Validation of a New Questionnaire with Generic and Disease-Specific Qualities: The Mcgill Copd Quality of Life Questionnaire by Smita Pakhale, Sharon Wood-Dauphinee, Adriana Spahija, Jean-Paul Collet, François Maltais, Sarah Bernard, Marc Baltzan, Michel Rouleau, Jean Bourbeau, for the Respiratory Health Network of the FRSQ

“…It assesses three domains: symptoms, physical function and feelings with 29 items (12 from the 36-item Short-Form Health Survey with 17 from the previously developed COPD-specific module).…”
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Extracting road maps from high-resolution satellite imagery using refined DSE-LinkNet by Prativa Das, Satish Chand

“…To address the imbalanced class distribution problem, a new aggregate loss function is proposed by integrating binary cross-entropy, Jaccard coefficient, and Lovasz sigmoid loss functions. …”
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Investigation of Ways of Dynamic Range Expansion for Broadband Receiver Microwave Devices in Multi-Signal Mode by S. A. Bogdanov, P. V. Kupriyanov, S. V. Nikolaev, S. A. Petrov

“…Suppression of intermodulation components of the third order exceeds 60 dB. Effective functioning of the broadband receiver in multisign mode is ensured.…”
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The role of long, non-coding RNA in the biology of tumors by O. A. Beylerli, I. F. Gareev

“…In this context, lncRNAs can regulate the main characteristics of cancer cells by controlling gene expression programs associated with their suppressive and oncogenic functions. Therefore, they can be excellent biomarkers and therapeutic targets for tumors.…”
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Advances in the Development of Mitochondrial Pyruvate Carrier Inhibitors for Therapeutic Applications by Henry Politte, Lingaiah Maram, Bahaa Elgendy

“…This review provides an overview of the MPC complex, examining its structural components, regulatory mechanisms, and biological functions. We explore the current understanding of transcriptional, translational, and post-translational modifications that modulate MPC function and highlight the clinical relevance of MPC dysfunction in metabolic and neurodegenerative diseases. …”
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Maternal Vitamin B12 in Pregnancy and Placental Development by Amrita Arcot, Rachel E. Walker, Kelly Gallagher, Kevin C. Klatt, Alison D. Gernand

“…Vitamin B12, or cobalamin, is an essential nutrient required for diverse physiological functions secondary to its role as a critical cofactor for two mammalian enzymes, methionine synthase and methylmalonyl-CoA mutase. …”
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Convolutional neural network for IT lung diagnostics by U. A. Vishniakou, T. He

“…The interface part implements the interactive user function and is responsible for entering audio data. …”
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Bloating: analysis of the origin of the symptom by Yu. O. Shulpekova

“…Butyrate supports colonocyte nutrition and differentiation, provides anti-inflammatory activity and modulates the functions of neurons and microglia.…”
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Estimation of Sidelobe Level Variations of Phased Codes in Presence of Random Interference for Bistatic Wideband Noise Radar by Ana Vazquez Alejos, Muhammad Dawood, Habeeb Ur-Rahman Mohammed

“…We discuss the importance of using the sidelobe level of the cross-correlation function as a criterion to implement a noise radar based on the transmission of wideband binary waveforms. …”
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Phosphatase Dysregulation in Cancer: Signaling Pathways and Therapeutic Opportunities by Maryam Jama, Michael Overduin, Khaled H. Barakat

“…This review presents an in‐depth overview of phosphatase classification based on catalytic domain similarities and explores their diverse functions as tumor suppressors, oncogenic drivers, or context‐dependent regulators. …”
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Towards a Universal Translator: Decoding the PTMs That Regulate Orthoflavivirus Infection by Hannah M. Schmidt, Stacy M. Horner

“…Post-translational modifications (PTMs) serve as critical regulators of protein function across biological systems, including during viral infection. …”
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Mammalian Tribbles Homologs at the Crossroads of Endoplasmic Reticulum Stress and Mammalian Target of Rapamycin Pathways by Robyn Cunard

“…The following review will discuss metazoan homologs of Drosophila tribbles, their structure, expression patterns, and functions. In particular, we will focus on TRB3 function in the kidney in podocytes. …”
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MicroRNA Regulation of Brain Tumour Initiating Cells in Central Nervous System Tumours by Neha Garg, Thusyanth Vijayakumar, David Bakhshinyan, Chitra Venugopal, Sheila K. Singh

“…Characterization and functional studies on oncogenic or tumour suppressive microRNAs are made possible because of developments in sequencing and microarray techniques. …”
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Broadening horizons: microbiota as a novel biomarker and potential treatment for endometriosis by Min Wang, Wei Liu, Lianwen Zheng, Shuai Ma, Lianhai Jin, Donghai Zhao, Dandan Li

“…Certain key microbial species and their metabolites can induce functional alterations in endometrial cells through various mechanisms, often preceding the emergence of clinical symptoms. …”
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Pathophysiologic Mechanisms of Severe Spinal Cord Injury and Neuroplasticity Following Decompressive Laminectomy and Expansive Duraplasty: A Systematic Review by Eleftherios Archavlis, Davide Palombi, Dimitrios Konstantinidis, Mario Carvi y Nievas, Per Trobisch, Irina I. Stoyanova

“…Data on pathophysiological changes, molecular markers, and functional outcomes were extracted. Results: From 1240 initial articles, 43 studies were included, encompassing both animal models and human clinical data. …”
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Translating Exosomal microRNAs from Bench to Bedside in Parkinson’s Disease by Oscar Arias-Carrión, María Paulina Reyes-Mata, Joaquín Zúñiga, Daniel Ortuño-Sahagún

“…This review integrates findings from preclinical models, patient-derived samples, and systems biology to delineate the functional impact of exosomal miRNAs in PD. We propose mechanistic hypotheses linking miRNA dysregulation to molecular pathogenesis and present an interactome model highlighting therapeutic nodes. …”
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Antimicrobial Peptides: A Promising Solution to the Rising Threat of Antibiotic Resistance by Tarequl Islam, Noshin Tabassum Tamanna, Md Shahjalal Sagor, Randa Mohammed Zaki, Muhammad Fazle Rabbee, Maximilian Lackner

“…AMPs are being developed as potential medicines, and current computational and experimental tools aim to facilitate their preclinical and clinical development. Structural and functional constraints as well as a more stringent regulatory framework have impeded clinical translation of AMPs as possible therapeutic agents. …”
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Microbiota and Autism: A Review on Oral and Gut Microbiome Analysis Through 16S rRNA Sequencing by Federico Anaclerio, Maria Minelli, Ivana Antonucci, Valentina Gatta, Liborio Stuppia

“…The use of 16S rRNA gene sequencing has become a pivotal tool in profiling the microbial communities associated with ASD, offering valuable insights into bacterial diversity, composition, and potential functional roles. This review aims to provide a comprehensive analysis of current findings on the relationship between the gut and oral microbiota with ASD, and a particular focus on studies utilizing 16S rRNA sequencing. …”
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Exploring the potential mechanisms of m6A modification in septic acute respiratory distress syndrome: a bioinformatics analysis by Shaoyang Zhang, Qinghui Fu, Zhipeng Xu, Mingjie Fu, Jianfeng Zhao, Wenqiao Yu

“…Validation experiments confirmed high expression levels of WTAP and MYC in lung tissues. Functional assays further demonstrated that WTAP enhances ARDS progression. …”
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Diagnostics and treatment of biliary dyskinesia: clinical guidelines of the Russian gastroenterological Association by V. T. Ivashkin, I. V. Mayev, Yu. O. Shulpekova, Ye. K. Baranskaya, A. V. Okhlobystin, A. S. Trukhmanov, T. L. Lapina, A. A. Sheptulin

“…The gallbladder dyskinesia and sphincter of Oddi dyskinesia are defined as the diseases of functional origin caused by motility and visceral sensitivity disorders. …”
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