Erythropoiesis and Iron Sulfur Cluster Biogenesis by Hong Ye, Tracey A. Rouault

“…GLRX5 is involved in the production and ABCB7 in the export of an unknown factor that may function as a gauge of mitochondrial iron status, which may indirectly modulate activity of iron regulatory proteins (IRPs). …”
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FOOD SECURITY AND INCOME DIVERSIFICATION NEXUS: USDA APPROACH by Kazeem Oriyomi ABOABA, Akeem Adesina AKAMO, Damilare Michael FADIJI, Tohib Oyeyode OBALOLA

“…The result of the information function revealed that the scale is adaptable for this study. …”
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An acidic microenvironment in Tuberculosis increases extracellular matrix degradation by regulating macrophage inflammatory responses. by Ashley M Whittington, Frances S Turner, Friedrich Baark, Sam Templeman, Daniela E Kirwan, Candice Roufosse, Nitya Krishnan, Brian D Robertson, Deborah L W Chong, Joanna C Porter, Robert H Gilman, Jon S Friedland

“…Collectively, our findings show that an acidic microenvironment modulates immune function to reduce protective inflammatory responses and increase extracellular matrix degradation in Tuberculosis. …”
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Root remodeling mechanisms and salt tolerance trade-offs: The roles of HKT1, TMAC2, and TIP2;2 in Arabidopsis. by Nouf O Alshareef, Vanessa J Melino, Noha Saber, Annamaria De Rosa, Elodie Rey, Jian You Wang, Salim AlBabili, Caitlin Byrt, Mark A Tester, Magdalena M Julkowska

“…We identified TMAC2, a negative ABA regulator, and TIP2:2, a tonoplast aquaporin, as key modulators of root development under salt stress. While TIP2:2 function was conserved, TMAC2 exhibited genotype-specific effects on ABA accumulation and HKT1-mediated salt sensitivity. …”
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Advances in gut-lung axis research: clinical perspectives on pneumonia prevention and treatment by Fang Ye, Linnan Li, Jiao Wang, Hongfeng Yang

“…Furthermore, gut microbial communities have significant impacts on metabolic function and immune responses. Their metabolites not only regulate gastrointestinal immune systems but may also affect distant organs such as the lungs and brain. …”
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Tissue-specific roles of regulatory T cells: mechanisms of suppression and beyond along with emerging therapeutic insights in autoimmune indications by Bat-Erdene Jugder, Eunchong Park, Lijuan Du, Lijuan Du, Chetan Jawale, Nikolay Popov, Zengli Guo, Zengli Guo, Kyle J. Bednar, Tatiana Ort

“…This review delves into the multifaceted, tissue-specific mechanisms of Tregs, highlighting their roles in tissue repair, inflammatory modulation, and tolerance maintenance. We explore the developmental, functional, and metabolic pathways that drive Treg specialization across distinct organs, such as the central nervous system, gastrointestinal tract, joints, skin, and lungs, and examine how these insights advance the design of novel, targeted therapies for autoimmune and inflammatory disorders. …”
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YBX1: A Multifunctional Protein in Senescence and Immune Regulation by Wenze Zhang, Ying Liu, Zhe Zhao, Yizhi Zhang, Yujuan Liang, Wanxia Wang

“…It plays a crucial role in immune modulation, senescence, and disease progression. This review presents a comprehensive analysis of the specific functions and mechanisms of YBX1 in these areas. …”
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Gpr35 Expression Mitigates Neuroinflammation and Enriches Gut Lactobacillus to Relieve Parkinson’s Disease by Tianyu Meng, Yufei Zhang, Shoupeng Fu, Shaohua Ma

“…Parkinson’s disease (PD) is associated with gut–brain axis and gut microbiota alterations, but the functioning mechanism remains to be elucidated. In this study, we identified G protein-coupled receptor 35 (Gpr35) as a key regulator for the gut–brain association under the PD context. …”
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Hippocampal Viral-Mediated Urokinase Plasminogen Activator (uPA) Overexpression Mitigates Stress-Induced Anxiety and Depression in Rats by Increasing Brain-Derived Neurotrophic Fac... by Amine Bahi, Jean-Luc Dreyer

“…Emerging evidence suggests the serine protease, urokinase plasminogen activator (uPA), may play an important role in the modulation of mood and cognitive functions. Also, preliminary evidence indicates that uPA modulates BDNF activity that is known to be involved in the pathogenesis of mood disorders. …”
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Characterization of Human Cytomegalovirus (HCMV) Long Non-Coding RNA1.2 During Lytic Replication by Salomé Manska, Andrew Hagemann, Janna Magana, Cyprian C. Rossetto, Subhash C. Verma

“…Viral lncRNAs can have a variety of functions, some of which are necessary for viral production and the modulation of host processes during infection. …”
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IFI16 Mediates Deacetylation of KSHV Chromatin via Interaction with NuRD and Sin3A Co-Repressor Complexes by Anandita Ghosh, Bala Chandran, Arunava Roy

“…Our study expands the known functions of IFI16 and identifies a novel epigenetic mechanism by which it modulates herpesviral chromatin states.…”
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Remodeling of the chromatin landscape in peripheral blood cells in patients with severe Delta COVID-19 by Vasiliy E. Akimov, Dmitriy I. Tychinin, Olga A. Antonova, Abusaid M. Shaymardanov, Maria D. Voronina, Kseniia A. Deinichenko, Oleg D. Fateev, Vladimir S. Yudin, Sergey M. Yudin, Vladimir E. Mukhin, Svetlana V. Romanova, Aleksandra I. Nekrasova, Anastasia S. Zhdanova, Anastasia V. Tsypkina, Ivan S. Vladimirov, Antonida V. Makhotenko, Anton A. Keskinov, Sergey A. Kraevoy, Ekaterina A. Snigir, Dmitry V. Svetlichnyy, Veronika I. Skvortsova

“…COVID-19 is characterized by systemic pro-inflammatory shifts with the development of serious alterations in the functioning of the immune system. Investigations of the gene expression changes accompanying the infection state provide insight into the molecular and cellular processes depending on the sickness severity and virus variants. …”
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FACE-Q Head and Neck Cancer Questionnaire for Brazilian Portuguese: Translation, Cross-Cultural Adaptation, and Linguistic Validation by Vitor Penteado Figueiredo Pagotto, Rodolfo Costa Lobato, Adriana Margarita Buelvas Bustillo, Cristiane Pereira Lopes, Rafael Mamoru Carneiro Tutihashi, Fábio de Freitas Busnardo, Rolf Gemperli

“…This difficulty in assessing the success of treatment led to the development of the FACE-Q Head and Neck Cancer Module, a questionnaire of patient-reported outcomes that measure the appearance, facial function, quality of life, and experience of care to head and neck neoplasms. …”
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FAK inhibition disrupts tumor growth, apoptosis, and transcriptional regulation in GI-NETs by Lara Toffoli, Angeliki Ditsiou, Luca Triboli, Victorine Hamm, Eva Moschioni, Francesca D’Este, Teresa Gagliano

“…Methods: Human GI-NET cell lines (GOT1 and COLO320DM) were treated with Y15, a kinase inhibitor, and PROTAC-FAK (BI-0319), a degrader that abrogates both enzymatic and scaffold functions. siRNA-mediated knockdown of FAK was employed for functional validation. …”
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Integration of active ingredients from traditional Chinese medicine with nano-delivery systems for tumor immunotherapy by Hao Zheng, Yiquan Chen, Wei Luo, Shiqi Han, Mengjuan Sun, Min Lin, Chenghan Wu, Lili Gao, Tian Xie, Na Kong

“…The active ingredients of traditional Chinese medicine (TCM) demonstrate a variety of anti-tumor activities and mechanisms, including the modulation of immune cell functions and inhibiting tumor-related suppressive factors, thereby potentially enhancing anti-tumor immune responses. …”
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Surface Engineering‐Induced d‐Band Center Down‐Regulation in High‐Entropy Alloy Nanowires for Enhanced Nanozyme Catalysis by Kunyang Feng, Hanting Wang, Song Zhou, Wei Zhang, Chonghai Gong, Yuxin He, Yusen Wang, Wenchong Dai, Jianbo Li, Zhengwei Zhang, Siqiao Li

“…However, precisely modulating the enzyme‐like activity of HEAs and enhancing their biocompatibility for biological applications remain severely challenging. …”
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Use of Drosophila as an Evaluation Method Reveals imp as a Candidate Gene for Type 2 Diabetes in Rat Locus Niddm22 by Kurenai Kawasaki, Sawaka Yamada, Koki Ogata, Yumiko Saito, Aiko Takahama, Takahisa Yamada, Kozo Matsumoto, Hiroyuki Kose

“…Here we utilized Drosophila melanogaster as a secondary model organism for functional evaluation of the candidate gene. We demonstrate that the tissue specific knockdown of a homologue of igf2bp2 RNA binding protein leads to increased sugar levels similar to that found in the OLETF rat. …”
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The positive implication of natural antioxidants on oxidative stress-mediated diabetes mellitus complications by Shouvik Mallik, Bijoy Paria, Sayed Mohammad Firdous, Hesham S. Ghazzawy, Nashi K. Alqahtani, Yong He, Xiaoli Li, Mostafa M. Gouda

“…Therefore, the current review addresses the important role of natural functional antioxidants in DM management and its association with its OS complications.…”
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Tuning Isomerism Effect in Organic Bulk Additives Enables Efficient and Stable Perovskite Solar Cells by Qi Zhang, Qiangqiang Zhao, Han Wang, Yiguo Yao, Lei Li, Yulin Wei, Ruida Xu, Chenyang Zhang, Erik O. Shalenov, Yongguang Tu, Kai Wang, Mingjia Xiao

“…Highlights By anchoring the perovskite sites with the functional groups of CzBP (P = O···Pb, N–H···I and P = O···N–H), the bulk nonradiative recombination is suppressed and ion migration is inhibited. …”
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Primary auditory thalamus relays directly to cortical layer 1 interneurons by Lucas G. Vattino, Christine Junhui Liu, Cathryn P. MacGregor, Carolyn G. Sweeney, Steven Minderler, Anne E. Takesian

“…Moreover, these interneurons receive robust functional monosynaptic MGBv inputs that are comparable to those recorded in the L4 excitatory pyramidal neurons. …”
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