Transdiagnostic Effects of Schizophrenia Polygenic Scores on Treatment Outcomes in Major Psychiatric Disorders by Serretti A, Baune BT

“…Initially developed to capture the common variant risk for SCZ, accumulating evidence highlights the transdiagnostic impact of SCZ PRS on clinical severity, treatment response, and functional outcomes. This review synthesizes recent findings on the relationship between SCZ PRS and treatment outcomes across SCZ, BD, and MDD. …”
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Optimal Spatial Configuration for Energy and Solar Use in Alpine-Frigid Resettlement Communities by Bo Liu, Wei Song, Yu Liu, Chuanming Wang, Jie Song

“…This study investigates solar-optimized spatial configurations that enhance passive energy performance while addressing functional settlement needs. Through parametric modeling and climate-responsive simulations, four key spatial parameters are examined: building spacing, courtyard depth, density, and volumetric ratio. …”
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Plasma metabolome predicts trained immunity responses after antituberculosis BCG vaccination. by Valerie A C M Koeken, Cancan Qi, Vera P Mourits, L Charlotte J de Bree, Simone J C F M Moorlag, Vidhisha Sonawane, Heidi Lemmers, Helga Dijkstra, Leo A B Joosten, Arjan van Laarhoven, Cheng-Jian Xu, Reinout van Crevel, Mihai G Netea, Yang Li

“…Modulation of metabolic pathways may be a novel strategy to improve vaccine and trained immunity responses.…”
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NUF2 Is a Potential Immunological and Prognostic Marker for Non-Small-Cell Lung Cancer by Xia Li, Lianlian Zhang, Zhongquan Yi, Jing Zhou, Wenchun Song, Panwen Zhao, Jixiang Wu, Jianxiang Song, Qinggan Ni

“…Then, the identified differentially expressed genes (DEGs) were subjected to functional enrichment analyses. The protein-protein interaction (PPI) network was built after which module analysis was conducted via the Search Tool for Retrieval of Interacting Genes/Proteins (STRING) and Cytoscape. …”
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Transcriptome Analysis of Ullrich Congenital Muscular Dystrophy Fibroblasts Reveals a Disease Extracellular Matrix Signature and Key Molecular Regulators. by Sonia Paco, Teresa Casserras, Maria Angels Rodríguez, Cristina Jou, Montserrat Puigdelloses, Carlos I Ortez, Jordi Diaz-Manera, Eduardo Gallardo, Jaume Colomer, Andrés Nascimento, Susana G Kalko, Cecilia Jimenez-Mallebrera

“…Results were validated by real-time PCR, western blotting and functional assays.<h4>Findings</h4>We found significant changes in the expression levels of almost 600 genes between collagen VI deficient and control fibroblasts. …”
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HDN-DDI: a novel framework for predicting drug-drug interactions using hierarchical molecular graphs and enhanced dual-view representation learning by Jinchen Sun, Haoran Zheng

“…Recently, substructure-based DDI prediction has garnered much attention due to the dominant influence of functional groups and substructures on drug properties. …”
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Decoding estrogen receptor and GPER biology: structural insights and therapeutic advances in ERα−positive breast cancer by Taniya Saha, Kiven Erique Lukong

“…This review explores the structural and functional intricacies of ERα, the impact of ESR1 mutations on its ligand-binding domain (ERα−LBD) and their contribution to ET resistance, and the role of GPER-mediated signaling in ERα−positive BC. …”
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Extraction, purification, structural characterization, and anti-skin aging activity of a homogeneous polysaccharide from Durvillaea antarctica by Jiahui Wu, Yonglei Yuan, Liping Qu

“…These findings suggest that DAG-1 is a potential anti-aging ingredient for functional food, cosmetic, and medicine development. …”
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N6-Isopentenyladenosine promoted HeLa cell apoptosis through inhibitions of AKT and transforming growth factor β–activated kinase 1 activation by Miao Li, Yonghao Qi, Jing Wei, Lulu Lu, Xuan Zhao, Lijun Zhou

“…Anti-proliferation properties of iPA are likely due to its binding at the really interesting new gene domain of tumor necrosis factor receptor–associated factor 6 and loss of AKT and transforming growth factor β–activated kinase 1 activities as a result of functional modulations of tumor necrosis factor receptor–associated factor 6. …”
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Comprehensive Comparative Analysis of Lower Limb Exoskeleton Research: Control, Design, and Application by Sk Hasan, Nafizul Alam

“…These controllers support personalized and adaptive interaction, enabling real-time intent recognition, torque modulation, and gait phase synchronization across different users and tasks. …”
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Discriminative learning of receptive fields from responses to non-Gaussian stimulus ensembles. by Arne F Meyer, Jan-Philipp Diepenbrock, Max F K Happel, Frank W Ohl, Jörn Anemüller

“…Analysis of sensory neurons' processing characteristics requires simultaneous measurement of presented stimuli and concurrent spike responses. The functional transformation from high-dimensional stimulus space to the binary space of spike and non-spike responses is commonly described with linear-nonlinear models, whose linear filter component describes the neuron's receptive field. …”
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Virtual Reconstruction Method of Regional 3D Image Based on Visual Transmission Effect by Jing Yin, Jong Hoon Yang

“…In order to solve the problems of poor user experience and low human-computer interaction efficiency, this paper designs a 3D image virtual reconstruction system based on visual communication effects. First, the functional framework diagram and hardware structure diagram of the image 3D reconstruction system are given. …”
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Mechanistic insights of neuronal death and neuroprotective therapeutic approaches in stroke by Chun Li, Yuping Luo, Siguang Li

“…We also discussed advancements in neuroprotective therapeutics, encompassing a range of interventions from pharmacological modulation to stem cell-based therapies, aimed at reducing neuronal injury and enhancing functional recovery following ischemic stroke. …”
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Improved coloration of hemp fabrics via low-pressure argon plasma assisted surface modification by Kunal S. Bapat, T.P. Kee, S.J. Russell, L. Lin

“…Fourier-transform infrared spectroscopy and Raman spectroscopy of argon plasma pretreated hemp fabrics produced no noticeable changes in the functional groups of the fibres, but a physiochemical modification was observed in terms of the density of polar groups. …”
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Model of quality of life in a group of people with chronic low back pain by Urszula Ziętalewicz, Kamilla Bargiel-Matusiewicz

“…We conducted a cross-sectional study in which a multi-module self-administered questionnaire examining biological factors, personality traits, personal values, body assessment, symptoms of depression and anxiety, functional status, general perception of health, life satisfaction, received social support, economic support, satisfaction of health care and sociodemographic factors was adopted. …”
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Optimization of Naringin Extraction, Synthesis of Dihydrochalcone and Its Effects on Reducing Blood Lipid Levels In Vitro by Xiaolei Yu, Haowei Wu, Lei Zhang, Dongliang Fei

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Substance P immunoreactivity exhibits frequent colocalization with kisspeptin and neurokinin B in the human infundibular region. by Erik Hrabovszky, Beáta Á Borsay, Kálmán Rácz, László Herczeg, Philippe Ciofi, Stephen R Bloom, Mohammad A Ghatei, Waljit S Dhillo, Zsolt Liposits

“…Presence of SP in NKB and KP neurons increases the functional complexity of the putative pulse generator network. …”
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Evaluation of N-(3-(dimethyl hexadecyl ammonio)propyl) palmitamide bromide as cationic surfactant corrosion inhibitor for API N80 steel in acidic environment by A.S. Fouda, M.A. Elmorsi, Samy M. Shaban, T. Fayed, O. Azazy

“…A clear correlation was found between corrosion inhibition efficiency and theoretical parameters obtained using density functional theory (DFT). Keywords: Steel, Cationic surfactant, Potentiodynamic polarization, EIS, EFM, Quantum chemical calculation…”
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Biodegradable nanomaterials in boosting seed vigor and germination: seed coating towards sustainability by Pazhani Durgadevi, Koyeli Girigoswami, Agnishwar Girigoswami

“…This study explores the latest advances in biodegradable nanomaterials used in seed coating, focusing on natural polymers such as polysaccharides, proteins, and polymers. The functional mechanisms by which biodegradable nanomaterials improve seed performance are critically analyzed. …”
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Cross-organ protection of MSC-derived extracellular vesicles in ischemia-reperfusion injury: angiogenic synergy in kidney, brain, and heart by Zhuhong Lai, Dong Li, Caidong Luo, Qingyan Qiu, Rong Li, Min Dai

“…Notably, hypoxia-induced angiogenesis and vascular remodeling serve as critical adaptive processes for functional recovery, supporting neuronal plasticity in stroke, myocardial salvage in infarction, and tubular regeneration in renal ischemia-reperfusion injury. …”
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