Pentoxifylline ameliorates carbamazepine-induced hepatotoxicity via down expression of CYP3A4 and NF-kB gene expression in the rat: in vivo study by Farah Rafie Mohammed, Yassir Mustafa Kamal Al Mulla Hummadi, Muthanna I. Al-Ezzi

“…Additionally, it exerts an anti-inflammatory impact by modulating NF-κB gene expression.…”
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Emerging approaches for ocular surface and corneal stromal regeneration: Recent advances and future perspectives by Rashmi Deshmukh, Vineet Joshi, Vivek Singh, Sayan Basu

“…Cell-based therapies, including cultivated limbal epithelial and mesenchymal stem cell treatments, aim to restore corneal function through the modulation of native cell behavior. …”
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Robust DOA Estimation via a Deep Learning Framework with Joint Spatial–Temporal Information Fusion by Yonghong Zhao, Xiumei Fan, Jisong Liu

“…Furthermore, a customized FD loss function, combining Focal Loss and Dice Loss, is introduced to emphasize low-confidence samples and promote sparsity in the spatial spectrum, thereby improving the precision and overall effectiveness of DOA estimation. …”
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Evolutionary computation for bottom-up hypothesis generation on emotion and communication by Casper Hesp, Bram T. Heerebout, R. Hans Phaf

“…An adaptive communicative function evolved, as shown by fitness benefits relative to (1) a non-communicative reference simulation and (2) lesioning of the connections used for communication. …”
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Recruitment to the nuclear periphery can alter expression of genes in human cells. by Lee E Finlan, Duncan Sproul, Inga Thomson, Shelagh Boyle, Elizabeth Kerr, Paul Perry, Bauke Ylstra, Jonathan R Chubb, Wendy A Bickmore

“…However, a crucial issue is whether this level of nuclear organisation directly affects gene function, rather than merely reflecting it. To directly investigate whether proximity to the nuclear periphery can influence gene expression in mammalian cells, here we relocate specific human chromosomes to the nuclear periphery by tethering them to a protein of the inner nuclear membrane. …”
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Contour wavelet diffusion – a fast and high-quality facial expression generation model by Chenwei Xu, Yuntao Zou

“…We also include a reconstruction loss function to enhance convergence speed. Experimental results demonstrate the effectiveness of our approach in boosting the training and inference speeds of diffusion models without sacrificing image quality. …”
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Safeguarding accuracy for CT imaging with industrial robots: Efficient calibration methods for arbitrary trajectories by Anton Weiss, Simon Wittl, Gabriel Herl, Simon Zabler, Anna Trauth, Markus G. R. Sause

“…Image quality metrics such as the Modulation Transfer Function, Shannon entropy and Tenengrad variance are utilized to evaluate and compare the reconstruction quality of the various correction and calibration approaches. …”
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Causal relationship among immune cells, basal cell carcinoma, and gut microbiome: a two-sample Mendelian randomization analysis and mediation analysis by Hequn Li, Liang Chen

“…Moreover, the MR demonstrated that CD33-HLA DR-AC (− 0.015, 95% CI − 0.144, 0.115) mediated a portion of the causative function of p_Firmicutes.c_Clostridia on BCC, it represented − 8.92% of the total effect. …”
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Real-time Detection and Tracking for Operating Vehicles in Complex Mining Environments by KANG Gaoqiang, LIN Jun, LIU Shiwang, YUE Wei, XIONG Qunfang, TONG Hao

“…The model framework is constructed based on the lightweight backbone network YOLO combined with the multi-scale feature fusion module. The model uses DIoU as loss function, uses <italic>K</italic>-means clustering to regress the size of candidate frame, and learns image features through the lightweight backbone network. …”
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P75 | MICROBIOTA-GUT-BRAIN AXIS IN AN AUTISM SPECTRUM DISORDER ANIMAL MODEL

“…There is increasing evidence that supports the interaction between gut microbiota and brain development and function, contributing to define the concept of the “microbiota-gutbrain axis”1-3. …”
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Design and Analysis of Backplane Mechanism for New Nursing Bed Chair by Zhongren Zhou, Chengtao Yu, Xiangyu Zhou, Xuebin Sun

“…A serial backplane spatial combination mechanism is formed by connecting multiple mechanisms with single function，and its spatial freedom is analyzed to meet the motion demand. …”
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PROSPECTS FOR ANTI-B-CELL THERAPY IN RHEUMATOLOGY by E. L. Nasonov

“…Its efficiency is determined by various mechanisms, such as suppression of pathogenic autoantibody synthesis; modulation of the function of B-cells (antigen presentation, cytokine synthesis, and costimulation), T-lymphocytes and dendritic cells. …”
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Ultrasound-Guided Stellate Ganglion Block Combined with Pharmacological Treatment for Rosacea: A Report of Two Cases by Gao C, Wang F, Zhou L, Zhan W, Min R

“…The stellate ganglion block (SGB) technique can restore balance to autonomic nervous function by interrupting the impulse conduction of preganglionic and postganglionic sympathetic nerve fibers, thereby alleviating excessive peripheral blood vessel contraction, enhancing tissue blood supply, balancing hormone secretion, and modulating immune responses. …”
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Chronic Persistent Asthma: A Review of Medicines in the Step-Up Approach by Elvis Irusen

“…With this therapeutic armamentarium the practitioner should aim to achieve the goals of asthma therapy that are focused on clinical and lung function parameters. The concept of complete asthma control is the current benchmark. …”
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In human monocyte derived dendritic cells SOCS1 interacting with CYTIP induces the degradation of CYTIP by the proteasome. by Daniela Grabher, Susanne Hofer, Daniela Ortner, Christine Heufler

“…We here describe a newly identified binding partner of CYTIP, SOCS-1, and confirm its function in regulating the degradation of CYTIP by the proteasome.…”
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An agent-based model of signal transduction in bacterial chemotaxis. by Jameson Miller, Miles Parker, Robert B Bourret, Morgan C Giddings

“…We present the Chemoscape model: a collection of agents representing both fixed membrane-embedded and mobile cytoplasmic proteins, each governed by a set of rules representing knowledge or hypotheses about their function. When the agents were placed in a simulated cellular space and then allowed to move and interact stochastically, the model exhibited many properties similar to the biological system including adaptation, high signal gain, and wide dynamic range. …”
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Ferroptosis in ocular diseases: mechanisms, crosstalk with other cell death pathways, and therapeutic prospects by Shuai Huang, Yuying Sun, Xinxin Yu, Xuan Ren, Lei Wang, Yan Sun, Aijun Deng

“…Such aberrant ferritin deposits not only compromise the structure and function of ocular cells but also accelerate disease progression. …”
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The role of acetylation and deacetylation in cancer metabolism by Cuicui Wang, Xiaoxin Ma

“…These modifications influence signalling pathways critical for tumour metabolism. They modulate the activity of transcription factors that drive gene expression changes. …”
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Tiny but Mighty: Small RNAs—The Micromanagers of Bacterial Survival, Virulence, and Host–Pathogen Interactions by Rajdeep Banerjee

“…While the role of transcription factors in bacterial virulence is well documented, emerging evidence highlights the significant contribution of small regulatory RNAs (sRNAs) in bacterial pathogenesis. These sRNAs function as posttranscriptional regulators that fine-tune gene expression, enabling bacteria to adapt rapidly to challenging environments. …”
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SEC14-like condensate phase transitions at plasma membranes regulate root growth in Arabidopsis. by Chen Liu, Andriani Mentzelopoulou, Fotini Papagavriil, Prashanth Ramachandran, Artemis Perraki, Lucas Claus, Sebastian Barg, Peter Dörmann, Yvon Jaillais, Philipp Johnen, Eugenia Russinova, Electra Gizeli, Gabriel Schaaf, Panagiotis Nikolaou Moschou

“…Protein function can be modulated by phase transitions in their material properties, which can range from liquid- to solid-like; yet, the mechanisms that drive these transitions and whether they are important for physiology are still unknown. …”
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