cardiac rehabilitation in the integrated telemedicine system "IS-Cardio" by E. V. Kotelnikova, O. M. Posnenkova, T. M. Bogdanova, V. N. Senchikhin, V. I. Gridnev

“…The object of a single-center pilot study was the safety algorithm for home physical training (PT) programs embedded in the TMS "ISCardio" cardiac rehabilitation module. Its functionality ensured the implementation of 12-week aerobic PT programs with an intensity of 55-70%, duration 90-300 min/week and a target level of individual exercise tolerance of 8-12 on the 6-20 Borg scale. …”
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Gut Microbiota Composition and Metabolites as the new Determinants of Cardiovascular Pathology Development by O. M. Drapkina, A. N. Kaburova

“…The described interactions draw attention to the opportunity to influence on the certain mechanisms of CVD pathogenesis through the modulation of microbiota composition and function. The review is aimed at highlighting the current data about the mechanisms by which the gut microbiota and its metabolites may increase cardiovascular risk and events rate as well as discussing the existing results and future perspective of bacterial systemic effects modulation.…”
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Current Ideas About the Regulation of the Activity of Thyroid Hormones and the Mechanism of Their Action at the Cellular Level (Review) by Yuliya A. Shatyr, Galina A. Sroslova, Nikita O. Nazarov, Ruslan I. Glushakov

“…They participate in the regulation of the nervous, respiratory, cardiovascular, muscular, and osteoarticular systems, as well as in the processes of thermogenesis, sleep and wakefulness, and reproductive function, and modulate a number of neurotransmitter systems in the brain. …”
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Melittin Constrains the Expression of Identified Key Genes Associated with Bladder Cancer by Zidan Jin, Jie Yao, Nianlin Xie, Libo Cai, Shuai Qi, Zhan Zhang, Bai Li

“…Functional assays revealed that melittin could constrain the proliferative and migrated abilities of BC cells. …”
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Memory T Cells in Respiratory Virus Infections: Protective Potential and Persistent Vulnerabilities by Henry Sutanto, Febrian Ramadhan Pradana, Galih Januar Adytia, Bagus Aditya Ansharullah, Alief Waitupu, Bramantono Bramantono, Deasy Fetarayani

“…Understanding the underlying mechanisms governing the formation, maintenance, and functional deployment of memory T cells in respiratory mucosa is critical for improving immunological interventions. …”
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Artificial simulated saliva, gastric and intestinal digestion and fermentation in vitro by human gut microbiota of intrapolysaccharide from Paecilomyces cicadae TJJ1213 by Juanjuan Tian, Xiaomeng Wang, Xueliang Zhang, Xiaohong Chen, Mingsheng Dong, Xin Rui, Qiuqin Zhang, Mei Jiang, Wei Li

“…These results indicated that IPS from P. cicadae TJJ1213 could be used as potential candidates for new functional foods.…”
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Cryo-EM structure of a blue-shifted channelrhodopsin from Klebsormidium nitens by Yuzhu Z. Wang, Koki Natsume, Tatsuki Tanaka, Shoko Hososhima, Rintaro Tashiro, Fumiya K. Sano, Hiroaki Akasaka, Satoshi P. Tsunoda, Wataru Shihoya, Hideki Kandori, Osamu Nureki

“…The unique architecture of the C-terminal region reveals its role in the allosteric modulation of channel kinetics, enhancing our understanding of its functional dynamics. …”
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