Stanniocalcin-1: A Novel Mediator in Diabetic Kidney Disease and Cardiovascular Disease by Souradip Mookerjee, Guy Whitley, Debasish Banerjee

“…Cardiovascular complications are a major cause of mortality for these patients.Stanniocalcin (STC), originally identified in bony fish as a hormone regulating calcium levels, has since been found in mammals, including humans. In fish, STC functions as an antihypercalcemic factor. Mammals possess 2 STC orthologues, STC-1 and STC-2, with STC-1 demonstrating significant sequence and functional conservation across species. …”
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The role of gut microbiota at different developmental stages in the adaptation of the Etiella zinckenella to a plant host by Liangyue Chen, Zeshuai He, Dazhi Zhang, Fuqiang Zhao, Yuan Zhang, Rongrong Ding

“…Notably, carbohydrate metabolism functions were significantly more abundant during the larval stage, while lipid metabolism functions were substantially lower. …”
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Dysphagia, Voice Problems and Health Related Quality of Life Among Head and Neck Cancer Survivors by Vaishali Sharma, Jisa George T, R Velmurugan, Rajesh Pasricha

“…The overall QOL mean (SD) score was high in cognitive functioning 80.76 (22.19) and role functioning 80.30 (25.54) of the functional domain. …”
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Target detection technology of coal mine wheeled robot combining improved CNN and self attention mechanism by Junfei TANG, Hailong XING, Su LI, Taotao ZHANG, Heng LIU, Shiyu YAO

“…On this basis, the bidirectional feature pyramid network module is designed to further strengthen the feature extraction function. …”
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Regulatory T Lymphocytes in Periodontitis: A Translational View by Carla Alvarez, Carolina Rojas, Leticia Rojas, Emilio A. Cafferata, Gustavo Monasterio, Rolando Vernal

“…Certainly, as our knowledge of Treg biology increases, we will be capable to develop new therapies designed to enhance the stability and function of Tregs during periodontitis.…”
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Target neutrophil heterogeneity and plasticity in cancer by Ye Feng, Guang Liu, Haiqing Li, Lin Cheng

“…Finally, future research directions are proposed to further elucidate the mechanisms underlying neutrophil heterogeneity and plasticity, with the aim of developing novel therapeutic approaches to modulate neutrophil function in cancer.…”
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γδ T cells in hematological malignancies: mechanisms and therapeutic strategies by Xingchi Chen, Guangyu Sun, Xiaoyu Zhu

“…In this review, we summarize the current knowledge on γδ T cell biology and function in hematological malignancies and HSCT complications. …”
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THE RELATIONSHIP BETWEEN COGNITIVE IMPAIRMENT AND THE LEVEL OF BDNF IN YOUNG PEOPLE by Надежда Павловна Белоусова, Ольга Алексеевна Громова, Евгений Геннадьевич Пепеляев, Анатолий Васильевич Субботин, Владимир Александрович Семенов

“…The aim of the study is to study the quantitative content of the cerebral neurotrophic factor of human blood serum (BDNF) and its effect on cognitive function in young people. The material of the study was the results of psychological testing of two groups of persons (19-27 years and 41-60 years), data on the level of BDNF in the sera of the interviewed. …”
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MetaFlowTrain: a highly parallelized and modular fluidic system for studying exometabolite-mediated inter-organismal interactions by Guillaume Chesneau, Johannes Herpell, Sarah Marie Wolf, Silvina Perin, Stéphane Hacquard

“…Abstract Metabolic fluxes between cells, organisms, or communities drive ecosystem assembly and functioning and explain higher-level biological organization. …”
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Research progress on the association between periodontitis and inflammatory bowel disease by SHEN Yue, QIAN Jun, YAN Fuhua

“…There are significant differences between the salivary microbiota of periodontitis patients and healthy individuals, and periodontal pathogens can enter the intestinal tract with saliva and participate in the development of IBD by influencing the interactions between gut microbiota composition, immune responses, metabolite production, and intestinal barrier function. Current gut microbiota-targeted intervention strategies, such as fecal microbiota transplantation (FMT) and probiotic supplementation, have shown potential therapeutic value in the treatment of periodontitis. …”
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Design and Ground Verification of Space Station Manipulator Control Method for Orbital Replacement Unit Changeout by Bingshan Hu, Feng Chen, Liangliang Han, Huanlong Chen, Hongliu Yu

“…To verify the ORU changeout task flow and corresponding control algorithms, a ground experiment platform is designed, which includes a 6-DOF manipulator with a camera and a force/torque sensor, an end effector with clamp/release and screwing function, ORU module, and ORU store. At last, the task flow and control algorithms are verified on the test platform. …”
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Redox Biology and Insulin-like Growth Factor-Binding Protein-6: A Potential Relationship by Anna Rita Daniela Coda, Arcangelo Liso, Francesco Bellanti

“…These IGF-independent actions involve interactions with redox-sensitive signaling pathways that influence mitochondrial metabolism, neutrophil function, and fibroblast activity, all of which are central to redox-dependent processes in inflammation and fibrosis. …”
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A Combined Diffusion Model and Reinforcement Learning Approach for Solving the Vehicle Routing Problem With Multiple Soft Time Windows by Yu Qiao, Jianjun Miao, Xiaoying Huang

“…Subsequently, the RL module fine-tunes these paths by optimizing the objective function, which minimizes the number of vehicles, travel distance, and time window penalties. …”
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Research Advances in Targeting the YAP/TAZ Signaling Pathway 
to Improve Cancer Immunotherapy by Pingxu ZHANG, Yiyi ZHAN

“…They directly regulate the expression of immune checkpoints, mediate the formation of an immunosuppressive microenvironment, inhibit T cell function, and interact with other signaling pathways to promote immune escape. …”
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Alzheimer's Disease: Another Target for Heparin Therapy by Luigi Bergamaschini, Emanuela Rossi, Carlo Vergani, Maria Grazia De Simoni

“…AD is also accompanied by an inflammatory response that contributes to irreversible changes in neuronal viability and brain function, and accumulating evidence supports the pivotal role of complement and contact systems in its pathogenesis and progression. …”
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Boosting energy metabolism and biosynthesis in diverse organisms by a common bacterial salvage lipoylation protein by Runqing Yang, Yingying Wang, Minghua Kong, Zhijuan Hu, Zhe Zhang, Kun Shen, Jiali Meng, An-Ping Zeng

“…By expressing E. coli-derived lipoate protein ligase A (LplA) from the salvage pathway, we enhance lipoylation and the activities of the pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase complexes and glycine cleavage system in mammalian, algal and fungal cells, leading to improved energy metabolism, cofactor supply, mitochondrial function, and overall cell physiology. Our approach specifically targets multiple metabolic hubs through PTM modulation. …”
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Energy landscape of a Kv channel revealed by temperature steps while perturbing its electromechanical coupling by Bernardo I. Pinto-Anwandter, Carlos A. Z. Bassetto, Ramon Latorre, Francisco Bezanilla

“…Understanding these transitions helps us comprehend their molecular function. Here, we used sudden and sustained temperature changes (Tstep) combined with different voltage protocols and mutations to dissect the energy landscape of the Shaker K+ channel. …”
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The Different Effects of Atorvastatin and Pravastatin on Cell Death and PARP Activity in Pancreatic NIT-1 Cells by Ya-Hui Chen, Yi-Chun Chen, Chin-San Liu, Ming-Chia Hsieh

“…The objective of this study was to elucidate the signaling pathway and biological function between necrosis and autophagy induced by atorvastatin (AS) and pravastatin (PS). …”
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Exploring the Impact of Imaging Resolution and Sharpness on Dermatological Diagnostics Using eSFR Measurements by Bogdan Dugonik, Marjan Golob

“…Captured images were analysed, and the modulation transfer function (MTF) was defined to evaluate the performance of different camera optical systems applied for dermatological imaging. …”
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Multiyear Measurements of the Aerosol Absorption Coefficient Near the Surface in a Small-Sized Urban Area in Portugal by Sérgio Nepomuceno Pereira, Frank Wagner, Ana Maria Silva

“…Also, a strong negative correlation between the aerosol absorption coefficient and the wind speed was verified, and an exponential decay function was found to fit very well to the data. The wind direction seems to be not correlated with the aerosol absorption coefficient.…”
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