Herb pair of Astragali Radix-Descurainiae Semen attenuate heart failure through the myosin VI-Tom1 complex mediated autophagy by Mengyue Wang, Songlin Ni, Tong Wang, Mo Sun, Qiaolan Wu, Xiaolin Wu, Guangying Lu, Guangying Lu, Peiwei Su, Zu Gao, Qian Chen, Qian Chen

“…Molecular docking to detect the binding energy and binding site of the MYO6-Tom1 complex to the major components of AR-DS.ResultsAR-DS effectively improved cardiac function and mitigated myocardial pathology in heart failure rats; it reduced serum levels of BNP, NT-pro BNP, and ANP, and suppressed cardiomyocyte apoptosis; AR-DS significantly downregulated the gene and protein expression of LC3 and Beclin1, upregulated p62, and reduced autophagy in myocardial tissue; AR-DS can effectively down-regulate the gene and protein expression of MYO6 and Tom1 in heart failure rat myocardium; protein docking results demonstrated the formation of a stable MYO6-Tom1 complex; lastly, the molecular docking results showed that the binding energies of the main components of AR-DS: Ononin, Astragaloside-IV, Rutin, Folic-acid, Daidzein, Isorhamnetin, Quercetin, Beta-Sitosterol, Kaempferol, and Formononetin can bind to the MYO6-Tom1 complex.ConclusionsAR-DS exerts a protective effect on myocardial tissue in heart failure rats by inhibiting myocardial autophagy, potentially through the modulation of the MYO6-Tom1 complex. …”
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Lysinibacillus sphaericus exposure impedes Anopheles dirus’s oviposition via downregulating vitellogenin by Shasha Yu, Zhilong Liu, Jing Wang, Hong Zheng, Shiqian Han, Feifei Zheng, Dan Zheng, Caizhi Zhao, Xin Li, Tingting Liu, Xuesen Yang, Ying Wang

“…Conclusions Exposure An. dirus larvae to L. sphaericus resulted in the persistence of L. sphaericus in surviving adult mosquitoes and significantly suppressed female oviposition by downregulating Vg expression via inhibition of lysosomal function and the TOR signaling pathway. This study offers novel insights into the interaction between L. sphaericus and its mosquito host and identifies potential molecular targets for controlling mosquito population density by modulating oviposition behavior. …”
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Randomised, controlled clinical trial evaluating the effects of preoperative insomnia treatment on postoperative pain control and recovery: a protocol for the Promoting Sleep to Al... by Martin Kraepelien, Michael R Irwin, Eva Kosek, Michael T Smith, Martin F Bjurström, Kristoffer Bothelius, Pernilla Maathz, Susanna Jernelöv, Alexander H C Rosenström, Andrea Niklasson, Richard Olmstead, Patrick H Finan

“…Secondary outcome measures include long-term postoperative pain control, changes in quantitative sensory testing variables (eg, temporal summation, conditioned pain modulation), sleep, cognition (eg, attention, memory, processing speed, executive function), mental health, health-related function, physical activity, quality of life and blood biomarkers. …”
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<i>AtAUEs</i>, a Small Family of ABA Up-Regulated EAR Motif-Containing Proteins Regulate ABA Responses in Arabidopsis by Wei Wang, Xutong Wang, Xiaoyu Liu, Yating Wang, Yingying Li, Saddam Hussain, Xiaoxiao Jing, Siyu Chen, Shucai Wang

“…These findings suggest that <i>AtAUEs</i> function redundantly to regulate ABA responses in Arabidopsis, likely by modulating the expression of key regulatory genes in ABA-signaling pathway.…”
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New insights on anti-tumor immunity of CD8+ T cells: cancer stem cells, tumor immune microenvironment and immunotherapy by Yibin Lin, Yifu Song, Yaochuan Zhang, Xiaodong Li, Liang Kan, Sheng Han

“…Tumor cells and tumor stem cells will resist or evade destruction through various mechanisms as CD8+ T cells exert their anti-tumor function. This paper reviews the research on the regulation of tumor development and prognosis by cancer stem cells that directly or indirectly alter the role of tumor-infiltrating CD8+ T cells. …”
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Autophagy Regulation on Pyroptosis: Mechanism and Medical Implication in Sepsis by Ran Guo, Hao Wang, Na Cui

“…In the past decade, its function in negatively modulating pyroptosis and inflammation during sepsis has attracted increased attention. …”
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Arv1; a “Mover and Shaker” of Subcellular Lipids by J. Jose Corbalan, Karla K. Frietze, Joseph Nickels, Stephen L. Sturley

“…Murine in vivo studies point to a role for ARV1 in regulating obesity, glucose tolerance, insulin sensitivity and brain function. Multiple human ARV1 variants have been associated with epileptic encephalopathy, cerebellar ataxia, and severe intellectual deficits. …”
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Therapeutic mechanisms of polysaccharides in the management of rheumatoid arthritis: a comprehensive review by Wenlong Liu, Youqian Kong, Xiaoyu Wang, Yuanyuan Yang, Qi Yan, Zeguang Li

“…It focuses on the mechanisms of polysaccharides in the alleviation of RA, mainly through the modulation of immune cell function, inhibition of inflammation, regulation of gut microbiota, promotion of bone formation and repair, and influence on related pathways. …”
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Prediction of the Effect of Polymer Membrane Composition in a Dry Air Humidification Process via Neural Network Modeling by M. Fakhroleslam, A. Samimi, S.A. Mousavi, R. Rezaei

“…The three mentioned models included Feed- Forward Back- Propagation (FBP), Radial Basis Function (RBF), and Feed- Forward Genetic Algorithm (FFGA). …”
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Gut microbiome and lung cancer: mechanisms, interactions, and dietary interventions by Jayashri Chakraborty, Ngashepam Lanchenba Singh, Bhrigu Kumar Das

“…Several studies have shown that the gut microbiome is vital in maintaining healthy lung function through the gut-lung axis. A comparison between the gut microflora of healthy volunteers and lung cancer patients revealed that changes in the composition of gut microflora occur in lung cancer patients. …”
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Hybrid Multi-Granularity Approach for Few-Shot Image Retrieval with Weak Features by Aiguo Lu, Zican Li, Yanwei Liu, Pandi Liu, Ke Wang

“…At the same time, the Bi-Level Routing Attention mechanism adaptively focuses on key regions, boosting the model’s discriminative ability for targets in complex backgrounds. The optimized loss function further enhances the robustness and distinctiveness of features, improving retrieval accuracy. …”
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An Improved YOLOv7-Tiny-Based Algorithm for Wafer Surface Defect Detection by Mengyun Li, Xueying Wang, Hongtao Zhang, Xiaofeng Hu

“…Finally, the loss function is optimized by adopting IoU with minimum points distance (MPDIoU) to address issues such as small sizes and dense distributions. …”
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High Conversion Efficiency Photonic Microwave Mixer With Image Rejection Capability by J. Zhang, E. H. W. Chan, X. Wang, X. Feng, B. Guan

“…It is based on an integrated dual-parallel Mach&#x2013;Zehnder modulator (MZM) with a 90&#x00B0; polarization rotator on one branch of the modulator. …”
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A proteomics–bioinformatics approach to assess the molecular and physicochemical properties of brewer's spent grain protein concentrates: Effect of alkali-heat treatment by Toktam Farjami, Animesh Sharma, Ida-Johanne Jensen, Eva Falch

“…Overall, these findings demonstrate that moderate heating during alkaline extraction can modulate the physicochemical and molecular properties of BSG proteins, providing insights into tailoring their functionality for specific industrial applications.…”
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Selective reduction in epitaxial SrFe0.5Co0.5O2.5 and its reversibility by Joonhyuk Lee, Yu-Seong Seo, Krishna Chaitanya Pitike, Gowoon Kim, Sangkyun Ryu, Hyeyun Chung, Su Ryang Park, Sangmoon Yoon, Younghak Kim, Valentino R. Cooper, Hiromichi Ohta, Jinhyung Cho, Hyoungjeen Jeen

“…Abstract Oxygen-vacancy engineering in transition metal oxides enables programmable functionalities by modulating the valence states and local coordination of constituents. …”
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The Contribution of the Skin Microbiome to Psoriasis Pathogenesis and Its Implications for Therapeutic Strategies by Diana Sabina Radaschin, Alin Tatu, Alina Viorica Iancu, Cristina Beiu, Liliana Gabriela Popa

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Inventory control strategy based on neural network and fuzzy algorithm in intelligent warehousing system by Chunmei Xie, Cong Xie

“…Abstract To cope with the inventory control problem of an intelligent warehousing system, this paper proposes a neuro-fuzzy dynamic inventory regulation model (NFDIRM), which integrates radial basis function neural network (RBFNN) and fuzzy logic algorithm, aiming to solve the problems of poor prediction accuracy and poor decision flexibility of traditional models. …”
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A Cumulant-Based Method for Acquiring GNSS Signals by He-Sheng Wang, Hou-Yu Wang, Dah-Jing Jwo

“…However, BOC signals introduce multiple side-peaks in their autocorrelation function, which can lead to significant errors during the acquisition process. …”
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Synaptic plasticity-based regularizer for artificial neural networks by Qais Yousef, Pu Li

“…To address this optimization problem, a single-wave scheme is introduced to decompose the problem into smaller, parallel sub-problems that minimize the inner cost function while ensuring the aggregated solution to minimize the outer one. …”
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Educational aspects of the electronic learning process implementation in the conditions of the economic crisis by Savely Evgenievich Cherkezov, Elena Vladimirovna Efimova, Natalya Alexandrovna Rutta

“…In this regard the ability of the domestic vocational education system to fully function through electronic, mobile and remote forms and means of carrying out educational activities is of particular importance. …”
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