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8961
Odors drive feeding through gustatory receptor neurons in Drosophila
Published 2025-08-01“…Odor-evoked PER requires the function of sugar-sensing GRNs but not olfactory organs. …”
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8962
Cellular senescence: from homeostasis to pathological implications and therapeutic strategies
Published 2025-02-01“…Finally, we thoroughly explore the function and mechanism of m6A methylation modification in cellular senescence, revealing its critical role in regulating gene expression and maintaining cellular homeostasis. …”
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8963
Research on Rate Adaptation of Underwater Optical Communication with Joint Control of Photoelectric Domain
Published 2024-10-01“…In the electrical domain, the constellation distribution is optimized according to the desired probability mass function, and the modulation order is adjusted in real time by estimating the received signal-to-noise ratio of the link. …”
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8964
Reversible gating of singlet fission by tuning the role of a charge-transfer state
Published 2025-03-01“…Here we design a meta-diethynylphenylene-linked tetracene dimer featuring pyridyl endgroups that function as an acid/base-responsive switch, enabling the reversible modulation of singlet fission. …”
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8965
A Role for Bcl-2 in Notch1-Dependent Transcription in Thymic Lymphoma Cells
Published 2012-01-01“…Our data suggest that Bcl-2 plays a role in modulating Notch1 function in T cells.…”
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8966
Research progress on the regulation of autophagy in cardiovascular diseases by chemokines
Published 2025-06-01“…These proteins are crucial for maintaining cardiac function and for managing myocardial cell damage under various stress conditions. …”
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8967
Neurodegeneration in Alzheimer Disease: Role of Amyloid Precursor Protein and Presenilin 1 Intracellular Signaling
Published 2012-01-01“…The molecular mechanisms underlying neurodegeneration in AD as well as the physiological function of APP are not yet known. A recent theory has proposed that APP and PS1 modulate intracellular signals to induce cell-cycle abnormalities responsible for neuronal death and possibly amyloid deposition. …”
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8968
Exploring the Cardiovascular Benefits of Extra Virgin Olive Oil: Insights into Mechanisms and Therapeutic Potential
Published 2025-02-01“…EVOO also promotes endothelial function by increasing nitric oxide (NO) bioavailability, thus favoring vasodilation, lowering blood pressure (BP), and supporting vascular integrity. …”
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8969
A Novel Technique for Transmission of M-Ary Signal through Wireless Fading Channel Using Wavelet Denoising
Published 2011-01-01“…A detailed step by step wavelet decomposition and reconstruction processes are discussed here to transform a signal function into wavelet coefficients using simulation software like MATLAB. …”
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8970
Flexi-YOLO: A lightweight method for road crack detection in complex environments.
Published 2025-01-01“…We designed Wise-IoU as the model's loss function to optimize the regression accuracy of its bounding boxes and enhance robustness to low-quality samples. …”
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8971
Exploring the Potential of Ribes nigrum L., Aronia melanocarpa (Michx.) Elliott, and Sambucus nigra L. Fruit Polyphenol-Rich Composition and Metformin Synergy in Type 2 Diabetes Ma...
Published 2024-01-01“…Additionally, concerns regarding its impact on hepatic function have led to its discontinuation in cirrhotic patients. …”
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8972
Generation and clearance of myelin debris after spinal cord injury
Published 2026-04-01“…Our analysis indicates that myelin debris phagocytosis is not limited to monocyte-derived macrophages, but also involves microglia, astrocytes, and microvascular endothelial cells. By modulating the expression of genes related to phagocytosis and lipid metabolism, it is possible to modulate lipid metabolism disorders and influence inflammatory phenotypes, ultimately affecting the recovery of motor function following spinal cord injury. …”
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8973
Redistribution of DAT/α-synuclein complexes visualized by "in situ" proximity ligation assay in transgenic mice modelling early Parkinson's disease.
Published 2011-01-01“…In particular, α-synuclein may affect dopaminergic neuron function as it interacts with a key protein modulating dopamine (DA) content at the synapse: the DA transporter (DAT). …”
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8974
Role of NF-E2 related factor 2 (Nrf2) on chemotherapy resistance in acute myeloid leukemia (AML) and the effect of pharmacological inhibition of Nrf2.
Published 2017-01-01“…This study demonstrates that Nrf2 could be an ideal druggable target in AML, more so to the drugs that function through ROS, suggesting the possibility of using Nrf2 inhibitors in combination with chemotherapeutic agents to modulate drug resistance in AML.…”
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8975
Optimized Marine Target Detection in Remote Sensing Images with Attention Mechanism and Multi-Scale Feature Fusion
Published 2025-04-01“…The proposed YOLOv5-ASC integrates three core components: an Attention-based Receptive Field Enhancement Module (ARFEM), an optimized SIoU loss function, and a Deformable Convolution Module (C3DCN). …”
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8976
KPMapNet: Keypoint Representation Learning for Online Vectorized High-Definition Map Construction
Published 2025-03-01“…Moreover, a novel point-line matching loss function is introduced to further refine the training process. …”
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8977
The SUMOylation pathway suppresses arbovirus replication in Aedes aegypti cells.
Published 2020-12-01“…SUMOylation is a post-translational modification that leads to the covalent attachment of the Small Ubiquitin-like MOdifier (SUMO) protein to host factors, which in turn can modulate their stability, interaction networks, sub-cellular localisation, and biochemical function. …”
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8978
Research on underwater disease target detection method of inland waterway based on deep learning
Published 2025-04-01“…Then, EIoU is used as the frame loss function to speed up the network convergence rate and solve the problem of difficult and easy sample imbalance. …”
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8979
Understanding crosstalk between the gut and liver microbiome: pathogenesis to therapeutic approaches in liver cancer
Published 2025-07-01“…Perturbations in gut barrier function and Toll-like receptor 4 (TLR4) activation drive chronic inflammation, promoting tumor progression. …”
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8980
FPGA-Based Synchronization of Frequency-Domain Interferometer for QKD
Published 2025-01-01“…We derive mathematical expressions for sideband power as a function of the phase difference between RF signals at transmitter and receiver. …”
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