Harnessing a high cargo-capacity transposon for genetic applications in vertebrates. by Darius Balciunas, Kirk J Wangensteen, Andrew Wilber, Jason Bell, Aron Geurts, Sridhar Sivasubbu, Xin Wang, Perry B Hackett, David A Largaespada, R Scott McIvor, Stephen C Ekker

“…Both the 8.5-kb Tol2 transposon and 5.8-kb miniTol2 engineered elements readily function to revert the deficiency of fumarylacetoacetate hydrolase in an animal model of hereditary tyrosinemia type 1. …”
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TUH-NAS: A Triple-Unit NAS Network for Hyperspectral Image Classification by Feng Chen, Baishun Su, Zongpu Jia

“…We also adopted a composite loss function to enhance the model’s focus on hard-to-classify samples. …”
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A new archipelago on the horizon: type 1 interferonopathies by Elif Kucuk, Fatih Haslak

“…Mutations in genes involved in nucleic acid sensing, degradation, proteasome function, and IFN signaling lead to the accumulation of self-deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) in the cytoplasm and a sustained type 1 IFN response, causing tissue damage and autoimmunity. …”
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Cardiac Glycosides Activate the Tumor Suppressor and Viral Restriction Factor Promyelocytic Leukemia Protein (PML). by Snezana Milutinovic, Susanne Heynen-Genel, Elizabeth Chao, Antimone Dewing, Ricardo Solano, Loribelle Milan, Nikki Barron, Min He, Paul W Diaz, Shu-ichi Matsuzawa, John C Reed, Christian A Hassig

“…Curiously, genomic deletion of PML in human cancer cells failed to abrogate the cytotoxic effects of CGs and other apoptotic stimuli such as ceramide and arsenic trioxide that were previously shown to function through PML in mice. These findings suggest that alternative pathways can compensate for PML loss to mediate apoptosis in response to CGs and other apoptotic stimuli.…”
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Enhanced boundary perception and streamlined instance segmentation by Junyong Shi, Guangzhi Chen, Yu Chen

“…BorderMask comprises three key innovations: the Multiscale Boundary Perception Enhanced Attention (MBPEA) module, which iteratively optimizes multi-scale boundary features; the Cross-modal Link Structure (CMLS), which enables information exchange between detection and segmentation branches; and the Equilibrium Map loss function, which mitigates class imbalance issues. …”
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Higher-order thalamic input to cortex selectively conveys state information by Garrett T. Neske, Jessica A. Cardin

“…However, the relative contributions of corticocortical and thalamocortical inputs to higher-order cortical function remain unclear. Using imaging of neurons and axon terminals in combination with optogenetic manipulations, we find that the higher-order visual thalamus of mice has a unique impact on the posterior medial visual cortex (PM). …”
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New insights on microRNAs in diabetic nephropathy: potential biomarkers for diagnosis and therapeutic targets by Elena Sergeevna Kamyshova, Irina Nikolaevna Bobkova, Irina Mikhailovna Kutyrina

“…Diabetic nephropathy (DN) is a severe complication of diabetes mellitus associated with the progressive deterioration of renal function. Although microalbuminuria is considered as a gold standard for DN diagnosis, it has limited predictive powers and specificity as a diagnostic tool for the early stage of DN. …”
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Review of Fast Computation Methods for Finite-State Predictive Control of Multi-Phase Drives by Esteban Marsal, Manuel R. Arahal, Manuel G. Satué, Manuel Perales

“…Optimizing the cost function in predictive control of multi-phase drives is computationally intensive. …”
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Mitochondria as a Disease-Relevant Organelle in Rheumatoid Arthritis: A Key Breakout in Fight Against the Disease by Antonella Iaconis, Francesco Molinari, Roberta Fusco, Rosanna Di Paola

“…Mitochondrial activity influences many aspects of the disease that will be discussed in terms of their correlation with the onset and persistence of RA, starting from mitochondrial dynamics up to bone homeostasis, passing through DAMPs and affecting immune cell functionality. Recent therapeutic approaches aim to improve mitochondrial function, reduce oxidative stress, modulate mitochondria-mediated inflammation and restore energy metabolism homeostasis.…”
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Fermentation characteristics and probiotic activity of a purified fraction of polysaccharides from Fuzhuan brick tea by Guijie Chen, Ziqi Zeng, Minhao Xie, Yujia Peng, Wangting Zhou, Weiqi Xu, Yi Sun, Xiaoxiong Zeng, Zhonghua Liu

“…Polysaccharides from Fuzhuan brick tea (FBTPS), one of most important bioactive components in tea, showed various health-promoting functions. Our previous work demonstrated that the crude FBTPS (CFBTPS) could modulate the gut microbiota. …”
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The role of polysaccharides in immune regulation through gut microbiota: mechanisms and implications by Ting Zhao, Congyue Wang, Yuhan Liu, Bo Li, Mingjia Shao, Wuyang Zhao, Chuang Zhou

“…Polysaccharides, as complex carbohydrates, play a pivotal role in immune modulation and interactions with the gut microbiota. …”
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T-cell agonists in cancer immunotherapy by Gennaro Ciliberto, Aung Naing, Joud Hajjar, Cara L Haymaker, Yeonjoo Choi, Yaoyao Shi

“…Other mechanisms for promoting antitumor T-cell function are the targeting of costimulatory molecules expressed on the surface of T cells, such as 4-1BB, OX40, inducible T-cell costimulator and glucocorticoid-induced tumor necrosis factor receptor. …”
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The gut–brain axis in irritable bowel syndrome: neuroendocrine and epigenetic pathways by Lemonica Koumbi, Maria-Anna Giannelou, Lorys Castelli

“…Serotonin, histamine, and dopamine further modulate pain perception, stress responses, and gut function, while sex hormones contribute to IBS’s sex-based prevalence. …”
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The Genus <i>Cordyceps</i> Sensu Lato: Their Chemical Constituents, Biological Activities, and Therapeutic Effects on Air Pollutants Related to Lung and Vascular Diseases by Hye-Jin Park

“…<i>Cordyceps</i> supplementation may support lung health and enhance respiratory function. Although further clinical data are necessary, many preclinical studies have found a connection between <i>Cordyceps</i> and improved lung health. …”
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Wireless Monitoring of Household Electrical Power Meter Using Embedded RFID with Wireless Sensor Network Platform by Wasana Boonsong, Widad Ismail

“…WSN through ZigBee technology is applied to monitor data and to read the load consumption from the electrical household power meter by embedding a tag module into the meter. In-house built-in tag was embedded into an electrical power meter with a power management circuit communicating to a reader at an RF signal of 2.45 GHz based on the star network topology with the sleep mode function. …”
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Enrichment of rare CFTR variants in Finnish patients with congenital chloride diarrhea. by Satu Wedenoja, Jarmo Ritari, Jukka Partanen, Juha Kere, Kaija-Leena Kolho

“…<h4>Objective</h4>The autosomal recessive disease congenital chloride diarrhea (CLD), caused by loss-of-function mutations in the solute carrier family 26 member 3 (SLC26A3) gene, shows association with inflammatory bowel disease (IBD). …”
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<i>Lactobacillus</i> sp. for the Attenuation of Metabolic Dysfunction-Associated Steatotic Liver Disease in Mice by Titilayo Olotu, Jessica M. Ferrell

“…Part of the significant progress made in understanding the pathogenesis of steatosis has come from identifying the complex interplay between the gut microbiome and liver function. Recently, probiotics have shown beneficial effects for the treatment and prevention of steatosis and MASLD in rodent models and in clinical trials. …”
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C. elegans dopaminergic D2-like receptors delimit recurrent cholinergic-mediated motor programs during a goal-oriented behavior. by Paola Correa, Brigitte LeBoeuf, L René García

“…Calcium imaging and optogenetics suggest that heightened DA-expressing ray neuron activities coincide with the cholinergic cloacal ganglia function during spicule insertion attempts. D2-like receptor signaling also attenuates the excitability of additional mating circuits to reduce the duration of mating attempts with unproductive and/or inappropriate partners. …”
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Using In Vitro Models to Study the Interactions Between Environmental Exposures and Human Microbiota by Qiwen Cheng, Shengxi Chen

“…Exposure to environmental factors, such as chemical contaminants and biological agents, has the potential to alter the composition and function of microbiota, thereby influencing health outcomes. …”
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A case series on neurocysticercosis without seizures in alcohol-dependent patients by Mohd R. Alam, Richa Tripathi, Hina Bano, Manoj Prithviraj

“…The absence of seizures may relate to alcohol’s complex modulation of immune function and neuronal excitability. …”
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