Tanshinone regulated gut microbiota and TMAO to improve high-fat diet induced atherosclerosis in APOE−/− mice by Aiming Zhou, Nian Peng, Lin Yang, Siyuan Yang, Jiawen Wang

“…Conversely, in the model group, lactobacillus levels diminished, whereas proteobacteria and lachnospiraceae levels increased. The primary functional enrichment of species in both groups was closely associated with lipid metabolism, with a more pronounced enhancement of lipid metabolism noted in the tanshinone group. …”
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The role of lipid particle-laden interfaces in regulating the co-delivery of two hydrophobic actives from o/w emulsions by Georgia I. Sakellari, Hannah Batchelor, Fotis Spyropoulos

“…Herein, the capacity to provide such control was explored by utilizing Pickering emulsions stabilized by lipid particles, namely solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs). These dual functional species, regarding their concurrent Pickering stabilization and active carrying/delivery capabilities, were formulated with different solid lipid and surfactant types, and the effect on the release and co-release modulation of two hydrophobic actives separately encapsulated within the lipid particles themselves and within the emulsion droplets was investigated. …”
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Natural anticancer agents: prospection of medicinal and aromatic plants in modern chemoprevention and chemotherapy by Patricia Quintero-Rincón, Karina Caballero-Gallardo, Jesus Olivero-Verbel

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circ_0008285 Regulates Glioma Progression via the miR-384/HMGB1 Axis by Manli Yan, Caihong Hu, Qi Hu, Heran Ma, Changjiang Lei, Yamei Liu

“…Mechanism studies indicated that circ_0008285 regulated HMGB1 by sponging miR-384. Functional experiments demonstrated that circ_0008285 promoted the malignant phenotype of glioma cells by miR-384/HMGB1 axis. …”
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Computational identification of phospho-tyrosine sub-networks related to acanthocyte generation in neuroacanthocytosis. by Lucia De Franceschi, Giovanni Scardoni, Carlo Tomelleri, Adrian Danek, Ruth H Walker, Hans H Jung, Benedikt Bader, Sara Mazzucco, Maria Teresa Dotti, Angela Siciliano, Antonella Pantaleo, Carlo Laudanna

“…These networks include the most likely paths of functional influence of Xk and chorein on phosphorylated proteins. …”
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Mendelian randomization analysis reveals the potential of the IKZF1 gene as a therapeutic target in colorectal cancer by Junzuo Lin, Qian Xu, Zhengfei Zhao

“…Phenome-wide association study (PheWAS), protein–protein interaction (PPI) network construction, and enrichment analyses were performed to elucidate the functional profiles of the targets. Molecular docking and dynamics simulations were employed to evaluate the therapeutic potential of the identified targets. …”
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Perioperative immunonutrition intervention on postoperative outcomes among gynecological cancer patients under enhanced recovery after surgery setting: A study protocol of explanat... by ChiouYi Ho, Zulfitri Azuan Mat Daud, Barakatun Nisak Mohd Yusof, Hazreen Abdul Majid

“…Study outcomes include hospitalization duration, change in nutrition status, biochemical profile, functional status, and quality of life. Additionally, the secondary outcome focuses on evaluating the perception of the intervention approach. …”
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Wnt5a suppresses colorectal cancer progression via TGF-β/NOTUM/OLFM4 axis in patient-derived organoids by Yewei Huang, Jiahao Huang, Jiazi Yu, Songlin Zhuang, Ming Liu

“…Methods Using patient-derived CRC organoids (PDOs) and functional assays, we investigated the role of stromal-secreted Wnt5a. …”
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Barriers and Strategies for Oral Peptide and Protein Therapeutics Delivery: Update on Clinical Advances by Kshitis Chandra Baral, Ki Young Choi

“…Furthermore, structural modifications such as lipidation, peptide cyclization, and polyethylene glycosylation are promising alternatives to render stability, prolong circulation time, and membrane permeability. In particular, functional biomaterials, active targeting, and lymphatic transport strategies have provided new platforms for oral PP delivery. …”
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Tracking tripartite interaction dynamics: isolation, integration, and influence of bacteriophages in the Paraburkholderia-Dictyostelium discoideum symbiosis system by Susanne DiSalvo, Negar Maness, Andrew Braun, My Tran, Andrew Hofferkamp

“…We also identified a functional prophage from monocultures of one of the Paraburkholderia symbiont strains implemented in the enrichment approach. …”
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Cordycepin ameliorates diabetic nephropathy injury by activating the SLC7A11/GPX4 pathway by Bing Wu, Jing Wang, Xiaohui Yan, Gang Jin, Qiong Wang

“…Methods High glucose (HG)‐induced mouse podocyte cell line (MPC5) was used for in vitro functional analyses. Cell proliferation and apoptosis were determined using cell counting kit‐8 assay, 5‐ethynyl‐2′‐deoxyuridine assay, and flow cytometry, respectively. …”
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Sensorimotor correlates of sit-to-stand in healthy adults by Caitlin McDonald, John Jairo Villarejo Mayor, Olive Lennon

“…Despite the obvious association between neurological disorders and impairment of sit-to-stand, the neurophysiological basis of this functional movement is not well understood, particularly at brain level.MethodsSubjects (N = 20, 4 males) performed fifteen sets of five sit-to-stand transitions on an armless, backless seat adjusted to the knee joint height of each participant. …”
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Adaptive variation regulates the expression of the human SGK1 gene in response to stress. by Francesca Luca, Sonal Kashyap, Catherine Southard, Min Zou, David Witonsky, Anna Di Rienzo, Suzanne D Conzen

“…Identifying such functional variants may shed light on the mechanisms underlying inter-individual variation in response to environmental stressors and to hormonal therapy, as well as in the susceptibility to hormone-dependent diseases.…”
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Acupotomy for Musculoskeletal Pain: Exploring Therapeutic Potential and Future Directions by Hu J, Tong H, Zhang J, Jiang L

“…Preliminary evidence suggests that acupotomy holds promise in effectively alleviating pain, improving functional outcomes, and facilitating myofascial tissue healing in individuals with musculoskeletal pain. …”
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Fat-tail allele-specific expression genes may affect fat deposition in tail of sheep. by Hossein Mansourizadeh, Mohammad Reza Bakhtiarizadeh, Luciana Correia de Almeida Regitano, Jennifer Jessica Bruscadin

“…Using a rigorous computational pipeline, 115 differential ASE genes were identified, which were narrowed down to four genes (LPL, SOD3, TCP1 and LRPAP1) for being detected in at least two studies. Functional analysis revealed that the ASE genes were mainly involved in fat metabolism. …”
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Dissecting the Molecular Mechanism of 10-HDA Biosynthesis: Role of Acyl-CoA Delta(11) Desaturase and Transcriptional Regulators in Honeybee Mandibular Glands by Yunchang Li, Xiaojing Zhang, Zhenyu Xia, Yue Hao

“…A five-step biosynthetic pathway for 10-HDA was proposed, and cross-species analysis of <i>Apis mellifera</i> and <i>A. cerana</i> revealed the conserved expression patterns of 15 key enzymes involved. Functional validation via RNA interference (RNAi) demonstrated that knockdown of acyl-CoA Delta(11) desaturase (<i>d11ds</i>, LOC551527), a key enzyme in FA desaturation, led to a 50% reduction in 10-HDA levels. …”
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H3K9me-independent gene silencing in fission yeast heterochromatin by Clr5 and histone deacetylases. by Klavs R Hansen, Idit Hazan, Sreenath Shanker, Stephen Watt, Janne Verhein-Hansen, Jürg Bähler, Robert A Martienssen, Janet F Partridge, Amikam Cohen, Geneviève Thon

“…Hence Clr5, like the multi-functional Atf1 transcription factor which also modulates chromatin structure in the mating-type region, controls sexual differentiation and genome integrity at several levels. …”
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Noncoding elements in wheat defence response to fusarium head blight by Tugdem Muslu, Kadriye Kahraman, Bala Ani Akpinar, Halise Busra Cagirici, Egan Jaronski, Cliff Bradley, Hikmet Budak

“…Our analysis revealed not only common but also cultivar- and condition-specific miRNAs and lncRNA transcripts, showing the unique regulatory responses exhibited by these wheat varieties under Fusarium stress. Furthermore, the functional properties of the identified miRNAs were investigated by identifying their putative coding sequence (CDS) targets. …”
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Exploring novel and potent glycogen synthase kinase-3β inhibitors through systematic drug designing approach by Shabir Ahmad Ganai, Suma Mohan, Shahid Ahmad Padder

“…Notably, the e-Pharmacophores mapping was performed to address the level of complementarity of the most potent molecule and AZD1080 with the functional site of GSK-3β. Using various techniques, we identified the molecule with PubChem CID: 11167509 as the strongest molecule for obstructing GSK-3β, which may serve as a promising therapeutic after the meticulous evaluation on diverse models.…”
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STRIPAK complex defects result in pseudosexual reproduction in Cryptococcus neoformans. by Patricia P Peterson, Sarah Croog, Yeseul Choi, Sheng Sun, Joseph Heitman

“…Overexpression of PPG1, a related phosphatase, rescued growth and developmental defects in pph22Δ mutants, and restored the preference for α-a sexual reproduction over pseudosexual reproduction during mating, suggesting functional redundancy within the STRIPAK signaling network. …”
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