Paralanguage as a tool for shaping stress response in Listeners: Multimodal physiological sensing study by Marina Saskovets, Mykhailo Lohachov, Zilu Liang

“…Prefrontal cortex (PFC) hemodynamic activity was recorded using functional near-infrared spectroscopy (fNIRS), while stress biomarkers, including salivary cortisol and electrodermal activity (EDA), were measured at multiple time points. …”
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Characterizing temporal and global host innate immune responses against SARS-CoV-1 and -2 infection in pathologically relevant human lung epithelial cells. by Vivian Y Tat, Aleksandra K Drelich, Pinghan Huang, Kamil Khanipov, Jason C Hsu, Steven G Widen, Chien-Te Kent Tseng, George Golovko

“…Total RNA extracted at 12, 24, and 48 hours after β-CoVs or mock infection of Calu-3/2B4 cells were subjected to RNA sequencing and functional enrichment analysis to select genes whose expressions were significantly modulated post-infection. …”
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The kinase NEK6 positively regulates LSD1 activity and accumulation in local chromatin sub-compartments by Franziska Knodel, Jürgen Eirich, Sabine Pinter, Stephan A. Eisler, Iris Finkemeier, Philipp Rathert

“…This suggest that phase separation is crucial for the regulatory function of LSD1 and our findings highlight the role of NEK6 in modulating LSD1 activity and phase separation, expanding our understanding of LSD1 regulation and its implications in cellular processes.…”
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Increasing spatial working memory in mice with Akkermansia muciniphila by Ji-Seon Ahn, Sura Kim, Eui-Jeong Han, Seong-Tshool Hong, Hea-Jong Chung

“…Abstract Recent research has shown the gut microbiome’s impact on memory, yet limitations hinder the identification of specific microbes linked to cognitive function. We measured spatial working memory in individual mice before and after fecal microbiota transplantation (FMT) to develop a targeted analysis that identifies memory-associated strains while minimizing host genetic effects. …”
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Causal relationships between inflammatory mediators, sleep traits, and cardiac magnetic resonance imaging-derived cardiac phenotypes by Shuhui Cao, Hongjie Xu, Yangfeng Tang, Zhiyun Xu, Shangyi Yu

“…This research highlights crucial cytokines and chemokines that modulate cardiac function through their relationships with cardiovascular phenotypes.…”
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The immunological perspective of major depressive disorder: unveiling the interactions between central and peripheral immune mechanisms by Wenli Jiao, Jiayi Lin, Yanfang Deng, Yelin Ji, Chuoyi Liang, Sijia Wei, Xi Jing, Fengxia Yan

“…Peripherally, systemic inflammation, gut immune dysregulation, and immune dysfunction in organs including gut, liver, spleen and adipose tissue influence brain function through neural and molecular pathways. Within the central nervous system, aberrant microglial and astrocytes activation, cytokine imbalances, and compromised blood-brain barrier integrity propagate neuroinflammation, disrupting neurotransmission, impairing neuroplasticity, and promoting neuronal injury. …”
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The roles of Cryptochrome-1: the circadian clock as a control point in cancer therapy by Yijia Liu, Yanzhe Huang, Hongliang Luo, Xueqin Lin

“…We propose that its function represents a novel therapeutic target that could pave the way for new cancer treatments. …”
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YOLO11m-SCFPose: An Improved Detection Framework for Keypoint Extraction in Cucumber Fruit Phenotyping by Huijiao Yu, Xuehui Zhang, Jun Yan, Xianyong Meng

“…The Focaler-IoU loss function is employed to improve keypoint localization accuracy. …”
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A consensus definition for deep layer 6 excitatory neurons in mouse somatosensory, visual, and motor cortex by Su-Jeong Kim, Travis A. Babola, Kiwoong Lee, Alina C. Spiegel, Kihwan Lee, Chanel J. Matney, Michael H. Liew, Eva M. Schulteis, Austin E. Coye, Mikhail Proskurin, Hyunwook Kang, Julia A. Kim, Maxime Chevée, Juhyun Lee, Alec G. Cabalinan, Seong Yeol An, Samuel P. Bronckers, Patrick O. Kanold, Loyal A. Goff, Juhyun Kim, Solange P. Brown

“…Summary: To understand neocortical function, it is helpful to define cortical cell types. …”
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Effect of Extracellular Vesicles Derived From Tumor Cells on Immune Evasion by Xuanfan Liu, Kenneth K.W. To, Qinsong Zeng, Liwu Fu

“…Second, how tumor cells modulate immune cell differentiation, activation, and function via TEVs to evade immune surveillance is illustrated. …”
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When Cells Suffocate: Autophagy in Cancer and Immune Cells under Low Oxygen by Katrin Schlie, Jaeline E. Spowart, Luke R. K. Hughson, Katelin N. Townsend, Julian J. Lum

“…In light of the fact that autophagy is crucial for immune cell proliferation as well as their effector functions such as antigen presentation and T cell-mediated killing of tumor cells, anticancer treatment strategies based on autophagy modulation will need to consider the impact of autophagy on the immune system.…”
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SIRPα blockade therapy potentiates immunotherapy by inhibiting PD-L1+ myeloid cells in hepatocellular carcinoma by Da Huang, Min Xu, Hui Wang, Yufei Zhao, Zihao Zhang, Mincheng Yu, Mingqin Zhou, Jingying Pan, Hong Zeng, Zichuan Yu, Qiang Yu, Mengyuan Wu, Wenxin Xu, Binghai Zhou, Bo Zhang, Hui Li, Lei Guo, Peiyi Xie

“…We found that anti-SIRPα inhibited immunosuppressive function, migration and PD-L1 expression of myeloid cells. …”
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Application of bifidobacterium in tumor therapy by Yinwu Kong, Han Bai, Feifei Deng, Yaomin Zhao, Qianyan Li, Li Chang

“…Recent advancements in synthetic biology and bacterial engineering have enabled the modification of Bifidobacterium as a microrobot for molecular imaging, drug or gene delivery, and other therapeutic functions. Compared to nanomaterials, Bifidobacterium-based bacterial therapy holds promise in overcoming certain limitations while potentially enhancing comprehensive cancer treatment by modulating the tumor microenvironment and boosting host immune responses. …”
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Macrophage Heterogeneity and Plasticity: Impact of Macrophage Biomarkers on Atherosclerosis by Joselyn Rojas, Juan Salazar, María Sofía Martínez, Jim Palmar, Jordan Bautista, Mervin Chávez-Castillo, Alexis Gómez, Valmore Bermúdez

“…Indeed, monocytes may develop heterogeneous functional phenotypes depending on the predominating pro- or anti-inflammatory microenvironment within the lesion, resulting in classic, intermediate, and non-classic monocytes, each with strikingly differing features. …”
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Lab-on-device investigation of phase transition in MoOx semiconductors by Xiaoci Liang, Dongyue Su, Younian Tang, Bin Xi, Chunzhen Yang, Huixin Xiu, Jialiang Wang, Chuan Liu, Mengye Wang, Yang Chai

“…Here, we develop a lab-on-device system for molybdenum oxide to probe operando hydrogenation mechanisms through in situ electrical and spectral characterization with density functional theory calculations, revealing threshold-driven proton dynamics that govern the transition between nonvolatile memory operation and catalytic hydrogen evolution. …”
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Cepharanthine hydrochloride: a novel ferroptosis-inducing agent for prostate cancer treatment by Jing-Song Guan, Jing Jia, Ze-Xiu Huang, Yu-Qing Zhou, Jing-Jie Zheng, Qi-Man Lin, Yi-Fei Wang, Jiang-Lin Fan, Yao Wang, Yao Wang

“…The drug cepharanthine, commonly used to treat leukopenia, has been discovered to function as an anticancer agent to multiple types of cancer via diverse mechanisms. …”
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The Bidirectional Interplay Between Substances of Abuse and Gut Microbiome Homeostasis by Alejandro Borrego-Ruiz, Juan J. Borrego

“…Specific gut microorganisms and their metabolic by-products have been identified as key regulators of host physiology, contributing to the modulation of the immune system, inflammatory processes, brain function, and behavior, which highlights the gut microbiome as a potential modulator of the neurobiological mechanisms involved in substance use disorders. …”
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Facial recognition targeted attack algorithm based on multiscale frequency decomposition and meta-learning by CAI Jun, HUANG Tianqiang, ZHENG Aokun, YE Feng, XU Chao

“…During this process, a meta-learning attack module was introduced to calculate the loss function and update parameters. …”
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SDA-YOLO: An Object Detection Method for Peach Fruits in Complex Orchard Environments by Xudong Lin, Dehao Liao, Zhiguo Du, Bin Wen, Zhihui Wu, Xianzhi Tu

“…First, in the backbone network, the LSKA module is embedded into the SPPF module to construct an SPPF-LSKA fusion module, enhancing multi-scale feature representation for peach targets. …”
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CSCA-YOLOv8: A lightweight network model for evaluating drought resistance in mung bean. by Dongshan Jiang, Jinyang Liu, Haomiao Zhang, Wenxiang Liang, Ziqiu Luo, Wenlong An, Shicong Li, Xin Chen, Xingxing Yuan, Shangbing Gao

“…Finally, the SIoU loss function is used to replace CIoU to accelerate the convergence of the model. …”
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