Abnormal lipid metabolism and atherosclerosis: a new perspective on organelle function regulation and ferroptosis by Xize Wu, Yuxi Huang, Jiaqi Ren, Xue Pan, Qiuying Wu, Qicheng Cai, Ruiying Wang, Teng Feng, Shan Gao, Bo Wang, Meijia Cheng, Meijia Cheng, Yue Li, Lihong Gong

“…Single-cell data analysis results suggested that these genes were highly expressed in foam cells, inflammatory macrophages, smooth muscle cells, and helper T cells.ConclusionIn AS, abnormal lipid metabolism may drive ferroptosis via key regulatory genes (CYBB, HMOX1, IL1B, TYROBP, CSF1R), while also reshaping the immune microenvironment, potentially through the modulation of organelle function.…”
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A Quantitative Model of Chemotherapeutic Drug Sensitivity as a Function of P-Glycoprotein Expression by Cara M. Robertus, Nisha Kannan, David Putnam

“…Additionally, we model the kinetics of calcein-AM, a P-gp substrate, as a function of P-gp expression. (3) Results: For both cell lines, a robust linear relationship governs chemotherapeutic sensitivity as a function of P-gp expression, demonstrating that characterization of P-gp surface density is a strong indicator of drug response in drug-resistant cells. …”
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Early nanoparticle intervention preserves motor function following cervical spinal cord injury by Sarah E. Hocevar, Brian C. Ross, Yinghao Wang, Cecelia R. Crowther, Samantha R. Schwartz, Brain J. Cummings, Aileen J. Anderson, Lonnie D. Shea

“…Herein, we investigated the window in time during which poly(lactide‐co‐glycolide) nanoparticles (NPs) administration can successfully modulate the immune response and promote functional sparing. …”
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A catechol-O-methyltransferase genetic variant impacts functional movement in tactical athletes. by Marcus K Taylor, Lisa M Hernández, Richard C Allsopp, John J Fraser

“…The rs737865 variant also modulated the influence of trauma on functional movement. …”
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The Effect of Karst Carbonate Rock Dissolution on Nitrogen Metabolism Microorganisms and Their Functions in Paddy Soils by Fengling Liu, Hu Wang, Bing Wang, Xu Mao, Jianbo Cheng, Chengwu Fan, Tengbing He, Tianling Fu

“…The effects of CRD on N-metabolizing microorganisms and functional genes in N metabolism were investigated using metagenomic sequencing technology. …”
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Enriched environment improves memory function by promoting synaptic remodeling in vascular dementia rats by Shuang Lin, Chuan-Jie Wang, Peng-Kun Yang, Bing Li, Yi Wu, Ke-Wei Yu

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The active site of a carbohydrate esterase displays divergent catalytic and noncatalytic binding functions. by Cedric Montanier, Victoria A Money, Virginia M R Pires, James E Flint, Benedita A Pinheiro, Arun Goyal, José A M Prates, Atsushi Izumi, Henrik Stålbrand, Carl Morland, Alan Cartmell, Katarina Kolenova, Evangelos Topakas, Eleanor J Dodson, David N Bolam, Gideon J Davies, Carlos M G A Fontes, Harry J Gilbert

“…In contrast to this view, a potential example of multifunctional recruitment into a single protein domain is provided by CtCel5C-CE2, which contains an N-terminal module that displays cellulase activity and a C-terminal module, CtCE2, which exhibits a noncatalytic cellulose-binding function but also shares sequence identity with the CE2 family of esterases. …”
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Biological Function of Medium-Chain Fatty Acids and Their Application in Aquatic Animals: A Review by Haiyan Liu, Wenzong Zhou, Chenggang Cai, Fengqin Feng, Haiying Cai, Hang Yang

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Protocol for embedded 3D bioprinting of arterial models with customized contractile and metabolic functions by Huilong Du, Shuyuan Yu, Ziqi Gao, Yuxuan Wang, Huayong Yang, Hongzhao Zhou, Qi Li

“…Here, we present a protocol for constructing multilayered arterial tissues with cellular alignment that enhances vascular smooth muscle function by modulating contractile and synthetic pathways. …”
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Subjective complaints of memory, objective performance and related neuropsychological functions. A systematic review by Carlos Mias, Belen Causse

“…Modulating variables are identified, such as depression and other psychological ones. 73.91% of the studies recommend attending SMC in older adults, considered a risk variable, increasing its value in combination with objective measures of neuropsychological functions. …”
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Research advances in functional roles of Th17 and IL-17 in acute kidney injury by Pang Hao-wen, An Ning, Yang Chen, Liu Hua-feng

“…Acute kidney injury（AKI）is a clinical syndrome characterized by a rapid decline of renal function.Renal infiltrated immune cells and releases of inflammatory cytokines are key factors affecting the progression and outcome of AKI.Th17 cells and its inflammatory factors such as IL-17 are involved in immune regulation and mucosal defense and play key roles in autoimmune diseases.Recent studies have shown that Th17 cells and IL-17 not only affected the degree of kidney injury, but also modulated the recovery after AKI.This review summarized the latest research advances in the functional role of Th17 and IL-17 in AKI and discussed the therapeutic strategy by targeting Th17 cells and IL-17 in the treatment of AKI.…”
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Comparative analysis of frameworks and automation tools in terms of functionality and performance on the Salesforce CRM Platform by Damian Ciechan

“…DML operations insert, update, delete were compared in terms of performance and each technology was analyzed in terms of provided functionalities and limitations. It was concluded that the most efficient automation tool is Flow Builder and the Lightning Web Components framework is the best choice for developing graphical user interfaces. …”
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Osteocytes function as biomechanical signaling hubs bridging mechanical stress sensing and systemic adaptation by Ma Yuze, Jin Hu, Lv Jun, Xu Cheng, Xin Tianwen, Zhang Junqiang

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Recent advances in functional assays of WRKY transcription factors in plant immunity against pathogens by Wenjing Wang, Haihui Cao, Jiahao Wang, Hongbo Zhang

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Functional Significance of Probiotic Bacterial Interactions with Milk Fat Globules in a Human Host by Withanage Prasadini Wasana, Mark Waterland, David W. Everett, Caroline Thum

“…This review discusses current knowledge on the structure and functionality of the milk fat globule membrane (MFGM) and the structural components contributing to the mechanisms of interactions with probiotic bacteria. …”
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Caffeine Effect on Cognitive Function during a Stroop Task: fNIRS Study by Yafei Yuan, Guanghao Li, Haoran Ren, Wei Chen

“…Acting as a brain stimulant, coffee resulted in heightening alertness, keeping arousal, improving executive speed, maintaining vigilance, and promoting memory, which are associated with attention, mood, and cognitive function. Functional near-infrared spectroscopy (fNIRS) is a noninvasive optical method to monitor brain activity by measuring the absorption of the near-infrared light through the intact skull. …”
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Writers and Readers of DNA Methylation/Hydroxymethylation in Physiological Aging and Its Impact on Cognitive Function by Rodrigo F. Torres, Ricardo Kouro, Bredford Kerr

“…DNA modifications are incorporated by specific sets of enzymes—the writers—and the modified DNA-interacting partners—the readers—are ultimately responsible for maintaining a functional epigenetic landscape. Therefore, understanding how these epigenetic mediators—writers and readers—are modulated in physiological aging will contribute to unraveling how aging-associated neuronal disturbances arise and contribute to the cognitive decline associated with this period of life. …”
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A comprehensive review on the impact of polyphenol supplementation and exercise on depression and brain function parameters by Shihong Jie, Aili Fu, Chuan Wang, Sogand Rajabi

“…The findings demonstrate that both exercise and polyphenols independently contribute to mood enhancement, reduced anxiety, and improved cognitive function through mechanisms such as neurogenesis, neurotransmitter modulation, and anti-inflammatory effects. …”
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Health benefits and functional properties of ciceritol, a novel prebiotic derived from chickpeas by Ali Ikram, Qaswaa Yousif Jameel, Farhan Saeed, Gaurav Sanghvi, Anirudh Gupta, Ali Imran, Faiyaz Ahmed, Musarrat Rasheed, Aasma Asghar, Muhammad Afzaal, Mohd Asif Shah

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Biogenesis, function and role of circular RNA in Gall Bladder Carcinoma-A narrative review by Anurag Singh, Nidhi Anand, Pallavi Srivastava

“…This review explores circRNA biogenesis and function, the signaling pathways it influences, and the latest research advances in gallbladder carcinoma.…”
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