Comprehensive genomic analysis and evaluation of in vivo and in vitro safety of Heyndrickxia coagulans BC99 by Ying Wu, Zhiyi Wu, Yinyin Gao, Yixuan Fan, Yao Dong, Yinan Zhang, Zhonghui Gai, Shaobin Gu

“…Abstract This study aimed to evaluate the safety profile and beneficial effects of Heyndrickxia coagulans strain BC99 (BC99) for potential use in functional foods and pharmaceuticals. We began with whole genome sequencing of BC99, followed by a comprehensive safety assessment comprising genome analysis, hemolysis, cytotoxicity, antibiotic susceptibility tests, and cell adhesion and tolerance studies, along with acute and subacute oral toxicity studies in animal models. …”
Get full text

Full color visible imaging with crystalline silicon meta-optics by Johannes E. Fröch, Luocheng Huang, Zhihao Zhou, Virat Tara, Zhuoran Fang, Shane Colburn, Alan Zhan, Minho Choi, Arnab Manna, Andrew Tang, Zheyi Han, Karl F. Böhringer, Arka Majumdar

“…For this purpose, we employ an inverse design approach, which maximizes the volume under the broadband modulation transfer function of the meta-optics. Beyond that, we demonstrate polarization-multiplexed functionality in the visible. …”
Get full text

Platelets, thrombo-inflammation and cancer by E. V. Slukhanchuk, V. O. Bitsadze, J. Kh. Khizroeva, M. V. Tretyakova, A. G. Solopova, V. N. Galkin, A. S. Shkoda, V. I. Tsibizova, V. I. Linnikov, Ismail Elalamy, J.-С. Gris, B. Brenner, A. D. Makatsariya

“…During oncological process, the platelet function becomes modulated via their activation and increased aggregation being one of the risk factors for developing thrombosis in cancer patients. …”
Get full text

MFAFNet: Multi-Scale Feature Adaptive Fusion Network Based on DeepLab V3+ for Cloud and Cloud Shadow Segmentation by Yijia Feng, Zhiyong Fan, Ying Yan, Zhengdong Jiang, Shuai Zhang

“…Finally, an innovative loss function is employed in the experiments, significantly improving the accuracy of cloud and cloud shadow segmentation. …”
Get full text

Lactate and lactylation: emerging roles in autoimmune diseases and metabolic reprogramming by Wenjun Liu, Wenjun Liu, Ruhui Yang, Ruhui Yang, Yuxin Zhan, Yuxin Zhan, Xuanyu Yang, Haimin Zeng, Haimin Zeng, Bofan Chen, Bofan Chen, Jiahao Zeng, Jiahao Zeng, Tianheng Hu, Tianheng Hu, Jie Hu, Qi Xiao, Yinjin Shao, Xiang Chen

“…Lactylation impacts immune cell function by regulating metabolic reprogramming and signaling pathways. …”
Get full text

Unveiling the Therapeutic Potential: Targeting Fibroblast-like Synoviocytes in Rheumatoid Arthritis by Siran Yue, Junyu Fan, Duoli Xie, Chunhao Cao, Zhuqian Wang, Jie Huang, Fang Qiu, Xu Yang, Dongyi He, Aiping Lu, Chao Liang

“…A deeper understanding of the molecular and functional heterogeneity of FLS may pave the way for more effective and precise therapeutic interventions in RA.…”
Get full text

The role of the tryptophan metabolites in gut microbiota-brain axis and potential treatments: a focus on ischemic stroke by Na Qin, Xiaodi Xie, Rong Deng, Shiman Gao, Ting Zhu

“…This suggests that modulating TRP metabolite levels through various methods can enhance the prognosis of central nervous system diseases and restore microbiota-gut-brain axis functions.…”
Get full text

Mechanisms of tendon-bone interface healing: biomechanics, cell mechanics, and tissue engineering approaches by Zhixiong Xu, Wensheng Xu, Tao Zhang, Long Luo

“…Cells regulate behavior, including growth, differentiation, and migration, by sensing mechanical signals and translating them into biochemical responses, which are critical in the healing process. Cellular mechanics modulate intracellular signaling, thereby influencing biological function and healing capacity. …”
Get full text

A MPCC-Based Variable Sampling Time Interleaving Method for a Two-Phase Totem-Pole Bridgeless Boost PFC Converter by Hyun-Gyu Koh, Hyeon-Joon Ko, Yeong-Jun Choi

“…However, since ON/OFF of the switch is determined through model-based cost function comparison, the switching frequency is variable and a separate modulator is not used. …”
Get full text

A TB40/E-derived human cytomegalovirus genome with an intact US-gene region and a self-excisable BAC cassette for immunological research by Kerstin Laib Sampaio, Anja Weyell, Narmadha Subramanian, Zeguang Wu, Christian Sinzger

“…The degree of MHC-I down-regulation by this virus was consistent with functional restoration of US2–US6. To enable detection of infected cells by flow cytometry, an enhanced green fluorescent protein (EGFP)-expression cassette was inserted downstream of US34A, yielding the fluorescent virus RV-TB40-BACKL7-SE-EGFP.…”
Get full text

Tuning properties of CTAB-HSA-AuNR nanocomposite antibacterial thin films by Krishna Halder, Kabira Sabnam, Atri Sen, Swagata Dasgupta

“…Proteins can be utilized to create such materials with specific functional characteristics. We report the preparation of transparent human serum albumin thin films in presence of CTAB-capped gold nanorods with different compositions of protein as well as the plasticizer i.e., sorbitol. …”
Get full text

Putative Endoplasmic Reticulum Stress Inducers Enhance Triacylglycerol Accumulation in <i>Chlorella sorokiniana</i> by Yoomi Roh, Sujeong Je, Naeun Sheen, Chang Hun Shin, Yasuyo Yamaoka

“…This study enhances our understanding of <i>Chlorella</i> lipid metabolism, providing valuable insights for optimizing lipid production, particularly TAGs enriched with PUFA content, for applications in functional foods, nutraceuticals, and sustainable bioresources.…”
Get full text

Cofilin in Cancer: A Molecular Review of Its Role in Tumor Plasticity and Progression by J. Renukadevi, D. S. Mridula, K. Nimithasree, V. Sanjay

“…This review explores the structural, functional, and regulatory roles of cofilin in cancer biology and highlights its emerging therapeutic potential. …”
Get full text

Semantic Modeling for SNPs Associated with Ethnic Disparities in HapMap Samples by HyoYoung Kim, Won Gi Yoo, Junhyung Park, Heebal Kim, Byeong-Chul Kang

“…To analyze the biologically functional implications for ethnicity-specific SNPs, we focused on constructing a semantic network model. …”
Get full text

N7-methylguanosine modification in cancers: from mechanisms to therapeutic potential by Qihui Wu, Xiaodan Fu, Guoqian Liu, Xiaoyun He, Yimin Li, Chunlin Ou

“…This review consolidates the discovery, identification, detection methodologies, and functional roles of m7G modification, analysing the mechanisms by which m7G modification-associated molecules contribute to tumour development, and exploring their potential clinical applications in cancer diagnostics and therapy, thereby providing innovative strategies for tumour identification and targeted treatment.…”
Get full text

Inherited Nitrogen Distribution Control in Covalent Organic Framework Cathodes for Efficient Electrochemical Lithium Recovery via Capacitive Deionization by Rajesh Dhanushkotti, Abdul Khayum Mohammed, Kayaramkodath Chandran Ranjeesh, Hema Mylnahalli Krishnegowda, Najat Maher Aldaqqa, Dinesh Shetty

“…Through controlled COFs, density functional theory (DFT) analysis, and post‐electrode characterizations, we elucidate the pivotal role of nitrogen distribution in lithium recovery.…”
Get full text

TMSB10 drives prostate cancer aggressiveness via immune microenvironment regulation by Haoran Xia, Jiaxin Ning, Xiaoxiao Guo, Hongchen Song, Xuanhao Li, Xuan Wang

“…Pan-cancer analysis from The Cancer Genome Atlas (TCGA) revealed that TMSB10 is upregulated across multiple cancer types, particularly in prostate cancer, where high TMSB10 expression correlates with poorer patient outcomes. Functional assays using prostate cancer cell lines LNCaP and DU145 showed that TMSB10 silencing suppresses cell proliferation, migration, and invasion, while overexpression enhances these oncogenic processes. …”
Get full text

Enhanced Mask R-CNN Incorporating CBAM and Soft-NMS for Identification and Monitoring of Offshore Aquaculture Areas by Jiajun Zhang, Yonggui Wang, Yaxin Zhang, Yanxin Zhao

“…Furthermore, monitoring and analysis of aquaculture areas have revealed that despite the reduction in illegal aquaculture acreage since 2017 due to the implementation of functional zone planning for marine aquaculture areas, illegal aquaculture activities remain prevalent in prohibited and restricted zones in Xiapu, accounting for a considerable proportion.…”
Get full text

Behavioural and neural effects of eccentricity and visual field during covert visuospatial attention by Tianlu Wang, Lena M. Hofbauer, Dante Mantini, Céline R. Gillebert

“…The attentional priority map plays a key role in the distribution of attention, and is modulated by bottom-up sensory as well as top-down task-dependent factors. …”
Get full text

Differential behavior responses and genetic alteration underpinning exercise effectiveness in stress-susceptible mice by Dong-Joo Hwang, Ji-Eun Kim, Joon-Yong Cho, Jung-Hoon Koo, Yongchul Jang, Tae-Kyung Kim

“…SER mice exhibited limited behavior resilience and distinct transcriptomic profiles enriched in structural adaptation without functional resilience and glial cell differentiation marked by astrocyte activation or differentiation. …”
Get full text