Empagliflozin Plays Vasoprotective Role in Spontaneously Hypertensive Rats via Activation of the SIRT1/AMPK Pathway by Monika Kloza, Anna Krzyżewska, Hanna Kozłowska, Sandra Budziak, Marta Baranowska-Kuczko

“…Functional (wire myography, organ bath) and biochemical (Western blot) studies were conducted on the third-order of the superior mesenteric arteries (sMAs) and/or aortas. …”
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Characterization of the Active Ingredients and Prediction of the Potential Anticolitis Mechanism of the Feng-Liao-Chang-Wei-Kang Capsule via Mass Spectrometry and Network Pharmacol... by Tingting Liu, Zhijiang He, Witiao Lv, Liyun Deng, Xizhe Sun, Yanfei Chen

“…A network pharmacology study, including target gene prediction and functional enrichment, was applied to screen the active ingredients of the FLCWK capsule and explore its potential mechanism for the treatment of colitis. …”
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Antimicrobial Activity of Lavender Essential Oil from <i>Lavandula angustifolia</i> Mill.: In Vitro and In Silico Evaluation by Sylvia Stamova, Neli Ermenlieva, Gabriela Tsankova, Emilia Georgieva

“…In silico analysis identified functional protein clusters potentially modulated by LEO constituents, including targets related to membrane integrity and metabolic regulation. …”
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Electro-magnetic radiation of terahertz range, NO molecular specter frequencies, and coagulation hemostasis in patients with various angina forms by S. S. Parshina, V. F. Kirichuk, T. V. Golovacheva, T. N. Afanasyeva, V. D. Tupikin, A. P. Krenitsky, A. V. Mayborodin, N. A. Lopatina

“…Braunwald classification), or effort angina, Functional Class II-IV (Canadian Cardiovascular Society). …”
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Improving the performance of glucose oxidase biofuel cell by methyl red and chitosan composite electrodes by Facheng Su, Yujyun Wu, Hsiharng Yang

“…Experiment including Fourier transform infrared spectroscopy (FTIR) to analyze the distribution of functional groups after modification of the carbon cloth electrode, and through the comparison of the ultraviolet–visible spectrometer (UV–Vis), it can be known that the concentration ratio of [MR-CS] is 1:5, the glucose oxidase load can be maximized. …”
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Structural characterization and protective effects of polysaccharides isolated from Berberis dasystachya M. fruits on H2O2-induced oxidative damage in RINm5F pancreatic β-cells by Xiaohang Lu, Lijuan Han, Yongrong Deng

“…BDP-I intervention at concentrations ranging from 0.0625 to 0.5 mg/mL significantly improved cell viability, reduced reactive oxygen species (ROS) and thiobarbituric acid reactive substances (TBARS), and enhanced superoxide dismutase (SOD) and catalase (CAT) activities in a dose-dependent manner.Untargeted metabolomics revealed that BDP-I regulated 46 potential biomarkers, effectively reversing metabolic disturbances caused by oxidative stress. In addition, BDP-I modulated the expression of genes associated with apoptosis and mitochondrial damage, including iNOS and NF-κB.These findings suggest that BDP-I exerts protective effects against oxidative damage in pancreatic islet cells through multiple mechanisms, highlighting its potential as a targeted antioxidant agent for functional food or therapeutic applications.…”
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Proteome-wide identification of druggable targets and inhibitors for multidrug-resistant Pseudomonas aeruginosa using an integrative subtractive proteomics and virtual screening ap... by Divya Vemula, Vasundhra Bhandari

“…Through a rigorous, multi-stage process, we excluded human homologs, identified essential proteins, mapped functional pathways, determined subcellular localization, and assessed virulence and resistance factors. …”
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Porcine decellularized nerve matrix hydrogel attenuates neuroinflammation after peripheral nerve injury by inhibiting the TLR4/MyD88/NF-κB axis by Rui Li, Jianquan Liu, Liuxun Li, Guotian Luo, Xinrong Yuan, Shichao Shen, Yongpeng Shi, Jianlong Wu, Bin Yan, Lei Yang

“…Using peripheral nerve injury model rats treated with porcine decellularized nerve matrix hydrogel, we evaluated structural and functional recovery, macrophage phenotype alteration, specific cytokine expression, and changes in related signaling molecules in vivo. …”
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The Impact of Walking on BDNF as a Biomarker of Neuroplasticity: A Systematic Review by Mohamed Hesham Khalil

“…Background/Objectives: The brain-derived neurotrophic factor (BDNF) is a critical exercise-induced modulator of various neuroplasticity processes, including adult hippocampal neurogenesis. …”
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Voxel-based versus network-analysis of changes in brain states in patients with auditory verbal hallucinations using the Eriksen Flanker task. by Lydia Brunvoll Sandøy, Katarzyna Kazimierczak, Frank Riemer, Alexander R Craven, Lars Ersland, Lin Lilleskare, Erik Johnsen, Kenneth Hugdahl, Renate Grüner

“…The present functional magnetic resonance imaging (fMRI) study investigated neural correlates of switching between task-processing and periods of rest in a conventional ON-OFF block-design in patients with auditory verbal hallucinations (AVHs) and healthy controls. …”
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ARACOV-02. Specialized nutritional intervention and telerehabilitation in patients with long COVID: Protocol of a randomized controlled trial. by Beatriz Carpallo-Porcar, Carolina Jiménez-Sánchez, Sandra Calvo, Pilar Irún, Elena Kolesnyk-Sumskaya, Ana Isabel Aller-Blanco, Esther Del Corral Beamonte

“…Specialized Pro Resolving Mediators (SPMs) (17-HAD, 14-HAD and 18_HEPE) that could be useful in Post COVID Condition modulating the inflammatory response. The objective is to determine the change in quality of life, inflammatory profile, functional capacity and emotional variables in a group taking a nutritional supplement (SPMs) plus a telerehabilitation programme.…”
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From biogenesis to biomarkers: the role of piRNAs and PIWI proteins in cervical cancer and beyond by Pushpendra D. Pratap, Syed Tasleem Raza, Sharique Ahmad, Muneshwar Rajput

“…This review highlights the functional relevance of the PIWI/piRNA pathway in cervical carcinogenesis and explores its potential application in the diagnosis, prognosis, and therapeutic targeting of cervical cancer. …”
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Domain-specific neural substrates underlie the framing effect by Sai Sun, Jianping Hu, Rongjun Yu

“…We then checked the commonality and distinctiveness of the framing effect across gain and loss domains using a similar experimental design combined with functional magnetic resonance imaging (fMRI). Behaviorally, participants showed comparable framing effects in both domains, suggesting a domain-general decision bias. …”
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CircDock6 drives metabolic dysfunction–associated steatotic liver disease progression in mice and mouse hepatocytes via mmu-let-7g-5p/insulin-like growth factor 1 receptor regulati... by Hongpeng Lu, Xiaoyun Ding, Peifei Li

“…This study sought to examine the functional role and molecular mechanism of circDock6 in metabolic dysfunction–associated steatotic liver disease. …”
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The Use of Road Microsimulation Software within BIM Environments: A Preliminary Assessment by Marilisa Botte, Amedeo Zampi, Cristina Oreto, Luca D’Acierno

“…The use of Building Information Modelling (BIM) is becoming increasingly adopted worldwide to support the creation and management of digital environments in which physical and functional features of a facility are modelled. Due to its characteristic flexibility and interoperability, it rapidly extends beyond the boundaries of applications for which it was originally conceived, thus being implemented in other contexts such as the infrastructure sector. …”
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Gene set enrichment in eQTL data identifies novel annotations and pathway regulators. by Chunlei Wu, David L Delano, Nico Mitro, Stephen V Su, Jeff Janes, Phillip McClurg, Serge Batalov, Genevieve L Welch, Jie Zhang, Anthony P Orth, John R Walker, Richard J Glynne, Michael P Cooke, Joseph S Takahashi, Kazuhiro Shimomura, Akira Kohsaka, Joseph Bass, Enrique Saez, Tim Wiltshire, Andrew I Su

“…Genes comprising trans-eQTL bands were screened for enrichments in functional gene sets representing known biological pathways, and genes located at associated trans-eQTL band loci were considered candidate transcriptional modulators. …”
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Interaction Between <i>Enterococcus faecalis</i> and <i>Fusobacterium nucleatum</i> Regulated Macrophage Transcriptional Profiling and Reprogrammed Cellular Immune and Metabolic Re... by Jingheng Liang, Wenling Huang, Poukei Chan, Lihong Guo

“…In this study, we further investigated the synergistic effect of coaggregated <i>E. faecalis</i> and <i>F. nucleatum</i> on modulating Mφ immune and metabolic responses. Using transmission electron microscope, flow cytometry, RNA-seq and functional assays, we demonstrated that coaggregated <i>E. faecalis</i> and <i>F. nucleatum</i> caused nuclear shrinkage and increased mitochondria in Mφ while inducing M1 polarization, ROS production, and lipid accumulation of Mφ. …”
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Biomimetic Visual Information Spatiotemporal Encoding Method for In Vitro Biological Neural Networks by Xingchen Wang, Bo Lv, Fengzhen Tang, Yukai Wang, Bin Liu, Lianqing Liu

“…These results demonstrate that the proposed method significantly enhances the functional connectivity and cross-module information exchange in BNNs.…”
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IFN-γ-Licensed Mesenchymal Stem Cells Are More Susceptible to Death when Exposed to Quorum-Sensing Signal Molecule OdDHL and Less Effective in Inhibiting the Growth of Pseudomonas... by Marielly Reis Resende Sousa, Amandda Évelin Silva-Carvalho, Maurício Gonçalves da Costa Sousa, Danilo César Mota Martins, Emãnuella Melgaço Garcez, Luma Dayane de Carvalho Filiú Braga, Juliana Lott de Carvalho, Tanise Vendruscolo Dalmolin, Taia Maria Berto Rezende, Felipe Saldanha-Araujo

“…Currently, a series of licensing strategies has been investigated to enhance the functional properties of mesenchymal stem cells (MSCs). …”
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Clerodendranthus spicatus [Orthosiphon aristatus (Blume) Miq.] maintains uric acid homeostasis via regulating gut microbiota and restrains renal inflammation in hyperuricemic nephr... by Yang Wang, Kaiwen Li, Siya Yan, Ge Li, Meifang Cheng, Qian Chen, Yuzheng Wu, Dan Wang, Dan Wang, Tao Wang, Tao Wang

“…Establish pseudo-sterile mice through the combined treatment of ampicillin, neomycin, and vancomycin to verify the role of gut microbiota in improving HN in C. spicatus.ResultsIn HN mice, C. spicatus could significantly reduce serum uric acid levels and improve renal function. In addition, C. spicatus modulated gut microbiota and decreased the relative abundance of Bacteroides, Prevotellaceae_UCG-001 and Alistipes, and increased the abundance of Alloprevotella and Lachnospiraceae_NK4A136_group.C.spicatus altered the expression of the renal urate transporter and key enzymes in hepatic urate synthesis, leading to a decrease in serum uric acid levels. …”
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