The molecular etiology and treatment of glucocorticoid-induced osteoporosis by Cheng-Huan Peng, Wen-Ying Lin, Kuang-Ting Yeh, Ing-Ho Chen, Wen-Tien Wu, Ming-Der Lin

“…When bone formation and resorption are out of balance, abnormalities in bone structure or function may occur. Excess glucocorticoids disrupt the bone homeostasis by promoting osteoclast formation and prolonging osteoclasts' lifespan, leading to an increase in bone resorption. …”
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Liquid metal-based stretchable bioelectronic fiber for electrical stimulation and drug delivery in minimally invasive cardiac therapy by Chanhui Park, Yesol Kim, Seonghyeon Nam, Hyejeong Kang, Joonho Moon, Ji Hoon Kim, Gi doo Cha, Seung-Pyo Lee, Sung-Hyuk Sunwoo, Dae-Hyeong Kim

“…In this regard, a soft implantable device has been considered for cardiac applications, but invasiveness in their implantation procedure and difficulty in compact integration of multiple functions are unmet challenges. To address these issues, we develop a stretchable, multi-functional fiber designed for emergent cardiac intervention, offering electrogram recording, electrical modulation, and drug therapy directly at the epicardial surface. …”
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The NR_109/FUBP1/c-Myc axis regulates TAM polarization and remodels the tumor microenvironment to promote cancer development by Baoen Shan, Cong Zhang, Guogui Sun, Hongtao Zhang, Xiaoya Li, Sisi Wei, Suli Dai, Huixia Wang, Lianmei Zhao

“…Among those differentially expressed lncRNAs, NR_109 was further studied, for its function in M2-like macrophage polarization and the effects of the condition medium or macrophages mediated by NR_109 on tumor proliferation, metastasis and TME remodeling both in vitro and in vivo. …”
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Investigating SMYD3 role during oocyte maturation in a 3D follicle-enclosed oocyte in vitro model in sheep by Chiara Camerano Spelta Rapini, Alessia Peserico, Chiara Di Berardino, Giulia Capacchietti, Camila Rojo-Fleming, Andrada-Ioana Damian-Buda, Irem Unalan, Aldo Roberto Boccaccini, Valentina Grossi, Mauro Mattioli, Barbara Barboni

“…Despite its established involvement in somatic cell function and oncogenesis, its role in mammalian oogenesis and early embryonic development remains unclear. …”
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The effects of dopamine receptor 1 and 2 agonists and antagonists on sexual and aggressive behaviors in male green anoles. by Alexandra N Smith, David Kabelik

“…However, the D1 agonist treatment was also found to impair motor function, suggesting that those effects were likely nonspecific. …”
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The Expanding Role of GLP-1 Receptor Agonists: Advancing Clinical Outcomes in Metabolic and Mental Health by Mohamad Al Qassab, Mohammad Mneimneh, Ahmad Jradi, Bassem Derbas, Dana Dabboussi, Justine Khoury Baini, Nadia Katrib, Nadim Chaarani, Philippe Attieh, Amjad Kanaan, Frederic Harb, Sami Azar, Hilda E. Ghadieh

“…Furthermore, they promote natriuresis and stabilize renal function. Moreover, GLP-1 RAs present significant cardiovascular benefits, including improved myocardial function, reduced atherosclerosis progression, enhanced endothelial health, and decreased major adverse cardiovascular events (MACEs). …”
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Facial Expression Recognition with Multi-perspective Feature Fusion Under Deep Residual Convolution by GUAN Xiaorui, GAO Lu, SONG Wenbo, LIN Kezheng

“…Then use the RReLu activation function to replace the original ReLu to avoid deactivation of some nodes when the gradient is large.Finally, the global average pooling layer is used instead of the fully connected layer to achieve dimensionality reduction, and the generated feature vector is sent to Softmax for classification Experiments show that the proposed method produces excellent results on the CK+ and RaFD datasets, which can effectively improve the accuracy of facial expression recognition.…”
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Machine learning algorithms can predict emotional valence across ungulate vocalizations by Romain A. Lefèvre, Ciara C.R. Sypherd, Élodie F. Briefer

“…Summary: Vocalizations can vary as a function of their context of production and provide an immediate measure of an animal’s affective states. …”
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The clinical significance and potential therapeutic target of tumor-associated macrophage in non-small cell lung cancer by Jiazheng Sun, Sirui Zhou, Yalu Sun, Yulan Zeng

“…Consequently, TAM assumes a multifaceted and intricate function in the onset, progression, and therapeutic response of NSCLC, serving as a crucial focal point for comprehending the tumor microenvironment and formulating novel therapeutic methods. …”
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Viral Infection: A Potent Barrier to Transplantation Tolerance by David M. Miller, Thomas B. Thornley, Dale L. Greiner, Aldo A. Rossini

“…Many experimental approaches have been developed in animal models that permit long-term allograft survival in the absence of chronic immunosuppression. These approaches function by inducing peripheral or central tolerance to the allograft. …”
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Targeting PGK1: A New Frontier in Breast Cancer Therapy Under Hypoxic Conditions by Jiayong Cui, Shengjun Chai, Rui Liu, Guoshuang Shen

“…This review consolidates current research on the regulation of glucose metabolism and the function of PGK1 in breast cancer within hypoxic conditions. …”
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A Morphological Filtering Method Based on Particle Swarm Optimization for Railway Vehicle Bearing Fault Diagnosis by Yan Huang, Jianhui Lin, Zechao Liu, Chenguang Huang

“…The MF is a nonlinear signal processing method which can extract the modulated faulty information via reshaping the analyzed signal. …”
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Exploring the role and therapeutic potential of lipid metabolism in acute kidney injury by Xiaoyu Zhang, Wen Wu, Yiming Li, Zhiyong Peng

“…In addition to their energy-supplying function, lipids contribute to the formation of renal biomembranes and the establishment of the renal microenvironment. …”
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Liraglutide attenuates autoimmune myocarditis by inhibiting NLRP3 and NF-κb pathways by Lijuan Zhang, Lishuai Han, Yang Lu, Quanzhou Chen

“…Echocardiography showed improved left ventricular function, while immunofluorescence and RT-qPCR analyses revealed decreased T-cell and macrophage infiltration and reduced expression of pro-inflammatory cytokines. …”
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Radiation-Induced Brain Injury: Mechanistic Insights and the Promise of Gut–Brain Axis Therapies by Mengting Li, Fan Tong, Bian Wu, Xiaorong Dong

“…Adverse effects may encompass focal cerebral necrosis, cognitive function compromise, cerebrovascular pathology, spinal cord injury, and detriment to the neural fibers constituting the brachial plexus. …”
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Aircraft Bearing Fault Diagnosis Method Based on LSTM-IDRSN by Lei Wang, Kun He, Haipeng Fu, Weixing Chen

“…A fully connected layer with a SoftMax activation function is then used to classify faults in the training set. …”
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Revealing a signaling role of phytosphingosine‐1‐phosphate in yeast by L Ashley Cowart, Matthew Shotwell, Mitchell L Worley, Adam J Richards, David J Montefusco, Yusuf A Hannun, Xinghua Lu

“…This class of lipids has important functions in stress responses; however, determining which sphingolipid mediates specific events has remained encumbered by the numerous metabolic interconnections of sphingolipids, such that modulating a specific lipid of interest through manipulating metabolic enzymes causes ‘ripple effects’, which change levels of many other lipids. …”
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Understanding the complex role of exosomes in intestinal ischemia-reperfusion injury: from pathogenesis to protection by Qin Ye, Zi-Hang Yu, Liang Nie, Fei-Xiang Wang, Guo Mu, Bin Lu

“…Exosomes demonstrate multifaceted functions: they regulate cellular homeostasis through the elimination of redundant or detrimental intracellular components, function as mediators in intercellular signaling pathways, and serve as potential vectors for both diagnostic and therapeutic applications. …”
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Mechanisms of <i>Aletris spicata</i> (Thunb.) Franch. Extract in Asthma Therapy: Oxidative Stress, Inflammation, and Gut Microbiota by Jing Yang, Zhiyong Chen, Yue Zhu, Teng Chen, Ying Zhou, Zuhua Wang

“…These findings indicate that AS mitigates asthma through antioxidant effects (Nrf2/HO-1 pathway), anti-inflammatory actions (NF-κB pathway), and gut microbiota modulation. The study provides a scientific basis for developing AS as a natural anti-asthma treatment or functional food. …”
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Neuron-Glial2 (NG2) cells: A promising target for neuroinflammation-related neurodegeneration by Zaw Myo Hein, Che Mohd Nasril Che Mohd Nassir, Muhammad Danial Che Ramli, Ibrahim El-Serafi, Banthit Chetsawang

“…Methods: This narrative review synthesizes current literature on the molecular and functional properties of NG2 cells with a focus on their involvement in neuroinflammation and neurodegeneration. …”
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