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8381
The role of gut microbiota in autoimmune disease progression and therapy: a comprehensive synthesis
Published 2025-05-01“…Emerging evidence underscores the bidirectional interactions between microbiota and immune pathways, particularly through mechanisms like mucosal immune modulation and regulatory T-cell activity. Microbiota dysbiosis, characterized by altered diversity and function, is consistently associated with autoimmune conditions such as rheumatoid arthritis, multiple sclerosis, and type 1 diabetes. …”
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8382
Research and Realization of Wind Farm Inertia Response and Primary Frequency Regulation Scheme
Published 2022-02-01“…In order to improve the grid stability and the anti-interference ability of grid frequency, wind farms urgently need to have frequency regulation function and increase frequency response speed. According to the latest technical requirements such as starting time and adjustment time of grid, this paper analyzes the current mainstream frequency regulation schemes in the market. …”
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8383
Small target detection of bearing surface defects based on improved YOLOv5s.
Published 2025-01-01“…Finally, an original loss function is replaced with Normalized Wasserstein Distance (NWD) to decrease the susceptibility to small object positional deviations. …”
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8384
Analytical Model for Photonic Compressive Sensing With Pulse Stretch and Compression
Published 2019-01-01“…The time-domain compression of the stretched pulse was regarded as the integration function in the CS process (but it has never been proved), which is a key to realize time-domain downsampling or single-pixel imaging. …”
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8385
Spectrum Allocation Using Integer Linear Programming and Kerr Optical Frequency Combs
Published 2024-11-01“…The proposed approach offers a flexible cost function that prioritizes system constraints such as transmission distance and bandwidth requirements, resulting in significant improvements to the bandwidth blocking rate (BBR). …”
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8386
A Crowd Density Detection Algorithm for Tourist Attractions Based on Monitoring Video Dynamic Information Analysis
Published 2020-01-01“…In this paper, novel scale perception module and inverse scale perception module are designed to further facilitate the mining of multiscale information by the counting model; the main function of the third stage is to generate the population distribution density map, which mainly consists of three columns of void convolution with different void rates and generates the final population distribution density map using the feature maps of different branch regressions. …”
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8387
Revealing arginine-cysteine and glycine-cysteine NOS linkages by a systematic re-evaluation of protein structures
Published 2025-05-01“…Abstract Nitrogen-oxygen-sulfur (NOS) linkages act as allosteric redox switches, modulating enzymatic activity in response to redox fluctuations. …”
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8388
Egocentric and allocentric representations in auditory cortex.
Published 2017-06-01“…A key function of the brain is to provide a stable representation of an object's location in the world. …”
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8389
The Multilayer Connectome of Caenorhabditis elegans.
Published 2016-12-01“…Connectomics has focused primarily on the mapping of synaptic links in the brain; yet it is well established that extrasynaptic volume transmission, especially via monoamines and neuropeptides, is also critical to brain function and occurs primarily outside the synaptic connectome. …”
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8390
Genistein partly eases aging and estropause-induced primary cortical neuronal changes in rats.
Published 2014-01-01“…Gonadal hormones can modulate brain morphology and behavior. Recent studies have shown that hypogonadism could result in cortical function deficits. …”
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8391
<italic>M</italic>-ary overmodulation based on cyclic shift symbols for pilot-free short packet communication scheme
Published 2024-08-01“…The scheme adopted cycle code shift keying (CCSK) to modulate pseudo noise (PN) sequences, and used <italic>M</italic>-ary overmodulation sequences to perform secondary modulation on multiple CCSK symbols. …”
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8392
Deubiquitination of epidermal growth factor receptor by ubiquitin-specific peptidase 54 enhances drug sensitivity to gefitinib in gefitinib-resistant non-small cell lung cancer cel...
Published 2025-01-01“…While the significance of USP54 in tumorigenesis is known, its specific function in cancer progression remains unclear. This study investigates the role of USP54 in gefitinib sensitivity in gefitinib-resistant non-small cell lung cancer (NSCLC) cells. …”
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8393
Uncovering key regulatory pathways and prognostic biomarkers in the tumor microenvironment of high-grade serous ovarian cancer through single-cell RNA sequencing and experimental v...
Published 2025-05-01“…Our findings offer new insights into the molecular mechanisms governing the TME of HGSOC, although further investigation is needed to fully elucidate the functional role of SDC4 in ovarian cancer progression.…”
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8394
High-content image-based pooled screens reveal regulators of synaptogenesis
Published 2025-07-01“…Summary: Synapse formation is a fundamental process that shapes the connectivity and function of the nervous system, but the mechanisms regulating synaptogenesis are incompletely understood. …”
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8395
GelMA Core–Shell Microgel Preparation Based on a Droplet Microfluidic Device for Three-Dimensional Tumor Ball Culture and Its Drug Testing
Published 2025-08-01“…These outcomes confirmed both the protective function of the core–shell architecture during encapsulation and the overall biocompatibility of the microgels. …”
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8396
Tailhook Recognition for Carrier-Based Aircraft Based on YOLO with Bi-Level Routing Attention
Published 2024-11-01“…Additionally, the loss function was optimized to accelerate the bounding box regression process. …”
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8397
Regulation of Hazelnut Leaf Polyphenols on Oxidative Stress in Chronic Alcoholic Liver Injury
Published 2025-06-01“…Additionally, HLP improves liver function by modulating the Nrf2/Keap1 pathway, reducing ALT and AST levels in mice, and correcting the body's redox imbalance. …”
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8398
Liquid–liquid phase separation regulates gene expression in plants
Published 2025-06-01“…Liquid–liquid phase separation (LLPS) is recognized as a key process for the efficient organization of macromolecules, including numerous proteins and nucleic acids, within cells, facilitating the formation and function of various membraneless organelles. Growing evidence shows that environmental cues, including light, temperature, hormones, and pathogens, trigger the LLPS of phase-separating proteins with intrinsically disordered or multimerization regions, thereby modulating plant growth and development. …”
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8399
The role and mechanisms of exosome microRNA in regulating metastasis within the tumor microenvironment of prostate cancer
Published 2025-06-01“…Recent studies have highlighted the important function of exosome microRNAs (miRNAs) in governing metastatic processes within the tumor microenvironment (TME). …”
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8400
KRAS and NRF2 drive metabolic reprogramming in pancreatic cancer cells: the influence of oxidative and nitrosative stress
Published 2025-06-01“…In addition, we highlight a novel function of NRF2 in regulating the expression of NOS2 by binding to a DNA enhancer element, thereby modulating the production of reactive nitrogen species (RNS). …”
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